{"id":26019,"date":"2024-04-04T13:27:06","date_gmt":"2024-04-04T20:27:06","guid":{"rendered":"https:\/\/ameripharmaspecialty.com\/hemlibra-a-promising-medication-for-hemophilia-a-patients\/"},"modified":"2024-08-13T15:50:03","modified_gmt":"2024-08-13T22:50:03","slug":"hemlibra-a-promising-medication-for-hemophilia-a-patients","status":"publish","type":"post","link":"https:\/\/ameripharmaspecialty.com\/zh\/hemophilia\/hemlibra-a-promising-medication-for-hemophilia-a-patients\/","title":{"rendered":"Hemlibra\uff1a\u4e00\u79cd\u6709\u671b\u6cbb\u6108\u8840\u53cb\u75c5A\u7684\u836f\u7269"},"content":{"rendered":"\n<p><span style=\"font-weight: 400;\">If you have <\/span><a href=\"https:\/\/ameripharmaspecialty.com\/hemophilia\/classic-hemophilia-types-symptoms-treatment\/\"><span style=\"font-weight: 400;\">hemophilia A<\/span><\/a><span style=\"font-weight: 400;\">, your doctor might suggest Hemlibra as a treatment option. Approved by the <\/span><a href=\"https:\/\/www.fda.gov\/\"><span style=\"font-weight: 400;\">FDA<\/span><\/a><span style=\"font-weight: 400;\"> on November 16, 2017, this medicine is used to prevent or reduce bleeding episodes in people with hemophilia A. Hemlibra is seen as a promising alternative to the usual treatments for this condition. In this article, we will discuss Hemlibra, its side effects, dosing information, and much more.<\/span><\/p>\n\n\n\n<div  id=\"call-to-action-4eff9b4c572a345b7ce7e7aa69079e53\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tSpeak to a Specialist About Copay Assistance\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"#form\">Schedule a Consultation<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/hemophilia\/hemlibra-a-promising-medication-for-hemophilia-a-patients\/#What_Is_Hemlibra\" >What Is Hemlibra?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/hemophilia\/hemlibra-a-promising-medication-for-hemophilia-a-patients\/#What_Is_Hemlibra_Used_To_Treat\" >What Is Hemlibra Used To Treat?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/hemophilia\/hemlibra-a-promising-medication-for-hemophilia-a-patients\/#How_Does_Hemlibra_Work\" >How Does Hemlibra Work?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/hemophilia\/hemlibra-a-promising-medication-for-hemophilia-a-patients\/#Side_Effects\" >Side Effects<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/hemophilia\/hemlibra-a-promising-medication-for-hemophilia-a-patients\/#Common_Side_Effects\" >Common Side Effects<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/hemophilia\/hemlibra-a-promising-medication-for-hemophilia-a-patients\/#Severe_Side_Effects\" >Severe Side Effects<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/hemophilia\/hemlibra-a-promising-medication-for-hemophilia-a-patients\/#Dosing_Information\" >Dosing Information<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/hemophilia\/hemlibra-a-promising-medication-for-hemophilia-a-patients\/#Hemlibra_Cost\" >Hemlibra Cost<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/hemophilia\/hemlibra-a-promising-medication-for-hemophilia-a-patients\/#FAQs\" >FAQs<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_Is_Hemlibra\"><\/span>What Is Hemlibra?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Hemlibra (emicizumab-kxwh) is a medication made by <\/span><a href=\"https:\/\/www.gene.com\/\"><span style=\"font-weight: 400;\">Genentech<\/span><\/a><span style=\"font-weight: 400;\">, a subsidiary of the Roche corporation. This medication is used for preventing or reducing bleeding episodes in people with hemophilia A, whether they have factor VIII inhibitors or not. It was first approved by the FDA on November 16, 2017, for hemophilia A patients with factor VIII inhibitors [<a href=\"https:\/\/www.fda.gov\/drugs\/resources-information-approved-drugs\/fda-approves-emicizumab-kxwh-prevention-and-reduction-bleeding-patients-hemophilia-factor-viii\">1<\/a>]. Later, on October 4, 2018, the approval was extended for patients with hemophilia A without factor VIII inhibitors [<a href=\"https:\/\/www.fda.gov\/drugs\/drug-approvals-and-databases\/fda-approves-emicizumab-kxwh-hemophilia-or-without-factor-viii-inhibitors\">2<\/a>].<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">People with hemophilia A don&#8217;t have enough of a protein called factor VIII in their bodies. <\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">This protein plays a very crucial role in the blood clotting process. Therefore, when someone with hemophilia A gets a cut or injury, their blood doesn&#8217;t clot properly. This can lead to longer bleeding, internal bleeding, and more problems.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Before the FDA approved Hemlibra, factor VIII replacement therapy was the primary <a href=\"https:\/\/ameripharmaspecialty.com\/conditions-treatments\/hemophilia\/\">treatment for hemophilia A<\/a>. This therapy involved injecting external factor VIII proteins to compensate for the deficiency in hemophilia A patients. However, a common problem with this therapy is that, over time, some people develop inhibitors. Inhibitors are antibodies that attack factor VIII, making the treatment ineffective. Hemlibra offers a solution to this issue. It can prevent bleeding in people with hemophilia A, whether they have inhibitors or not.<\/span>&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_Is_Hemlibra_Used_To_Treat\"><\/span>What Is Hemlibra Used To Treat?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Hemlibra is a breakthrough medication that is primarily used to treat hemophilia A. Hemophilia A is a rare genetic disorder that affects blood clotting due to a deficiency in clotting factor VIII.&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Hemlibra is prescribed to be taken regularly. It prevents or reduces bleeding episodes in patients of all ages, including newborns, with hemophilia A [<a href=\"https:\/\/www.gene.com\/download\/pdf\/hemlibra_prescribing.pdf\">3<\/a>]. This medication is effective for both adults and children with this condition, whether they have factor VIII inhibitors or not.<\/span>&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_Does_Hemlibra_Work\"><\/span>How Does Hemlibra Work?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Hemophilia A is a bleeding disorder caused by a missing <\/span><a href=\"https:\/\/5minuteconsult.com\/collectioncontent\/2-152244\/lab-tests\/clotting-factors#:~:text=Definition,which%20are%20provided%20by%20platelets.\"><span style=\"font-weight: 400;\">clotting factor<\/span><\/a><span style=\"font-weight: 400;\"> called factor VIII, which is a protein that helps in blood clotting. When you have an insufficient amount of factor VIII, your blood struggles to form clots when you have an injury.&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Hemlibra is an antibody that mimics factor VIII, the missing protein in hemophilia A. <\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Normally, factor VIII links factor IX and factor X to aid in blood clotting. However, in hemophilia A, this link is missing. Hemlibra fills this gap by bringing factor IX and factor X together, helping clot formation. This action reduces the danger of bleeding episodes, providing relief to people who have hemophilia A.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">The usual treatment for hemophilia A is replacing factor VIII. However, some people may develop inhibitors over time, which can make this treatment ineffective. However, Hemlibra works uniquely. Rather than directly replacing factor VIII, Hemlibra performs the same function as factor VIII by joining other blood proteins. This means it remains effective, even if inhibitors are present.<\/span>&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Side_Effects\"><\/span>Side Effects<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Like all medications, Hemlibra can also cause side effects. In rare cases, it can cause severe side effects.&nbsp;<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Common_Side_Effects\"><\/span>Common Side Effects<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright\"><img decoding=\"async\" src=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/04\/joint-pain.jpg\" alt=\"Woman with joint pain as a side effect of Hemlibra\" class=\"wp-image-24013\"\/><\/figure>\n<\/div>\n\n\n<p><br><span style=\"font-weight: 400;\">The following are some common side effects:<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Joint Pain<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Reactions at the injection site, including redness, warmth, itching, or tenderness<\/span><\/li>\n<\/ul>\n\n\n\n<p><span style=\"font-weight: 400;\">These side effects usually go away on their own after a short time. But, if they worsen or do not go away, consult your doctor or pharmacist.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Severe_Side_Effects\"><\/span>Severe Side Effects<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Severe side effects from Hemlibra are rare, but they can occur. Contact your doctor right away if you encounter any severe side effects, which include:<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">Blood clots and injury to small blood vessels that cause harm to the kidney, brain, and other organs<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Blood clots that may form in blood vessels in your arms, legs, lungs, or head<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Stomach, chest, and back pain<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Confusion and weakness<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Swelling, pain, or redness<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Eye pain or trouble seeing<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Shortness of breath, coughing up blood<\/span><\/li>\n<\/ul>\n\n\n\n<p><span style=\"font-weight: 400;\">The above list of Hemlibra side effects is not exhaustive. If you encounter any other side effects that are not mentioned above, please consult your doctor.<\/span>&nbsp;<\/p>\n\n\n\n<div  id=\"call-to-action-aa4dd60e20572594cc9685340be7583e\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tGet Financial Assistance\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"tel:8777780318\">(877) 778-0318<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dosing_Information\"><\/span>Dosing Information<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Hemlibra is administered subcutaneously through injections. The dosing depends on various factors like your weight and treatment history. Hemlibra treatment usually starts with loading doses, followed by maintenance doses. Loading doses rapidly increase the drug&#8217;s concentration in your body. They are higher than maintenance doses.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">The first four doses are loading doses. They are given at 3 mg\/kg of body weight once weekly. After that, each subsequent dose is known as a maintenance dose. They are given as:<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">1.5 mg\/kg of body weight once weekly, or<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">3 mg\/kg of body weight once every 2 weeks, or<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">6 mg\/kg of body weight once every 4 weeks<\/span><\/li>\n<\/ul>\n\n\n\n<p><span style=\"font-weight: 400;\">You have to discontinue the use of <a href=\"https:\/\/hemophilianewstoday.com\/bypassing-agents\/#:~:text=What%20are%20bypassing%20agents%3F,against%20its%20own%20clotting%20factors.\">bypassing agents<\/a> the day before starting Hemlibra treatment. If you miss a dose, take it as soon as you remember and then continue with your regular dosing schedule.<\/span>\u00a0<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Hemlibra_Cost\"><\/span>Hemlibra Cost<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Hemlibra can be expensive, priced at around $122 per mg [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK570443\/table\/stpe0651.app1.tab1\/\">5<\/a>]. The total cost of treatment varies based on your weight. For example, if you weigh 80 kg, the cost of treatment for the first year would be $411,136. For the following years, it would be $381,841. Please remember that this is a rough estimation. The real cost of treatment varies depending on your insurance plan, region, and pharmacy.<\/span>&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"FAQs\"><\/span>FAQs<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Here are some answers to frequently asked questions about Hemlibra:<\/span><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><b>Is Hemlibra Safe for Use During Pregnancy or Breastfeeding?<\/b><\/h4>\n\n\n\n<p><span style=\"font-weight: 400;\">Hemlibra was mainly tested in males. There is no information about whether Hemlibra can cause harm to an unborn child or if it is present in breast milk. Hemlibra should only be used during pregnancy or breastfeeding if the benefits outweigh the risks.<\/span><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Can Hemlibra Be Used in Patients With Liver or Kidney Disease?<\/h4>\n\n\n\n<p><span style=\"font-weight: 400;\">If you have mild liver or kidney disease, you can still use Hemlibra without needing any changes to the dosage. Data for use in patients with severe liver or kidney disease is insufficient to provide specific recommendations [<a href=\"https:\/\/assets.roche.com\/f\/173850\/x\/e0145f9e2a\/hemlibra_pm_e.pdf\">6<\/a>]. Please consult your doctor.<\/span><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Does Hemlibra Cure Hemophilia A?<\/h4>\n\n\n\n<p><span style=\"font-weight: 400;\">Unfortunately, there is currently no cure for hemophilia A. Hemlibra can only prevent or reduce the occurrences of bleeding episodes. It cannot cure the disease.<\/span>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5982\u679c\u60a8\u60a3\u6709\u8840\u53cb\u75c5 A\uff0c\u533b\u751f\u53ef\u80fd\u4f1a\u5efa\u8bae\u60a8\u4f7f\u7528 Hemlibra \u4f5c\u4e3a\u6cbb\u7597\u9009\u62e9\u3002\u8be5\u836f\u7269\u4e8e 2017 \u5e74 11 \u6708 16 \u65e5\u83b7\u5f97 FDA \u6279\u51c6\uff0c\u7528\u4e8e\u9884\u9632\u6216\u51cf\u5c11\u8840\u53cb\u75c5 A \u60a3\u8005\u7684\u51fa\u8840\u53d1\u4f5c\u3002<\/p>","protected":false},"author":25,"featured_media":25921,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[6],"tags":[31],"class_list":["post-26019","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-hemophilia","tag-dr-mark-alfonso"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Hemlibra: A Promising Medication for Hemophilia A Patients - AmeriPharma\u00ae Specialty Care<\/title>\n<meta name=\"description\" content=\"This article provides essential Hemlibra drug information. Topics include how the drug works, what it treats, side effects, cost, and more.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/hemophilia\/hemlibra-a-promising-medication-for-hemophilia-a-patients\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hemlibra: A Promising Medication for Hemophilia A Patients - AmeriPharma\u00ae Specialty Care\" \/>\n<meta property=\"og:description\" content=\"This article provides essential Hemlibra drug information. 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