How Assistance Works
Streamlining our patient’s specialty pharmacy experience with unmatched full-service convenience
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1. Check Your Coverage/Benefits Verification
Our team of expert billers finds the best avenues of coverage that minimize out-of-pocket costs.
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2. Transfer Prescription to AmeriPharma®
We process your prescription by working with your previous pharmacy or prescriber, making the transition quick and easy.
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3. Prior Authorization
Our team of specialists obtains approval from your insurance companies within 24 to 72 hours.
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4. Copay Assistance & Financial Aid
We secure financial aid and decrease copays, out-of-pocket expenses, and high deductibles. To date, AmeriPharma® Specialty Care has secured $55 million in financial assistance for our patients.
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5. Nursing Care Coordination If Needed
AmeriPharma® puts your schedule and home environment first when scheduling and coordinating one of our specialized nurses for your in-home infusions.
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6. Delivery Coordination
Medications are always delivered in strict compliance with the specific requirements for shipping. Next-day and overnight cold-chain deliveries are coordinated around your schedule.
Tretten Introduction and Uses
Tretten is a brand-name prescription product. It contains catridecacog, a recombinant form of coagulation factor XIII A-subunit. Tretten belongs to a drug class known as coagulation factors or hemostatics.
Tretten is produced using recombinant DNA technology and is not derived from human plasma.
A healthcare provider may prescribe this medication to prevent bleeding in children and adults with congenital factor XIII (FXIII) A-subunit deficiency.
Congenital factor XIII (FXIII) A-subunit deficiency is a rare inherited bleeding disorder. It is estimated to affect 1 in every 1 to 3 million people. In people with this disorder, the blood doesn’t clot properly, leading to a higher risk of [1]:
- Life-threatening bleeds (most notably, spontaneous bleeding within the brain)
- Delayed wound healing
- Recurrent spontaneous abortion in women
Currently, Tretten is the first and only recombinant therapy for people with congenital factor XIII (FXIII) A-subunit deficiency. All other approved treatments are derived from plasma.
This medication shouldn’t be used to treat another similar bleeding disorder called congenital factor XIII B‑subunit deficiency.
Note: Tretten is sold under the brand name NovoThirteen in the EU, Switzerland, and Australia.
Tretten Mechanism of Action
Factor XIII A-subunit plays a crucial role in blood clotting. When bleeding occurs, the body forms a mesh of fibrin proteins to create a blood clot. Activated factor XIII helps strengthen and stabilize the clot by linking fibrin strands together.
When you have factor XIII A-subunit deficiency, blood clots become unstable and fragile. As a result, blood clots may break down too easily, increasing the risk of potentially life-threatening bleeding.
Tretten is a lab-created protein that works the same way as the naturally occurring factor XIII-A subunit in the body. Thus, it helps stabilize clots and prevent bleeding.
Important Tretten Warnings and Precautions
Allergic Reactions
This medication may cause allergic reactions. Seek emergency medical care if you experience:
- Rash
- Chest tightness
- Wheezing
You should not use this medication if you have a history of allergic reactions to this product or any product component.
Inhibitor Production
In some cases, your body can make proteins called “inhibitors” that can stop this medication from working as well as it should.
If your immune system makes inhibitors, Tretten may become less effective. Your healthcare provider may test for inhibitors if the medication stops working as expected or your factor XIII activity is lower than expected.
Risk of Blood Clots
If you have a higher risk of blood clots, your healthcare provider will monitor you after administering Tretten. Do not use Tretten together with recombinant factor VIIa, as this combination may increase the risk of blood clots.
How Tretten Copay Assistance Works
AmeriPharma® Specialty Pharmacy alleviates financial burdens for patients and their families
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Advanced software locates funding sources to match you with top-dollar foundation programs
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One of our copay assistance specialists will assist with the application process
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Automatic updates will be sent to you and your physician on the status of the funding
Tretten Dosage
The recommended dose of Tretten for routine bleeding prevention is 35 IU/kg of body weight, administered once every 28 days. Your healthcare provider may monitor factor XIII activity and adjust treatment to maintain trough FXIII activity at or above 10%.
Tretten Administration and Proper Use
- Your healthcare provider will inject the reconstituted medicine into your vein once monthly.
- The dose is individualized based on your body weight.
- You may inject it yourself after receiving instructions from your healthcare provider.
- Strictly follow the instructions about proper use, dose, and techniques for administration. If you are unclear about anything, ask your healthcare provider for help.
- Tretten comes as a powder, which must be mixed with sterile water before injection. The sterile water comes in a separate vial.
- If you need a smaller dose, you may dilute the medicine with 0.9% sodium chloride.
- Administer Tretten as a slow intravenous injection at a rate not exceeding 1–2 ml per minute, following your healthcare provider’s instructions.
- Do not mix Tretten with other infusion solutions or administer it as an IV drip.
- Open the package only when you are ready to administer the medicine.
- Don’t use expired or damaged medicine.
Tretten Side Effects
Allergic Reactions
Seek emergency medical care if you experience any of the following signs and symptoms after receiving Tretten:
- Shortness of breath
- Rash
- Itching
- Redness of the skin
- Fainting
- Dizziness
Blood Clots
Seek emergency medical care if you experience any of the following signs and symptoms after receiving Tretten:
- Pain, swelling, warmth, redness, or a lump in the legs or arms
- Chest pain
- Sudden severe headache
- Fainting
Call your doctor immediately if you have any unexpected bleeding.
Other side effects can include:
- Pain in the arms or legs
- Headache
- Pain at the injection site
- Increased D-dimer levels (a laboratory finding related to blood clot formation and breakdown)
Insurances Accepted
We accept Medicare, multi-state Medicaid, Medi-Cal, Blue Shield, and most private insurances. Call us to find out more about your coverage.
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