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Liều dùng Vonvendi

Vonvendi comes as a powder that is reconstituted before administration and is given intravenously. Dosing is individualized according to factors such as body weight, the type and severity of bleeding, the clinical situation, and VWF and factor VIII levels. Your healthcare provider will determine the appropriate dose and treatment schedule. The following summarizes dosing recommendations from the prescribing information:

Dùng để điều trị và kiểm soát các đợt chảy máu theo yêu cầu: Đối với các trường hợp chảy máu nhẹ, chẳng hạn như chảy máu cam hoặc chảy máu miệng, liều khởi đầu được khuyến cáo là 40–50 IU/kg. Các liều tiếp theo 40–50 IU/kg có thể được dùng mỗi 8–24 giờ nếu cần thiết về mặt lâm sàng.

For major bleeding, the recommended initial dose is 50–80 IU/kg. Subsequent doses of 40–60 IU/kg may be administered every 8–24 hours for approximately 2–3 days, or as clinically required.

Đối với phẫu thuật: Perioperative dosing is individualized according to the type of surgery and the patient’s VWF and factor VIII levels. For elective surgery, a preoperative dose of Vonvendi may be given 12–24 hours before surgery when needed to allow the patient’s factor VIII level to increase. VWF and factor VIII levels are assessed before surgery, and an additional dose may be administered within 1 hour before the procedure to achieve appropriate target levels. Emergency surgery and postoperative dosing require individualized management based on factor levels and clinical response.

Đối với điều trị dự phòng định kỳ: The recommended dose for adults is 40–60 IU/kg twice weekly.