How Assistance Works
Streamlining our patient’s specialty pharmacy experience with unmatched full-service convenience
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1. Check Your Coverage/Benefits Verification
Our team of expert billers finds the best avenues of coverage that minimize out-of-pocket costs.
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2. Transfer Prescription to AmeriPharma®
We process your prescription by working with your previous pharmacy or prescriber, making the transition quick and easy.
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3. Prior Authorization
Our team of specialists obtains approval from your insurance companies within 24 to 72 hours.
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4. Copay Assistance & Financial Aid
We secure financial aid and decrease copays, out-of-pocket expenses, and high deductibles. To date, AmeriPharma® Specialty Care has secured $55 million in financial assistance for our patients.
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5. Nursing Care Coordination If Needed
AmeriPharma® puts your schedule and home environment first when scheduling and coordinating one of our specialized nurses for your in-home infusions.
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6. Delivery Coordination
Medications are always delivered in strict compliance with the specific requirements for shipping. Next-day and overnight cold-chain deliveries are coordinated around your schedule.
Cladribine (Mavenclad) Introduction and Uses
Mavenclad is a brand-name prescription medication. The active ingredient is cladribine, a purine antimetabolite that works by reducing certain immune cells involved in multiple sclerosis.
The FDA approved cladribine tablets in 2019 to treat adults with relapsing forms of multiple sclerosis. Because Mavenclad carries serious risks, including an increased risk of cancer and fetal harm, it is generally reserved for people who have had an inadequate response to or cannot tolerate another MS treatment.
Mavenclad is available as 10 mg oral tablets. The tablets are round and white to off-white in color.
Mavenclad is not recommended for use in people with symptoms similar to multiple sclerosis but don’t meet the criteria for a multiple sclerosis diagnosis.
Cladribine (Mavenclad) Mechanism of Action
The exact mechanism of action of cladribine in multiple sclerosis is not fully understood. According to the manufacturer, it works by reducing the number of immune cells, particularly B and T lymphocytes, that contribute to inflammation and damage to the protective covering of nerves (myelin). By reducing the number of these immune cells, Mavenclad helps reduce disease activity and relapses. After treatment, the immune system gradually rebuilds over time.
How Effective Is Cladribine (Mavenclad)?
Clinical studies have shown that Mavenclad can significantly reduce disease activity in people with relapsing forms of multiple sclerosis. In the phase 3 CLARITY clinical trial, people treated with Mavenclad experienced fewer relapses, fewer new MRI brain lesions, and slower disability progression than those who received a placebo. Because treatment is given over two yearly courses rather than continuously, many patients experience lasting benefits without taking the medication every day. Your response to treatment will depend on factors such as your disease severity, previous therapies, and overall health.
How Cladribine Copay Assistance Works
AmeriPharma® Specialty Pharmacy alleviates financial burdens for patients and their families
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Advanced software locates funding sources to match you with top-dollar foundation programs
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One of our copay assistance specialists will assist with the application process
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Automatic updates will be sent to you and your physician on the status of the funding
Cladribine (Mavenclad) Dosing
Your healthcare provider will determine the dose based on your body weight. Mavenclad is given as two yearly treatment courses. The recommended total dose is 1.75 mg/kg per treatment course. Each course is divided into 2 treatment cycles.
First treatment course (year 1)
Treatment cycle 1: Take the recommended dose once daily for 4 to 5 days in a row.
Treatment cycle 2: Repeat the dosage 23 to 27 days later.
Second treatment course (year 2)
Treatment cycle 1: Take the recommended dose once daily for 4 to 5 days in a row at least 43 weeks after the final dose of cycle 2 of the first course.
Treatment cycle 2: Repeat the dosage 23 to 27 days later.
Proper Use
- Take Mavenclad exactly as prescribed by your healthcare provider. Don’t take more than two tablets daily.
- Swallow the entire tablet immediately after opening the pack.
- Avoid crushing, chewing, or breaking the tablets.
- You may take this medication with or without food.
- Complete each treatment cycle exactly as prescribed, and talk to your healthcare provider before making any changes to your treatment plan.
- Keep your hands dry while handling the tablets. Immediately after you take a tablet, wash your hands properly.
- Minimize direct contact between the tablet and your skin. Don’t touch your nose, eyes, and other body parts.
- If the tablet comes in contact with a surface, wash the surface immediately with water.
- Take your dose at least 3 hours apart from other oral drugs.
- If you miss a dose, take the missed dose immediately after you remember, on the same day. If the day has passed, take the missed dose the following day. Never take 2 doses at the same time.
Cladribine Side Effects
Common side effects include:
- Upper respiratory infection
- Low white blood cell count
- Headache
Severe side effects include:
- Fever, sore throat, chills, muscle pain, cough, or other signs of infection
- Cough, chest pain, coughing up blood or mucus, tiredness, weight loss, loss of appetite, chills, fever, night sweats
- Painful rash with blisters
- Burning, tingling, numbness, or itchiness of the skin
- Rash, difficulty breathing or swallowing, swelling of the face, lips, tongue, or throat
- Chills, fever, nausea, vomiting, pain in your back, side, or groin, frequent and painful urination
- Unusual bleeding or bruising
- Weakness on one side of your body, loss of coordination in your arms or legs, decreased strength, problems with balance, confusion, changes in your vision, thinking, memory, or personality
- Shortness of breath, fast heartbeat, headache, dizziness, pale skin, confusion, tiredness
- Nausea, vomiting, extreme tiredness, loss of appetite, pain in the upper right part of stomach, yellowing of the skin or eyes, dark urine
- Shortness of breath, fast or irregular heartbeat, swelling in a part of your body
Insurances Accepted
We accept Medicare, multi-state Medicaid, Medi-Cal, Blue Shield, and most private insurances. Call us to find out more about your coverage.
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