援助如何运作
通过无与伦比的全方位服务便利性，简化患者的专业药房体验
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1. 检查您的保险范围/福利验证
我们的专业出纳员团队会找到最佳的保险途径，以最大程度地减少自付费用。
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2. 将处方转移到 AmeriPharma®
我们与您之前的药房或处方人员合作来处理您的处方，使过渡变得快速而简单。
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3. 事先授权
我们的专家团队将在 24 至 72 小时内获得您保险公司的批准。
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4. 共付额援助和经济援助
我们确保患者获得经济援助，并降低共付额、自付费用和高额免赔额。迄今为止，AmeriPharma® 专科护理已为患者争取到 1TP4.4755 亿美元的经济援助。
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5. 必要时的护理协调
AmeriPharma® 在安排和协调我们的专业护士为您进行家庭输液时，会将您的日程安排和家庭环境放在首位。
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6. 交付协调
药品始终严格遵守运输的具体要求。次日或隔夜冷链配送将根据您的时间安排进行协调。
Tretten Introduction and Uses
Tretten is a brand-name prescription product. It contains catridecacog, a recombinant form of coagulation factor XIII A-subunit. Tretten belongs to a drug class known as coagulation factors or hemostatics.
Tretten is produced using recombinant DNA technology and is not derived from human plasma.
A healthcare provider may prescribe this medication to prevent bleeding in children and adults with congenital factor XIII (FXIII) A-subunit deficiency.
Congenital factor XIII (FXIII) A-subunit deficiency is a rare inherited bleeding disorder. It is estimated to affect 1 in every 1 to 3 million people. In people with this disorder, the blood doesn’t clot properly, leading to a higher risk of [1]:
- Life-threatening bleeds (most notably, spontaneous bleeding within the brain)
- 伤口愈合延迟
- Recurrent spontaneous abortion in women
Currently, Tretten is the first and only recombinant therapy for people with congenital factor XIII (FXIII) A-subunit deficiency. All other approved treatments are derived from plasma.
This medication shouldn’t be used to treat another similar bleeding disorder called congenital factor XIII B‑subunit deficiency.
Note: Tretten is sold under the brand name NovoThirteen in the EU, Switzerland, and Australia.
Tretten Mechanism of Action
Factor XIII A-subunit plays a crucial role in blood clotting. When bleeding occurs, the body forms a mesh of fibrin proteins to create a blood clot. Activated factor XIII helps strengthen and stabilize the clot by linking fibrin strands together.
When you have factor XIII A-subunit deficiency, blood clots become unstable and fragile. As a result, blood clots may break down too easily, increasing the risk of potentially life-threatening bleeding.
Tretten is a lab-created protein that works the same way as the naturally occurring factor XIII-A subunit in the body. Thus, it helps stabilize clots and prevent bleeding.
Important Tretten Warnings and Precautions
过敏反应
This medication may cause allergic reactions. Seek emergency medical care if you experience:
- 皮疹
- 胸闷
- 哮鸣
You should not use this medication if you have a history of allergic reactions to this product or any product component.
抑制剂生产
In some cases, your body can make proteins called “inhibitors” that can stop this medication from working as well as it should.
If your immune system makes inhibitors, Tretten may become less effective. Your healthcare provider may test for inhibitors if the medication stops working as expected or your factor XIII activity is lower than expected.
Risk of Blood Clots
If you have a higher risk of blood clots, your healthcare provider will monitor you after administering Tretten. Do not use Tretten together with recombinant factor VIIa, as this combination may increase the risk of blood clots.
How Tretten Copay Assistance Works
AmeriPharma® 特药药房减轻了患者及其家人的经济负担
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先进的软件可以定位资金来源，为您匹配高额的基金会项目
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我们的一位共付额援助专家将协助您完成申请流程
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自动更新信息将发送给您和您的医生，告知您资金状况
Tretten Dosage
The recommended dose of Tretten for routine bleeding prevention is 35 IU/kg of body weight, administered once every 28 days. Your healthcare provider may monitor factor XIII activity and adjust treatment to maintain trough FXIII activity at or above 10%.
Tretten Administration and Proper Use
- Your healthcare provider will inject the reconstituted medicine into your vein once monthly.
- The dose is individualized based on your body weight.
- You may inject it yourself after receiving instructions from your healthcare provider.
- Strictly follow the instructions about proper use, dose, and techniques for administration. If you are unclear about anything, ask your healthcare provider for help.
- Tretten comes as a powder, which must be mixed with sterile water before injection. The sterile water comes in a separate vial.
- If you need a smaller dose, you may dilute the medicine with 0.9% sodium chloride.
- Administer Tretten as a slow intravenous injection at a rate not exceeding 1–2 ml per minute, following your healthcare provider’s instructions.
- Do not mix Tretten with other infusion solutions or administer it as an IV drip.
- Open the package only when you are ready to administer the medicine.
- Don’t use expired or damaged medicine.
Tretten Side Effects
过敏反应
Seek emergency medical care if you experience any of the following signs and symptoms after receiving Tretten:
- 气促
- 皮疹
- 瘙痒
- 皮肤发红
- 昏厥
- 头晕
血栓
Seek emergency medical care if you experience any of the following signs and symptoms after receiving Tretten:
- Pain, swelling, warmth, redness, or a lump in the legs or arms
- 胸痛
- Sudden severe headache
- 昏厥
Call your doctor immediately if you have any unexpected bleeding.
其他副作用包括：
- 手臂或腿部疼痛
- 头痛
- 注射部位疼痛
- Increased D-dimer levels (a laboratory finding related to blood clot formation and breakdown)
接受保险
我们接受 Medicare、跨州 Medicaid、Medi-Cal、Blue Shield 以及大多数私人保险。请致电我们，了解更多您的保险信息。
