How Assistance Works
Streamlining our patient’s specialty pharmacy experience with unmatched full-service convenience
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1. Check Your Coverage/Benefits Verification
Our team of expert billers finds the best avenues of coverage that minimize out-of-pocket costs.
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2. Transfer Prescription to AmeriPharma®
We process your prescription by working with your previous pharmacy or prescriber, making the transition quick and easy.
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3. Prior Authorization
Our team of specialists obtains approval from your insurance companies within 24 to 72 hours.
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4. Copay Assistance & Financial Aid
We secure financial aid and decrease copays, out-of-pocket expenses, and high deductibles. To date, AmeriPharma® Specialty Care has secured $55 million in financial assistance for our patients.
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5. Nursing Care Coordination If Needed
AmeriPharma® puts your schedule and home environment first when scheduling and coordinating one of our specialized nurses for your in-home infusions.
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6. Delivery Coordination
Medications are always delivered in strict compliance with the specific requirements for shipping. Next-day and overnight cold-chain deliveries are coordinated around your schedule.
What Is Koāte?
Koāte-DVI (also marketed as KOĀTE) is an FDA-approved injectable drug used for the control and prevention of bleeding in people with hemophilia A. It works by temporarily replacing the clotting factor VIII protein and helps the blood clot properly.
Koāte-DVI is also known by its generic name, antihemophilic factor (human), meaning it is derived from donated human plasma. Koāte-DVI belongs to the coagulation factors and hemostatic drug class and is only available with a doctor’s prescription.
Indication
Koāte-DVI (antihemophilic factor [human]) is used to control and prevent bleeding episodes in people with hemophilia A. It is also used to manage bleeding during emergency or elective surgery in people with hemophilia A.
This drug is not indicated for the treatment of von Willebrand disease.
Mechanism of Action
In patients with hemophilia A, the clotting factor VIII is either missing or not functioning properly. As a result, people with hemophilia A may bleed longer and more frequently than people with a normal amount of clotting factor VIII in their body.
Koāte-DVI, a human plasma-derived Factor VIII, temporarily replaces the missing or nonfunctional clotting factor VIII when infused and helps control bleeds in people with hemophilia A. The half-life of Koāte-DVI can vary between patients.
Koāte-DVI: Drug Form
Koāte-DVI is available as a lyophilized powder for reconstitution in single-use vials containing 250 IU (yellow), 500 IU (blue), and 1,000 IU (red) of Factor VIII activity.
Every vial of Koāte-DVI comes with a Mix2Vial transfer device, allowing for needle-free reconstitution. You can ask your healthcare provider about the Mix2Vial Practice Kit for step-by-step Koāte-DVI administration instructions to help you become comfortable with the reconstitution process.
How Koāte Copay Assistance Works
AmeriPharma® Specialty Pharmacy alleviates financial burdens for patients and their families
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Advanced software locates funding sources to match you with top-dollar foundation programs
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One of our copay assistance specialists will assist with the application process
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Automatic updates will be sent to you and your physician on the status of the funding
Koāte-DVI: Dosage
The dosage and frequency of Koāte-DVI are adjusted according to the patient’s clinical condition, the severity of the Factor VIII deficiency, and the location and extent of bleeding.
Koāte-DVI Dosage by Type of Bleeding Episodes
The recommended dosage of Koāte-DVI based on the type of bleeding is as follows:
Minor bleeding
If you experience a minor bleed such as large bruises, significant cuts or scrapes, or uncomplicated joint hemorrhage, a dose of 15 IU/kg may be given every 12 hours until bleeding stops and healing occurs (usually 1–2 days).
Moderate bleeding
If you experience moderate bleeding (e.g., from the nose, mouth, or gums), dental extractions, or hematuria, a dose of 25 IU/kg may be given every 12 hours until healing occurs (an average of 2–7 days).
Major bleeding
If you experience major bleeding such as joint or muscle hemorrhage, major trauma, hematuria, or intracranial or intraperitoneal bleeding, an initial dose of 40–50 IU/kg may be given, followed by a maintenance dose of 25 IU/kg every 12 hours. Treatment may continue until healing is achieved, for up to 10 days. Intracranial bleeding may require prophylactic therapy for up to 6 months.
Koāte-DVI Dosage for Surgery
The recommended dosage of Koāte-DVI for surgery is as follows:
- Before surgery, you may receive a dose of 40–50 IU/kg once to achieve an FVIII level of 80–100%.
- After surgery, a dose of 30–50 IU/kg every 12 hours is recommended to maintain FVIII levels of 60–100% for 7–10 days or until healing is achieved.
Koāte Side Effects
Common side effects include:
- Nervousness
- Headache
- Abdominal pain (stomach ache)
- Nausea
- Tingling sensation, “pins and needles” in your face, arms, or ears
- Blurred vision
Severe side effects include:
- Hives
- Chest tightness
- Wheezing
- Difficulty breathing
- Feeling light-headed
- Fainting
- Swelling of your face, lips, tongue, or throat
- Stomach cramps
- Joint pain
- Low blood pressure
Insurances Accepted
We accept Medicare, multi-state Medicaid, Medi-Cal, Blue Shield, and most private insurances. Call us to find out more about your coverage.
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