How Assistance Works
Streamlining our patient’s specialty pharmacy experience with unmatched full-service convenience
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1. Check Your Coverage/Benefits Verification
Our team of expert billers finds the best avenues of coverage that minimize out-of-pocket costs.
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2. Transfer Prescription to AmeriPharma®
We process your prescription by working with your previous pharmacy or prescriber, making the transition quick and easy.
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3. Prior Authorization
Our team of specialists obtains approval from your insurance companies within 24 to 72 hours.
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4. Copay Assistance & Financial Aid
We secure financial aid and decrease copays, out-of-pocket expenses, and high deductibles. To date, AmeriPharma® Specialty Care has secured $55 million in financial assistance for our patients.
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5. Nursing Care Coordination If Needed
AmeriPharma® puts your schedule and home environment first when scheduling and coordinating one of our specialized nurses for your in-home infusions.
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6. Delivery Coordination
Medications are always delivered in strict compliance with the specific requirements for shipping. Next-day and overnight cold-chain deliveries are coordinated around your schedule.
What Is Rebinyn?
Rebinyn is a prescription medicine used to treat patients with hemophilia B. It is a recombinant protein, which means it is designed synthetically by humans to mimic the function of naturally occurring clotting factor IX protein in the body. This blood clotting protein helps to prevent excessive blood loss in healthy individuals.
Rebinyn belongs to the “clotting factors” drug class and is used to stop bleeding by helping the blood clot in patients with hemophilia B. This medication was first approved by the U.S. Food and Drug Administration (FDA) on May 31, 2017, based on the positive results of four completed clinical trials.
This medication is available in a single-use vial and can only be obtained via a doctor’s prescription.
What Is Rebinyn Used to Treat?
Rebinyn is indicated to:
- Control active bleeding episodes in hemophilia B patients.
- Prevent frequency of bleeding episodes in patients with hemophilia B.
- Prevent bleeding during surgery in patients with hemophilia B.
It is typically prescribed to adults and children with hemophilia B, and cannot be used as immune tolerance therapy in patients with hemophilia B.
How Does Rebinyn Work?
In patients with hemophilia B, clotting Factor IX is either missing or does not work properly, which causes excessive bleeding in these patients, even with a minor dental injury.
Rebinyn works to replace the faulty or missing factor IX and helps the blood form a clot at the bleeding site. It has an approximately extended half-life (5 times longer than older coagulation factor Ⅸ drugs such as BeneFix), which means it stays in your blood longer to control bleeding and reduces the number of infusions needed.
Copay and Financial Assistance
AmeriPharma® Specialty Pharmacy alleviates financial burdens for patients and their families
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Advanced software locates funding sources to match you with top-dollar foundation programs
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One of our copay assistance specialists will assist with the application process
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Automatic updates will be sent to you and your physician on the status of the funding
What Are the Available Dosage Forms and Strengths?
Rebinyn is available in lyophilized powder form in a single-dose vial with concentrations (strengths) of 500, 1,000, 2,000, and 3,000 IU per vial. The powder is reconstituted with 4 ml of histidine diluent, which gives the following concentrations per ml:
- 500 IU (125 IU/ml)
- 1,000 IU (250 IU/ml)
- 2,000 IU (500 IU/ml)
- 3,000 IU (750 IU/ml)
What Is the Usual Dose for Patients With Hemophilia B?
The dose of Rebinyn is adjusted according to the patient’s weight and the type of bleeding or surgery they experienced.
For Minor-To-Moderate Bleeding, Prevention, or Minor Surgery:
If a patient has minor and moderate bleeding, such as joint bleeds, minor muscular bleeds, or mucosal or subcutaneous bleeds, the recommended dosage of Rebinyn is 40 IU/kg (body weight).
The recommended dosage for minor surgery, such as skin biopsies and dental procedures, is also 40 IU/kg (body weight).
For Major Bleeding or Surgical Procedures:
If a patient has major bleeding or a surgical procedure, the recommended dosage is 80 IU/kg (body weight). Moreover, an additional dose of 40 IU/kg (body weight) can be given if required by the patient.
Rebinyn Side Effects
Common side effects include:
- Infusion site reaction, such as bruising, bleeding, swelling, pain, or redness (seen in ≥ 1% of patients during trials)
- Itching (seen in ≥ 1% of patients during trials)
- Rash
- The presence of factor IX inhibitors
Allergic Reactions:
Though it is rare, hypersensitivity or allergic reactions can progress into severe anaphylaxis (including anaphylactic shock). The early signs of allergic reactions, which can progress to anaphylaxis, may include:
- Angioedema (swelling of the lips, face, tongue, or throat)
- Chest tightness
- Dyspnea (trouble breathing)
- Wheezing
- Urticaria (hives)
- Pruritus (itching)
Insurances Accepted
We accept Medicare, multi-state Medicaid, Medi-Cal, Blue Shield, and most private insurances. Call us to find out more about your coverage.
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