How Assistance Works
Streamlining our patient’s specialty pharmacy experience with unmatched full-service convenience
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1. Check Your Coverage/Benefits Verification
Our team of expert billers finds the best avenues of coverage that minimize out-of-pocket costs.
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2. Transfer Prescription to AmeriPharma®
We process your prescription by working with your previous pharmacy or prescriber, making the transition quick and easy.
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3. Prior Authorization
Our team of specialists obtains approval from your insurance companies within 24 to 72 hours.
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4. Copay Assistance & Financial Aid
We secure financial aid and decrease copays, out-of-pocket expenses, and high deductibles. To date, AmeriPharma® Specialty Care has secured $55 million in financial assistance for our patients.
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5. Nursing Care Coordination If Needed
AmeriPharma® puts your schedule and home environment first when scheduling and coordinating one of our specialized nurses for your in-home infusions.
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6. Delivery Coordination
Medications are always delivered in strict compliance with the specific requirements for shipping. Next-day and overnight cold-chain deliveries are coordinated around your schedule.
What Is Ixinity?
Ixinity is a prescription medication that is given as an intravenous (IV) infusion to hemophilia B patients. Ixinity helps to manage and prevent prolonged bleeding caused by injuries, surgery, or even spontaneous internal bleeding in people with hemophilia B.
It is also known by its generic name, coagulation factor IX (recombinant), and received its first approval from the U.S. Food and Drug Administration (FDA) in April 2015 as an on-demand treatment for managing bleeds in hemophilia B patients (ages 12 years and older). Later, in March 2024, the FDA expanded Ixinity approval to include children younger than 12 years old with hemophilia B.
If a healthcare provider has prescribed Ixinity to you or your child, then it is important to understand key information about this medication, including what it is, how it works, how it is used, and what to expect during treatment.
Ixinity: Usage or Indication
Ixinity (coagulation factor IX) is commonly used to treat and prevent certain types of bleeding episodes in people with hemophilia B. These bleeding episodes can occur due to an injury or surgery, or without any clear cause.
Ixinity is prescribed to both adults and children with hemophilia B under the following conditions:
- To treat bleeding episodes when they occur
- To manage excessive bleeding before, during, or after a surgical procedure
- For routine prophylaxis to prevent or reduce the frequency of bleeding episodes
You should NOT take Ixinity if you have hemophilia A with factor VIII deficiency.
Working Mechanism
To understand how Ixinity works, let’s first briefly review what hemophilia B is.
Hemophilia B is an inherited bleeding disorder caused by a deficiency in coagulation factor IX (a protein that causes blood clotting). This results in more frequent bleeding into joints, muscles, or internal organs, either spontaneously or as a result of accidental or surgical trauma.
Ixinity is a lab-produced version of human coagulation factor IX that closely mimics the natural protein (factor IX) found in the body. When a person with Hemophilia B receives Ixinity, the infused recombinant factor IX enters the bloodstream and temporarily replaces the missing or low levels of natural factor IX.
Once in circulation, Ixinity helps the blood to clot more efficiently and prevents excessive blood loss in hemophilia B patients.
How Ixinity Copay Assistance Works
AmeriPharma® Specialty Pharmacy alleviates financial burdens for patients and their families
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Advanced software locates funding sources to match you with top-dollar foundation programs
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One of our copay assistance specialists will assist with the application process
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Automatic updates will be sent to you and your physician on the status of the funding
Dosage and Administration
The dose and frequency depend on the patient’s body weight (kg), severity of factor IX deficiency, extent of bleeding, and whether it is used for treatment or for surgery.
The recommended dose is first mixed with a diluent and administered through intravenous (IV) infusion (injected directly into a vein).
1. Ixinity Dosage for Routine Prophylaxis
For routine prophylaxis, Ixinity is typically administered twice a week at 40-70 international units per kilogram of body weight (IU/kg), in people aged 12 years and older, and at 35-75 IU/kg for children younger than 12.
Children often clear clotting factors more quickly, so their doses may be adjusted within this range to maintain good protection against bleeding.
2. Dosage for On-Demand Treatment
When Ixinity is used to treat active bleeding rather than for routine prevention, doses are calculated to raise the person’s factor IX level to a desired target based on the severity of the bleed. Treatment is given until healing is achieved. For:
- Minor bleeds: Factor IX levels are raised to 30–60 IU/dl, with Ixinity given once every 24 hours for 1–3 days.
- Moderate bleeds: Factor IX levels are increased to 40–60 IU/dl, with dosing every 24 hours for 2–7 days.
- Major or life-threatening bleeds: Higher factor IX levels of 60–100 IU/dl are needed, with Ixinity given every 12–24 hours for 2–14 days or longer under medical supervision.
3. Dosage To Control Bleeding Surrounding Surgery
Ixinity is also used to control bleeding before or after surgery in hemophilia B patients. For a minor surgical procedure, Ixinity is given every 24 hours after surgery to maintain factor IX activity levels at 30–80 IU/dl.
For major surgical procedures, higher and more carefully controlled factor IX levels are required. Before surgery, levels are raised to 60–80 IU/dl. After surgery, factor IX levels are maintained at 40–60 IU/dl during the early recovery period, gradually reduced to 30–50 IU/dl, and then to 20–40 IU/dl as healing continues.
Ixinity Side Effects
The most common side effect observed in >2% of patients in clinical trials was headache. Though it’s rare, Ixinity may also cause serious side effects, which include:
- Allergic reactions: Signs of an allergic reaction may include swelling, hives, chest or throat tightness, low blood pressure, lethargy, nausea, vomiting, difficulty swallowing, abnormal sensations, wheezing, or difficulty breathing.
- Kidney problems (nephrotic syndrome)
- Blood clots (thromboembolism)
Insurances Accepted
We accept Medicare, multi-state Medicaid, Medi-Cal, Blue Shield, and most private insurances. Call us to find out more about your coverage.
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