{"id":26685,"date":"2024-10-25T13:19:11","date_gmt":"2024-10-25T20:19:11","guid":{"rendered":"https:\/\/ameripharmaspecialty.com\/?p=26685"},"modified":"2024-10-25T13:19:15","modified_gmt":"2024-10-25T20:19:15","slug":"hemophilia-c-seven-frequently-asked-questions-answered","status":"publish","type":"post","link":"https:\/\/ameripharmaspecialty.com\/zh\/hemophilia\/hemophilia-c-seven-frequently-asked-questions-answered\/","title":{"rendered":"\u4e19\u578b\u8840\u53cb\u75c5\uff1a\u4e03\u4e2a\u5e38\u89c1\u95ee\u9898\u53ca\u89e3\u7b54"},"content":{"rendered":"\n<p>Hemophilia C is a rare blood disorder in which a clotting factor called factor XI is missing, low, or doesn\u2019t work as it should. Because clotting factors are essential for clotting, having hemophilia C can put you at a higher risk of prolonged bleeding, especially after surgery, dental procedures, or injury.&nbsp;<\/p>\n\n\n\n<div  id=\"call-to-action-1d0495095f8146e4685134474d9b61e8\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tSpeak to a Specialist\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"cta__sub__heading\">\n\t\t\t\t\t\t\tAbout Copay Assistance\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"tel:8777780318\">(877) 778-0318<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<p>Other names for this condition are:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Plasma thromboplastin antecedent deficiency<\/li>\n\n\n\n<li>PTA deficiency<\/li>\n\n\n\n<li>Rosenthal syndrome<\/li>\n\n\n\n<li>Factor XI deficiency<\/li>\n<\/ul>\n\n\n\n<p>In this article, we will cover the most frequently asked questions about this blood disorder.<\/p>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/hemophilia\/hemophilia-c-seven-frequently-asked-questions-answered\/#1_How_Common_Is_Hemophilia_C\" >1. How Common Is Hemophilia C?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/hemophilia\/hemophilia-c-seven-frequently-asked-questions-answered\/#2_How_Is_Hemophilia_C_Inherited\" >2. How Is Hemophilia C Inherited?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/hemophilia\/hemophilia-c-seven-frequently-asked-questions-answered\/#3_What_Is_Acquired_Hemophilia_C\" >3. What Is Acquired Hemophilia C?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/hemophilia\/hemophilia-c-seven-frequently-asked-questions-answered\/#4_What_Are_the_Symptoms\" >4. What Are the Symptoms?\u00a0\u00a0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/hemophilia\/hemophilia-c-seven-frequently-asked-questions-answered\/#5_What_Is_the_Most_Common_Treatment_for_This_Condition\" >5. What Is the Most Common Treatment for This Condition?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/hemophilia\/hemophilia-c-seven-frequently-asked-questions-answered\/#6_How_Is_Hemophilia_C_Treated_During_Pregnancy\" >6. How Is Hemophilia C Treated During Pregnancy?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/hemophilia\/hemophilia-c-seven-frequently-asked-questions-answered\/#7_What_Is_the_Difference_Between_Hemophilia_A_and_C\" >7. What Is the Difference Between Hemophilia A and C?<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"1_How_Common_Is_Hemophilia_C\"><\/span>1. How Common Is Hemophilia C?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ol class=\"wp-block-list\"><\/ol>\n\n\n\n<p>Hemophilia C is a rare blood disorder. It affects about 1 in 100,000 people, according to the National Bleeding Disorders Foundation [<a href=\"https:\/\/www.bleeding.org\/bleeding-disorders-a-z\/types\/other-factor-deficiencies\">1<\/a>].<\/p>\n\n\n\n<p>Hemophilia C can affect people of any age, sex, race, or ethnicity. Nonetheless, a higher prevalence \u2014 1 in 450 individuals \u2014 has been reported in people of Ashkenazi Jewish descent [<a href=\"https:\/\/medlineplus.gov\/genetics\/condition\/factor-xi-deficiency\/#frequency\">2<\/a>].<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2_How_Is_Hemophilia_C_Inherited\"><\/span>2. How Is Hemophilia C Inherited?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ol start=\"2\" class=\"wp-block-list\"><\/ol>\n\n\n\n<p>Changes (mutations) in the gene that encodes clotting factor XI cause hemophilia C. Typically, these mutations pass from the parents to the child in an <a href=\"https:\/\/www.cancer.gov\/publications\/dictionaries\/genetics-dictionary\/def\/autosomal-recessive-inheritance\">autosomal recessive pattern<\/a>. This means an affected person gets the mutated gene from both parents.&nbsp;<\/p>\n\n\n\n<p>The parents who carry one copy of the gene have partial factor XI deficiency. So they\u2019re unlikely to have severe signs and symptoms of the condition.<\/p>\n\n\n\n<p>Sometimes, a person may inherit the mutated gene in an <a href=\"https:\/\/www.cancer.gov\/publications\/dictionaries\/genetics-dictionary\/def\/autosomal-dominant-inheritance\">autosomal dominant pattern<\/a>. This means they may get hemophilia C even if only one parent has the condition.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"3_What_Is_Acquired_Hemophilia_C\"><\/span>3. What Is Acquired Hemophilia C?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ol start=\"3\" class=\"wp-block-list\"><\/ol>\n\n\n\n<p>Acquired factor XI deficiency is when a person gets the condition later in life. Unlike the inherited form, it doesn\u2019t run in families.&nbsp;<\/p>\n\n\n\n<p>The most common cause is liver disorder, which affects the production of factor XI. You may develop acquired hemophilia C if you\u2019ve received a liver transplant from a factor XI-deficient donor.&nbsp;<\/p>\n\n\n\n<p>In some cases, your immune system mistakenly produces proteins (autoantibodies) that attack factor XI, leading to factor XI deficiency.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"4_What_Are_the_Symptoms\"><\/span>4. What Are the Symptoms?\u00a0\u00a0<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"420\" height=\"280\" src=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/10\/nosebleed-1.jpg\" alt=\"Woman with hemophilia c experiencing a nosebleed\" class=\"wp-image-26688\" srcset=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/10\/nosebleed-1.jpg 420w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/10\/nosebleed-1-300x200.jpg 300w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/10\/nosebleed-1-330x220.jpg 330w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/10\/nosebleed-1-86x57.jpg 86w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/10\/nosebleed-1-167x111.jpg 167w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/10\/nosebleed-1-280x187.jpg 280w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/10\/nosebleed-1-370x247.jpg 370w\" sizes=\"auto, (max-width: 420px) 100vw, 420px\" \/><\/figure>\n<\/div>\n\n\n<ol start=\"4\" class=\"wp-block-list\"><\/ol>\n\n\n\n<p>Not all people with a factor XI deficiency experience symptoms. Unlike <a href=\"https:\/\/ameripharmaspecialty.com\/hemophilia\/classic-hemophilia-types-symptoms-treatment\/\">other forms of hemophilia<\/a>, lower levels of factor XI in the bloodstream don\u2019t always result in more severe symptoms.<\/p>\n\n\n\n<p>Symptoms can include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Frequent nosebleeds<\/li>\n\n\n\n<li>Easy bruising<\/li>\n\n\n\n<li>Blood in urine<\/li>\n\n\n\n<li>Unusual bleeding after dental procedures, surgery, or trauma<\/li>\n\n\n\n<li>Heavy menstrual bleeding<\/li>\n\n\n\n<li>Bleeding after childbirth<\/li>\n<\/ul>\n\n\n\n<p>People with this condition rarely get joint and muscle bleeds.<\/p>\n\n\n\n<p>Also Read: <a href=\"https:\/\/ameripharmaspecialty.com\/hemophilia\/hemophilia-and-joint-health-how-to-prevent-and-treat-joint-damage\/\">Hemophilia and Joint Health: How To Prevent and Treat Joint Damage<\/a><\/p>\n\n\n\n<div  id=\"call-to-action-bb3598f742e217780ed1bb658ca396b3\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tGet Financial Assistance\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"#form\">Learn More<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"5_What_Is_the_Most_Common_Treatment_for_This_Condition\"><\/span>5. What Is the Most Common Treatment for This Condition?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ol start=\"5\" class=\"wp-block-list\"><\/ol>\n\n\n\n<p>Treatment may not always be necessary, especially if bleeding isn\u2019t problematic. However, those with mild symptoms may need to restrict activities that increase the risk of injury, such as contact sports.&nbsp;<\/p>\n\n\n\n<p>You\u2019ll usually need treatment before undergoing surgery or other procedures. In severe cases, you\u2019ll need fresh frozen plasma (FFP), which is a clotting factor-rich blood derivative obtained from donors.&nbsp;<\/p>\n\n\n\n<p>Other treatment options can include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.cancer.gov\/publications\/dictionaries\/cancer-terms\/def\/antifibrinolytic-agent\">Antifibrinolytics<\/a>, such as aminocaproic acid and tranexamic acid, to treat bleeding in the mouth and menstrual bleeding.\u00a0<\/li>\n\n\n\n<li>Medications to prevent the breakdown of replacement clotting factors.\u00a0<\/li>\n\n\n\n<li>Birth control pills for heavy menstrual bleeding<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"6_How_Is_Hemophilia_C_Treated_During_Pregnancy\"><\/span>6. How Is Hemophilia C Treated During Pregnancy?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ol start=\"6\" class=\"wp-block-list\"><\/ol>\n\n\n\n<p>There are no evidence-based guidelines for hemophilia C treatment during pregnancy. The standard treatment is administering fresh frozen plasma at the time of delivery.&nbsp;<\/p>\n\n\n\n<p>Treatment during pregnancy is anticipatory and requires a multidisciplinary care team.&nbsp;<\/p>\n\n\n\n<p>The authors of a 2020 review recommend [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7605282\/\">3<\/a>]:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Early pregnancy consultation with a hematologist and perinatologist\u00a0<\/li>\n\n\n\n<li>Third-trimester consultation with an anesthesiologist<\/li>\n\n\n\n<li>Measuring third-trimester factor XI level<\/li>\n\n\n\n<li>Delivery at a tertiary care<\/li>\n\n\n\n<li>Prophylactic antifibrinolytic at the time of delivery<\/li>\n\n\n\n<li>Avoiding invasive procedures during delivery<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"7_What_Is_the_Difference_Between_Hemophilia_A_and_C\"><\/span>7. What Is the Difference Between Hemophilia A and C?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ol start=\"7\" class=\"wp-block-list\"><\/ol>\n\n\n\n<p>Both are inherited blood disorders; however, there are differences, as shown below:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>Hemophilia A&nbsp;<\/strong><\/td><td><strong>Hemophilia C<\/strong><\/td><\/tr><tr><td>Caused by Factor VIII deficiency<\/td><td>Caused by Factor XI deficiency<\/td><\/tr><tr><td>An X-linked disorder that mainly affects males<\/td><td>An autosomal recessive disorder that equally affects males and females<\/td><\/tr><tr><td>Joint bleeds are a hallmark of hemophilia A<\/td><td>Joint bleeds are less frequent<\/td><\/tr><tr><td>Common (affects nearly 1 in 5,000 newborn males)<\/td><td>Rare (affects 1 in 100,000 people)<\/td><\/tr><tr><td>A more severe form of hemophilia&nbsp;<\/td><td>Less severe than hemophilia A<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>\u8840\u53cb\u75c5C\u662f\u4e00\u79cd\u7f55\u89c1\u7684\u8840\u6db2\u75be\u75c5\uff0c\u60a3\u8005\u4f53\u5185\u6709\u4e00\u79cd\u540d\u4e3aXI\u56e0\u5b50\u7684\u51dd\u8840\u56e0\u5b50\u7f3a\u5931\u3001\u6c34\u5e73\u4f4e\u4e0b\u6216\u65e0\u6cd5\u6b63\u5e38\u53d1\u6325\u4f5c\u7528\u3002\u7531\u4e8e\u51dd\u8840\u56e0\u5b50\u5bf9\u4e8e\u51dd\u8840\u81f3\u5173\u91cd\u8981\uff0c\u56e0\u6b64\u8840\u53cb\u75c5C\u60a3\u8005\u53ef\u80fd\u4f1a\u9762\u4e34\u66f4\u9ad8\u7684\u957f\u671f\u51fa\u8840\u98ce\u9669\uff0c\u5c24\u5176\u662f\u5728\u624b\u672f\u3001\u7259\u79d1\u624b\u672f\u6216\u53d7\u4f24\u540e\u3002<\/p>","protected":false},"author":26,"featured_media":26686,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":true,"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[6],"tags":[32],"class_list":["post-26685","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-hemophilia","tag-dr-robert-hakim"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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