How Assistance Works
Streamlining our patient’s specialty pharmacy experience with unmatched full-service convenience
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1. Check Your Coverage/Benefits Verification
Our team of expert billers finds the best avenues of coverage that minimize out-of-pocket costs.
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2. Transfer Prescription to AmeriPharma®
We process your prescription by working with your previous pharmacy or prescriber, making the transition quick and easy.
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3. Prior Authorization
Our team of specialists obtains approval from your insurance companies within 24 to 72 hours.
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4. Copay Assistance & Financial Aid
We secure financial aid and decrease copays, out-of-pocket expenses, and high deductibles. To date, AmeriPharma® Specialty Care has secured $55 million in financial assistance for our patients.
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5. Nursing Care Coordination If Needed
AmeriPharma® puts your schedule and home environment first when scheduling and coordinating one of our specialized nurses for your in-home infusions.
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6. Delivery Coordination
Medications are always delivered in strict compliance with the specific requirements for shipping. Next-day and overnight cold-chain deliveries are coordinated around your schedule.
What Is Amvuttra?
This prescription drug was first approved by the FDA on June 13, 2022, based on data from a single clinical trial, where it was administered to 122 patients suffering from hereditary transthyretin-mediated amyloidosis (hATTR). The trial results concluded that Amvuttra significantly improved neuropathy impairment in patients.
Amvutra is the first and only injection that is given four times a year to treat polyneuropathy of hATTR amyloidosis in adult patients.
How Does It Work?
Amvuttra contains an active component, vutrisiran, which is a type of small interfering ribonucleic acid (siRNA). The siRNA is a short piece of genetic material designed to attach to and stop the mutated TRR gene responsible for producing TRR protein.
This significantly reduces the production of defective TRR protein, which results in decreased formation of amyloid deposits.
Who Can Take Amvuttra?
Patients with stage I and stage II polyneuropathy (nerve damage) hATTR amyloidosis can take Amvuttra.
Stage I nerve damage is when the patient feels leg weakness but can walk without help.
In Stage II nerve damage, the patient can still walk but requires support.
Patients whose disease progresses to stage III can still take this medication if the benefits outweigh the risks.
What Is the Available Dosage Form and Strength?
Amvuttra is available in 25 mg/0.5 ml in a single-dose pre-filled syringe. It can only be obtained with a doctor’s prescription.
How Is Amvuttra Given?
Amvuttra is given as a subcutaneous injection (under the skin) once every 3 months by an experienced healthcare provider. It is usually injected around an area of the abdomen, thighs, or upper arm.
Copay and Financial Assistance
AmeriPharma® Specialty Pharmacy alleviates financial burdens for patients and their families
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Advanced software locates funding sources to match you with top-dollar foundation programs
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One of our copay assistance specialists will assist with the application process
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Automatic updates will be sent to you and your physician on the status of the funding
What Precautions Should You Take?
Before taking Amvuttra, it is important to consult your healthcare provider and share your current health status and medical history. Be sure to tell your doctor if you are:
- Pregnant or intending to become pregnant: Since there is no available data on the effects of Amvuttra on an unborn baby, it is important to consult your healthcare provider before taking Amvuttra.
- Breastfeeding: It is not clear whether Amvuttra passes into breast milk; therefore, you should avoid taking it if you’re breastfeeding.
What Important Things Should You Know About Amvuttra?
Amvuttra can cause low vitamin A levels. As discussed earlier, TRR protein is responsible for transporting retinol (vitamin A) through the body. Taking Amvuttra can significantly lower the amount of vitamin A in your blood.
Severe vitamin A deficiency can result in vision problems (e.g., night blindness). Therefore, it is important to take vitamin A supplements with a dosage of 2,500 IU to 3,000 IU every day.
Amvuttra Side Effects
Common side effects:
Amvuttra has some side effects, along with its potential benefits. The most commonly reported side effects that have been seen in over 5% of patients after taking the medication include:
- Pain in the extremities (arms and legs)
- Arthralgia (joint pain)
- Shortness of breath (dyspnea)
- Low vitamin A levels
Insurances Accepted
We accept Medicare, multi-state Medicaid, Medi-Cal, Blue Shield, and most private insurances. Call us to find out more about your coverage.
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How Much Can You Save?
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