Jynarque and Samsca are brand-name prescription medications. Both contain the same active ingredient, tolvaptan. However, these products treat different conditions and should not be used interchangeably.
Nhận hỗ trợ tài chính
Jynarque
Jynarque is used to slow kidney function decline in adults who are at risk of rapidly progressing autosomal dominant polycystic kidney disease (ADPKD).
ADPKD is an inherited kidney disease in which fluid-filled sacs (cysts) form in the kidneys. These cysts gradually impair kidney function as they grow and may lead to kidney failure. There’s no cure for this condition.
Samsca
Samsca is used to treat clinically significant low blood sodium levels (hyponatremia) in certain adults, including some people with heart failure or Syndrome of Inappropriate Antidiuretic Hormone (SIADH).
Jynarque vs. Samsca
| Brands | Jynarque | Samsca |
| Nhà sản xuất | Otsuka Pharmaceutical Co., Ltd. | Otsuka Pharmaceutical Co., Ltd. |
| Sự chấp thuận của FDA | 2018 | 2009 |
| Drug class | Vasopressin V2 receptor antagonists | Vasopressin V2 receptor antagonists |
| Dosage form | Viên uống | Viên uống |
| Điểm mạnh hiện có | 15 mg, 30 mg, 45 mg, 60 mg, and 90 mg | 15 mg and 30 mg |
| Duration of treatment for the indicated condition | Years, decades, or until kidney failure occurs | No longer than 30 days |
| Khả dụng | Available only through the Tolvaptan for ADPKD Shared System REMS* | Not restricted by REMS* for hyponatremia. Should be initiated or reinitiated in a hospital |
*REMS (Risk Evaluation and Mitigation Strategies) is a drug safety program. The FDA requires REMS for certain medicines that have serious risks.
Important Tolvaptan (Jynarque/Samsca) Information and Warnings
Jynarque
This medication can cause serious liver problems, which can be fatal or require you to have a liver transplant. That’s why it is available only through the Tolvaptan for ADPKD Shared System REMS.
Stop taking this medication and call your healthcare provider immediately if you have:
- Mệt mỏi bất thường
- Mất cảm giác thèm ăn
- Buồn nôn
- Pain in the right upper stomach
- Nôn mửa
- Sốt
- Phát ban
- Ngứa
- Yellowing of the skin and eyes (jaundice)
- Nước tiểu sẫm màu
- Phân nhạt màu
Your healthcare provider will order blood tests to check your liver before you start Jynarque, 2 weeks and 4 weeks after starting treatment, monthly for the first 18 months, and every 3 months thereafter.
Nhận hỗ trợ đồng thanh toán ngay
Samsca
This medication may cause blood sodium levels to rise too quickly, potentially leading to osmotic demyelination syndrome (ODS). ODS is a serious neurological condition that can occur when severely low sodium levels are corrected too rapidly. It can cause serious neurological problems, coma, or death.
Call your healthcare provider immediately if you have:
- Difficulty speaking or swallowing
- Buồn ngủ
- Lú lẫn
- Thay đổi tâm trạng
- Weakness or difficulty controlling movements in the arms or legs
- Động kinh
The following factors may increase the risk of ODS. Inform your healthcare provider if you have any of them.
- Bệnh gan
- Suy dinh dưỡng
- Extremely low blood levels of sodium
- Chronic alcoholism
To lower the risk of ODS, your healthcare provider will start and restart treatment with Samsca in a hospital, where you can be monitored closely. You should drink water when you are thirsty. Also, you should keep water readily available at all times during treatment.
Samsca may cause potentially fatal liver problems. Call your healthcare provider immediately if you have:
- Mệt mỏi bất thường
- Mất cảm giác thèm ăn
- Buồn nôn
- Pain in the right upper stomach
- Nôn mửa
- Sốt
- Phát ban
- Ngứa
- Yellowing of the skin and eyes (jaundice)
- Nước tiểu sẫm màu
- Phân nhạt màu
Samsca should not be taken for more than 30 days because of the risk of liver injury. It should generally be avoided in people with underlying liver disease, including cirrhosis.
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Về Trợ cấp đồng thanh toánBefore Taking Tolvaptan (Jynarque/Samsca)
Jynarque
Before you receive your first dose of Jynarque, inform your provider if you:
- Bạn bị dị ứng với sản phẩm này hoặc bất kỳ thành phần nào của sản phẩm?
- Have a history of extremely low sodium levels
- Đang mang thai hoặc có ý định mang thai
- Are breastfeeding or plan to breastfeed (Avoid breastfeeding during treatment)
Taking Jynarque with certain medicines may raise blood levels of tolvaptan. Ask your healthcare provider which medicines you can take with Jynarque. Your dose of Jynarque may need to be reduced. Talk to your healthcare provider before starting a new medication.
Don’t take Jynarque if you:
- Have a history, signs, or symptoms of significant liver impairment or injury, other than uncomplicated polycystic liver disease
- Take certain medications that are strong CYP3A inhibitors
- Have an abnormal blood sodium level that has not been corrected
- Are unable to sense or appropriately respond to thirst
- Are dehydrated
- Have hypovolemia (abnormally low fluid volume in the body)
- Have a urinary tract obstruction that has not been corrected
- Are unable to produce urine
Samsca
Before you receive your first dose of Samsca, inform your provider if you:
- Bạn bị dị ứng với sản phẩm này hoặc bất kỳ thành phần nào của sản phẩm?
- Have kidney or liver problems
- Cannot make urine
- Are unable to feel that you are thirsty
- Đang mang thai hoặc có ý định mang thai
- Đang cho con bú hoặc có kế hoạch cho con bú
- Take desmopressin (dDAVP)
Don’t take Samsca if you:
- Are allergic to tolvaptan or any of the ingredients in Samsca
- Need an urgent increase in your blood sodium level
- Are unable to sense or appropriately respond to thirst
- Have hypovolemic hyponatremia (low blood sodium associated with low fluid volume)
- Take certain medications called strong CYP3A inhibitors
- Are unable to produce urine
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Tolvaptan (Jynarque/Samsca) Mechanism of Action
Tolvaptan belongs to a class of medications called vasopressin V2 receptor antagonists. It works by blocking the effects of vasopressin, a hormone that normally causes the kidneys to retain water.
In people with ADPKD, blocking vasopressin V2 receptors helps reduce processes involved in kidney cyst growth and slows the decline in kidney function.
Tolvaptan also causes the kidneys to remove more water through urine without proportionally increasing sodium loss. In people with certain types of hyponatremia, this loss of excess water can help increase the concentration of sodium in the blood.
Tolvaptan (Jynarque/Samsca) Dosing
Jynarque
The starting total dose is 60 mg orally per day, which is divided into: 45 mg upon waking and 15 mg 8 hours later. If tolerated, the dose may be increased to 90 mg orally per day (60 mg upon waking and 30 mg 8 hours later).
The highest dose is 120 mg orally per day (90 mg upon waking and 30 mg 8 hours later).
Samsca
The usual starting dose is 15 mg orally with or without food. The dose may be increased to 30 mg orally once daily after at least 24 hours. The maximum dose is 60 mg orally once daily. Don’t take this medication for longer than 30 days in order to reduce the risk of liver injury.
Tolvaptan (Jynarque/Samsca) Proper Use and Storage
- Hãy uống thuốc đúng theo chỉ dẫn. Uống thuốc vào khoảng cùng một thời điểm mỗi ngày.
- Bạn có thể dùng thuốc này cùng hoặc không cùng thức ăn.
- Avoid drinking grapefruit juice while on treatment with this medication.
- Drink enough water to prevent dehydration.
- Call your healthcare provider if you have vomiting or diarrhea.
- If you miss a dose, don’t double the dose. Continue your schedule as usual.
- If you think you have overdosed, call your healthcare provider immediately.
- If you need to stop taking Samsca because your healthcare provider told you to, ask them how much fluid you can take safely.
- Để thuốc xa tầm tay trẻ em và vật nuôi.
- Store Jynarque at77°F (25°C).
- Store Samsca between 68°F and 77°F (20°C and 25°C).
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Speak to a Specialist and Find OutTolvaptan (Jynarque/Samsca) Side Effects
Common Side Effects of Jynarque
- Khát nước
- Drinking more fluid than normal
- Đi tiểu thường xuyên
- Tăng lượng nước tiểu
- Urinating at night
Severe Side Effects of Jynarque
- Hypernatremia (elevated blood sodium levels)
- Dehydration and hypovolemia (loss of too much fluid from the body)
Jynarque increases water loss through urination and can cause dehydration and hypovolemia (abnormally low fluid volume). Drink enough water throughout the day and night to avoid becoming thirsty or dehydrated. If you cannot drink enough water for any reason, stop taking Jynarque and contact your healthcare provider.
Call your healthcare provider if you experience any of the following:
- Chóng mặt
- Ngất xỉu
- Giảm cân
- Changes in heart rhythm
- Lú lẫn
- Cực kỳ yếu đuối
Common Side Effects of Samsca
- Khát nước
- Khô miệng
- Điểm yếu
- Táo bón
- Đi tiểu thường xuyên
- Tăng lượng nước tiểu
- Elevated blood glucose levels
Severe Side Effects of Samsca
Call your healthcare provider immediately if you have signs of dehydration, such as dizziness or feeling like you are going to pass out. Tell your healthcare provider if you have vomiting or diarrhea and difficulty drinking fluids.
Tolvaptan (Jynarque/Samsca) Cost
Chi phí có thể thay đổi tùy thuộc vào gói bảo hiểm, địa điểm và hiệu thuốc của bạn. Hãy hỏi nhà cung cấp bảo hiểm xem gói bảo hiểm của bạn có chi trả cho loại thuốc này không hoặc bạn có cần phải xin phép trước không.
Otsuka offers copay assistance for eligible patients who have been prescribed Jynarque. Liên hệ với chúng tôi if you are interested in getting copay assistance for tolvaptan.
