援助如何运作
通过无与伦比的全方位服务便利性，简化患者的专业药房体验
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1. 检查您的保险范围/福利验证
我们的专业出纳员团队会找到最佳的保险途径，以最大程度地减少自付费用。
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2. 将处方转移到 AmeriPharma®
我们与您之前的药房或处方人员合作来处理您的处方，使过渡变得快速而简单。
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3. 事先授权
我们的专家团队将在 24 至 72 小时内获得您保险公司的批准。
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4. 共付额援助和经济援助
我们确保患者获得经济援助，并降低共付额、自付费用和高额免赔额。迄今为止，AmeriPharma® 专科护理已为患者争取到 1TP4.4755 亿美元的经济援助。
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5. 必要时的护理协调
AmeriPharma® 在安排和协调我们的专业护士为您进行家庭输液时，会将您的日程安排和家庭环境放在首位。
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6. 交付协调
药品始终严格遵守运输的具体要求。次日或隔夜冷链配送将根据您的时间安排进行协调。
What Is Rixubis?
Rixubis is a recombinant factor IX replacement medicine used to replace deficient factor IX in people with 血友病B. It contains recombinant (laboratory-produced) coagulation factor IX. Rixubis comes as a lyophilized powder that is mixed with sterile water before use. You will receive it by intravenous infusion (into a vein).
Rixubis was initially approved by the FDA in 2013 for adults with hemophilia B. Later in 2014, its approval was expanded to include children. Rixubis is available in several strengths, including 250 IU, 500 IU, 1,000 IU, 2,000 IU, and 3,000 IU.
What Is Rixubis Used For?
Rixubis is FDA-approved for adults and children with hemophilia B. It is FDA-approved for:
On-Demand Treatment and Control of Bleeding: A person with hemophilia B can use Rixubis when a bleeding episode occurs. Replacing factor IX increases the amount of clotting factor available in the bloodstream. This helps your body stop the bleeding.
Routine Prophylaxis: You can use Rixubis regularly as a preventive treatment. Regular use of Rixubis increases factor IX activity and helps reduce the frequency of bleeding episodes.
Perioperative Management: Rixubis can be used around the time of surgery to maintain adequate factor IX activity and reduce the risk of excessive bleeding.
Please note that Rixubis does not cure hemophilia B. Instead, it temporarily replaces the missing clotting factor and helps prevent or control bleeding.
How Does Rixubis Work?
Factor IX is a protein that plays an important role in blood clotting. It participates in a series of reactions known as the coagulation cascade. These reactions eventually produce thrombin, which helps convert fibrinogen into fibrin. Fibrin forms a strong mesh that stabilizes the blood clot.
People with hemophilia B have insufficient factor IX, so this clotting process does not work properly. As a result, they experience bleeding for an unusually long time.
Rixubis contains recombinant factor IX. When infused into a vein, it temporarily increases factor IX activity in the blood, supporting the coagulation cascade and helping the body form stable blood clots to prevent or control bleeding.
Before Starting Rixubis
Before you start Rixubis, tell your doctor your full medical history. Let them know if you:
- Have had an allergic reaction to Rixubis or any of its ingredients
- 对仓鼠蛋白过敏
- Have or have had factor IX inhibitors
- Have liver disease or problems with blood clotting
- 怀孕、计划怀孕或正在哺乳
- Take prescription medicines, over-the-counter medicines, vitamins, or herbal supplements
A few other things to keep in mind before you start:
- Rixubis is contraindicated in patients with known hypersensitivity to Rixubis or its components, including hamster protein.
- Tell your doctor about any signs of an allergic reaction during or after your infusion.
- Your doctor may monitor your factor IX levels and check for inhibitors during treatment.
- Don’t use Rixubis to induce immune tolerance. Its safety and effectiveness for that haven’t been established.
How Rixubis Copay Assistance Works
AmeriPharma® 特药药房减轻了患者及其家人的经济负担
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先进的软件可以定位资金来源，为您匹配高额的基金会项目
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我们的一位共付额援助专家将协助您完成申请流程
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自动更新信息将发送给您和您的医生，告知您资金状况
Dosing of Rixubis
Rixubis is given as an IV infusion after the powder is mixed with sterile water. Your dose and treatment schedule depend on your age, weight, factor IX activity, the location and severity of bleeding, and how you respond to treatment. Your healthcare provider will individualize the dose based on your clinical response and may measure factor IX activity to make sure the desired level is achieved.
For patients 12 and older, 1 IU/kg of Rixubis raises factor IX activity by about 0.9 IU/dl. For children younger than 12, the increase is about 0.7 IU/dl. Here is the usual recommended dosage:
常规预防： The recommended dose for adults and children 12 years of age and older is 40 to 60 international units per kg twice weekly. For children younger than 12, the recommended dose is 60–80 IU/kg twice weekly.
For Bleeding Episodes: The dose and treatment duration depend on the location and severity of bleeding and your individual response.
为了 minor bleeding, the desired factor IX activity is generally 20–30 IU/dl. Treatment is generally given every 12–24 hours for at least 1 day, until healing is achieved.
为了 moderate bleeding, the desired factor IX activity is generally 25–50 IU/dl. Treatment is generally given every 12–24 hours for 2–7 days, until bleeding stops and healing is achieved.
为了 major bleeding, the desired factor IX activity is generally 50–100 IU/dl. Treatment is generally given every 12–24 hours for 7–10 days, until bleeding stops and healing is achieved.
对于手术： Rixubis can be used before, during, and after surgery to maintain adequate factor IX activity and reduce the risk of excessive bleeding. For minor surgery, the target factor IX activity is generally 30–60 IU/dl, with treatment generally given every 24 hours for at least 1 day, until healing is achieved. For major surgery, the target is generally 80–100 IU/dl, with treatment generally given every 8–24 hours for 7–10 days, until healing is achieved. Dosing should be individualized based on factor IX activity and clinical response.
Rixubis Side Effects
常见的副作用包括：
- Unusual or altered taste in the mouth
- 手臂或腿部疼痛
- A positive test for furin antibodies
严重的副作用包括：
Serious side effects from Rixubis are rare, but they can happen. Serious side effects associated with Rixubis include:
严重过敏反应： Rixubis can cause serious allergic reactions, including anaphylaxis. Patients should be monitored for signs and symptoms of hypersensitivity. Get emergency care if you develop hives, swelling, chest tightness, trouble breathing, wheezing, dizziness, or fainting.
Factor IX Inhibitors: Some patients can develop neutralizing antibodies, called inhibitors, against factor IX. These inhibitors can reduce the effectiveness of factor IX replacement therapy. Your doctor may test your blood for inhibitors, especially if bleeding doesn’t stop as expected or your factor IX levels don’t rise enough.
血栓： Factor IX medicines have been linked to abnormal blood clot formation inside blood vessels. Your doctor may watch you more closely if you have liver disease, are having surgery, show signs of abnormal clotting, or have other risk factors.
Please note that this is not a list of all possible side effects. Contact your healthcare provider if you experience concerning side effects. Seek emergency medical care for symptoms of a severe allergic reaction, such as difficulty breathing, wheezing, chest tightness, dizziness, fainting, or swelling of the face or throat.
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