Serious side effects include:

Allergic Reactions

Some people receiving Bivigam might experience severe allergic reactions, including anaphylaxis. Anaphylaxis is a potentially life-threatening allergic reaction that causes difficulty breathing, tightness in the throat, and dizziness.

Seek emergency medical care right away if you develop the following symptoms after receiving this product:

• Rash and itching
• Hoarseness
• Breathing difficulty
• Trouble swallowing
• Swelling of your hands, face, or mouth

Blood Clots

This medication can cause blood clots, especially in older adults or people with clotting disorders and heart problems. Also, the risk may be higher in those:

• On long-term bed rest
• Taking oral birth control pills
• With a central intravenous catheter in place

Seek medical help immediately if you experience:

• Chest pain
• Breathing difficulty
• Fast heartbeats
• Numbness or weakness
• Swelling in your arm or leg

Acute Kidney Failure

Bivigam can worsen your kidney function, which can lead to kidney failure if not properly treated in time. The risk may be higher if you’re overweight, have diabetes, or use medications that harm your kidneys.

Seek immediate care if you experience:

• Swelling
• Rapid weight gain
• Little or no urination

Inflammation of the Membranes Surrounding the Brain

Health professionals call this type of inflammation aseptic meningitis syndrome or AMS. Though rare with Bivigam and other similar products, AMS can be dangerous.

Call your provider immediately if any of the following occurs:

• Severe headache
• Stiff neck
• Drowsiness
• Sensitivity to light
• Pain when moving your eye
• Nausea or vomiting

Premature Breakdown of Red Blood Cells 

A rapid breakdown of red blood cells can cause hemolytic anemia.

Call your healthcare provider immediately if any of the following occurs:

• Fatigue
• Increased heart rate
• Yellowing of skin or eyes
• Dark-colored urine

Acute Lung Injury

In some users, fluid may build up in the lungs after receiving Bivigam or other similar products. Symptoms usually appear within 1 to 6 hours after treatment.

Call your healthcare provider immediately if any of the following occurs:

• Trouble breathing
• Chest pain
• Blue lips
• Fever

Infectious Disease

Because Bivigam contains donor antibodies, there’s a small possibility that it may contain viruses or other disease-causing substances. Ask your provider about the risks and benefits of therapy.