How Assistance Works

Streamlining our patient’s specialty pharmacy experience with unmatched full-service convenience

1. Check Your Coverage/Benefits Verification

Our team of expert billers finds the best avenues of coverage that minimize out-of-pocket costs.
2. Transfer Prescription to AmeriPharma®

We process your prescription by working with your previous pharmacy or prescriber, making the transition quick and easy.
3. Prior Authorization

Our team of specialists obtains approval from your insurance companies within 24 to 72 hours.
4. Copay Assistance & Financial Aid

We secure financial aid and decrease copays, out-of-pocket expenses, and high deductibles. To date, AmeriPharma® Specialty Care has secured $55 million in financial assistance for our patients.
5. Nursing Care Coordination If Needed

AmeriPharma® puts your schedule and home environment first when scheduling and coordinating one of our specialized nurses for your in-home infusions.
6. Delivery Coordination

Medications are always delivered in strict compliance with the specific requirements for shipping. Next-day and overnight cold-chain deliveries are coordinated around your schedule.

What Is Ixifi?

Ixifi (infliximab-qbtx) is an FDA-approved biologic prescription medication made using living cells. It is used to treat certain inflammatory and autoimmune conditions like rheumatoid arthritis, Crohn’s disease, and ulcerative colitis.

The FDA first approved Ixifi on December 13, 2017. It was approved as a biosimilar to Remicade (infliximab), meaning it is highly similar to the reference product, with no clinically meaningful differences in safety, purity, or potency. Other infliximab biosimilars include Inflectra and Renflexis.

The active ingredient in Ixifi is infliximab. It works by blocking a protein called TNF-alpha, which causes inflammation in your body. Ixifi comes as a 100 mg powder in a single-dose vial that is mixed with liquid before it is given as an intravenous (IV) infusion.

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What Is Ixifi Used For?

Ixifi is an FDA-approved medication to treat the following conditions:

Crohn’s Disease: In adult patients with moderate to severe active Crohn’s disease, Ixifi can:

Reduce the signs and symptoms of the disease
Induce and maintain clinical remission when conventional treatments have not worked well
Reduce the number of draining enterocutaneous and rectovaginal fistulas
Help maintain fistula closure in adults with fistulizing Crohn’s disease

Pediatric Crohn’s Disease: Healthcare providers use Ixifi in children 6 years of age and older with moderate to severe active Crohn’s disease. It can reduce signs and symptoms of the disease and induce and maintain clinical remission.

Ulcerative Colitis: Ixifi is used in adults and children 6 years and older with moderate to severe active ulcerative colitis when conventional treatments have not worked well. Ixifi can reduce your symptoms, induce and maintain remission, promote mucosal healing, and help eliminate the need for corticosteroids in adults.

Rheumatoid Arthritis: If you have moderate to severe rheumatoid arthritis, you can use Ixifi in combination with methotrexate. It can help reduce the symptoms, slow the progression of structural joint damage, and improve physical function.

Ankylosing Spondylitis: Ixifi can reduce the symptoms in adults with ankylosing spondylitis.

Psoriatic Arthritis: Ixifi is used in adults with psoriatic arthritis. It can improve your symptoms, slow the progression of joint damage, and improve physical function.

Plaque Psoriasis: Ixifi is used in adults with chronic, severe plaque psoriasis who are candidates for treatment with systemic medications and when other systemic treatment options are medically less appropriate.

Please note that Ixifi does not cure these conditions. Instead, it blocks the activity of TNF-alpha (a protein that promotes inflammation) to control the inflammation responsible for many of the symptoms.

How Ixifi Copay Assistance Works

AmeriPharma® Specialty Pharmacy alleviates financial burdens for patients and their families

Advanced software locates funding sources to match you with top-dollar foundation programs
One of our copay assistance specialists will assist with the application process
Automatic updates will be sent to you and your physician on the status of the funding

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Dosing of Ixifi

Ixifi comes as a powder that is mixed with liquid before use. You’ll receive it through an intravenous (IV) infusion. The exact dose depends on the condition being treated, your body weight, and how you respond to treatment. Your healthcare provider will determine the right dosage for you. Below are the usual recommended dosages:

Crohn’s Disease: For adult patients, the usual initial dose is 5 mg/kg given at week 0, week 2, and week 6. After these initial doses, 5 mg/kg is given every 8 weeks. For those who initially responded to the treatment but later have an inadequate response, the doctor may increase the dose to 10 mg/kg every 8 weeks.

For children aged 6 years and older, the dosage is 5 mg/kg given at week 0, week 2, and week 6, followed by 5 mg/kg every 8 weeks.

Ulcerative Colitis: For adults and children aged 6 years and older, the recommended dose is 5 mg/kg at week 0, week 2, and week 6, followed by 5 mg/kg every 8 weeks.

Rheumatoid Arthritis: Ixifi is used in adult patients in combination with methotrexate. The recommended dosage is 3 mg/kg given at week 0, week 2, and week 6, followed by 3 mg/kg every 8 weeks. Some patients may benefit from increasing the dose to up to 10 mg/kg every 8 weeks or receiving treatment as frequently as every 4 weeks, depending on their response.

Ankylosing Spondylitis: The recommended adult dose is 5 mg/kg given at week 0, week 2, and week 6, followed by 5 mg/kg given every 6 weeks.

Psoriatic Arthritis and Plaque Psoriasis: The recommended adult dose is 5 mg/kg given at week 0, week 2, and week 6, followed by 5 mg/kg given every 8 weeks.

Ixifi Side Effects

Common side effects include:

Respiratory infections, such as sinus infections and sore throats
Headache
Coughing
Stomach pain
Infusion-related reactions
Viral infection

Serious side effects:

Serious side effects from Ixifi are rare, but they can occur. Here are some serious side effects and warnings associated with Ixifi:

Serious Infections: Ixifi can increase the risk of serious infections because it suppresses your immune system. These infections can include tuberculosis (TB), bacterial infections, and invasive fungal infections. Ixifi should be discontinued if you develop a serious infection or sepsis.

Cancer: Lymphoma and other malignancies, some fatal, have been reported in children and adults treated with TNF blockers, including infliximab products. Your doctor will consider the potential risks and benefits of treatment, particularly if you have risk factors for certain cancers.

Heart Failure: Ixifi can cause heart failure or make existing heart conditions worse. Tell your doctor if you have symptoms of heart failure, such as shortness of breath, swelling of the ankles or feet, or sudden weight gain.

Liver Problems: In rare cases, Ixifi can cause liver problems. Severe liver injury, including cases resulting in liver transplant or death, has been reported with infliximab products. Contact your doctor if you experience symptoms such as yellowing of the skin or eyes, dark urine, severe fatigue, fever, or pain on the right side of your abdomen.

Severe Allergic and Infusion Reactions: Ixifi can cause serious allergic or infusion reactions during or shortly after the infusion. Symptoms may include difficulty breathing, hives, chest pain, swelling, dizziness, or a significant change in blood pressure.

Please note that this is not a complete list of all possible side effects. Contact your doctor immediately if you experience any severe or unusual symptoms while receiving Ixifi.