{"id":26025,"date":"2024-03-06T12:03:12","date_gmt":"2024-03-06T20:03:12","guid":{"rendered":"https:\/\/ameripharmaspecialty.com\/hemolytic-disease-of-the-newborn-causes-symptoms-treatment-and-prevention\/"},"modified":"2024-06-30T19:49:05","modified_gmt":"2024-07-01T02:49:05","slug":"hemolytic-disease-of-the-newborn-causes-symptoms-treatment-and-prevention","status":"publish","type":"post","link":"https:\/\/ameripharmaspecialty.com\/zh\/other-health-conditions\/hemolytic-disease-of-the-newborn-causes-symptoms-treatment-and-prevention\/","title":{"rendered":"\u65b0\u751f\u513f\u6eb6\u8840\u75c5\uff1a\u75c5\u56e0\u3001\u75c7\u72b6\u3001\u6cbb\u7597\u548c\u9884\u9632"},"content":{"rendered":"\r\n<p><span style=\"font-weight: 400;\">Hemolytic disease of the newborn (HDN) is a blood problem that affects a newborn. It causes a baby\u2019s red blood cells (RBCs) to break down too early. This condition was previously known as erythroblastosis fetalis, but it\u2019s also known by other names, such as:<\/span><\/p>\r\n<ul>\r\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Erythroblastosis neonatorum<\/span><\/li>\r\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hemolytic disease of the fetus and newborn (HDFN)<\/span><\/li>\r\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anemia &#8211; HDN<\/span><\/li>\r\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blood incompatibility &#8211; HDN<\/span><\/li>\r\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">ABO incompatibility &#8211; HDN<\/span><\/li>\r\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rh incompatibility &#8211; HDN<\/span><\/li>\r\n<\/ul>\r\n\r\n\n<div  id=\"call-to-action-baca06484d6fbc75b637eac8aa46d46b\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tSpeak to a Specialist About Copay Assistance\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"tel:8777780318\">(877) 778-0318<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\r\n\r\n<span style=\"font-weight: 400;\">In the unborn baby, the effects of HDN can range from mild anemia (low red blood cell count) to total body swelling. Likewise, HDN may lead to jaundice and rarely permanent brain damage in the newborn.\u00a0<\/span>\r\n&nbsp;\r\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/other-health-conditions\/hemolytic-disease-of-the-newborn-causes-symptoms-treatment-and-prevention\/#What_Is_the_Cause_of_Hemolytic_Disease_of_the_Newborn\" >What Is the Cause of Hemolytic Disease of the Newborn?<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/other-health-conditions\/hemolytic-disease-of-the-newborn-causes-symptoms-treatment-and-prevention\/#Rh_Incompatibility\" >Rh Incompatibility<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/other-health-conditions\/hemolytic-disease-of-the-newborn-causes-symptoms-treatment-and-prevention\/#ABO_Incompatibility\" >ABO Incompatibility<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/other-health-conditions\/hemolytic-disease-of-the-newborn-causes-symptoms-treatment-and-prevention\/#Hemolytic_Disease_of_the_Newborn_Symptoms\" >Hemolytic Disease of the Newborn Symptoms<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/other-health-conditions\/hemolytic-disease-of-the-newborn-causes-symptoms-treatment-and-prevention\/#Hemolytic_Disease_of_the_Newborn_Treatment\" >Hemolytic Disease of the Newborn Treatment<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/other-health-conditions\/hemolytic-disease-of-the-newborn-causes-symptoms-treatment-and-prevention\/#Hemolytic_Disease_of_the_Newborn_Prevention\" >Hemolytic Disease of the Newborn Prevention<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/other-health-conditions\/hemolytic-disease-of-the-newborn-causes-symptoms-treatment-and-prevention\/#What_Causes_Hemolytic_Jaundice_in_Newborns\" >What Causes Hemolytic Jaundice in Newborns?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/other-health-conditions\/hemolytic-disease-of-the-newborn-causes-symptoms-treatment-and-prevention\/#Hemolytic_Disease_of_the_Newborn_Long-Term_Outlook\" >Hemolytic Disease of the Newborn Long-Term Outlook<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"What_Is_the_Cause_of_Hemolytic_Disease_of_the_Newborn\"><\/span>What Is the Cause of Hemolytic Disease of the Newborn?<span class=\"ez-toc-section-end\"><\/span><\/h2>\r\n<span style=\"font-weight: 400;\">Hemolytic disease of the newborn (HDN) occurs when a mother\u2019s immune system attacks and destroys the baby\u2019s RBCs. This can happen from one of two things: Rh incompatibility or ABO incompatibility.\u00a0<\/span>\r\n<h3><span class=\"ez-toc-section\" id=\"Rh_Incompatibility\"><\/span><span style=\"font-weight: 400;\">Rh Incompatibility<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\r\n<span style=\"font-weight: 400;\">The Rhesus factor, or Rh, is a protein found on the surface of red blood cells. Rh incompatibility is when the mother is Rh-negative, and the father is Rh-positive.\u00a0<\/span>\r\n<span style=\"font-weight: 400;\">If the baby is Rh-positive, like the father, the mother\u2019s immune system produces proteins (antibodies) that attack and destroy the baby\u2019s RBCs.\u00a0<\/span>\r\n<span style=\"font-weight: 400;\">Rh incompatibility is not much of an issue in the first pregnancy. However, in subsequent pregnancies with Rh-positive babies, it can cause severe problems.\u00a0<\/span>\r\n<h3><span class=\"ez-toc-section\" id=\"ABO_Incompatibility\"><\/span><span style=\"font-weight: 400;\">ABO Incompatibility<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\r\n<span style=\"font-weight: 400;\">Another reason why HDN may occur is due to ABO, or blood type, mismatch.\u00a0<\/span>\r\n<span style=\"font-weight: 400;\">This happens when the mother\u2019s blood type of A, B, or O doesn\u2019t match with the baby\u2019s blood type. HDN is most likely to occur when the mother\u2019s blood type is O, and the baby&#8217;s blood type is A or B.\u00a0<\/span>\r\n<span style=\"font-weight: 400;\">It is less harmful to the baby than Rh incompatibility in most cases.\u00a0<\/span>\r\n&nbsp;\r\n<h2><span class=\"ez-toc-section\" id=\"Hemolytic_Disease_of_the_Newborn_Symptoms\"><\/span>Hemolytic Disease of the Newborn Symptoms<span class=\"ez-toc-section-end\"><\/span><\/h2>\r\n<span style=\"font-weight: 400;\">After delivery, a baby with HDN may appear swollen, pale (due to anemia), or yellow (due to jaundice). They may also have an enlarged heart, liver, or spleen.\u00a0<\/span>\r\n<span style=\"font-weight: 400;\">Other symptoms can include:<\/span>\r\n<ul>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A faster heart rate<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Small red or brown spots on the skin<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Difficulty breathing<\/span><\/li>\r\n<\/ul>\r\n&nbsp;\r\n<h2><span class=\"ez-toc-section\" id=\"Hemolytic_Disease_of_the_Newborn_Treatment\"><\/span>Hemolytic Disease of the Newborn Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\r\n<span style=\"font-weight: 400;\">If diagnosed after birth, treatment options for babies with HDN may include:<\/span>\r\n<ul>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Frequent feeding and fluid administration.<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Light therapy (phototherapy) to break down extra <\/span><a href=\"https:\/\/medlineplus.gov\/lab-tests\/bilirubin-blood-test\/#:~:text=Bilirubin%20is%20a%20yellowish%20substance,the%20bilirubin%20from%20your%20body.\"><span style=\"font-weight: 400;\">bilirubin<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/ameripharmaspecialty.com\/ivig\/ivig\/\/ivig\/\"><span style=\"font-weight: 400;\">IVIG<\/span><\/a><span style=\"font-weight: 400;\"> to prevent the mother\u2019s antibodies from attacking the baby&#8217;s RBCs.<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drugs to raise blood pressure if it is extremely low.<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Exchange transfusion in severe cases. This involves removing the baby\u2019s blood and replacing it with donor blood.\u00a0<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Breathing support using a breathing machine.\u00a0<\/span><\/li>\r\n<\/ul>\r\n<span style=\"font-weight: 400;\">If diagnosed before birth, a healthcare provider may recommend preterm delivery. Another option may be administering blood to the baby through the umbilical cord. The blood helps treat anemia by providing the baby with red blood cells.\u00a0<\/span>\r\n&nbsp;\r\n<h2><span class=\"ez-toc-section\" id=\"Hemolytic_Disease_of_the_Newborn_Prevention\"><\/span>Hemolytic Disease of the Newborn Prevention<span class=\"ez-toc-section-end\"><\/span><\/h2>\r\n<span style=\"font-weight: 400;\">A medicine called <\/span><a href=\"https:\/\/www.rhogam.com\/\"><span style=\"font-weight: 400;\">RhoGAM<\/span><\/a><span style=\"font-weight: 400;\"> (Rho[D] immune globulin) is used to help prevent hemolytic disease due to Rh incompatibility. It\u2019s given as a shot that is typically administered at around the 28th week of pregnancy and 72 hours after birth.<\/span>\r\n<span style=\"font-weight: 400;\">Getting your blood checked before pregnancy or during the first prenatal visit helps your provider assess the risk. Your healthcare provider may also recommend testing for the baby\u2019s father\u2019s blood type.\u00a0<\/span>\r\n&nbsp;\r\n<h2><span class=\"ez-toc-section\" id=\"What_Causes_Hemolytic_Jaundice_in_Newborns\"><\/span>What Causes Hemolytic Jaundice in Newborns?<span class=\"ez-toc-section-end\"><\/span><\/h2>\r\n<span style=\"font-weight: 400;\">The three most common causes of hemolytic jaundice in newborn infants are:<\/span>\r\n<ol>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32809323\/#:~:text=Rh%2Dhemolytic%20disease%2C%20also%20known,by%20a%20process%20called%20isoimmunization.\"><span style=\"font-weight: 400;\">Rh hemolytic disease<\/span><\/a><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">ABO incompatibility\u00a0<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency and minor blood group incompatibility<\/span><\/li>\r\n<\/ol>\r\n&nbsp;\r\n\n<div  id=\"call-to-action-6c6a20acae4d38da3188fe1f4f2f5970\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tCan IVIG help?\u00a0|\u00a0Free IVIG Treatment Info\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"#form\">Schedule a Consultation<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\r\n&nbsp;\r\n<h2><span class=\"ez-toc-section\" id=\"Hemolytic_Disease_of_the_Newborn_Long-Term_Outlook\"><\/span>Hemolytic Disease of the Newborn Long-Term Outlook<span class=\"ez-toc-section-end\"><\/span><\/h2>\r\n<span style=\"font-weight: 400;\">Hemolytic disease can range from mild to severe or even fatal.\u00a0<\/span>\r\n<span style=\"font-weight: 400;\">While some babies have no signs and symptoms, others may die before or shortly after birth. The main cause of death in these cases is fluid accumulation in the vital organs.\u00a0<\/span>\r\n<span style=\"font-weight: 400;\">Because it has the potential to be life-threatening, it is critical to monitor infants with HDN for at least 3 months. If anemia is severe, they may need multiple blood transfusions.\u00a0<\/span>\r\n<span style=\"font-weight: 400;\">Fortunately, advancement in prenatal and postnatal care has dramatically reduced deaths due to HDN.\u00a0<\/span>\r\n&nbsp;\r\n","protected":false},"excerpt":{"rendered":"<p>\u65b0\u751f\u513f\u6eb6\u8840\u75c5 (HDN) \u662f\u4e00\u79cd\u5f71\u54cd\u65b0\u751f\u513f\u7684\u8840\u6db2\u75be\u75c5\u3002\u5b83\u4f1a\u5bfc\u81f4\u5a74\u513f\u7684\u7ea2\u7ec6\u80de (RBC) \u8fc7\u65e9\u5206\u89e3\u3002\u8fd9\u79cd\u75be\u75c5\u4ee5\u524d\u88ab\u79f0\u4e3a\u80ce\u513f\u7ea2\u7ec6\u80de\u589e\u591a\u75c7\uff0c\u4f46\u4e5f\u88ab\u79f0\u4e3a\u5176\u4ed6\u540d\u79f0\uff0c\u4f8b\u5982\uff1a\u65b0\u751f\u513f\u7ea2\u7ec6\u80de\u589e\u591a\u75c7<br \/>\n\u80ce\u513f\u548c\u65b0\u751f\u513f\u6eb6\u8840\u75c5 (HDFN)\u3001\u8d2b\u8840 \u2013 HDN\u3001\u8840\u578b\u4e0d\u5408 \u2013 HDN\u3001ABO \u8840\u578b\u4e0d\u5408 \u2013 HDN\u3001Rh \u8840\u578b\u4e0d\u5408 \u2013 HDN<\/p>","protected":false},"author":26,"featured_media":25910,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":true,"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[4],"tags":[32],"class_list":["post-26025","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-other-health-conditions","tag-dr-robert-hakim"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Hemolytic Disease of the Newborn: Causes, Symptoms, Treatment, and Prevention<\/title>\n<meta name=\"description\" content=\"This article explains what hemolytic disease of the newborn is, and explores the causes, symptoms, and treatment options of this condition.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" 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