How Assistance Works

Streamlining our patient’s specialty pharmacy experience with unmatched full-service convenience

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    1. Check Your Coverage/Benefits Verification

    Our team of expert billers finds the best avenues of coverage that minimize out-of-pocket costs.

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    2. Transfer Prescription to AmeriPharma®

    We process your prescription by working with your previous pharmacy or prescriber, making the transition quick and easy.

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    3. Prior Authorization

    Our team of specialists obtains approval from your insurance companies within 24 to 72 hours.

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    4. Copay Assistance & Financial Aid

    We secure financial aid and decrease copays, out-of-pocket expenses, and high deductibles. To date, AmeriPharma® Specialty Care has secured $55 million in financial assistance for our patients.

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    5. Nursing Care Coordination If Needed

    AmeriPharma® puts your schedule and home environment first when scheduling and coordinating one of our specialized nurses for your in-home infusions.

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    6. Delivery Coordination

    Medications are always delivered in strict compliance with the specific requirements for shipping. Next-day and overnight cold-chain deliveries are coordinated around your schedule.

What Is Corifact?

Corifact (also known by its generic name, factor XIII concentrate) is an injectable prescription medicine used to prevent excessive bleeding in people with congenital factor XIII deficiency, which is a rare inherited bleeding disorder. This condition affects around 1 in every 2 to 3 million people, with an incidence in the U.S. of approximately 150 people.

Corifact belongs to the drug class of coagulation factors and is also classified as a hemostatic agent that helps prevent and control bleeding by supporting proper blood clot formation.

This drug was approved by the U.S. Food and Drug Administration (FDA) in 2011 and is available in 12 different countries around the world under the brand name Fibrogammin®- P.

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Corifact Working Mechanism

Corifact contains a purified form of human factor XIII protein extracted from pooled human plasma donated by healthy individuals. It works like the body’s natural clotting protein and replaces the missing factor XIII in the bloodstream. Once infused, it:

  • Increases the level of Factor XIII in the blood
  • Strengthens blood clots
  • Helps clots stay in place long enough for proper healing
  • Reduces the risk of spontaneous or uncontrolled bleeding
  • Helps prevent spontaneous bleeding episodes

By maintaining adequate Factor XIII levels, Corifact helps the body form stronger, more stable clots, lowering the risk of serious bleeding episodes.

Copay and Financial Assistance

AmeriPharma® Specialty Pharmacy alleviates financial burdens for patients and their families

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    Advanced software locates funding sources to match you with top-dollar foundation programs

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    One of our copay assistance specialists will assist with the application process

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    Automatic updates will be sent to you and your physician on the status of the funding

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Dosage for Adults and Children

The dose of Corifact is based on body weight, not age. This means adults and children generally receive the same weight-based dosing schedule.

Routine Preventive Treatment (Prophylaxis)

Both adults and children with congenital Factor XIII deficiency receive a dose of 40 IU/kg body weight intravenously, once every 4 weeks (every 28 days).

The doctor may adjust the dose based on the factor XIII blood levels, bleeding history, or any upcoming surgeries or procedures.

For Perioperative Management of Surgical Bleeding

If you need surgery or experience a bleeding episode, your healthcare provider may adjust the dose based on your Factor XIII levels, the type of surgery, and your clinical response.

Corifact Side Effects

Common side effects include:
  • Joint inflammation
  • Joint pain (arthralgia)
  • Mild rash or itching
  • Headache
  • Pain at the injection site
  • Mild fever
  • Elevated thrombin-antithrombin levels
  • Increased blood lactate dehydrogenase
Serious side effects include:
  • Hypersensitivity or allergic reactions (rash, itching, swelling)
  • Acute ischemia

Insurances Accepted

We accept Medicare, multi-state Medicaid, Medi-Cal, Blue Shield, and most private insurances. Call us to find out more about your coverage.

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