AmeriPharma’s premier pharmacy services are available in multiple states throughout the US.
Mon - Fri: 9:00AM - 10:00PM Sat - Sun: Closed

Related Posts

Welcome to Infusion Center

How Often Do You Change TPN Tubing?

Home  /  TPN   /  How Often Do You Change TPN Tubing?
TPN tubing and supplies laid out on a table

Generally, TPN tubing should be replaced every 24 hours. Changing the tubing reduces the risk of catheter-associated blood infection. 


Get Financial Assistance for TPN


Total parenteral nutrition (TPN) delivers all your daily nutrients through a large vein. Because TPN solutions are concentrated and carry a risk of clots in the peripheral veins, they are usually administered through a central venous catheter (CVC). 

Over 4 in 10 individuals receiving parenteral nutrition (PN) are children or newborns. About 25,000 individuals receive PN at home [1].

This article discusses how often to change TPN tubing and the reason to do so. Also, you will find answers to the most common questions about TPN. 


Frequency of TPN Tubing Change: Understanding the Basics

How often you should change TPN tubing depends on the following factors:

  • Patient type specific (adult or children)
  • The presence/absence of lipids or fats in the solution 

In the case of parenteral nutrition without lipids, the TPN tubing should be changed every 24 hours (daily) for adults and at least every 96 hours for children. 

On the other hand, in the case of lipid-containing parenteral nutrition, you should change TPN tubing every 24 hours regardless of the patient type [2].


A Closer Look at the Guidelines

According to the “2014 ASPEN Parenteral Nutrition Safety Consensus Recommendations,” you should [3, 4]:

  • Replace the tubing and filter every 24 hours for both all-in-one and 2-in-1 parenteral nutrition. 
  • Change the set and filter every 12 hours if intravenous fat is administered separately. 

If intravenous fat is used for prolonged periods, divide the fat dose into two parts and use a new container and tubing every 12 hours. 

The 2016 Infusion Nurses Society (INS) recommends changing the administration set with each new parenteral nutrition container (or at least every 24 hours). 

On the other hand, “The Royal College of Physicians of Ireland Clinical Practice Guidelines” recommends changing:

  • Administration sets every 48 hours for 2-in-1 parenteral nutrition 
  • Lipid sets every 24 hours 

Note: These recommendations are for the general population. So, they should never replace a healthcare professional’s judgment about the specific circumstances of an individual patient.


Why Should You Change TPN Tubing Frequently?

The primary reason to change TPN tubing frequently is to prevent catheter-related bloodstream infections (CRBSI).

CRBSI is a common yet potentially lethal complication of parenteral nutrition. In CRBSI, bacteria originating at the catheter pass to your bloodstream. This triggers your immune system to respond aggressively, causing:

  • Fever
  • Increased white blood cells
  • Dangerously low blood pressure
  • Multiple organ failure

Death may occur in 3% to 25% of CRBSI cases [5].


Why Is TPN Tubing Changed More Frequently in Lipid-containing Parenteral Nutrition?

Lipids provide an ideal environment for the growth of bacteria responsible for catheter-related bloodstream infections (CRBSI). 

In a 2010 study, Japanese researchers concluded some bacterial species might grow in lipid-containing TPN solutions. They also noted that Candida (a type of fungus) grew rapidly, irrespective of the lipid content [6].

In general, it is safe to assume that lipid-containing solutions are more likely than lipid-free preparations to promote microbial growth. 


Ask About TPN Home Infusion


How Often Do You Change Your TPN Filter?

Professional organizations like ASPEN, INS, and the Royal College of Nursing recommend changing the TPN filter every:

  • 24 hours for all-in-one solutions. 
  • 12 hours for undiluted lipids. 


How Many Times Can You Reuse IV Tubing?

You should NEVER reuse IV tubing, syringes, or needles. 


Contact Us

By submitting, you agree to AmeriPharma’s Terms of UsePrivacy Policy, and Notice of Privacy Practice



  1. ASPEN | What Is Parenteral Nutrition.
  2. UNC Health Care. Infection Control Manual.
  3. Ayers, Phil; Adams, Stephen; Boullata, Joseph; Gervasio, Jane M.; Holcombe, Beverly; Kraft, Michael D.; Marshall, Neil; Neal, Antoinette; Sacks, Gordon; Seres, David S.; Worthington, Patricia; and American Society for Parenteral and Enteral Nutrition, “A.S.P.E.N. Parenteral Nutrition Safety Consensus Recommendations” (2014). Scholarship and Professional Work – COPHS. 1.
  4. Gill, Marianne et al. “Filtering Out the Facts: Recommendations to Optimize Performance of In-Line Filters for Parenteral Nutrition and Injectable Lipid Emulsion Infusions.” Journal of infusion nursing : the official publication of the Infusion Nurses Society vol. 45,3 (2022): 137-141. doi:10.1097/NAN.0000000000000464
  5. Stephen Fletcher, Catheter-related bloodstream infection, Continuing Education in Anaesthesia Critical Care & Pain, Volume 5, Issue 2, April 2005, Pages 49–51,
  6. Kuwahara, Takashi et al. “Growth of microorganisms in total parenteral nutrition solutions containing lipid.” International journal of medical sciences vol. 7,3 101-9. 18 May. 2010, doi:10.7150/ijms.7.101

This information is not a substitute for medical advice or treatment. Talk to your doctor or healthcare provider about your medical condition prior to starting any new treatment. AmeriPharma Specialty Care assumes no liability whatsoever for the information provided or for any diagnosis or treatment made as a result, nor is it responsible for the reliability of the content.

AmeriPharma Specialty Care does not operate all the websites/organizations listed here, nor is it responsible for the availability or reliability of their content. These listings do not imply or constitute an endorsement, sponsorship, or recommendation by AmeriPharma Specialty Care.

This webpage may contain references to brand-name prescription drugs that are trademarks or registered trademarks of pharmaceutical manufacturers not affiliated with AmeriPharma Specialty Care.