{"id":27376,"date":"2024-12-17T13:17:00","date_gmt":"2024-12-17T20:17:00","guid":{"rendered":"https:\/\/ameripharmaspecialty.com\/uncategorized\/exploring-xgeva-and-its-role-in-treating-bone-related-issues\/"},"modified":"2026-03-19T14:59:59","modified_gmt":"2026-03-19T21:59:59","slug":"understanding-xgeva-and-its-role-in-treating-bone-related-issues","status":"publish","type":"post","link":"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/understanding-xgeva-and-its-role-in-treating-bone-related-issues\/","title":{"rendered":"\u63a2\u7d22Xgeva\u53ca\u5176\u5728\u6cbb\u7597\u9aa8\u76f8\u5173\u95ee\u9898\u4e2d\u7684\u4f5c\u7528"},"content":{"rendered":"\n<p>If you are suffering from advanced cancer that has spread to your bones, then Xgeva is an option that can help you prevent bone-related complications. The FDA first approved this drug on November 18, 2010 [<a href=\"https:\/\/www.drugs.com\/history\/xgeva.html\" target=\"_blank\" rel=\"noreferrer noopener\">1<\/a>].<\/p>\n\n\n\n<p>Several studies have shown that Xgeva injections are more effective in managing bone-related complications than other medications. In this article, we will explore everything you need to know about Xgeva, including its uses, dosing, side effects, cost, and more.<\/p>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/understanding-xgeva-and-its-role-in-treating-bone-related-issues\/#What_Is_Xgeva\" >What Is Xgeva?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/understanding-xgeva-and-its-role-in-treating-bone-related-issues\/#What_Is_Xgeva_Used_To_Treat\" >What Is Xgeva Used To Treat?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/understanding-xgeva-and-its-role-in-treating-bone-related-issues\/#How_Do_Xgeva_Injections_Work\" >How Do Xgeva Injections Work?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/understanding-xgeva-and-its-role-in-treating-bone-related-issues\/#Side_Effects\" >Side Effects<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/understanding-xgeva-and-its-role-in-treating-bone-related-issues\/#Mild_Side_Effects\" >Mild Side Effects<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/understanding-xgeva-and-its-role-in-treating-bone-related-issues\/#Severe_Side_Effects\" >Severe Side Effects<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/understanding-xgeva-and-its-role-in-treating-bone-related-issues\/#Xgeva_Dosing_Information\" >Xgeva Dosing Information<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/understanding-xgeva-and-its-role-in-treating-bone-related-issues\/#Xgeva_Cost\" >Xgeva Cost<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/understanding-xgeva-and-its-role-in-treating-bone-related-issues\/#Before_You_Start\" >Before You Start<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/understanding-xgeva-and-its-role-in-treating-bone-related-issues\/#FAQs\" >FAQs<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\" id=\"h-what-is-xgeva\"><span class=\"ez-toc-section\" id=\"What_Is_Xgeva\"><\/span>What Is Xgeva?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Xgeva (denosumab) is a brand-name prescription medication used to prevent bone-related complications in patients whose cancer has spread to the bones.<\/p>\n\n\n\n<p>These complications can include bone fractures and pressure on the spinal cord. Xgeva can also be used to treat high blood levels of calcium caused by cancers when other medications are ineffective.<\/p>\n\n\n\n<p>Xgeva is a monoclonal antibody. It helps you by reducing bone damage and increasing bone density. In clinical studies, researchers found that this medication was more effective than other drugs in preventing bone-related problems in cancer patients.<\/p>\n\n\n\n<p>In patients with <a href=\"https:\/\/ameripharmaspecialty.com\/ivig\/ivig-for-multiple-myeloma-mm\/\">multiple myeloma<\/a>, a type of blood cancer, Xgeva injections helped prevent bone-related complications for about 23 months [<a href=\"https:\/\/www.pi.amgen.com\/-\/media\/Project\/Amgen\/Repository\/pi-amgen-com\/Xgeva\/xgeva_pi.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">2<\/a>].<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-what-is-xgeva-used-to-treat\"><span class=\"ez-toc-section\" id=\"What_Is_Xgeva_Used_To_Treat\"><\/span>What Is Xgeva Used To Treat?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Xgeva is FDA-approved for the following uses [<a href=\"https:\/\/www.pi.amgen.com\/-\/media\/Project\/Amgen\/Repository\/pi-amgen-com\/Xgeva\/xgeva_pi.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">2<\/a>]:<\/p>\n\n\n\n<p><strong>Prevention of Bone Fractures:<\/strong> Doctors use Xgeva to prevent bone fractures in adult patients with multiple myeloma and bone metastasis from solid tumors. Multiple myeloma is a type of blood cancer that affects the bone marrow. It can cause fractures in your bones, resulting in symptoms like pain in the back, ribs, hips, chest, or skull. Bone metastasis is a condition where cancer cells spread from their original location to the bones. Symptoms include neck and back pain, muscle weakness, fever, and low platelet count.<\/p>\n\n\n\n<p><strong>Treatment of Giant Cell Tumors of Bones:<\/strong> Doctors use this medication to treat adults and adolescents with giant cell tumors of the bone when the tumor cannot be completely removed through surgery or when surgery poses significant risks.<\/p>\n\n\n\n<p><strong>Treatment of Hypercalcemia Caused by Cancers:<\/strong> Hypercalcemia is a condition where there is too much calcium in the blood. It can cause complications in the bones, kidneys, stomach, brain, and heart. Xgeva is approved to treat adults with hypercalcemia caused by cancer, but only after they have tried a type of drug called bisphosphonate.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-how-do-xgeva-injections-work\"><span class=\"ez-toc-section\" id=\"How_Do_Xgeva_Injections_Work\"><\/span>How Do Xgeva Injections Work?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Xgeva (denosumab) is an FDA-approved medication used to prevent bone-related problems in patients whose <a href=\"https:\/\/ameripharmaspecialty.com\/conditions-treatments\/cancer\/\">cancer<\/a> has spread to the bones.<\/p>\n\n\n\n<p>In our bodies, there is a balance between bone-forming cells called osteoblasts and bone-destroying cells called osteoclasts. However, cancer that has spread to the bones breaks this balance. As a result, more and more bones start to break down.<\/p>\n\n\n\n<p>The active ingredient is denosumab, which is a monoclonal antibody. It works by attaching and blocking the activity of a protein called RANKL.<\/p>\n\n\n\n<p>RANKL is necessary to create and maintain osteoclasts (cells that break down bones). Xgeva works by blocking RANKL, which decreases bone loss and prevents bone-related problems like fractures [<a href=\"https:\/\/www.pi.amgen.com\/-\/media\/Project\/Amgen\/Repository\/pi-amgen-com\/Xgeva\/xgeva_pi.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">2<\/a>].<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-side-effects\"><span class=\"ez-toc-section\" id=\"Side_Effects\"><\/span>Side Effects<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"420\" height=\"280\" src=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/12\/lower-back-pain-xgeva.jpg\" alt=\"A woman in bed holding her lower back in pain\" class=\"wp-image-27445\" srcset=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/12\/lower-back-pain-xgeva.jpg 420w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/12\/lower-back-pain-xgeva-300x200.jpg 300w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/12\/lower-back-pain-xgeva-330x220.jpg 330w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/12\/lower-back-pain-xgeva-86x57.jpg 86w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/12\/lower-back-pain-xgeva-167x111.jpg 167w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/12\/lower-back-pain-xgeva-280x187.jpg 280w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/12\/lower-back-pain-xgeva-370x247.jpg 370w\" sizes=\"auto, (max-width: 420px) 100vw, 420px\" \/><\/figure>\n<\/div>\n\n\n<p>Like any other medication, Xgeva can have side effects. Here are some mild to severe side effects [<a href=\"https:\/\/www.pi.amgen.com\/-\/media\/Project\/Amgen\/Repository\/pi-amgen-com\/Xgeva\/xgeva_pi.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">2<\/a>][<a href=\"https:\/\/www.xgeva.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">3<\/a>]:<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-mild-side-effects\"><span class=\"ez-toc-section\" id=\"Mild_Side_Effects\"><\/span>Mild Side Effects<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Mild side effects include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Back and joint pain<\/li>\n\n\n\n<li>Nausea<\/li>\n\n\n\n<li>Difficulty breathing<\/li>\n\n\n\n<li>Tiredness and weakness<\/li>\n\n\n\n<li>Cough<\/li>\n\n\n\n<li>Headache<\/li>\n\n\n\n<li>Low levels of phosphate<\/li>\n\n\n\n<li>Appetite loss<\/li>\n\n\n\n<li>Toothache<\/li>\n\n\n\n<li>Swelling in your legs and arms<\/li>\n<\/ul>\n\n\n\n<p>These mild side effects usually go away on their own within a few days to a few weeks. However, if they do not go away or become worse, consult your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-severe-side-effects\"><span class=\"ez-toc-section\" id=\"Severe_Side_Effects\"><\/span>Severe Side Effects<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Anyone who uses Xgeva may experience severe side effects, such as:<\/p>\n\n\n\n<p><strong>Low Calcium Level in Blood:<\/strong> Xgeva can lower calcium levels in your blood. A low calcium level can cause symptoms like muscle spasms, stomach pain, extreme thirst, vomiting, and nausea.<\/p>\n\n\n\n<p><strong>Osteonecrosis of the Jaw:<\/strong> Xgeva injections can cause your jaw bones to die as it reduces blood supply to the jaw. As a result, patients can experience symptoms like jaw pain, numbness, swelling, and loose teeth. It is recommended that you maintain good oral hygiene and get regular dental check-ups while using this medication.<\/p>\n\n\n\n<p><strong>Allergic Reactions:<\/strong> Xgeva medication can cause severe allergic reactions in rare cases. Symptoms include rash, difficulty breathing, and itching.<\/p>\n\n\n\n<p><strong>Pneumonia:<\/strong> This is the most common severe side effect in multiple myeloma patients receiving Xgeva. Pneumonia is an infection of the lungs with symptoms like difficulty breathing, high fever, rapid breathing, cough, and rapid heart rate.<\/p>\n\n\n\n<p>Please note that this is not a list of all possible side effects. Contact your provider immediately if you encounter any serious side effects after receiving Xgeva.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-xgeva-dosing-information\"><span class=\"ez-toc-section\" id=\"Xgeva_Dosing_Information\"><\/span>Xgeva Dosing Information<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>The dosage of Xgeva depends on several factors, such as your age, current condition, and medical history. Your doctor will determine the right dosage based on your situation. You will receive Xgeva as a subcutaneous injection in your upper arms, upper thighs, or abdomen. The usual recommended dose for different conditions is given below [<a href=\"https:\/\/www.pi.amgen.com\/-\/media\/Project\/Amgen\/Repository\/pi-amgen-com\/Xgeva\/xgeva_pi.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">2<\/a>]:<\/p>\n\n\n\n<p><strong>Multiple Myeloma and Bone Metastasis From Solid Tumors:<\/strong> The recommended dose is 120 mg every 4 weeks. If calcium levels in your blood become too low, you may also be prescribed calcium and vitamin D supplements.<\/p>\n\n\n\n<p><strong>Giant Cell Tumor of Bone:<\/strong> The recommended dose is 120 mg every 4 weeks. In your first month of Xgeva treatment, you will receive two additional 120 mg doses on Day 8 and 15. You will also receive calcium and vitamin D supplements if the calcium levels in your blood become too low.<\/p>\n\n\n\n<p><strong>Hypercalcemia Caused by Cancers:<\/strong> The recommended dose is 120 mg every 4 weeks with additional two 120 mg doses on Day 8 and Day 15 of the first month of treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-xgeva-cost\"><span class=\"ez-toc-section\" id=\"Xgeva_Cost\"><\/span>Xgeva Cost<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Xgeva medication is available as a 120 mg\/1.7 ml solution in a single-dose vial. Each single-dose vial costs around $3,470 [<a href=\"https:\/\/www.drugs.com\/price-guide\/xgeva\" target=\"_blank\" rel=\"noreferrer noopener\">4<\/a>]. However, the actual cost of treatment will depend on your <a href=\"https:\/\/ameripharmaspecialty.com\/insurances-networks-accepted\/\">insurance coverage<\/a>, location, treatment plan, and the pharmacy you visit. <a href=\"https:\/\/ameripharmaspecialty.com\/contact-us\/\">Contact us<\/a> if you are interested in receiving <a href=\"https:\/\/ameripharmaspecialty.com\/financial-assistance\/\">financial assistance<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-before-you-start\"><span class=\"ez-toc-section\" id=\"Before_You_Start\"><\/span>Before You Start<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Before you start receiving Xgeva injections, there are some facts you need to be aware of to ensure that it is safe and appropriate for you:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Before starting your treatment, inform your doctor of your medical history. Also, tell them about all the medicines you are using, including over-the-counter drugs, vitamins, and herbal medicines.<\/li>\n\n\n\n<li>Tell your doctor if you are pregnant or want to become pregnant. Xgeva can harm your unborn baby. You need to have a negative pregnancy test before starting treatment.<\/li>\n\n\n\n<li>While receiving Xgeva medication, you should not take Prolia (another similar denosumab product).<\/li>\n\n\n\n<li>Xgeva can damage your jaw bones. So, while taking the medication, you should have good dental hygiene and regular dental check-ups.<\/li>\n\n\n\n<li>Xgeva injections are very expensive. Before starting the treatment, you need to discuss the cost with your doctor and insurance provider. You should also inquire about any financial assistance programs that can help you with the cost.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-faqs\"><span class=\"ez-toc-section\" id=\"FAQs\"><\/span>FAQs<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Here are some frequently asked questions about Xgeva:<\/p>\n\n\n\n<p><strong>1. Can I take Prolia instead of Xgeva?<\/strong><\/p>\n\n\n\n<p>Xgeva and Prolia are brand-name medications containing the same active ingredient, denosumab. However, they are used to treat different conditions and have different administration routes. So, if your doctor prescribed Xgevia, you can NOT use Prolia.<\/p>\n\n\n\n<p><strong>2. For how long do I have to take this medication?<\/strong><\/p>\n\n\n\n<p>You have to receive Xgeva injections once every 4 weeks for a long time. However, you should stop using it if Xgeva is ineffective for you or if you encounter severe side effects.<\/p>\n\n\n\n<p><strong>3. Can I use Xgeva if I have kidney problems?<\/strong><\/p>\n\n\n\n<p>Yes. You can use Xgeva, but you need to be careful. Anyone with a kidney problem who uses Xgeva has a higher chance of developing hypocalcemia (low calcium level in blood) [<a href=\"https:\/\/www.pi.amgen.com\/-\/media\/Project\/Amgen\/Repository\/pi-amgen-com\/Xgeva\/xgeva_pi.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">2<\/a>]. So, your calcium levels should be monitored regularly. Your doctor will prescribe calcium and vitamin D supplements if necessary.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>If you are suffering from advanced cancer that has spread to your bones, then Xgeva is an option that can help you prevent bone-related complications. The FDA first approved this drug on November 18, 2010 [1].<\/p>\n","protected":false},"author":13,"featured_media":27375,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":true,"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[64],"tags":[17],"class_list":["post-27376","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-discontinued","tag-dr-saba-rassouli"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Exploring Xgeva and Its Role in Treating Bone-Related Issues - AmeriPharma\u00ae Specialty Care<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/understanding-xgeva-and-its-role-in-treating-bone-related-issues\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploring Xgeva and Its Role in Treating Bone-Related Issues - AmeriPharma\u00ae Specialty Care\" \/>\n<meta property=\"og:description\" content=\"If you are suffering from advanced cancer that has spread to your bones, then Xgeva is an option that can help you prevent bone-related complications. 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