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Xembify Dosing

A patient’s pharmacokinetics and clinical response determine the dose of Xembify. The following sequence is adopted to determine the right amount. 

1. After initiating Xembify treatment, measure the serum IgG trough level of the patient as early as 5 weeks.
2. Continue monitoring IgG trough level every 2 to 3 months to determine if any subsequent dose adjustments are needed.
3. For frequent dosing (i.e., two to seven times per week), divide the calculated weekly dose by the desired number of infusions per week.  

Note: If a patient does not maintain adequate clinical response to Xembify therapy (or serum IgG level is not achieved to the level of a previous treatment), dose adjustments may be necessary. For dose adjustments, the doctor will calculate the difference of the IgG trough level from the target IgG trough level, then find the difference via the following table:

Dose Adjustment (ml per Week)

Locate the corresponding amount (in ml) by which to increase/decrease the weekly dose based on the patient’s body weight.

Example: If a patient with a body weight of 70 kg has IgG trough level of 900 mg/dl and the target level is 1000mg/dl, the difference is 100mg/dl. Thus, increase the weekly dose by 5 ml.