Contraindications (Who Should Not Take Odomzo)

Odomzo can cause severe birth defects or fetal death. It is strictly contraindicated in pregnant women. Women of childbearing potential must have a negative pregnancy test before starting the medication and they must use effective contraception during treatment and for 20 months after the last dose.

Men must use condoms during treatment and for 8 months after the last dose, as the drug can be present in semen.

Patients with a known allergy to sonidegib or any of its components should not take Odomzo.

Before You Start Odomzo: What To Tell Your Doctor

Always consult your healthcare provider before taking Odomzo if you:

• Have muscle pain or spasms, or have a history of a muscle disorder called rhabdomyolysis or myopathy
• Have any other medical conditions, like kidney disease
• Are pregnant or plan to become pregnant (Odomzo can cause embryo-fetal death or severe birth defects)
• Are breastfeeding or plan to breastfeed (Since it is not known whether Odomzo passes into breast milk, breastfeeding should be avoided during treatment and for up to 20 months after the last dose).
• Taking any prescription or non-prescription medicines, such as over-the-counter medications, supplements, or herbal products