援助如何运作
通过无与伦比的全方位服务便利性，简化患者的专业药房体验
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1. 检查您的保险范围/福利验证
我们的专业出纳员团队会找到最佳的保险途径，以最大程度地减少自付费用。
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2. 将处方转移到 AmeriPharma®
我们与您之前的药房或处方人员合作来处理您的处方，使过渡变得快速而简单。
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3. 事先授权
我们的专家团队将在 24 至 72 小时内获得您保险公司的批准。
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4. 共付额援助和经济援助
我们确保患者获得经济援助，并降低共付额、自付费用和高额免赔额。迄今为止，AmeriPharma® 专科护理已为患者争取到 1TP4.4755 亿美元的经济援助。
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5. 必要时的护理协调
AmeriPharma® 在安排和协调我们的专业护士为您进行家庭输液时，会将您的日程安排和家庭环境放在首位。
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6. 交付协调
药品始终严格遵守运输的具体要求。次日或隔夜冷链配送将根据您的时间安排进行协调。
What Is Profilnine SD?
Profilnine SD (Factor IX complex) is a replacement therapy used to prevent and control bleeding in people with factor IX deficiency due to 血友病B. Hemophilia B is an inherited bleeding disorder in which the body does not produce enough functional factor IX, a protein needed for normal blood clotting.
Profilnine SD is made from pooled human plasma and is administered intravenously (into a vein). It temporarily increases factor IX levels to help the blood clot properly and prevent or control excessive bleeding.
Profilnine SD is manufactured by Grifols Biologicals LLC and was originally approved by the FDA on July 20, 1981. In this article, we’ll discuss important information about Profilnine SD, including its uses, dosage, administration, side effects, warnings, and precautions.
Profilnine SD: Approved Uses
Profilnine SD is FDA-approved for the prevention and control of bleeding in people with factor IX deficiency due to hemophilia B.
Hemophilia B, sometimes called Christmas disease, is an inherited bleeding disorder caused by a deficiency or dysfunction of clotting factor IX. Without enough functional factor IX, the blood does not clot properly, which can cause prolonged or excessive bleeding.
Profilnine SD temporarily replaces deficient factor IX to help prevent or control bleeding.
作用方式
Profilnine SD contains clotting factor IX along with factors II and X and low levels of factor VII. In people with hemophilia B, Profilnine SD temporarily replaces deficient factor IX, increasing factor IX activity in the blood and helping the normal blood-clotting process occur.
The effects of factor IX replacement therapies are temporary, so additional doses may be necessary depending on the severity and location of bleeding, the desired factor IX level, and the patient’s response to treatment.
How Profilnine SD Copay Assistance Works
AmeriPharma® 特药药房减轻了患者及其家人的经济负担
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先进的软件可以定位资金来源，为您匹配高额的基金会项目
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我们的一位共付额援助专家将协助您完成申请流程
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自动更新信息将发送给您和您的医生，告知您资金状况
剂量和用法
Profilnine SD is administered intravenously after reconstitution. The infusion rate should not exceed 10 ml per minute because administering the medication too rapidly may cause vasomotor reactions. The appropriate dose varies from person to person and should be determined by a healthcare provider.
The dose may depend on factors such as:
- 体重
- Baseline factor IX level
- 期望的因子IX水平
- 出血部位和严重程度
- Individual response to treatment
- Whether treatment is needed around a surgical procedure
How Is the Profilnine SD Dose Calculated?
According to the prescribing information, approximately 1 unit of factor IX per kilogram of body weight can be expected to increase circulating factor IX levels by about 1%. However, individual responses may vary.
A healthcare provider may estimate the required dose using the following formula:
Body weight (kg) × desired increase in factor IX (%) × 1 unit/kg = factor IX units required
Factor IX levels should be monitored to help determine whether the desired level has been achieved and maintained.
Typical Dose of Profilnine SD for Hemophilia B
Factor IX dosing depends on bleeding severity. For minor to moderate bleeding, levels are raised to 20–30% every 16–24 hours, with treatment lasting 1–2 days for minor bleeds and 2–7 days for moderate ones.
For major bleeding, levels are first raised to 30–50%, then maintained at 20% until healing, typically over 3–10 days.
For surgery, levels are raised to 30–50% beforehand (up to 50% for dental extractions) and maintained until healing, usually 7–10 days, with doses given every 16–24 hours throughout. In short, more severe bleeding requires higher factor IX levels and longer treatment.
Profilnine SD Side Effects
副作用包括：
- 头痛
- 发烧
- 发冷
- 冲洗
- 恶心
- 呕吐
- 刺痛
- Lethargy (lack of energy)
- 麻疹
严重不良反应包括：
- Severe allergic or hypersensitivity reactions, including anaphylaxis
- Abnormal blood clot formation (thrombosis), including deep vein thrombosis (DVT) and pulmonary embolism (PE)
- Disseminated intravascular coagulation (DIC), a serious condition that causes abnormal clotting throughout the body’s blood vessels
- Development of factor IX inhibitors, which can make factor IX replacement therapy less effective
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我们接受 Medicare、跨州 Medicaid、Medi-Cal、Blue Shield 以及大多数私人保险。请致电我们，了解更多您的保险信息。
