{"id":23490,"date":"2023-11-06T12:00:46","date_gmt":"2023-11-06T20:00:46","guid":{"rendered":"https:\/\/ameripharmaspecialty.com\/?p=23490"},"modified":"2026-03-24T09:31:17","modified_gmt":"2026-03-24T16:31:17","slug":"considering-ivig-for-pans-pandas-heres-5-things-you-should-know","status":"publish","type":"post","link":"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/considering-ivig-for-pans-pandas-heres-5-things-you-should-know\/","title":{"rendered":"\u8003\u8651\u4f7f\u7528IVIG\u6cbb\u7597PANS\/PANDAS\uff1f\u4ee5\u4e0b5\u4ef6\u4e8b\u4f60\u5e94\u8be5\u77e5\u9053"},"content":{"rendered":"\n<ul class=\"wp-block-list\">\n<li>IVIG for PANS\/PANDAS is considered when symptoms are severe, disruptive, or rapidly onset after infection, especially if standard treatments have failed.<\/li>\n\n\n\n<li>Scientific evidence shows that IVIG therapy for PANS\/PANDAS can lead to significant symptom reduction, with some children experiencing improvements lasting for months to nearly a year.<\/li>\n\n\n\n<li>Severe risks of IVIG treatment for PANS\/PANDAS include allergic reactions, anemia, and aseptic meningitis-like illness.<\/li>\n\n\n\n<li>IVIG is costly and often used off-label as it\u2019s not FDA-approved specifically for this condition.<\/li>\n<\/ul>\n\n\n\n<p><span style=\"font-weight: 400;\">If your child is living with PANS\/PANDAS, <a href=\"https:\/\/ameripharmaspecialty.com\/ivig\/ivig\/\">IVIG<\/a> can be an effective treatment option for managing it, especially in severe cases.<\/span><\/p>\n\n\n\n<div  id=\"call-to-action-54ebf80fd715573d285f519cb3e14ba4\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tAsk About IVIG Home Infusion\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"tel:8777780318\">(877) 778-0318<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<p>For some families, however, the <a href=\"https:\/\/ameripharmaspecialty.com\/ivig\/cost-of-ivig-treatment\/\">cost of IVIG treatment<\/a> for PANDAS can be an issue. For others, the lack of access to IVIG can make things difficult as well.\u00a0<\/p>\n\n\n\n<p>In this article, you will get the latest information about when to consider IVIG therapy for PANS\/PANDAS, the treatment costs, potential risks, and more.<\/p>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/considering-ivig-for-pans-pandas-heres-5-things-you-should-know\/#A_Quick_Overview_of_PANSPANDAS\" >A Quick Overview of PANS\/PANDAS<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/considering-ivig-for-pans-pandas-heres-5-things-you-should-know\/#PANS\" >PANS<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/considering-ivig-for-pans-pandas-heres-5-things-you-should-know\/#PANDAS\" >PANDAS<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/considering-ivig-for-pans-pandas-heres-5-things-you-should-know\/#Are_PANS_and_PANDAS_Different_Conditions\" >Are PANS and PANDAS Different Conditions?<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/considering-ivig-for-pans-pandas-heres-5-things-you-should-know\/#1_When_To_Consider_IVIG_for_PANSPANDAS\" >1. When To Consider IVIG for PANS\/PANDAS<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/considering-ivig-for-pans-pandas-heres-5-things-you-should-know\/#When_Symptoms_Are_Severe_and_Disrupt_Daily_Functioning\" >When Symptoms Are Severe and Disrupt Daily Functioning<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/considering-ivig-for-pans-pandas-heres-5-things-you-should-know\/#When_Symptoms_Have_a_Rapid_Abrupt_Onset_Following_Infection\" >When Symptoms Have a Rapid, Abrupt Onset Following Infection<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/considering-ivig-for-pans-pandas-heres-5-things-you-should-know\/#When_Autoimmune_or_Neuroimmune_Biomarkers_Are_Elevated\" >When Autoimmune or Neuroimmune Biomarkers Are Elevated<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/considering-ivig-for-pans-pandas-heres-5-things-you-should-know\/#When_Standard_Treatments_Have_Failed_or_Are_Insufficient\" >When Standard Treatments Have Failed or Are Insufficient<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/considering-ivig-for-pans-pandas-heres-5-things-you-should-know\/#When_Long-Term_Management_Is_Needed_to_Sustain_Improvements\" >When Long-Term Management Is Needed to Sustain Improvements<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/considering-ivig-for-pans-pandas-heres-5-things-you-should-know\/#2_How_Effective_Is_IVIG_for_PANSPANDAS_A_Look_at_the_Scientific_Evidence\" >2. How Effective Is IVIG for PANS\/PANDAS? A Look at the Scientific Evidence<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/considering-ivig-for-pans-pandas-heres-5-things-you-should-know\/#Study_1\" >Study 1<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/considering-ivig-for-pans-pandas-heres-5-things-you-should-know\/#Study_2\" >Study 2<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/considering-ivig-for-pans-pandas-heres-5-things-you-should-know\/#3_What_Are_the_Potential_Risks_of_Using_IVIG_for_PANSPANDAS\" >3. What Are the Potential Risks of Using IVIG for PANS\/PANDAS?<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/considering-ivig-for-pans-pandas-heres-5-things-you-should-know\/#Potentially_Life-threatening_Allergic_Reactions\" >Potentially Life-threatening Allergic Reactions<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/considering-ivig-for-pans-pandas-heres-5-things-you-should-know\/#Anemia\" >Anemia<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/considering-ivig-for-pans-pandas-heres-5-things-you-should-know\/#Aseptic_Meningitis-like_Illness\" >Aseptic Meningitis-like Illness<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/considering-ivig-for-pans-pandas-heres-5-things-you-should-know\/#4_Is_IVIG_for_PANSPANDAS_FDA-Approved\" >4. Is IVIG for PANS\/PANDAS FDA-Approved?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/considering-ivig-for-pans-pandas-heres-5-things-you-should-know\/#5_What_Is_the_Cost_of_IVIG_for_PANSPANDAS\" >5. What Is the Cost of IVIG for PANS\/PANDAS?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/ivig\/considering-ivig-for-pans-pandas-heres-5-things-you-should-know\/#How_AmeriPharma%C2%AE_Specialty_Pharmacy_Can_Support_Your_Treatment_Journey\" >How AmeriPharma\u00ae Specialty Pharmacy Can Support Your Treatment Journey<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"A_Quick_Overview_of_PANSPANDAS\"><\/span>A Quick Overview of PANS\/PANDAS<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Before discussing the benefits of IVIG for PANS\/PANDAS, we must first understand the condition. Here is a quick overview of PANS and PANDAS.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"PANS\"><\/span><span style=\"font-weight: 400;\">PANS<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">PANS is an acronym for Pediatric Acute-onset Neuropsychiatric Syndrome.&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">It is a <a href=\"https:\/\/ameripharmaspecialty.com\/conditions-treatments\/\">medical condition<\/a> that causes children to develop abrupt, possibly overnight, <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/obsessive-compulsive-disorder\/symptoms-causes\/syc-20354432\">obsessive-compulsive disorder<\/a> (OCD) or eating restrictions. In addition, they may also exhibit symptoms of depression, irritability, anxiety, sleep disturbances, and problems with schoolwork.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">The exact cause is unknown. However, it is believed that infections, metabolic disturbances, or immune reactions may trigger PANS.&nbsp;&nbsp;<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"PANDAS\"><\/span><span style=\"font-weight: 400;\">PANDAS<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">PANDAS is an acronym for Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections.&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">IVIG is an effective solution for PANDAS, which is characterized by sudden OCD or tics (involuntary movements) following a recent streptococcal infection, such as strep throat or scarlet fever.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">PANDAS patients may also display symptoms of irritability, emotional changes, anxiety, and problems with schoolwork.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">PANS\/PANDAS is a rare condition. According to a new 2023 study, the estimated annual incidence of this condition is 1 in nearly 12,000 children between 3 and 12 years old annually [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10551157\/\">1<\/a>].<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Are_PANS_and_PANDAS_Different_Conditions\"><\/span>Are PANS and PANDAS Different Conditions?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>PANDAS is a type of PANS, specifically linked to streptococcal infections and characterized by sudden OCD or tics following strep.<\/p>\n\n\n\n<p>PANS, on the other hand, encompasses a broader range of triggers, including <a href=\"https:\/\/ameripharmaspecialty.com\/ivig\/ivig-and-chronic-infections-how-ivig-boosts-the-immune-system\/\">infections<\/a>, metabolic issues, and immune responses that lead to neuropsychiatric symptoms.<\/p>\n\n\n\n<p>Both conditions involve the immune system but differ in their underlying causes and diagnostic criteria. However, the two conditions also share many symptoms and treatments, hence why we refer to them as PANS\/PANDAS here.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"1_When_To_Consider_IVIG_for_PANSPANDAS\"><\/span>1. When To Consider IVIG for PANS\/PANDAS<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"682\" src=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/11\/anxiety-PANS-PANDAS-IVIG-1024x682.jpg\" alt=\"a mother talking to her anxious daughter\" class=\"wp-image-27805\" srcset=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/11\/anxiety-PANS-PANDAS-IVIG-1024x682.jpg 1024w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/11\/anxiety-PANS-PANDAS-IVIG-300x200.jpg 300w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/11\/anxiety-PANS-PANDAS-IVIG-768x512.jpg 768w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/11\/anxiety-PANS-PANDAS-IVIG-18x12.jpg 18w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/11\/anxiety-PANS-PANDAS-IVIG-600x400.jpg 600w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/11\/anxiety-PANS-PANDAS-IVIG-330x220.jpg 330w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/11\/anxiety-PANS-PANDAS-IVIG-86x57.jpg 86w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/11\/anxiety-PANS-PANDAS-IVIG-167x111.jpg 167w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/11\/anxiety-PANS-PANDAS-IVIG-280x187.jpg 280w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/11\/anxiety-PANS-PANDAS-IVIG-370x247.jpg 370w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/11\/anxiety-PANS-PANDAS-IVIG-960x640.jpg 960w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/11\/anxiety-PANS-PANDAS-IVIG.jpg 1280w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><span style=\"font-weight: 400;\">The PANDAS Physicians Network strongly recommends considering IVIG therapy for PANDAS if the symptoms cause significant interference with your child\u2019s daily functioning.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">You should work with your child\u2019s provider and specialists to decide if IVIG is appropriate for your child.&nbsp;<\/span><\/p>\n\n\n\n<p>Not all children need IVIG. Experts say that only 10% to 15% of children require IVIG. About 1 in 20 children will require long-term IVIG treatment for PANDAS [<a href=\"https:\/\/www.oregon.gov\/oha\/HPA\/DSI\/QHOCMeetingDocuments\/2022-06-QHOC%20Materials%20Packet.pdf\">2<\/a>].\u00a0<\/p>\n\n\n\n<p>Let\u2019s look closer at when it might be beneficial or even necessary to consider IVIG for PANS\/PANDAS.<\/p>\n\n\n\n<div  id=\"call-to-action-f9b6b1e3b7ac90981d854ec35d6f636a\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tGet IVIG Prior Authorization\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"#form\">Learn More<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"When_Symptoms_Are_Severe_and_Disrupt_Daily_Functioning\"><\/span>When Symptoms Are Severe and Disrupt Daily Functioning<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Sometimes your child\u2019s neuropsychiatric symptoms may disrupt daily activities such as attending school, interacting socially, and participating in family routines. In these instances, you should strongly consider <a href=\"https:\/\/ameripharmaspecialty.com\/conditions-treatments\/immune-globulin-ig\/\">IVIG<\/a> for treatment.<\/p>\n\n\n\n<p>When symptoms are debilitating and persistent despite behavioral or pharmacologic treatment, IVIG offers a promising option to reduce their severity and allow your child to enjoy ordinary activities.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"When_Symptoms_Have_a_Rapid_Abrupt_Onset_Following_Infection\"><\/span>When Symptoms Have a Rapid, Abrupt Onset Following Infection<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>In cases where neuropsychiatric symptoms such as OCD or tics develop suddenly over hours or days, particularly after a documented streptococcal infection or other immune-triggering illness, IVIG should be evaluated for PANS\/PANDAS.<\/p>\n\n\n\n<p>Rapid onset of symptoms suggests an immune-mediated process, possibly involving autoantibodies attacking brain structures like the basal ganglia. <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11484259\/\">Studies<\/a> support that immune modulation via IVIG can attenuate the autoimmune response, thereby reducing neuroinflammation and symptom severity.<\/p>\n\n\n\n<p>Considering IVIG therapy for PANDAS in these scenarios may prevent symptom escalation and facilitate a quicker recovery.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"When_Autoimmune_or_Neuroimmune_Biomarkers_Are_Elevated\"><\/span>When Autoimmune or Neuroimmune Biomarkers Are Elevated<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>If lab tests reveal elevated autoantibody levels (such as antineuronal antibodies), increased CaMKII activity, or other neuroimmune markers suggestive of immune dysregulation, the doctor may suggest IVIG.<\/p>\n\n\n\n<p>These <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0165572817300711\">biomarkers<\/a> imply an autoimmune component contributing to neuropsychiatric symptoms. IVIG\u2019s immunomodulatory effects offer several benefits for those with PANDAS and elevated levels of biomarkers. These effects can:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Neutralize pathogenic autoantibodies<\/li>\n\n\n\n<li>Suppress autoreactive immune cells<\/li>\n\n\n\n<li>Restore immune balance<\/li>\n<\/ul>\n\n\n\n<p>Using biomarkers as a guide can also help personalize treatment decisions and increase the likelihood of a positive outcome.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"When_Standard_Treatments_Have_Failed_or_Are_Insufficient\"><\/span>When Standard Treatments Have Failed or Are Insufficient<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>In children with PANS\/PANDAS who do not respond well to antibodies, anti-inflammatory agents, behavioral therapy, or steroids, IVIG should be evaluated as a subsequent therapeutic option.<\/p>\n\n\n\n<p>When symptoms persist or worsen despite conventional approaches, immune-based interventions like IVIG treatment may be effective for addressing underlying autoimmunity in PANS\/PANDAS patients.<\/p>\n\n\n\n<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9836706\/\">Clinical studies<\/a> also support IVIG\u2019s use for moderate to severe PANS\/PANDAS cases unresponsive to first-line therapies.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"When_Long-Term_Management_Is_Needed_to_Sustain_Improvements\"><\/span>When Long-Term Management Is Needed to Sustain Improvements<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>For children with recurrent or chronic symptoms, especially those who experience relapse after initial improvement, IVIG can serve as a maintenance or booster therapy.<\/p>\n\n\n\n<p>Research shows that multiple IVIG infusions can produce durable benefits, sometimes lasting months to nearly a year.&nbsp;<\/p>\n\n\n\n<p>When symptom recurrence aligns with immune activity or triggers, periodic IVIG therapy for PANS\/PANDAS patients may help:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Reduce flare-ups<\/li>\n\n\n\n<li>Manage the autoimmune process<\/li>\n\n\n\n<li>Improve quality of life over the long term<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2_How_Effective_Is_IVIG_for_PANSPANDAS_A_Look_at_the_Scientific_Evidence\"><\/span>2. How Effective Is IVIG for PANS\/PANDAS? A Look at the Scientific Evidence<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"682\" src=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/11\/IVIG-therapy-for-PANDAS-1024x682.jpg\" alt=\"A young girl holding up her thumb while receiving an infusion\" class=\"wp-image-27806\" srcset=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/11\/IVIG-therapy-for-PANDAS-1024x682.jpg 1024w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/11\/IVIG-therapy-for-PANDAS-300x200.jpg 300w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/11\/IVIG-therapy-for-PANDAS-768x512.jpg 768w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/11\/IVIG-therapy-for-PANDAS-18x12.jpg 18w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/11\/IVIG-therapy-for-PANDAS-600x400.jpg 600w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/11\/IVIG-therapy-for-PANDAS-330x220.jpg 330w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/11\/IVIG-therapy-for-PANDAS-86x57.jpg 86w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/11\/IVIG-therapy-for-PANDAS-167x111.jpg 167w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/11\/IVIG-therapy-for-PANDAS-280x187.jpg 280w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/11\/IVIG-therapy-for-PANDAS-370x247.jpg 370w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/11\/IVIG-therapy-for-PANDAS-960x640.jpg 960w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/11\/IVIG-therapy-for-PANDAS.jpg 1280w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>IVIG can be an effective treatment option for children who don\u2019t benefit from antibiotics, behavioral therapy (talk therapy), steroids, and NSAIDs (nonsteroidal anti-inflammatory drugs).&nbsp;<\/p>\n\n\n\n<p>In many cases, a single course of IVIG may reduce symptoms and even reverse PANDAS [<a href=\"https:\/\/www.kslegislature.org\/li_2022\/b2021_22\/committees\/ctte_s_fin_inst_ins_1\/documents\/testimony\/20220310_24.pdf\">3<\/a>]. Several studies suggest that IVIG therapy for PANDAS can dramatically improve symptoms. Let\u2019s take a closer look at each of these studies.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Study_1\"><\/span>Study 1<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>For example, in a 2021 study, researchers administered IVIG (Octagam 5%) infusions every 3 weeks for a total of 6 infusions over a period of 18 weeks to 21 participants between 4 and 16 years [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7984935\/\">4<\/a>].<\/p>\n\n\n\n<p>At the end of the study, they found that all the participants receiving IVIG for PANS\/PANDAS experienced over 50% improvement in their symptoms for at least 8 weeks following treatment.&nbsp;<\/p>\n\n\n\n<p>A subset of patients receiving IVIG treatment for PANDAS experienced improvement up to 46 weeks following treatment.&nbsp;<\/p>\n\n\n\n<div  id=\"call-to-action-377fcf5f5c2a0beabc637549dd9f26cc\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tSpeak to a Specialist\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"cta__sub__heading\">\n\t\t\t\t\t\t\tAbout Copay Assistance\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"#form\">Consult an IVIG Specialist<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Study_2\"><\/span>Study 2<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Swedish researchers observed similar results in a 2022 trial. In this trial, 10 children (median age 10 years) received IVIG 2 g\/kg monthly for 3 months. 9 children had at least 30% improvement in their symptoms [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9357317\/\">5<\/a>].<\/p>\n\n\n\n<p>Most members of the <a href=\"https:\/\/med.stanford.edu\/pans\/research\/PANS-consortium.html\">PANS Research Consortium<\/a> (PRC) prefer IVIG to oral or intravenous steroids for moderate-to-severe PANS [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7984935\/\">6<\/a>].<\/p>\n\n\n\n<p>In conclusion, research for the use of IVIG for PANS\/PANDAS is ongoing. Available evidence shows promising results, and IVIG is worth a try.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"3_What_Are_the_Potential_Risks_of_Using_IVIG_for_PANSPANDAS\"><\/span>3. What Are the Potential Risks of Using IVIG for PANS\/PANDAS?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/ameripharmaspecialty.com\/ivig\/ivig-headaches\/\">Headache<\/a>, nausea, vomiting, and fever are the <a href=\"https:\/\/ameripharmaspecialty.com\/ivig\/understanding-the-common-side-effects-of-ivig-treatment\/\">common side effects of IVIG<\/a> therapy for PANDAS patients. In rare cases, however, IVIG may cause more serious issues. Here is a closer look at some of them.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Potentially_Life-threatening_Allergic_Reactions\"><\/span>Potentially Life-threatening Allergic Reactions<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>One of the <a href=\"https:\/\/ameripharmaspecialty.com\/ivig\/understanding-the-potential-risks-of-ivig-therapy-2\/\">potential risks of IVIG therapy<\/a> is that it can cause severe allergic reactions. Some signs of these reactions include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Hives<\/li>\n\n\n\n<li>Rapid heartbeat<\/li>\n\n\n\n<li>Difficulty breathing<\/li>\n\n\n\n<li>Swelling of the face or throat<\/li>\n<\/ul>\n\n\n\n<p>These adverse reactions require immediate medical attention. While rare, they can be life-threatening if not treated promptly. Patients should be monitored closely during infusions, and healthcare providers must be ready to manage any allergic responses.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Anemia\"><\/span>Anemia<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Some children receiving IVIG for PANS\/PANDAS may develop <a href=\"https:\/\/ameripharmaspecialty.com\/other-health-conditions\/autoimmune-hemolytic-anemia-causes-diagnosis-and-treatment-options\/\">anemia<\/a>. In <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10409536\/\">this condition<\/a>, red blood cell levels drop significantly. Symptoms may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Fatigue<\/li>\n\n\n\n<li>Pale skin<\/li>\n\n\n\n<li>Weakness<\/li>\n\n\n\n<li>Shortness of breath<\/li>\n<\/ul>\n\n\n\n<p>Although uncommon, anemia can impact oxygen delivery to tissues and necessitate medical interventions such as blood transfusions.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Aseptic_Meningitis-like_Illness\"><\/span>Aseptic Meningitis-like Illness<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Another severe reaction that a few patients receiving IVIG therapy for PANDAS may experience is aseptic <a href=\"https:\/\/ameripharmaspecialty.com\/other-health-conditions\/ivig-and-meningitis-whats-the-link\/\">meningitis<\/a>-like illness. <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9267278\/\">This condition<\/a> results from inflammation of the membranes surrounding the brain and spinal cord. Symptoms may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Fevere<\/li>\n\n\n\n<li>Neck stiffness<\/li>\n\n\n\n<li>Sensitivity to light<\/li>\n\n\n\n<li>Severe headaches<\/li>\n<\/ul>\n\n\n\n<p>Typically, symptoms resolve with supportive care, but prompt diagnosis and treatment are essential to prevent further complications.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"4_Is_IVIG_for_PANSPANDAS_FDA-Approved\"><\/span>4. Is IVIG for PANS\/PANDAS FDA-Approved?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">No treatments, including IVIG, are FDA-approved for PANS\/PANDAS.&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">However, doctors may prescribe specific medications based on their clinical experience and available data. Such practice is known as off-label use.&nbsp;<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"5_What_Is_the_Cost_of_IVIG_for_PANSPANDAS\"><\/span>5. What Is the Cost of IVIG for PANS\/PANDAS?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Cost varies considerably depending on dose and weight. It can be as high as $25,000 [<a href=\"https:\/\/www.heraldnews.com\/story\/news\/2019\/07\/15\/high-cost-treating-pandas-disorder\/4691123007\/\">7<\/a>]. Because the FDA has yet to approve IVIG therapy for PANS\/PANDAS, Medicaid doesn\u2019t cover IVIG [<a href=\"https:\/\/mgaleg.maryland.gov\/2022RS\/fnotes\/bil_0000\/hb0820.pdf\">8<\/a>].<\/p>\n\n\n\n<p>Contact your insurance provider for questions related to coverage for IVIG treatment for PANS\/PANDAS. IVIG treatment may require prior authorization from your insurance company before administration.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_AmeriPharma%C2%AE_Specialty_Pharmacy_Can_Support_Your_Treatment_Journey\"><\/span>How AmeriPharma\u00ae Specialty Pharmacy Can Support Your Treatment Journey<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Navigating IVIG therapy for PANS\/PANDAS can be complex. However, with the right support, you don\u2019t have to face it alone. <a href=\"https:\/\/ameripharmaspecialty.com\/about-us\/\">AmeriPharma\u2122 Specialty Pharmacy<\/a> is committed to helping families access effective IVIG for PANS\/PANDAS.<\/p>\n\n\n\n<p>Our ACHC-accredited <a href=\"https:\/\/ameripharmaspecialty.com\/\">specialty pharmacy<\/a> offers hard-to-find medications and at-home IVIG treatments for those with complex conditions like PANS\/PANDAS in over 40 U.S. states and territories.<\/p>\n\n\n\n<p><a href=\"https:\/\/ameripharmaspecialty.com\/book-a-call\/\">Book a call<\/a> with us today to learn how we can support your family\u2019s journey toward managing PANS\/PANDAS with full-service coordination, <a href=\"https:\/\/ameripharmaspecialty.com\/financial-assistance\/\">copay assistance<\/a>, and 24\/7\/365 assistance.<span style=\"font-weight: 400;\">\u00a0\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5982\u679c\u60a8\u7684\u5b69\u5b50\u60a3\u6709 PANS\/PANDAS\uff0cIVIG \u53ef\u80fd\u662f\u4e00\u79cd\u6709\u6548\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u5c24\u5176\u662f\u5728\u75c5\u60c5\u4e25\u91cd\u7684\u60c5\u51b5\u4e0b\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u4e00\u4e9b\u5bb6\u5ead\u6765\u8bf4\uff0cIVIG \u6cbb\u7597\u7684\u8d39\u7528\u53ef\u80fd\u662f\u4e00\u4e2a\u95ee\u9898\u3002<\/p>","protected":false},"author":7,"featured_media":23492,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":true,"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[7],"tags":[8],"class_list":["post-23490","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ivig","tag-dr-christine-leduc"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>IVIG for PANS\/PANDAS: 5 Things to Know | AmeriPharma<\/title>\n<meta name=\"description\" content=\"Are you considering IVIG for your child with PANS\/PANDAS? 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issue.","_links":{"self":[{"href":"https:\/\/ameripharmaspecialty.com\/zh\/wp-json\/wp\/v2\/posts\/23490","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ameripharmaspecialty.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ameripharmaspecialty.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ameripharmaspecialty.com\/zh\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/ameripharmaspecialty.com\/zh\/wp-json\/wp\/v2\/comments?post=23490"}],"version-history":[{"count":0,"href":"https:\/\/ameripharmaspecialty.com\/zh\/wp-json\/wp\/v2\/posts\/23490\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ameripharmaspecialty.com\/zh\/wp-json\/wp\/v2\/media\/23492"}],"wp:attachment":[{"href":"https:\/\/ameripharmaspecialty.com\/zh\/wp-json\/wp\/v2\/media?parent=23490"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ameripharmaspecialty.com\/zh\/wp-json\/wp\/v2\/categories?post=23490"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ameripharmaspecialty.com\/zh\/wp-json\/wp\/v2\/tags?post=23490"}],"curies":[{"name":"\u53ef\u6e7f\u6027\u7c89\u5242","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}