BeneFIX injection is used to control active bleeding episodes, manage bleeding around surgery, and reduce the frequency of bleeding episodes in people with hemofilia B.
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Descúbrelo ahoraBeneFIX Introduction and Uses
BeneFIX is a brand-name prescription product. It contains the active ingredient recombinant coagulation factor IX.
This medication belongs to the drug class known as coagulation factors or hemostatics.
Un proveedor de atención médica puede recetar este medicamento a niños y adultos con hemofilia B para:
- Tratar y controlar los episodios de sangrado.
- Controlar el sangrado alrededor de la cirugía
- Reducir la frecuencia de los episodios de sangrado
En las personas con hemofilia B, la sangre no coagula correctamente debido a una deficiencia del factor de coagulación IX. Esta deficiencia causa sangrado anormal después de lesiones o cirugías. La hemofilia B grave puede causar hemorragias articulares o musculares espontáneas.
BeneFIX is not indicated for immune tolerance induction in people with hemophilia B.
BeneFIX comes as a white powder in single-use vials. The powder must be mixed with the provided liquid (diluent) before infusion into a vein.
Each BeneFIX kit contains:
- Single-use vial
- Sterile pre-filled diluent syringe
- Vial adapter reconstitution device
- Sterile infusion set
- Dos toallitas con alcohol
- Bandage
- Gauze pad
Las siguientes concentraciones están disponibles en EE. UU.:
- 250 UI
- 500 UI
- 1.000 UI
- 2.000 UI
- 3.000 UI
BeneFIX Mechanism of Action
BeneFIX temporarily replaces the missing clotting factor IX. This helps restore the clotting process and control bleeding.
Before Taking BeneFIX
Before you receive your first dose of BeneFIX for hemophilia B, inform your healthcare provider if you:
- Are allergic to any factor IX product or hamster proteins
- Tener o haber tenido alguna afección médica
- Have or have previously developed factor IX inhibitors
- ¿Está amamantando?
- ¿Está embarazada o planea quedar embarazada?
Don’t use BeneFIX if you are allergic to factor IX, any ingredients of this product, or hamster proteins.
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BeneFIX Dosing
Before administering BeneFIX, your healthcare provider will use a specific formula to determine the initial dose. The dose and duration of the treatment depend on:
- Edad
- Peso corporal
- Gravedad de la deficiencia del factor IX
- Nivel deseado de factor IX
- Estado del paciente
- Ubicación y extensión del sangrado
Dosing of BeneFIX to Control Bleeding Episodes and Manage Bleeding Around Surgery
Sangrado leve: The dose is calculated to achieve a factor IX activity of 20% to 30% of normal. May be repeated every 12 to 24 hours. Treatment lasts 1 to 2 days.
Sangrado moderado: The dose is calculated to achieve a factor IX activity of 25% to 50% of normal. May be repeated every 12 to 24 hours. Treatment lasts until bleeding stops or healing occurs. This is typically 2 to 7 days.
Sangrado mayor: The dose is calculated to achieve a factor IX activity of 50% to 100% of normal. May be repeated every 12 to 24 hours. Treatment lasts 7 to 10 days.
Dosificación para la prevención rutinaria de episodios hemorrágicos
For long-term protection against bleeding, the recommended dose is 100 IU/kg once weekly. Your healthcare provider may adjust the dose or frequency based on your clinical response.
Uso adecuado
- Use este o cualquier otro medicamento exactamente como se indica.
- Your healthcare provider may administer BeneFIX or teach you how to prepare and self-administer the medication.
- Ask your doctor or pharmacist if you have problems understanding any part of the Instructions for Use.
- The reconstituted solution should be clear and colorless. If it is not, don’t use it.
- Use the reconstituted solution immediately or within 3 hours of mixing.
- If you miss a scheduled dose, contact your healthcare provider for instructions.
- Call your healthcare provider immediately if you take more than the prescribed dose.
- Call your healthcare provider immediately if your bleeding does not stop after taking this medication. This may be a sign that the medication is not working as intended.
BeneFIX Storage and Handling
- Store BeneFIX at room temperature or in a refrigerator, between 2 and 30°C (36 and 86°F).
- No te congeles.
- Don’t use BeneFIX after the expiration date stated on the label.
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Acerca de la asistencia para copagosBeneFIX Side Effects
Efectos secundarios comunes
- Fiebre
- Tos
- Náuseas
- Pain, swelling, or redness at the injection site
- Dolor de cabeza
- Mareo
- Erupción
Reacciones alérgicas
Busque atención médica de emergencia si tiene:
- sibilancias
- Dificultad para respirar
- Opresión en el pecho
- Bluish lips and gums
- ritmo cardíaco acelerado
- Hinchazón de la cara
- Erupción
- Urticaria
Producción de inhibidores (anticuerpos)
Your healthcare provider will likely order tests to measure factor IX inhibitors in your blood if:
- El nivel de factor IX no aumenta como se esperaba después de iniciar el tratamiento
- El sangrado no se detiene con una dosis adecuada
Complicaciones debidas a vasos sanguíneos bloqueados
Los productos de factor IX pueden aumentar el riesgo de que un coágulo sanguíneo obstruya un vaso sanguíneo. El riesgo puede ser mayor si recibe infusiones continuas a través de una vena grande.
Contact your healthcare provider immediately if you have:
- Dolor en el pecho
- Dificultad para respirar
- Leg tenderness
- Hinchazón
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BeneFIX Cost and Financial Assistance
The amount you pay for BeneFIX can vary depending on your prescribed dose, treatment frequency, insurance coverage, pharmacy, and location. Because BeneFIX dosing is individualized, treatment costs can vary between patients.
Contact your insurance provider to find out if your plan covers BeneFIX or requires prior authorization. Insurance coverage and patient assistance programs may help reduce your out-of-pocket costs. Contáctanos si está interesado en explorar la asistencia financiera o copay assistance for BeneFIX.
