How Assistance Works
Streamlining our patient’s specialty pharmacy experience with unmatched full-service convenience
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1. Check Your Coverage/Benefits Verification
Our team of expert billers finds the best avenues of coverage that minimize out-of-pocket costs.
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2. Transfer Prescription to AmeriPharma®
We process your prescription by working with your previous pharmacy or prescriber, making the transition quick and easy.
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3. Prior Authorization
Our team of specialists obtains approval from your insurance companies within 24 to 72 hours.
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4. Copay Assistance & Financial Aid
We secure financial aid and decrease copays, out-of-pocket expenses, and high deductibles. To date, AmeriPharma® Specialty Care has secured $55 million in financial assistance for our patients.
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5. Nursing Care Coordination If Needed
AmeriPharma® puts your schedule and home environment first when scheduling and coordinating one of our specialized nurses for your in-home infusions.
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6. Delivery Coordination
Medications are always delivered in strict compliance with the specific requirements for shipping. Next-day and overnight cold-chain deliveries are coordinated around your schedule.
What Is Sevenfact?
Sevenfact is a brand-name prescription medication. The active ingredient in this product is coagulation factor VIIa (recombinant)-jncw, also called eptacog beta.
Sevenfact belongs to a class of medications known as hemostatics.
The term “recombinant” means this medication is made in a lab using recombinant DNA technology. The four lowercase letters “jncw” are used to distinguish Sevenfact from other similar products.
The U.S. FDA approved Sevenfact in April 2020 to treat and control bleeding in individuals 12 years and older with hemophilia A or B with inhibitors.
This product should not be used to treat individuals with congenital Factor VII deficiency.
What Is Sevenfact Used For?
Sevenfact is used to treat and control bleeding episodes in patients with hemophilia A or B who have developed inhibitors to standard clotting factor treatments.
Inhibitors are antibodies that develop in some patients and block standard clotting factor treatments, making bleeding more difficult to control.
Sevenfact Mechanism of Action
Recombinant coagulation Factor VIIa (rFVIIa) in Sevenfact helps the blood to clot by activating another clotting factor called Factor X.
Normally, activation of Factor X depends on Factors VIII and IX. Sevenfact bypasses this pathway, allowing clot formation even when these factors are absent. For this reason, it is known as a “bypassing agent.”
Copay and Financial Assistance
AmeriPharma® Specialty Pharmacy alleviates financial burdens for patients and their families
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Advanced software locates funding sources to match you with top-dollar foundation programs
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One of our copay assistance specialists will assist with the application process
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Automatic updates will be sent to you and your physician on the status of the funding
Sevenfact Dosing
This medication comes as a white to off-white powder for solution (reconstitution) for intravenous (IV) injection in single-dose vials.
The following strengths are available in the U.S.:
- 1 mg of coagulation factor VIIa (recombinant)-jncw
- 2 mg of coagulation factor VIIa (recombinant)-jncw
- 5 mg of coagulation factor VIIa (recombinant)-jncw
The liquid to prepare the solution comes in single-dose prefilled glass syringes. Each syringe contains 1.1 ml, 2.2 ml, or 5.2 ml of sterile water for injection.
The dose and duration of treatment depend on:
- Location and severity of bleeding
- Need for urgent bleeding control
- Frequency of administration
- Response to bypassing agents during earlier bleeding episodes
For Mild and moderate bleeding: 75 mcg/kg repeated every 3 hours until bleeding stops. Alternatively, a 225 mcg/kg initial dose may be used. If bleeding doesn’t stop within 9 hours, an extra dose of 75 mcg/kg every 3 hours may be given as needed to stop bleeding.
If bleeding doesn’t stop within 24 hours after the first dose, your healthcare provider will likely switch you to an alternative treatment.
For Severe bleeding: 225 mcg/kg initial dose. If needed after 6 hours, give 75 mcg/kg every 2 hours until bleeding stops.
The duration of treatment depends on the site and severity of bleeding.
Sevenfact Side Effects
Common side effects include:
- Headache
- Dizziness
- Pain, redness, or swelling at the infusion site
- Fever
- Joint pain
- Mild itching
- Nausea
- Vomiting
Serious side effects include:
Stroke
- Sudden numbness or weakness
- Severe headache
- Slurred speech
- Difficulty with vision or balance
Blood clot in the lung
- Chest pain
- Sudden cough or breathing difficulty
- Dizziness
- Coughing up blood
Blood clot deep in the body
- Pain, swelling, or warmth in one of your legs
Insurances Accepted
We accept Medicare, multi-state Medicaid, Medi-Cal, Blue Shield, and most private insurances. Call us to find out more about your coverage.
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