Carimune: A Comprehensive Guide to Its Benefits, Dosages, and Precautions

Carimune, also known by its generic name, immune globulin IGIV, is a medication typically prescribed to strengthen the immune system in patients who are at higher risk of certain infections. 

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Carimune belongs to the “immune globulins” drug class, and it is made up of highly purified and concentrated forms of IgG antibodies (96% of IgGs). This medication contains IgG immunoglobulins prepared from the pooled plasma of thousands of healthy donors. 

Carimune is available in sterile, lyophilized powder form that is reconstituted before infusion. Currently, this medication is being sold under various common brand names such as Bivigam, Flebogamma, Gammagard S/D, Gammaplex, Octagam, Panzyga, Privigen, Vigam, Vivaglobulin, and Carimune NP. 

What Is Carimune Used to Treat?

In addition to strengthening the patient’s immune system, Carimune can  also be prescribed for the following conditions:

IGIV may also be used off-label for other purposes not listed in this medication guide.

How Does It Work?

Since Carimune contains 96% of all IgG antibodies, it exerts a wide range of effects in patients with different conditions, which are as follows:

It Boosts the Immune System

Patients with primary immunodeficiency disorders such as X-linked agammaglobulinemia, common variable immunodeficiency, and severe combined immunodeficiency are more prone to various infections. 

Carimune works to boost the immune system by supplying the missing or deficient antibodies, ultimately reducing the frequency and severity of infection in these patients. 

It Increases Blood Clotting Cells (Platelets)

Patients with acute or chronic idiopathic thrombocytopenia purpura experience low levels of blood-clotting cells called platelets due to the attack of autoantibodies (abnormal antibodies produced by the immune system against healthy cells such as platelets).  

Carimune works to increase the level of platelets by neutralizing the effects of autoantibodies. 

It Modulates Hyperactive Immune Responses

Similarly, Carimune also neutralizes or blocks the action of autoantibodies in patients with CIDP or multifocal neuropathy (a disorder in which the immune system attacks the nerves).

It Prevents Infection and Aneurysm

In patients with B-cell chronic lymphocytic leukemia, Carimune helps to prevent certain infections. It also prevents aneurysms (which occur as a result of weakness in the main artery of the heart) in patients with Kawasaki disease.

What Are the Available Dosage Forms and Strengths?

Carimune comes in single-dose vials containing a white, lyophilized powder in the following strengths:

  • 3 g Carimune
  • 6 g Carimune
  • 12 g Carimune

You can only reconstitute the product in the following diluents: sterile water, 5% dextrose, or sterile (0.9%) sodium chloride injection USP. 

What Is the Usual Dosage of Carimune?

The dosage of Carimune is adjusted according to the patient’s body weight and disease severity. The following are the recommended doses of Carimune for ITP and primary immunodeficiency (PID). 

Dosage for ITP

For the treatment of ITP, a dose of 0.4g/kg of body weight should be administered in patients for 2 – 5 consecutive days.

Dosage for PID

The recommended dosage for the treatment of primary immunodeficiency in adults and children is 0.4 to 0.8 g/kg and should be administered once every 3 to 4 weeks. 

How Is Carimune Given?

Carimune is given as an intravenous infusion in the vein once every 3 to 4 weeks by an experienced healthcare provider.

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What Are the Side Effects of Carimune?

Doctor consulting with patient about the side effects of Carimune

Carimune has some side effects, along with its wide range of potential benefits. The following are the commonly reported side effects:

  • Arthralgia (joint pain)
  • Myalgia (muscle pain or weakness)
  • Transient skin reactions (such as rash, erythema, pruritus, urticaria, eczema or dermatitis)
  • Headache or dizziness
  • Nausea, diarrhea, or stomach pain
  • Fever
  • Increased blood pressure and heart rate
  • Sweating

Though it is rare, it can also cause some serious side effects, which include:

  • An increase in creatinine and blood urea nitrogen (BUN) 
  • Thrombosis
  • Renal (kidney) dysfunction such as acute renal failure, acute tubular necrosis, proximal tubular nephropathy, and osmotic nephrosis with progression to oliguria or anuria (little or no urine)
  • Lung problems such as difficulty breathing, chest pain, or blue-colored lips or skin
  • Dehydration
  • Aseptic meningitis
  • Blood clots

If you experience any side effects, immediately stop the infusion and consult your healthcare provider. 

What Precautions Should You Take?

Before taking Carimune infusion, it is important to consult your healthcare provider and share your current health status and medical history. Tell your doctor if you are:

  • Pregnant or intending to become pregnant: Since there is no data available on the effects of Carimune on an unborn baby, it is not known whether it can cause fetal harm or not. Therefore, it is important to consult your healthcare provider before taking Carimune infusion.
  • Breastfeeding: It is not clear whether Carimune passes to breastmilk; therefore, it is recommended that you avoid taking it if you are breastfeeding. 
  • IgA deficient, especially if you have known antibodies against IgA
  • Allergic to immunoglobulin products
  • Taking estrogen pills or contraceptives

Since this medication can cause blood clots or renal failure in older people or people with certain conditions, it is important to tell your doctor if you have ever had:

  • Diabetes mellitus
  • Sepsis
  • Kidney disease
  • Stroke or blood clot
  • Heart problems
  • Nephrotoxic drugs

Carimune is administered at a minimum concentration with a slow infusion rate in such patients. 

What Important Things Should You Know About Carimune?

Carimune can cause acute renal failure if you have a history of renal insufficiency. Similarly, it can also increase your risk of thrombosis if you have a history of venous or arterial thrombosis, hyperviscosity syndrome, or cardiovascular disease. 

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How Much Does Carimune Cost?

The cost of Carimune can be notably high for some patients. A single-dose vial of 6 g of intravenous powder costs about $611, and 12 g costs about $1,212. 

The cost of the medication can vary depending on the pharmacy you visit. However, if you are considering Carimune, it is advisable to consult with your healthcare provider about potential assistance programs that can help reduce out-of-pocket expenses.

Drug Summary

Carimune is a medication made up of immunoglobulins extracted from the blood plasma of healthy donors. It is used to reduce infection risks and treat conditions such as B-cell chronic lymphocytic leukemia, CIDP, ITP, PID, multiple focal neuropathies, and Kawasaki syndrome.


  1. The Food and Drug Administration (FDA): Carimune Prescribing Information:
  2. Berger, M., Cunningham-Rundles, C., Bonilla, F. A., Melamed, I., Bichler, J., Zenker, O., & Ballow, M. (2007). Carimune NF Liquid is a Safe and Effective Immunoglobulin Replacement Therapy in Patients with Primary Immunodeficiency Diseases. Journal of Clinical Immunology27(5), 503–509.
  3. Carimune, N. F., Flebogamma, D. I. F., & Oderda, G. (2015). Immune Globulin Agents (Human) Drug Class Review.
  4. Vo, A. A., Cam, V., Toyoda, M., Puliyanda, D. P., Lukovsky, M., Bunnapradist, S., … & Jordan, S. C. (2006). Safety and adverse events profiles of intravenous gammaglobulin products used for immunomodulation: a single-center experience. Clinical Journal of the American Society of Nephrology1(4), 844-852. DOI: 10.2215/CJN.01701105
  5. Levine, A. A., Levine, T. D., Clarke, K., & Saperstein, D. (2017). Renal and hematologic side effects of long-term intravenous immunoglobulin therapy in patients with neurologic disorders. Muscle & Nerve56(6), 1173-1176.
This information is not a substitute for medical advice or treatment. Talk to your doctor or healthcare provider about your medical condition prior to starting any new treatment. AmeriPharma™ Specialty Care assumes no liability whatsoever for the information provided or for any diagnosis or treatment made as a result, nor is it responsible for the reliability of the content. AmeriPharma™ Specialty Care does not operate all the websites/organizations listed here, nor is it responsible for the availability or reliability of their content. These listings do not imply or constitute an endorsement, sponsorship, or recommendation by AmeriPharma™ Specialty Care. This webpage may contain references to brand-name prescription drugs that are trademarks or registered trademarks of pharmaceutical manufacturers not affiliated with AmeriPharma™ Specialty Care.

Dr. Saba Rassouli, PharmD was born and raised in Iran. She received her pharmacy degree from Marshall B. Ketchum University in 2022, where she graduated cum laude. The most rewarding part of her job is having the opportunity to care for each patient as if they were family and hearing about how happy and satisfied they are with the services provided by AmeriPharma. In her free time, she likes to go on walks, read books, and try different restaurants and foods.

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