How Assistance Works
Streamlining our patient’s specialty pharmacy experience with unmatched full-service convenience
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1. Check Your Coverage/Benefits Verification
Our team of expert billers finds the best avenues of coverage that minimize out-of-pocket costs.
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2. Transfer Prescription to AmeriPharma®
We process your prescription by working with your previous pharmacy or prescriber, making the transition quick and easy.
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3. Prior Authorization
Our team of specialists obtains approval from your insurance companies within 24 to 72 hours.
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4. Copay Assistance & Financial Aid
We secure financial aid and decrease copays, out-of-pocket expenses, and high deductibles. To date, AmeriPharma® Specialty Care has secured $55 million in financial assistance for our patients.
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5. Nursing Care Coordination
AmeriPharma® puts your schedule and home environment first when scheduling and coordinating one of our specialized nurses for your in-home infusions.
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6. Delivery Coordination
Medications are always delivered in strict compliance with the specific requirements for shipping. Next-day and overnight cold-chain deliveries are coordinated around your schedule.
What Is Renflexis?
Renflexis is a prescription drug used to treat a range of autoimmune disorders. Autoimmune disorders occur when the immune cells attack healthy cells, mistaking them for foreign particles (bacteria or viruses).
Renflexis is a biological product belonging to a family of medicines called tumor necrosis factor (TNF) blockers or anti-TNF agents. Biological products, or simply biologics, are made using living cells.
The active ingredient in Renflexis—infliximab-abda— is a biosimilar to infliximab (brand name: Remicade). A biosimilar means that Renflexis is almost identical to Remicade in terms of its indication for use, recommended dosage, strength, preparation, and administration for use. Other biosimilars to Remicade include:
- Inflectra (infliximab-dyyb)
- Avsola (infliximab-axxq)
- Ixifi (infliximab-qbtx)
The 4-letter suffix following the non-proprietary name of the drug (infliximab in this case) is unique to each biological product. This helps healthcare professionals distinguish between different branded versions of a biologic.
What Is Renflexis Used To Treat?
Renflexis has been FDA-approved to treat several autoimmune disorders in adults and children 6 years and older.
Adults
- Crohn’s disease (CD). CD is a long-term condition that causes inflammation and irritation in the digestive tract, particularly the small intestine and upper part of the colon. Renflexis helps to improve the signs and symptoms of this condition. The goal of this therapy is to help induce and maintain a symptom-free state.
- Ulcerative colitis (UC). Patients with UC will mainly experience inflammation and irritation in the colon (the longest part of the large intestine). Renflexis helps to improve the signs and symptoms of this condition. This therapy aims to help induce and maintain a symptom-free state.
- Rheumatoid arthritis (RA). RA is a weakening condition that can cause joint pain, swelling, and stiffness. Renflexis helps to reduce the signs and symptoms, delay joint damage, and improve overall joint function.
- Ankylosing spondylitis. Ankylosing spondylitis (a form of arthritis) affects the spine. Renflexis helps to reduce the signs and symptoms and delay joint damage.
- Psoriatic arthritis. Psoriatic arthritis can occur in some people with psoriasis (visible patches of thick red skin and silvery scales present on the skin). Renflexis helps to reduce the signs and symptoms, delay joint damage, and help improve overall joint function.
- Plaque psoriasis. Renflexis improves symptoms in adults with chronic severe plaque psoriasis, a skin disease that causes scaly and painful skin patches (plaques).
Children
Renflexis is FDA-approved to treat children 6 years and older who have been diagnosed with Crohn’s disease and ulcerative colitis.
Copay and Financial Assistance
AmeriPharma™ Specialty Pharmacy alleviates financial burdens for patients and their families
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Advanced software locates funding sources to match you with top-dollar foundation programs
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One of our copay assistance specialists will assist with the application process
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Automatic updates will be sent to you and your physician on the status of the funding
Renflexis Side Effects
Side effects are generally mild, but can be severe or life-threatening.
Renflexis does carry a U.S. Boxed Warning, stating that this medication can cause serious infections and certain types of malignancy in both adults and children. Patients who have weakened immune systems, active TB, or a history of recent invasive infections should consult with their doctor prior to starting therapy. This medication can also lead to certain types of lymphoma or another rare type of T-cell lymphoma.
Common Side Effects
- Sinus infections (stuffy nose, breathing difficulty, and pain around the eyes)
- Sore throat
- Headache
- Coughing
- Stomach pain or diarrhea
- Feeling tired or weak
Talk to your doctor or pharmacist if any of these side effects worsen or persist.
Severe Side Effects
Call your doctor immediately if you experience any serious side effects. You should call 911 if you think your symptoms are life-threatening and seek medical attention immediately. The severe side effects with their symptoms are listed below:
Serious infections
- Fever
- Feeling very tired
- Coughing
- Flu-like symptoms
- Warm, red, or painful skin
Hepatitis (liver inflammation) or liver failure
- Pain on the upper right side of the stomach
- Dark brown urine
- Exhaustion
- Fever
- Jaundice (yellowing of skin and eyes)
New or worsening heart failure
- Shortness of breath
- Swelling in the ankles or feet
- Sudden weight gain
Heart attack, ischemia (decreased blood flow to the heart), or irregular heartbeat
These problems may occur within 24 hours after starting the infusion.
- Chest discomfort or pain
- Arm pain
- Stomach pain
- Shortness of breath
- Anxiety
- Lightheadedness
- Dizziness
- Fainting
- Sweating
- Nausea and vomiting
- Irregular heartbeat
- Feelings of a pounding heart
Blood problems
- Persistent fever
- Easy bruising or bleeding
- Pale skin
Problems affecting the brain, spinal cord, and nerves
- Vision changes
- Seizures
- Tingling or numbness that can affect any part of the body
Lupus-like syndrome
- Persistent chest pain or discomfort
- Shortness of breath
- Joint pain
- Rash on your cheeks or arms, which often gets worse in the sun
Infusion-Related Reactions
These symptoms may occur during or up to 2 hours after an infusion:
- Shortness of breath
- Flushing
- Headache
- Rash
- Chest pain
- Seizures
- Low or high blood pressure
Allergic Reactions
Seek emergency medical help if you experience the following:
- Chest pain
- Hives
- Shortness of breath
- High or low blood pressure
- Fever
- Chills
Renflexis Side Effects on Children
When used for ulcerative colitis, the risk of infections appears to be higher in children than adults. In addition, the side effects can differ among children and adults who take the drug for Crohn’s disease.
Clinical trials show that the following side effects are more common in children:
- Anemia (low red blood cell levels)
- Leukopenia (low white blood cell levels)
- Flushing
- Viral infection
- Neutropenia (low levels of specific immune cells)
- Bone fracture
- Bacterial infection
