How Assistance Works
Streamlining our patient’s specialty pharmacy experience with unmatched full-service convenience
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1. Check Your Coverage/Benefits Verification
Our team of expert billers finds the best avenues of coverage that minimize out-of-pocket costs.
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2. Transfer Prescription to AmeriPharma®
We process your prescription by working with your previous pharmacy or prescriber, making the transition quick and easy.
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3. Prior Authorization
Our team of specialists obtains approval from your insurance companies within 24 to 72 hours.
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4. Copay Assistance & Financial Aid
We secure financial aid and decrease copays, out-of-pocket expenses, and high deductibles. To date, AmeriPharma® Specialty Care has secured $55 million in financial assistance for our patients.
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5. Nursing Care Coordination If Needed
AmeriPharma® puts your schedule and home environment first when scheduling and coordinating one of our specialized nurses for your in-home infusions.
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6. Delivery Coordination
Medications are always delivered in strict compliance with the specific requirements for shipping. Next-day and overnight cold-chain deliveries are coordinated around your schedule.
What Is Vonvendi?
Vonvendi is an FDA-approved recombinant von Willebrand factor (VWF) medicine. In adults and children with von Willebrand disease (VWD), it is used for on-demand treatment and control of bleeding episodes and for perioperative management of bleeding. In adults, Vonvendi is also approved for routine preventive treatment (prophylaxis) to reduce the frequency of bleeding episodes.
The FDA first approved Vonvendi in the United States in 2015. Unlike plasma-derived VWF products, such as Humate-P, Vonvendi contains recombinant VWF and is not derived from human plasma.
Vonvendi comes as a powder that is mixed with sterile water before it is given as an intravenous (IV) injection.
What Is Vonvendi Used For?
Vonvendi is FDA-approved for certain uses in adults and children with von Willebrand disease (VWD), although not all approved uses apply to both age groups. Vonvendi contains a recombinant version of VWF, a protein that plays an important role in blood clotting. It temporarily replaces deficient or dysfunctional VWF in people with VWD. Vonvendi is FDA-approved for:
On-Demand Treatment and Control of Bleeding Episodes: People with VWD can use Vonvendi when they experience bleeding that requires replacement of von Willebrand factor (VWF). Depending on the severity and location of the bleeding, you may need several doses.
Management of Bleeding Around Surgery: Vonvendi can be used before, during, and after surgery to help manage bleeding.
Routine Preventive Treatment of Bleeding: Adults with VWD can receive Vonvendi regularly as routine prophylaxis to reduce the frequency of bleeding episodes.
Please note that Vonvendi does not cure von Willebrand disease (VWD). Instead, it temporarily replaces the missing or defective VWF and helps your body control bleeding.
How Vonvendi Copay Assistance Works
AmeriPharma® Specialty Pharmacy alleviates financial burdens for patients and their families
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Advanced software locates funding sources to match you with top-dollar foundation programs
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One of our copay assistance specialists will assist with the application process
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Automatic updates will be sent to you and your physician on the status of the funding
Vonvendi Dosage
Vonvendi comes as a powder that is reconstituted before administration and is given intravenously. Dosing is individualized according to factors such as body weight, the type and severity of bleeding, the clinical situation, and VWF and factor VIII levels. Your healthcare provider will determine the appropriate dose and treatment schedule. The following summarizes dosing recommendations from the prescribing information:
For On-Demand Treatment and Control of Bleeding Episodes: For minor bleeding, such as a nosebleed or oral bleeding, the recommended initial dose is 40–50 IU/kg. Subsequent doses of 40–50 IU/kg may be administered every 8–24 hours as clinically required.
For major bleeding, the recommended initial dose is 50–80 IU/kg. Subsequent doses of 40–60 IU/kg may be administered every 8–24 hours for approximately 2–3 days, or as clinically required.
For Surgery: Perioperative dosing is individualized according to the type of surgery and the patient’s VWF and factor VIII levels. For elective surgery, a preoperative dose of Vonvendi may be given 12–24 hours before surgery when needed to allow the patient’s factor VIII level to increase. VWF and factor VIII levels are assessed before surgery, and an additional dose may be administered within 1 hour before the procedure to achieve appropriate target levels. Emergency surgery and postoperative dosing require individualized management based on factor levels and clinical response.
For Routine Preventive Treatment: The recommended dose for adults is 40–60 IU/kg twice weekly.
Vonvendi Side Effects
Common side effects include:
- Headache
- Vomiting
- Nausea
- Dizziness
- Itching
Serious side effects:
Vonvendi can cause serious adverse reactions. Important risks and warnings include hypersensitivity reactions, thromboembolic events, and the development of neutralizing antibodies (inhibitors).
Hypersensitivity Reactions: Severe allergic reactions, including anaphylaxis, can occur with Vonvendi. Signs and symptoms may include hives, generalized itching, swelling, difficulty breathing, rapid heartbeat, chest tightness, dizziness, or low blood pressure. Stop the infusion and seek immediate medical attention if signs of a severe allergic reaction occur.
Blood Clots (Thromboembolic Events): Blood clots in arteries or veins have occurred in patients receiving Vonvendi, particularly in people with risk factors for thrombosis. Your healthcare provider may monitor you for signs of blood clots and may also monitor factor VIII levels when Vonvendi is given with recombinant factor VIII. Seek prompt medical attention for symptoms such as chest pain, shortness of breath, or pain or swelling in an arm or leg.
Development of Inhibitors: Neutralizing antibodies (inhibitors) against VWF and/or factor VIII can develop during treatment. If expected VWF activity or factor VIII levels are not achieved, or if bleeding is not controlled with an appropriate dose, your healthcare provider may perform tests for inhibitors.
Please note that this is not a complete list of all possible side effects. Contact your doctor immediately if you experience any severe side effects of Vonvendi.
Insurances Accepted
We accept Medicare, multi-state Medicaid, Medi-Cal, Blue Shield, and most private insurances. Call us to find out more about your coverage.
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