{"id":27951,"date":"2025-12-16T16:00:40","date_gmt":"2025-12-16T23:00:40","guid":{"rendered":"https:\/\/ameripharmaspecialty.com\/?p=27951"},"modified":"2025-12-16T16:00:45","modified_gmt":"2025-12-16T23:00:45","slug":"ivig-for-hyperimmunoglobulinemia-e-syndrome-hies","status":"publish","type":"post","link":"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/ivig-for-hyperimmunoglobulinemia-e-syndrome-hies\/","title":{"rendered":"\u9759\u8109\u6ce8\u5c04\u514d\u75ab\u7403\u86cb\u767d\u6cbb\u7597\u9ad8\u514d\u75ab\u7403\u86cb\u767dE\u7efc\u5408\u5f81\uff08HIES\uff09"},"content":{"rendered":"\n<p>Hyperimmunoglobulinemia E syndrome (HIES), commonly known as Job\u2019s Syndrome, is a rare primary immunodeficiency disorder where the immune system does not work properly. People with HIES typically have very high levels of immunoglobulin E (IgE) along with frequent infections and skin and lung problems [<a href=\"https:\/\/en.wikipedia.org\/wiki\/Hyperimmunoglobulin_E_syndrome\">1<\/a>][<a href=\"https:\/\/primaryimmune.org\/understanding-primary-immunodeficiency\/types-of-pi\/hyper-ige-syndrome\">2<\/a>]. Without proper treatment, HIES can cause permanent organ damage.\u00a0<\/p>\n\n\n\n<div  id=\"call-to-action-c05d6cd7fcc1bf241d493315de995423\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tDo You Qualify for $0 Copay?\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"cta__sub__heading\">\n\t\t\t\t\t\t\tTalk to a Specialist to Find Out\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"tel:8777780318\">(877) 778-0318<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<p>The good news is that modern medical care has advanced significantly. If you are diagnosed with HIES today, you have far better treatment options than before. In recent years, among the treatment options, <a href=\"https:\/\/ameripharmaspecialty.com\/ivig\/ivig\/\">intravenous immunoglobulin<\/a> (IVIG) has shown promising results. In this article, we will discuss everything you need to know about IVIG for hyperimmunoglobulinemia E syndrome (HIES).<\/p>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/ivig-for-hyperimmunoglobulinemia-e-syndrome-hies\/#Hyperimmunoglobulinemia_E_Syndrome_HIES_Overview\" >Hyperimmunoglobulinemia E Syndrome (HIES): Overview<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/ivig-for-hyperimmunoglobulinemia-e-syndrome-hies\/#Signs_and_Symptoms_of_HIES\" >Signs and Symptoms of HIES<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/ivig-for-hyperimmunoglobulinemia-e-syndrome-hies\/#Treatment_Options_for_HIES\" >Treatment Options for HIES<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/ivig-for-hyperimmunoglobulinemia-e-syndrome-hies\/#How_Does_IVIG_Help_Patients_With_Hyperimmunoglobulinemia_E_Syndrome_HIES\" >How Does IVIG Help Patients With Hyperimmunoglobulinemia E Syndrome (HIES)?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/ivig-for-hyperimmunoglobulinemia-e-syndrome-hies\/#Effectiveness_of_IVIG_in_Hyperimmunoglobulinemia_E_Syndrome_HIES_What_Studies_Say\" >Effectiveness of IVIG in Hyperimmunoglobulinemia E Syndrome (HIES): What Studies Say<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/ivig-for-hyperimmunoglobulinemia-e-syndrome-hies\/#FAQs\" >FAQs<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\" id=\"h-hyperimmunoglobulinemia-e-syndrome-hies-overview\"><span class=\"ez-toc-section\" id=\"Hyperimmunoglobulinemia_E_Syndrome_HIES_Overview\"><\/span><strong>Hyperimmunoglobulinemia E Syndrome (HIES): Overview<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Normally, your immune system protects you by fighting off foreign pathogens like viruses and bacteria. However, in hyperimmunoglobulinemia E syndrome (HIES) \u2014 a rare genetic immune disorder \u2014 the immune system does not work properly. As a result, you suffer from frequent infections, especially in your skin and lungs.&nbsp;<\/p>\n\n\n\n<p>People with HIES have a very high level of an antibody called immunoglobulin E (IgE), but it does not protect them from infections. There are mainly two types of HIES, and they share some common symptoms. However, their complications, treatment needs, and long-term outcomes are different. Below, they are described in detail [<a href=\"https:\/\/en.wikipedia.org\/wiki\/Hyperimmunoglobulin_E_syndrome\">1<\/a>][<a href=\"https:\/\/primaryimmune.org\/understanding-primary-immunodeficiency\/types-of-pi\/hyper-ige-syndrome\">2<\/a>]:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Autosomal Dominant HIES (AD-HIES):<\/strong> This type of HIES is usually caused by mutations in the STAT3 gene. You only need to inherit one defective copy of this gene to get this disease. This disease leads to very high immunoglobulin E (IgE) levels, frequent skin and lung infections, and facial, dental, and skeletal abnormalities.\u00a0<\/li>\n\n\n\n<li><strong>Autosomal Recessive HIES (AR-HIES):<\/strong> This type of HIES is most commonly caused by DOCK8 gene mutations. Mutations in other genes, such as TYK2, PGM3, and SPINK5, can also cause this disease. You need to inherit the mutated gene from both your parents to get this disease. Compared to AD-HIES patients, AR-HIES patients suffer from more severe viral infections and stronger allergies.\u00a0<\/li>\n<\/ol>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-signs-and-symptoms-of-hies\"><span class=\"ez-toc-section\" id=\"Signs_and_Symptoms_of_HIES\"><\/span><strong>Signs and Symptoms of HIES<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>The symptoms of HIES vary from person to person, depending on the type and severity. Some common symptoms include [<a href=\"https:\/\/primaryimmune.org\/understanding-primary-immunodeficiency\/types-of-pi\/hyper-ige-syndrome\">2<\/a>][<a href=\"https:\/\/www.immunodeficiencyuk.org\/wp-content\/uploads\/2022\/02\/ImmunodeficiencyUKHIESEdition2.pdf\">3<\/a>]:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Extremely high levels of an antibody called immunoglobulin E (IgE) in the blood<\/li>\n\n\n\n<li>Eczema and skin infections<\/li>\n\n\n\n<li>Recurrent lung infections<\/li>\n\n\n\n<li>Delayed loss of baby teeth<\/li>\n\n\n\n<li>Severe allergies and asthma<\/li>\n\n\n\n<li>Facial asymmetry (commonly in AD-HIES)<\/li>\n\n\n\n<li>Frequent fungal infections<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-treatment-options-for-hies\"><span class=\"ez-toc-section\" id=\"Treatment_Options_for_HIES\"><\/span><strong>Treatment Options for HIES<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Unfortunately, currently there is no cure for hyperimmunoglobulinemia E syndrome (HIES). The main goals of the current treatment options are to manage your symptoms and prevent infections. Here are some of the standard treatment options for HIES [<a href=\"https:\/\/primaryimmune.org\/understanding-primary-immunodeficiency\/types-of-pi\/hyper-ige-syndrome\">2<\/a>][<a href=\"https:\/\/www.immunodeficiencyuk.org\/wp-content\/uploads\/2022\/02\/ImmunodeficiencyUKHIESEdition2.pdf\">3<\/a>]:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Antibiotics:<\/strong> You need to frequently take antibiotics to treat and prevent bacterial infections.<\/li>\n\n\n\n<li><strong>Antiviral Medicines:<\/strong> If you develop infections from viruses, you need to take antiviral medicines. For example, to treat chicken pox, you need to take Aciclovir.<\/li>\n\n\n\n<li><strong>Skin Care:<\/strong> Moisturizers, topical steroids, and antiseptic baths help control eczema and prevent skin infections.<\/li>\n\n\n\n<li><strong>Surgery:<\/strong> You may need to drain skin and lung abscesses surgically.<\/li>\n\n\n\n<li><strong>Intravenous Immunoglobulin (IVIG):<\/strong> IVIG can be a very important supportive care for you. It can help you by boosting your immune function.<\/li>\n<\/ul>\n\n\n\n<div  id=\"call-to-action-58c8c92d00f7c3c0b13f151bdec6d9d4\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tTalk With a Copay Assistance Specialist\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"#form\">Schedule a Consultation<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-how-does-ivig-help-patients-with-hyperimmunoglobulinemia-e-syndrome-hies\"><span class=\"ez-toc-section\" id=\"How_Does_IVIG_Help_Patients_With_Hyperimmunoglobulinemia_E_Syndrome_HIES\"><\/span><strong>How Does IVIG Help Patients With Hyperimmunoglobulinemia E Syndrome (HIES)?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"420\" height=\"299\" src=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2025\/12\/ivig-at-home-1.jpg\" alt=\"Patient on bed receiving IVIG at home\" class=\"wp-image-27954\" srcset=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2025\/12\/ivig-at-home-1.jpg 420w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2025\/12\/ivig-at-home-1-300x214.jpg 300w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2025\/12\/ivig-at-home-1-18x12.jpg 18w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2025\/12\/ivig-at-home-1-86x61.jpg 86w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2025\/12\/ivig-at-home-1-167x119.jpg 167w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2025\/12\/ivig-at-home-1-280x199.jpg 280w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2025\/12\/ivig-at-home-1-370x263.jpg 370w\" sizes=\"auto, (max-width: 420px) 100vw, 420px\" \/><\/figure>\n<\/div>\n\n\n<p>Intravenous Immunoglobulin (IVIG) is a purified blood product that contains <a href=\"https:\/\/ameripharmaspecialty.com\/ivig\/immunoglobulins-ig\/\">antibodies<\/a> from thousands of healthy plasma donors. In HIES, your immune system does not work properly. IVIG can help since it contains ready-made antibodies that help regulate and strengthen your immune system. Here is how IVIG helps patients with HIES:<br><\/p>\n\n\n\n<p><strong>It Strengthens the Immune System:<\/strong> In HIES, although you have a very high level of IgE, your antibody function is weak. IVIG contains various antibodies, which may help you fight infections more effectively [<a href=\"https:\/\/www.uptodate.com\/contents\/intravenous-immune-globulin-ivig-beyond-the-basics\/print\">4<\/a>].<\/p>\n\n\n\n<p><strong>It Reduces Infection Frequencies:<\/strong> In HIES, the biggest challenge that you face is recurrent skin and lung infections. Several studies showed that IVIG can reduce the frequency of infections [<a href=\"https:\/\/doi.org\/10.1016\/j.jaci.2006.12.084\">5<\/a>][<a href=\"https:\/\/doi.org\/10.1016\/j.anai.2016.09.275\">7<\/a>].<\/p>\n\n\n\n<p><strong>It Modulates the Immune System:<\/strong> In HIES, your immune system may sometimes react too strongly, causing eczema, allergies, and severe inflammation. IVIG can calm your immune system by suppressing harmful immune cells and cytokines [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK554446\/\">6<\/a>].<\/p>\n\n\n\n<p><strong>It Prevents Lung Damage:<\/strong> HIES can cause repeated lung infections, which can lead to permanent lung damage. IVIG can help prevent long-term lung damage by reducing the frequency of lung infections.<\/p>\n\n\n\n<p>Overall, IVIG is not a cure for HIES. But it plays an important supportive role. If you use it under proper medical supervision, it can improve your quality of life, reduce complications, and prevent long-term organ damage.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-effectiveness-of-ivig-in-hyperimmunoglobulinemia-e-syndrome-hies-what-studies-say\"><span class=\"ez-toc-section\" id=\"Effectiveness_of_IVIG_in_Hyperimmunoglobulinemia_E_Syndrome_HIES_What_Studies_Say\"><\/span><strong>Effectiveness of IVIG in Hyperimmunoglobulinemia E Syndrome (HIES): What Studies Say<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Because HIES is very rare, large-scale clinical trials are limited. Most of what we know about IVIG for hyperimmunoglobulinemia E syndrome (HIES) comes from small studies and case reports. Although the evidence is limited, these studies suggest that IVIG may help reduce the frequency of infections and improve many immune-related symptoms in HIES patients.&nbsp;<\/p>\n\n\n\n<p>Over the years, clinical research has produced mixed results. This is partly due to the differences in patient characteristics and disease severity. Some have indicated that IVIG can play a supportive role in managing the condition. For example, a 2007 study presented the case of a 12-year-old boy who suffered from recurrent infections due to HIES. Once IVIG therapy began, he experienced significant clinical improvements and remained free of recurrent infections [<a href=\"https:\/\/doi.org\/10.1016\/j.jaci.2006.12.084\">5<\/a>]. Similarly, another study also supports the role of IVIG in treating recurrent infections in HIES [<a href=\"https:\/\/doi.org\/10.1016\/j.anai.2016.09.275\">7<\/a>]. Additionally, some research concluded that IVIG is effective in treating severe eczema and atopic dermatitis in HIES patients by reducing inflammation and stabilizing the immune response [<a href=\"https:\/\/doi.org\/10.1016\/s0091-6749(95)70185-0\">8<\/a>].<\/p>\n\n\n\n<p>Other reports highlight similar outcomes. A 2001 case report presented the incident of a 37-year-old woman with HIES who suffered from pneumonia. IVIG at a moderate dose improved her pneumonia symptoms [<a href=\"https:\/\/www.researchgate.net\/publication\/12242639_Moderate-dose_intravenous_immunoglobulin_treatment_of_Job's_syndrome_Case_report\">9<\/a>]. Similarly, another 2001 report presented the case of a 12-month-old infant with severe eczema and pulmonary infection due to HIES. After 35 days of IVIG therapy, the patient showed improvement [<a href=\"https:\/\/www.e-cep.org\/journal\/view.php\/journal\/view.php?number=2001441112\">10<\/a>].&nbsp;<\/p>\n\n\n\n<p>However, not all findings are positive. In a 1998 study, researchers used high-dose IVIG in one patient with HIES. Their results did not show meaningful clinical improvement in the HIES patient. The researchers observed no significant reduction in IgE levels, IgE synthesis, or other major immune functions [<a href=\"https:\/\/doi.org\/10.1016\/s1081-1206(10)62802-5\">11<\/a>].<\/p>\n\n\n\n<p>In summary, while we lack large-scale studies, small studies and case reports suggest that IVIG can help some HIES patients \u2014 especially those with recurrent infections, severe eczema, or poor response to standard treatments. Results vary from patient to patient, and some studies show little to no benefit. Overall, IVIG is most effective as a supportive therapy rather than a standalone treatment.<\/p>\n\n\n\n<div  id=\"call-to-action-b582e85f22fad563be1d363f812c25fc\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tGet Financial Assistance\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"tel:8777780318\">(877) 778-0318<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-faqs\"><span class=\"ez-toc-section\" id=\"FAQs\"><\/span><strong>FAQs<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Here are some frequently asked questions about IVIG for hyperimmunoglobulinemia E syndrome (HIES).<\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-does-ivig-cure-hyperimmunoglobulinemia-e-syndrome-hies\"><strong>Does IVIG cure hyperimmunoglobulinemia E syndrome (HIES)?<\/strong><\/h4>\n\n\n\n<p>No. Intravenous Immunoglobulin (IVIG) does not cure HIES. It can reduce the frequency of infections and improve the quality of life.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-is-ivig-fda-approved-for-treating-hies\"><strong>Is IVIG FDA-approved for treating HIES?<\/strong><\/h4>\n\n\n\n<p>No. IVIG is not FDA-approved for treating HIES. However, it is widely used off-label by doctors to control infections and support immune functions in HIES.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-how-long-does-it-take-for-ivig-to-work-in-hies-patients\"><strong>How long does it take for IVIG to work in HIES patients?<\/strong><\/h4>\n\n\n\n<p>The response time varies from patient to patient, depending on the severity of the disease and the patient\u2019s overall health. Many patients begin to notice improvements, such as fewer infections, within a few weeks to a few months of starting IVIG.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hyperimmunoglobulin E syndrome (HIES), commonly known as Job\u2019s Syndrome, is a rare primary immunodeficiency disorder where the immune system does not work properly. People with HIES typically have very high levels of immunoglobulin E (IgE) along with frequent infections and skin and lung problems [1][2].<\/p>\n","protected":false},"author":13,"featured_media":27952,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[7],"tags":[17],"class_list":["post-27951","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ivig","tag-dr-saba-rassouli"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>IVIG for Hyperimmunoglobulinemia E Syndrome (HIES) - AmeriPharma\u00ae Specialty Care<\/title>\n<meta name=\"description\" content=\"Learn how IVIG supports patients with Hyperimmunoglobulinemia E Syndrome (HIES), reducing infections, modulating immunity, and improving quality of life.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/ivig-for-hyperimmunoglobulinemia-e-syndrome-hies\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"IVIG for Hyperimmunoglobulinemia E Syndrome (HIES) - 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People with HIES typically have very high levels of immunoglobulin E (IgE) along with frequent infections and skin and lung problems [1][2].","rttpg_featured_image_url":{"full":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2025\/12\/ivig-for-HIES.jpg",1280,853,false],"landscape":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2025\/12\/ivig-for-HIES.jpg",1280,853,false],"portraits":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2025\/12\/ivig-for-HIES.jpg",1280,853,false],"thumbnail":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2025\/12\/ivig-for-HIES-150x150.jpg",150,150,true],"medium":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2025\/12\/ivig-for-HIES-300x200.jpg",300,200,true],"large":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2025\/12\/ivig-for-HIES-1024x682.jpg",1024,682,true],"1536x1536":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2025\/12\/ivig-for-HIES.jpg",1280,853,false],"2048x2048":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2025\/12\/ivig-for-HIES.jpg",1280,853,false],"trp-custom-language-flag":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2025\/12\/ivig-for-HIES-18x12.jpg",18,12,true],"block-image-html-large":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2025\/12\/ivig-for-HIES-600x400.jpg",600,400,true],"ct-gallery":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2025\/12\/ivig-for-HIES-330x220.jpg",330,220,true],"ct-section-header":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2025\/12\/ivig-for-HIES-1146x380.jpg",1146,380,true],"ct-thumb":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2025\/12\/ivig-for-HIES-86x57.jpg",86,57,true],"ct-thumb-large":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2025\/12\/ivig-for-HIES-167x111.jpg",167,111,true],"ct-small":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2025\/12\/ivig-for-HIES-280x187.jpg",280,187,true],"ct-medium":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2025\/12\/ivig-for-HIES-370x247.jpg",370,247,true],"ct-xmedium":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2025\/12\/ivig-for-HIES-960x640.jpg",960,640,true],"ct-large":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2025\/12\/ivig-for-HIES.jpg",1280,853,false]},"rttpg_author":{"display_name":"Dr. Saba Rassouli, PharmD","author_link":"https:\/\/ameripharmaspecialty.com\/zh\/author\/saba-rassouli\/"},"rttpg_comment":0,"rttpg_category":"<a href=\"https:\/\/ameripharmaspecialty.com\/zh\/category\/ivig\/\" rel=\"category tag\">IVIG<\/a>","rttpg_excerpt":"Hyperimmunoglobulin E syndrome (HIES), commonly known as Job\u2019s Syndrome, is a rare primary immunodeficiency disorder where the immune system does not work properly. People with HIES typically have very high levels of immunoglobulin E (IgE) along with frequent infections and skin and lung problems [1][2].","_links":{"self":[{"href":"https:\/\/ameripharmaspecialty.com\/zh\/wp-json\/wp\/v2\/posts\/27951","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ameripharmaspecialty.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ameripharmaspecialty.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ameripharmaspecialty.com\/zh\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/ameripharmaspecialty.com\/zh\/wp-json\/wp\/v2\/comments?post=27951"}],"version-history":[{"count":0,"href":"https:\/\/ameripharmaspecialty.com\/zh\/wp-json\/wp\/v2\/posts\/27951\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ameripharmaspecialty.com\/zh\/wp-json\/wp\/v2\/media\/27952"}],"wp:attachment":[{"href":"https:\/\/ameripharmaspecialty.com\/zh\/wp-json\/wp\/v2\/media?parent=27951"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ameripharmaspecialty.com\/zh\/wp-json\/wp\/v2\/categories?post=27951"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ameripharmaspecialty.com\/zh\/wp-json\/wp\/v2\/tags?post=27951"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}