{"id":20173,"date":"2022-05-11T11:58:51","date_gmt":"2022-05-11T18:58:51","guid":{"rendered":"https:\/\/ameripharmaspe.wpengine.com\/staging\/?p=19120"},"modified":"2026-03-26T14:16:10","modified_gmt":"2026-03-26T21:16:10","slug":"cyclophosphamide","status":"publish","type":"post","link":"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/cyclophosphamide\/","title":{"rendered":"Cyclophosphamide"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Cyclophosphamide<\/span><span style=\"font-weight: 400;\"> \u662f\u4e00\u79cd\u5316\u7597\u836f\u7269\uff0c\u76ee\u524d\u6709\u901a\u7528\u540d\u548c\u5546\u6807\u540d Cytoxan \u548c Neosar\u3002<\/span> <span style=\"font-weight: 400;\">\u8fd9\u79cd\u836f\u7269\u6709\u53e3\u670d\u7247\u5242\u6216\u80f6\u56ca\u5f62\u5f0f\uff0c\u5fc5\u987b\u6574\u7247\u541e\u670d\uff0c\u4e5f\u6709\u6ce8\u5c04\u6db2\u5f62\u5f0f\uff0c\u9700\u8981\u9759\u8109\u6ce8\u5c04\u3002<\/span> <span style=\"font-weight: 400;\">Cyclophosphamide \u7528\u4e8e\u6cbb\u7597 <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=cef038cc-efab-46d9-99c2-95bb11d6c9bc#leftmenu\"><span style=\"font-weight: 400;\">\u591a\u79cd\u764c\u75c7<\/span><\/a><span style=\"font-weight: 400;\">\u764c\u75c7\uff0c\u4f8b\u5982\u4e73\u817a\u764c\u548c\u767d\u8840\u75c5\u3002\u8f93\u6db2\u901a\u5e38\u7531\u7ecf\u8fc7\u57f9\u8bad\u7684\u533b\u7597\u4fdd\u5065\u4e13\u4e1a\u4eba\u5458\u5728\u533b\u751f\u529e\u516c\u5ba4\/\u8bca\u6240\u6216\u533b\u9662\u8fdb\u884c\u3002\u8fd9\u79cd\u836f\u7269\u53ef\u7528\u4e8e <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK553087\/#:~:text=Cyclophosphamide%20is%20a%20medication%20primarily,anti%2Dneoplastic%20effects%20through%20alkylation.\"><span style=\"font-weight: 400;\">\u4e0e\u5176\u4ed6\u836f\u7269\u8054\u5408\u4f7f\u7528<\/span><\/a><span style=\"font-weight: 400;\">\uff0c\u53d6\u51b3\u4e8e\u6cbb\u7597\u65b9\u6848\u3002<\/span><\/p>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"\u5207\u6362\u76ee\u5f55\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">\u5207\u6362<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/cyclophosphamide\/#Cyclophosphamide_Uses\" >Cyclophosphamide\u7528\u9014<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/cyclophosphamide\/#How_It_Works\" >\u5de5\u4f5c\u539f\u7406<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/cyclophosphamide\/#Cyclophosphamide_Side_Effects\" >Cyclophosphamide \u526f\u4f5c\u7528<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/cyclophosphamide\/#Serious_Side_Effects\" >\u4e25\u91cd\u7684\u526f\u4f5c\u7528<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/cyclophosphamide\/#Warnings\" >\u8b66\u544a<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/cyclophosphamide\/#Infertility_and_Birth_Defects_Warning\" >\u4e0d\u5b55\u4e0d\u80b2\u548c\u51fa\u751f\u7f3a\u9677\u8b66\u544a<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/cyclophosphamide\/#Blood_in_the_Urine_Warning\" >\u5c3f\u8840\u8b66\u544a<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/cyclophosphamide\/#Infections\" >\u611f\u67d3<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/cyclophosphamide\/#Secondary_Malignancy_Risk\" >\u7ee7\u53d1\u6027\u6076\u6027\u80bf\u7624\u98ce\u9669<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/cyclophosphamide\/#Allergy_Warning\" >\u8fc7\u654f\u8b66\u544a<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/cyclophosphamide\/#Disease-specific_Considerations\" >\u75be\u75c5\u7279\u5f02\u6027\u8003\u8651<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/cyclophosphamide\/#For_Patients_With_Kidney_Disease\" >\u5bf9\u4e8e\u80be\u75c5\u60a3\u8005\uff1a<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/cyclophosphamide\/#For_Patients_With_Liver_Disease\" >\u5bf9\u4e8e\u809d\u75c5\u60a3\u8005\uff1a<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/cyclophosphamide\/#Individuals_With_Urinary_Outflow_Obstruction\" >\u5c3f\u8def\u963b\u585e\u60a3\u8005\uff1a<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/cyclophosphamide\/#Cyclophosphamide_Drug_Interactions\" >Cyclophosphamide\u836f\u7269\u76f8\u4e92\u4f5c\u7528<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/cyclophosphamide\/#How_To_Take_Cyclophosphamide\" >\u5982\u4f55\u670d\u7528 Cyclophosphamide<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/cyclophosphamide\/#Missed_Doses\" >\u6f0f\u670d\u5242\u91cf<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/cyclophosphamide\/#Treatment_Monitoring\" >\u6cbb\u7597\u76d1\u6d4b&nbsp;<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Cyclophosphamide_Uses\"><\/span>Cyclophosphamide\u7528\u9014<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">\u764c\u75c7\u76f8\u5173\u7528\u9014\uff1a<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">\u5375\u5de2\u764c<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u4e73\u817a\u764c<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u767d\u8840\u75c5<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u76ae\u80a4T\u7ec6\u80de\u6dcb\u5df4\u7624<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u548c\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u591a\u53d1\u6027\u9aa8\u9ad3\u7624<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u6210\u795e\u7ecf\u7ec6\u80de\u7624<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u89c6\u7f51\u819c\u6bcd\u7ec6\u80de\u7624<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u5c0f\u7ec6\u80de\u80ba\u764c\uff08\u975e\u8bf4\u660e\u4e66\u7528\u836f\uff09<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u6a2a\u7eb9\u808c\u8089\u7624\uff08\u975e\u8bf4\u660e\u4e66\u7528\u836f\uff09<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u5c24\u6587\u6c0f\u8089\u7624\uff08\u975e\u8bf4\u660e\u4e66\u7528\u836f\uff09<\/span><\/li>\n<\/ul>\n\n\n\n<p><span style=\"font-weight: 400;\">\u5176\u4ed6\u7528\u9014\uff08\u6807\u7b7e\u5916\u7528\u9014\uff09\uff1a<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">\u80be\u75c5\u7efc\u5408\u5f81<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u72fc\u75ae\u6027\u80be\u708e<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u76ae\u808c\u708e\/<a href=\"https:\/\/ameripharmaspecialty.com\/zh\/other-health-conditions\/polymyositis\/\">\u591a\u53d1\u6027\u808c\u708e<\/a><\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\u9884\u9632<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u9020\u8840\u5e72\u7ec6\u80de\u6216\u9aa8\u9ad3\u79fb\u690d<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u81ea\u8eab\u514d\u75ab\u6027\u6eb6\u8840\u6027\u8d2b\u8840<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u7ed3\u8282\u6027\u591a\u52a8\u8109\u708e<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u95f4\u8d28\u6027\u80ba\u708e<\/span><\/li>\n<\/ul>\n\n\n\n<p><span style=\"font-weight: 400;\">\u73af\u78f7\u9170\u80fa\u7684\u5242\u91cf\u548c\u4f18\u9009\u7ed9\u836f\u9014\u5f84\u56e0\u8bca\u65ad\u800c\u5f02\u3002\u5982\u6709\u6307\u5f81\uff0c\u8bf7\u52a1\u5fc5\u4e0e\u5904\u65b9\u533b\u751f\u8be6\u7ec6\u8ba8\u8bba\u6cbb\u7597\u65b9\u6848\u3002 <\/span><b>\u670d\u7528\u8be5\u836f\u7269\u65f6\uff0c\u9075\u533b\u5631\u6cbb\u7597\u81f3\u5173\u91cd\u8981<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_It_Works\"><\/span>\u5de5\u4f5c\u539f\u7406<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Cyclophosphamide \u5c5e\u4e8e\u70f7\u5316\u5242\u7c7b\u836f\u7269\u3002\u5b83\u901a\u8fc7\u7834\u574f\u7ec6\u80de\u5206\u88c2\u8fc7\u7a0b\u4e2d\u7684 DNA \u5408\u6210\u6765\u6cbb\u7597\u764c\u75c7\uff0c\u4ece\u800c\u963b\u6b62\u7ec6\u80de\u5206\u88c2\u3002\u8fd9\u4f1a\u5bfc\u81f4 <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK304336\/\"><span style=\"font-weight: 400;\">\u6291\u5236\u591a\u79cd\u764c\u7ec6\u80de\u7684\u751f\u957f<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Cyclophosphamide \u5bf9\u764c\u7ec6\u80de\u6ca1\u6709\u9009\u62e9\u6027\u3002\u56e0\u6b64\uff0c\u5b83\u7684\u4f5c\u7528\u4e5f\u53ef\u80fd\u5f71\u54cd\u4e00\u4e9b\u4eba\u4f53\u5065\u5eb7\u7ec6\u80de\uff0c\u5c24\u5176\u662f\u53c2\u4e0e\u514d\u75ab\u7cfb\u7edf\u7684\u7ec6\u80de\u3002\u56e0\u6b64\uff0c\u5b83\u5177\u6709\u663e\u8457\u7684\u514d\u75ab\u6291\u5236\u6d3b\u6027\uff0c\u53ef\u7528\u4e8e\u6cbb\u7597\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3002<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Cyclophosphamide_Side_Effects\"><\/span>Cyclophosphamide \u526f\u4f5c\u7528<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">\u5e38\u89c1\u7684\u526f\u4f5c\u7528\u5305\u62ec <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=cef038cc-efab-46d9-99c2-95bb11d6c9bc#leftmenu\"><span style=\"font-weight: 400;\">\u6076\u5fc3\u3001\u5455\u5410\u3001\u89c6\u529b\u6a21\u7cca\u3001\u5934\u6655\u548c\u98df\u6b32\u4e0d\u632f<\/span><\/a><span style=\"font-weight: 400;\">\u3002\u7531\u4e8e\u73af\u78f7\u9170\u80fa\u4f1a\u635f\u5bb3\u89c6\u529b\u548c\u7cbe\u795e\u654f\u9510\u5ea6\uff0c <\/span><b>\u907f\u514d\u5728\u53d7\u5176\u5f71\u54cd\u65f6\u9a7e\u9a76\u6216\u4f7f\u7528\u91cd\u578b\u673a\u68b0<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n\n\n\n<p>Cyclophosphamide\u7a81\u53d8\u901a\u5e38\u4f1a\u5bfc\u81f4\u9aa8\u9ad3\u6291\u5236\uff0c\u8fdb\u800c\u53ef\u80fd\u5bfc\u81f4\u767d\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\uff08\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff09\u3001\u8d2b\u8840\u548c\u8840\u5c0f\u677f\u8ba1\u6570\u964d\u4f4e\uff08\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\uff09\u3002\u8fd9\u4f1a\u589e\u52a0\u611f\u67d3\u3001\u75b2\u52b3\u548c\u51fa\u8840\u7684\u98ce\u9669\u3002.<\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">\u4e0b\u9762\u5217\u51fa\u4e86\u5176\u4ed6\u4e00\u4e9b <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9104732\/\"><span style=\"font-weight: 400;\">\u53ef\u80fd\u4ea7\u751f\u7684\u526f\u4f5c\u7528<\/span><\/a><span style=\"font-weight: 400;\"> \u4e0e\u73af\u78f7\u9170\u80fa\u76f8\u5173\u7684\uff1a<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">\u611f\u67d3<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u6307\u7532\u989c\u8272\u7684\u53d8\u5316<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u76ae\u80a4\u989c\u8272\u53d8\u5316<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u76ae\u75b9<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u8131\u53d1<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u53e3\u8154\u6e83\u75a1<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u8179\u6cfb<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u80c3\u75db<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u8eab\u4f53\u75bc\u75db<\/span><\/li>\n<\/ul>\n\n\n\n<p><span style=\"font-weight: 400;\">\u5927\u591a\u6570\u60c5\u51b5\u4e0b\uff0c\u5982\u679c\u526f\u4f5c\u7528\u8f83\u8f7b\uff0c\u53ef\u80fd\u4f1a\u5728\u51e0\u5929\u6216\u51e0\u5468\u5185\u968f\u7740\u8eab\u4f53\u9002\u5e94\u836f\u7269\u800c\u6d88\u5931\u3002\u5982\u679c\u526f\u4f5c\u7528\u6301\u7eed\u5b58\u5728\u6216\u52a0\u5267\uff0c\u8bf7\u8054\u7cfb\u533b\u751f\u6216\u836f\u5242\u5e08\u5bfb\u6c42\u8fdb\u4e00\u6b65\u6307\u5bfc\u3002<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Serious_Side_Effects\"><\/span>\u4e25\u91cd\u7684\u526f\u4f5c\u7528<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">\u6709\u4e9b\u526f\u4f5c\u7528\u6bd4\u8f83\u4e25\u91cd\uff0c\u9700\u8981\u7acb\u5373\u5c31\u533b\u3002\u8fd9\u4e9b\u526f\u4f5c\u7528\u5305\u62ec\uff1a<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">\u611f\u67d3\uff08\u89c1\u201c<\/span><a href=\"#warnings\"><span style=\"font-weight: 400;\">\u8b66\u544a<\/span><\/a><span style=\"font-weight: 400;\">\u201c \u4ee5\u4e0b\uff09<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u51fa\u8840\u6027\u8180\u80f1\u708e\/\u80be\u6bd2\u6027\uff08\u53c2\u89c1\u201c<\/span><a href=\"#warnings\"><span style=\"font-weight: 400;\">\u8b66\u544a<\/span><\/a><span style=\"font-weight: 400;\">\u201c \u4ee5\u4e0b\uff09\uff1a<\/span>\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">\u8180\u80f1\u75bc\u75db<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u5c3f\u6db2\u4e2d\u5e26\u8840<\/span><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u5fc3\u810f\u95ee\u9898\uff08\u9ad8\u5242\u91cf\u65f6\u66f4\u5e38\u89c1\uff09\uff1a<\/span>\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">\u5fc3\u5f8b\u4e0d\u9f50<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u80f8\u75db<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u6c14\u4fc3<\/span><\/li>\n\n\n\n<li>\u5fc3\u529b\u8870\u7aed\u7684\u8ff9\u8c61\uff0c\u4f8b\u5982\u817f\u90e8\u80bf\u80c0\u6216\u4f53\u91cd\u7a81\u7136\u589e\u52a0\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u80ba\u90e8\u75be\u75c5\uff08\u5305\u62ec\u95f4\u8d28\u6027\u80ba\u708e\u6216\u80ba\u7ea4\u7ef4\u5316\uff09\uff1a<\/span>\n<ul class=\"wp-block-list\">\n<li>\u6c14\u4fc3<\/li>\n\n\n\n<li>\u6301\u7eed\u54b3\u55fd<\/li>\n\n\n\n<li>\u547c\u5438\u56f0\u96be\u52a0\u91cd<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u809d\u810f\u75be\u75c5\uff1a<\/span>\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">\u4e0a\u8179\u90e8\u75bc\u75db<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u6df1\u8272\u5c3f\u6db2<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u82cd\u767d\u8272\u6216\u767d\u57a9\u8272\u7684\u5927\u4fbf<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u76ae\u80a4\u6216\u773c\u767d\u53d1\u9ec4<\/span><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u4f24\u53e3\u6108\u5408\u5ef6\u8fdf<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u4e0d\u5b55\u4e0d\u80b2\uff08\u89c1\u201c<\/span><a href=\"#warnings\"><span style=\"font-weight: 400;\">\u8b66\u544a<\/span><\/a><span style=\"font-weight: 400;\">\u201c \u4ee5\u4e0b\uff09<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u6297\u5229\u5c3f\u6fc0\u7d20\u5206\u6ccc\u4e0d\u5f53\u7efc\u5408\u5f81 (SIADH)\uff0c\u662f\u6307\u4f53\u5185\u6c34\u5206\u6ede\u7559\u8fc7\u591a\u7684\u4e00\u79cd\u75be\u75c5\u3002\u5176\u75c7\u72b6\u53ef\u80fd\u5305\u62ec\uff1a<\/span>\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">\u660f\u8ff7<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u766b\u75eb<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u5e7b\u89c9<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u56f0\u60d1<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u808c\u8089\u65e0\u529b<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u6076\u5fc3\u548c\u5455\u5410<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u808c\u8089\u75c9\u631b<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u98df\u6b32\u4e0d\u632f<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u70e6\u8e81\u4e0d\u5b89<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><b>\u7b14\u8bb0\uff1a<\/b><span style=\"font-weight: 400;\"> \u6211\u4eec\u7684\u76ee\u6807\u662f\u4e3a\u60a8\u63d0\u4f9b\u6700\u65b0\u3001\u6700\u51c6\u786e\u7684\u4fe1\u606f\u3002\u7136\u800c\uff0c\u7531\u4e8e\u6bcf\u4e2a\u4eba\u7684\u60c5\u51b5\u4e0d\u540c\uff0c\u6211\u4eec\u65e0\u6cd5\u4fdd\u8bc1\u8fd9\u4e9b\u4fe1\u606f\u6db5\u76d6\u6240\u6709\u6f5c\u5728\u7684\u526f\u4f5c\u7528\u3002\u8bf7\u52a1\u5fc5\u54a8\u8be2\u4e13\u4e1a\u7684\u533b\u7597\u673a\u6784\u8fdb\u884c\u786e\u8ba4\u3002<\/span><\/p>\n\n\n\n<div id=\"warnings\">\n<h2><span class=\"ez-toc-section\" id=\"Warnings\"><\/span>\u8b66\u544a<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Infertility_and_Birth_Defects_Warning\"><\/span>\u4e0d\u5b55\u4e0d\u80b2\u548c\u51fa\u751f\u7f3a\u9677\u8b66\u544a<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Cyclophosphamide \u53ef\u80fd\u5bfc\u81f4\u7537\u6027\u548c\u5973\u6027\u4e0d\u53ef\u9006\u6027\u4e0d\u80b2\u3002\u5728\u5973\u6027\u4e2d\uff0c\u53ef\u80fd\u8868\u73b0\u4e3a\u95ed\u7ecf\uff08\u6708\u7ecf\u505c\u6b62\uff09\u6216\u5375\u5de2\u65e9\u8870\u3002\u5728\u7537\u6027\u4e2d\uff0c\u53ef\u80fd\u5bfc\u81f4\u7cbe\u5b50\u751f\u6210\u51cf\u5c11\uff08\u5c11\u7cbe\u75c7\uff09\u6216\u5b8c\u5168\u65e0\u7cbe\u75c7\uff0c\u6839\u636e\u7d2f\u79ef\u5242\u91cf\u548c\u6cbb\u7597\u6301\u7eed\u65f6\u95f4\uff0c\u8fd9\u79cd\u60c5\u51b5\u53ef\u80fd\u662f\u6c38\u4e45\u6027\u7684\u3002\u7814\u7a76\u8868\u660e\uff0c\u8be5\u836f\u7269\u53ef\u76f4\u63a5\u5e72\u6270\u5375\u5b50\u548c\u7cbe\u5b50\u7684\u53d1\u80b2\u3002\u5373\u4f7f\u6210\u529f\u6000\u5b55\uff0c\u73af\u78f7\u9170\u80fa\u4e5f\u5df2\u77e5\u4f1a\u5bf9\u80ce\u513f\u9020\u6210\u76f4\u63a5\u635f\u5bb3\uff0c\u5305\u62ec\u5148\u5929\u6027\u7f3a\u9677\u3001\u6d41\u4ea7\u548c\u53d1\u80b2\u8fdf\u7f13\u3002\u56e0\u6b64\uff0c\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u5e94\u91c7\u53d6\u9002\u5f53\u63aa\u65bd\u3002 <strong>\u6cbb\u7597\u671f\u95f4\u907f\u514d\u6000\u5b55<\/strong> \u548c <strong>\u505c\u836f\u540e\u957f\u8fbe 1 \u5e74<\/strong>\u5982\u679c\u5728\u6000\u5b55\u671f\u95f4\u4e0d\u53ef\u907f\u514d\u5730\u8981\u4f7f\u7528\u8fd9\u79cd\u836f\u7269\uff0c\u90a3\u4e48\u5904\u65b9\u533b\u751f\u5e94\u8be5\u4ed4\u7ec6\u8003\u8651\u5176\u6240\u6709\u6f5c\u5728\u7684\u98ce\u9669\u548c\u76ca\u5904\u3002<\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Cyclophosphamide \u5df2\u77e5\u4e5f\u5b58\u5728\u4e8e\u6bcd\u4e73\u4e2d\u3002\u56e0\u6b64\uff0c<\/span><b> \u54fa\u4e73\u671f\u6bcd\u4eb2\u5e94\u907f\u514d\u6bcd\u4e73\u5582\u517b<\/b><span style=\"font-weight: 400;\"> \u5982\u679c\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\u6709\u4f7f\u7528\u6307\u5f81\uff0c\u5219\u5e94\u8003\u8651\u4f7f\u7528\u3002\u63a5\u89e6\u73af\u78f7\u9170\u80fa\u7684\u5a74\u513f\u53ef\u80fd\u4f1a\u51fa\u73b0\u53d1\u80b2\u8fdf\u7f13\u6216\u6c38\u4e45\u6027\u667a\u529b\u548c\u8eab\u4f53\u6b8b\u75be\u3002<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Blood_in_the_Urine_Warning\"><\/span>\u5c3f\u8840\u8b66\u544a<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Cyclophosphamide \u4ee3\u8c22\u540e\u4f1a\u751f\u6210\u4e00\u79cd\u53eb\u505a\u4e19\u70ef\u919b\u7684\u5316\u5408\u7269\uff0c\u4e19\u70ef\u919b\u4f1a\u523a\u6fc0\u5e76\u635f\u4f24\u8180\u80f1\u548c\u5c3f\u9053\u7684\u5185\u58c1\u3002\u957f\u671f\u63a5\u89e6\u4e19\u70ef\u919b\u53ef\u80fd\u5bfc\u81f4\u4e00\u79cd\u79f0\u4e3a\u5c3f\u8def\u611f\u67d3\u7684\u75be\u75c5\u3002 <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2938536\/#:~:text=Hemorrhagic%20cystitis%20is%20defined%20as,usually%20responds%20promptly%20to%20treatment.\">\u51fa\u8840\u6027\u8180\u80f1\u708e<\/a>\u5176\u7279\u5f81\u662f\u5267\u70c8\u7684\u5355\u4fa7\u4e0b\u80cc\u90e8\u75bc\u75db\u3001\u8180\u80f1\u75bc\u75db\u6216\u8840\u5c3f\u3002\u5982\u679c\u6000\u7591\u51fa\u73b0\u4e00\u79cd\u6216\u591a\u79cd\u8fd9\u4e9b\u75c7\u72b6\uff0c\u8bf7\u7acb\u5373\u5c31\u533b\u3002<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">\u589e\u52a0\u6db2\u4f53\u6444\u5165\u91cf\u53ef\u4ee5\u964d\u4f4e\u53d1\u751f\u51fa\u8840\u6027\u8180\u80f1\u708e\u7684\u98ce\u9669\uff0c\u4e00\u822c\u6700\u591a\u53ef\u589e\u52a0 2 <\/span><span style=\"font-weight: 400;\">\u2013<\/span><span style=\"font-weight: 400;\"> \u5927\u591a\u6570\u4eba\u6bcf\u59293\u5347\u3002\u4f60\u4e5f\u53ef\u80fd\u88ab\u5f00\u4e00\u79cd\u53eb\u505a <\/span><a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a613013.html\"><span style=\"font-weight: 400;\">Mesna<\/span><\/a><span style=\"font-weight: 400;\">\u53ef\u5728\u670d\u7528\u73af\u78f7\u9170\u80fa\u540e4\u5929\u5185\u670d\u7528\u3002\u9996\u5242\u901a\u5e38\u9759\u8109\u6ce8\u5c04\uff0c\u4e4b\u540e\u7684\u5242\u91cf\u53ef\u4ee5\u836f\u4e38\u5f62\u5f0f\u670d\u7528\u3002\u670d\u7528Mesna\u671f\u95f4\u4fdd\u6301\u5145\u8db3\u7684\u6db2\u4f53\u6444\u5165\u5bf9\u4e8e\u786e\u4fdd\u5176\u5145\u5206\u53d1\u6325\u4e2d\u548c\u73af\u78f7\u9170\u80fa\u80be\u6bd2\u6027\u7684\u4f5c\u7528\u81f3\u5173\u91cd\u8981\u3002<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Infections\"><\/span>\u611f\u67d3<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Cyclophosphamide \u4f1a\u6291\u5236\u9aa8\u9ad3\u529f\u80fd\u5e76\u524a\u5f31\u514d\u75ab\u7cfb\u7edf\u3002\u56e0\u6b64\uff0c\u670d\u7528\u6b64\u836f\u7684\u60a3\u8005\u53ef\u80fd\u66f4\u5bb9\u6613\u51fa\u73b0\u4ee5\u4e0b\u60c5\u51b5\uff1a <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25455720\/\">\u4e25\u91cd\u751a\u81f3\u81f4\u547d\u7684\u611f\u67d3<\/a>\u6709\u6d3b\u52a8\u6027\u611f\u67d3\u7684\u60a3\u8005\u5e94\u907f\u514d\u670d\u7528\u73af\u78f7\u9170\u80fa\uff0c\u76f4\u81f3\u75c5\u60c5\u5f97\u5230\u5145\u5206\u6cbb\u7597\u3002\u5982\u679c\u60a8\u51fa\u73b0\u4ee5\u4e0b\u4efb\u4f55\u75c7\u72b6\uff0c\u8bf7\u7acb\u5373\u901a\u77e5\u533b\u751f\uff1a<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">\u8eab\u4f53\u75bc\u75db<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u53d1\u51b7<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u53d1\u70e7 100.4\u00b0F (38\u00b0C) \u6216\u66f4\u9ad8<\/span><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Secondary_Malignancy_Risk\"><\/span><strong>\u7ee7\u53d1\u6027\u6076\u6027\u80bf\u7624\u98ce\u9669<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u957f\u671f\u4f7f\u7528\u73af\u78f7\u9170\u80fa\u4e0e\u7ee7\u53d1\u6027\u764c\u75c7\u98ce\u9669\u589e\u52a0\u6709\u5173\uff0c\u5c24\u5176\u662f\u8180\u80f1\u764c\u3001\u6025\u6027\u767d\u8840\u75c5\u548c\u5176\u4ed6\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u3002\u98ce\u9669\u4e0e\u5242\u91cf\u76f8\u5173\uff0c\u5e76\u968f\u7528\u836f\u65f6\u95f4\u5ef6\u957f\u800c\u589e\u52a0\u3002\u5982\u51fa\u73b0\u5c3f\u8840\u6216\u4efb\u4f55\u5f02\u5e38\u75c7\u72b6\uff0c\u8bf7\u7acb\u5373\u544a\u77e5\u60a8\u7684\u533b\u7597\u4fdd\u5065\u63d0\u4f9b\u8005\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Allergy_Warning\"><\/span>\u8fc7\u654f\u8b66\u544a<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">\u4e0e\u4efb\u4f55\u7269\u8d28\u4e00\u6837\uff0c\u73af\u78f7\u9170\u80fa\u53ef\u80fd\u4f1a\u5f15\u8d77 <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK553087\/#:~:text=Cyclophosphamide%20is%20a%20medication%20primarily,anti%2Dneoplastic%20effects%20through%20alkylation.\"><span style=\"font-weight: 400;\">\u5371\u53ca\u751f\u547d<\/span> <span style=\"font-weight: 400;\">\u8fc7\u654f\u53cd\u5e94<\/span><\/a><span style=\"font-weight: 400;\"> \u654f\u611f\u60a3\u8005\u3002\u4e00\u4e9b\u6f5c\u5728\u7684\u4f53\u5f81\u548c\u75c7\u72b6\u5305\u62ec\uff1a<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">\u9707\u60ca<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u5455\u5410<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u5934\u6655<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u54ee\u9e23<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u9762\u90e8\u6216\u5589\u5499\u80bf\u80c0<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u9ebb\u75b9<\/span><\/li>\n<\/ul>\n\n\n\n<p><span style=\"font-weight: 400;\">\u5982\u679c\u5728\u5f00\u59cb\u670d\u7528\u73af\u78f7\u9170\u80fa\u540e\u51fa\u73b0\u4efb\u4f55\u8fd9\u4e9b\u75c7\u72b6\uff0c\u5e94\u7acb\u5373\u505c\u836f\u5e76\u5bfb\u6c42\u7d27\u6025\u533b\u7597\u6551\u52a9\u3002\u8fd9\u79cd\u8fc7\u654f\u53cd\u5e94\u662f\u73af\u78f7\u9170\u80fa\u7684\u7981\u5fcc\u75c7\uff0c\u7edd\u5bf9\u4e0d\u80fd\u518d\u6b21\u4f7f\u7528\u3002.<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Disease-specific_Considerations\"><\/span>\u75be\u75c5\u7279\u5f02\u6027\u8003\u8651<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"For_Patients_With_Kidney_Disease\"><\/span>\u5bf9\u4e8e\u80be\u75c5\u60a3\u8005\uff1a<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Cyclophosphamide \u53ef\u80fd\u5728\u80be\u529f\u80fd\u4e0d\u5168\u60a3\u8005\u4f53\u5185\u84c4\u79ef\u3002\u56e0\u6b64\uff0c\u5728\u5f00\u59cb\u670d\u7528\u6b64\u836f\u524d\u4ee5\u53ca\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u68c0\u67e5\u80be\u529f\u80fd\u81f3\u5173\u91cd\u8981\u3002\u6839\u636e\u75c5\u60c5\u4e25\u91cd\u7a0b\u5ea6\uff0c\u533b\u751f\u53ef\u80fd\u9700\u8981\u8c03\u6574\u5242\u91cf\uff0c\u4ee5\u9632\u6b62\u51fa\u73b0\u6bd2\u6027\u53cd\u5e94\u3002<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"For_Patients_With_Liver_Disease\"><\/span>\u5bf9\u4e8e\u809d\u75c5\u60a3\u8005\uff1a<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">\u809d\u810f\u8d1f\u8d23\u6fc0\u6d3b\u548c\u4ee3\u8c22\u73af\u78f7\u9170\u80fa\u3002\u56e0\u6b64\uff0c\u809d\u810f\u75be\u75c5\u53ef\u80fd\u4f1a\u964d\u4f4e\u8be5\u836f\u7269\u7684\u7597\u6548\uff0c\u5e76\u589e\u52a0\u5176\u6bd2\u6027\u98ce\u9669\u3002\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u5bb3\u901a\u5e38\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002\u7136\u800c\uff0c\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u5bb3\u60a3\u8005\u53ef\u80fd\u56e0\u7597\u6548\u964d\u4f4e\u800c\u7981\u7528\u3002<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Individuals_With_Urinary_Outflow_Obstruction\"><\/span>\u5c3f\u8def\u963b\u585e\u60a3\u8005\uff1a<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">\u4e2a\u4eba <\/span><a href=\"https:\/\/medlineplus.gov\/ency\/article\/000507.htm#:~:text=Obstructive%20uropathy%20is%20a%20condition,injure%20one%20or%20both%20kidneys.\"><span style=\"font-weight: 400;\">\u963b\u585e\u6027\u5c3f\u8def\u75c5<\/span><\/a><span style=\"font-weight: 400;\"> \u5e94\u907f\u514d\u670d\u7528\u73af\u78f7\u9170\u80fa\u3002\u7531\u4e8e\u8be5\u836f\u7269\u4e3b\u8981\u901a\u8fc7\u5c3f\u6db2\u6392\u6cc4\uff0c\u56e0\u6b64\u5728\u6ca1\u6709\u80be\u529f\u80fd\u635f\u5bb3\u7684\u60c5\u51b5\u4e0b\uff0c\u8fd9\u79cd\u60c5\u51b5\u53ef\u80fd\u4f1a\u964d\u4f4e\u8eab\u4f53\u6e05\u9664\u836f\u7269\u7684\u80fd\u529b\u3002<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Cyclophosphamide_Drug_Interactions\"><\/span>Cyclophosphamide\u836f\u7269\u76f8\u4e92\u4f5c\u7528<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Cyclophosphamide \u4e0e\u8bb8\u591a\u5176\u4ed6\u836f\u7269\u3001\u8349\u836f\u8865\u5145\u5242\u548c\u7ef4\u751f\u7d20\u540c\u65f6\u670d\u7528\u65f6\u53ef\u80fd\u4f1a\u53d1\u751f\u76f8\u4e92\u4f5c\u7528\u3002\u8fd9\u53ef\u80fd\u4f1a\u5bfc\u81f4\u6240\u6709\u76f8\u5173\u7269\u8d28\u7684\u8840\u6e05\u6c34\u5e73\u53d1\u751f\u53d8\u5316\uff0c\u4ece\u800c\u4ea7\u751f\u6f5c\u5728\u7684\u6bd2\u6027\u3002\u8bf7\u4fdd\u5b58\u60a8\u76ee\u524d\u6b63\u5728\u670d\u7528\u7684\u6240\u6709\u836f\u7269\u7684\u6700\u65b0\u6e05\u5355\u3002\u5728\u5f00\u59cb\u670d\u7528\u73af\u78f7\u9170\u80fa\u6216\u4efb\u4f55\u836f\u7269\u4e4b\u524d\uff0c\u8bf7\u52a1\u5fc5\u5c06\u6e05\u5355\u63d0\u4ea4\u7ed9\u60a8\u7684\u533b\u751f\u548c\u836f\u5242\u5e08\uff0c\u4ee5\u8bc4\u4f30\u662f\u5426\u5b58\u5728\u4efb\u4f55\u7591\u8651\u3002 <\/span><span style=\"font-weight: 400;\">\u672a\u4e8b\u5148\u54a8\u8be2\u60a8\u7684\u533b\u7597\u670d\u52a1\u63d0\u4f9b\u8005\uff0c\u8bf7\u52ff\u5f00\u59cb\u3001\u505c\u6b62\u6216\u66f4\u6539\u4efb\u4f55\u836f\u7269\u7684\u5242\u91cf\u3002<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">\u4efb\u4f55\u6291\u5236\u9aa8\u9ad3\u529f\u80fd\u7684\u836f\u7269\u4e0e\u73af\u78f7\u9170\u80fa\u5408\u7528\u65f6\uff0c\u90fd\u53ef\u80fd\u589e\u52a0\u4e25\u91cd\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u8d2b\u8840\u6216\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u7684\u98ce\u9669\u3002\u4ee5\u4e0b\u5217\u51fa\u4e00\u4e9b\u53ef\u80fd\u4e0e\u73af\u78f7\u9170\u80fa\u53d1\u751f\u76f8\u4e92\u4f5c\u7528\u7684\u7269\u8d28\uff1a<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><b>\u522b\u560c\u5464\u9187\uff1a <\/b><span style=\"font-weight: 400;\">\u589e\u5f3a\u9aa8\u9ad3\u6291\u5236<\/span><\/li>\n\n\n\n<li><b>\u80fa\u7898\u916e\uff1a <\/b><span style=\"font-weight: 400;\">\u589e\u52a0\u80ba\u6bd2\u6027\u7684\u53ef\u80fd\u6027<\/span><\/li>\n\n\n\n<li><b>\u84bd\u73af\u7c7b\u836f\u7269\uff08\u5373\u963f\u9709\u7d20\u3001\u4f0a\u8fbe\u6bd4\u661f\uff09\uff1a<\/b><span style=\"font-weight: 400;\"> \u589e\u5f3a\u5fc3\u810f\u6bd2\u6027\u4f5c\u7528<\/span><\/li>\n\n\n\n<li><b>\u786b\u5511\u560c\u5464\uff1a<\/b><span style=\"font-weight: 400;\"> \u53ef\u80fd\u4f1a\u589e\u52a0\u809d\u6bd2\u6027\u7684\u98ce\u9669<\/span><\/li>\n\n\n\n<li><b>\u751f\u7269\u5236\u5242\uff08\u963f\u5e03\u66ff\u5c3c\u3001\u5df4\u745e\u66ff\u5c3c\u3001\u5730\u8bfa\u5355\u6297\u3001\u4f9d\u90a3\u897f\u666e\u3001\u90a3\u4ed6\u73e0\u5355\u6297\u3001\u5965\u745e\u73e0\u5355\u6297\u3001\u5965\u6cd5\u6728\u5355\u6297\u3001\u82a6\u53ef\u66ff\u5c3c\u3001\u6258\u6cd5\u66ff\u5c3c\u3001\u4e4c\u5e15\u66ff\u5c3c\u7b49\uff09\uff1a<\/b><span style=\"font-weight: 400;\"> \u589e\u5f3a\u514d\u75ab\u6291\u5236<\/span><\/li>\n\n\n\n<li><b>\u5511\u7c7b\u6297\u771f\u83cc\u836f\uff08\u5373\u4f0a\u66f2\u5eb7\u5511\u3001\u916e\u5eb7\u5511\uff09\uff1a<\/b><span style=\"font-weight: 400;\"> \u53ef\u80fd\u4f1a\u589e\u5f3a\u73af\u78f7\u9170\u80fa\u7684\u6bd2\u6027\u4f5c\u7528<\/span><\/li>\n\n\n\n<li><b>\u6c2f\u4e19\u55ea\uff1a<\/b><span style=\"font-weight: 400;\"> \u589e\u5f3a\u9aa8\u9ad3\u6291\u5236<\/span><\/li>\n\n\n\n<li><b>\u514b\u62c9\u5c48\u6ee8\uff1a<\/b><span style=\"font-weight: 400;\"> \u589e\u5f3a\u9aa8\u9ad3\u6291\u5236\u548c\u514d\u75ab\u6291\u5236<\/span><\/li>\n\n\n\n<li><b>\u6c2f\u6c2e\u5e73\uff1a<\/b><span style=\"font-weight: 400;\"> \u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u7684\u98ce\u9669\u589e\u52a0<\/span><\/li>\n\n\n\n<li><b>\u73af\u5b62\u83cc\u7d20\uff1a<\/b><span style=\"font-weight: 400;\"> \u529f\u6548\u964d\u4f4e<\/span><\/li>\n\n\n\n<li><b>Deferiprone\uff1a<\/b><span style=\"font-weight: 400;\"> \u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u7684\u98ce\u9669\u589e\u52a0<\/span><\/li>\n\n\n\n<li><b>\u7d2b\u9525\u83ca\uff1a<\/b><span style=\"font-weight: 400;\"> \u53ef\u80fd\u4f1a\u964d\u4f4e\u73af\u78f7\u9170\u80fa\u7684\u6cbb\u7597\u6548\u679c<\/span><\/li>\n\n\n\n<li><b>\u975e\u6614\u785d\u5511\uff1a<\/b><span style=\"font-weight: 400;\"> \u589e\u5f3a\u9aa8\u9ad3\u6291\u5236<\/span><\/li>\n\n\n\n<li><b><a href=\"https:\/\/ameripharmaspecialty.com\/zh\/other-health-conditions\/filgrastim-zarxio\/\">\u975e\u683c\u53f8\u4ead<\/a>:<\/b><span style=\"font-weight: 400;\"> \u589e\u52a0\u80ba\u6bd2\u6027\u98ce\u9669<\/span><\/li>\n\n\n\n<li><b>\u6765\u6c1f\u7c73\u7279\uff1a<\/b><span style=\"font-weight: 400;\"> \u589e\u5f3a\u514d\u75ab\u6291\u5236<\/span><\/li>\n\n\n\n<li><b>\u86cb\u767d\u9176\u6291\u5236\u5242\uff08\u5373\u5229\u6258\u90a3\u97e6\u3001\u8fbe\u82a6\u90a3\u97e6\u3001\u6c99\u594e\u90a3\u97e6\u3001\u831a\u5730\u90a3\u97e6\u3001\u6d1b\u5339\u90a3\u97e6\u3001\u963f\u624e\u90a3\u97e6\u7b49\uff09\uff1a<\/b><span style=\"font-weight: 400;\"> \u53ef\u80fd\u4f1a\u589e\u52a0\u73af\u78f7\u9170\u80fa\u6bd2\u6027\u7684\u98ce\u9669<\/span><\/li>\n\n\n\n<li><b>\u7425\u73c0\u80c6\u78b1\uff1a<\/b><span style=\"font-weight: 400;\"> \u7425\u73c0\u80c6\u78b1\u7684\u8840\u6e05\u6d53\u5ea6\u53ef\u80fd\u4f1a\u5347\u9ad8<\/span><\/li>\n\n\n\n<li><b>Tacrolimus\uff1a<\/b><span style=\"font-weight: 400;\"> \u611f\u67d3\u98ce\u9669\u589e\u52a0<\/span><\/li>\n\n\n\n<li><b>\u567b\u55ea\u7c7b\u5229\u5c3f\u5242\uff08\u5373\u6c22\u6c2f\u567b\u55ea\u3001\u7f8e\u6258\u62c9\u5b97\u3001\u5432\u8fbe\u5e15\u80fa\u7b49\uff09\uff1a<\/b><span style=\"font-weight: 400;\"> \u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u7684\u98ce\u9669\u589e\u52a0<\/span><\/li>\n\n\n\n<li><b>\u75ab\u82d7\uff08\u706d\u6d3b\uff09\uff1a <\/b><span style=\"font-weight: 400;\">\u529f\u6548\u964d\u4f4e<\/span><\/li>\n\n\n\n<li><b>\u75ab\u82d7\uff08\u6d3b\uff09\uff1a <\/b><span style=\"font-weight: 400;\">\u75ab\u82d7\u76f8\u5173\u611f\u67d3\u7684\u98ce\u9669<\/span><\/li>\n\n\n\n<li><b>\u52a0\u538b\u7d20\uff1a<\/b><span style=\"font-weight: 400;\"> \u6297\u5229\u5c3f\u4f5c\u7528\u589e\u5f3a\u7684\u98ce\u9669<\/span><\/li>\n<\/ul>\n\n\n\n<p><b>\u7b14\u8bb0\uff1a<\/b><span style=\"font-weight: 400;\"> \u8bf7\u6ce8\u610f\uff0c\u4ee5\u4e0a\u6e05\u5355\u5e76\u975e\u8be6\u5c3d\u65e0\u9057\u3002\u8bf7\u52a1\u5fc5\u54a8\u8be2\u60a8\u7684\u533b\u751f\u6216\u836f\u5242\u5e08\uff0c\u4ee5\u83b7\u53d6\u6709\u5173\u60a8\u7684\u836f\u7269\u6e05\u5355\u7684\u5b8c\u6574\u8bc4\u4f30\u3002<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_To_Take_Cyclophosphamide\"><\/span>\u5982\u4f55\u670d\u7528 Cyclophosphamide<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Cyclophosphamide \u53ef\u901a\u8fc7\u9759\u8109\u6ce8\u5c04 (IV) \u6216\u53e3\u670d (PO) \u7ed9\u836f\u3002\u5242\u91cf\u548c\u7ed9\u836f\u9014\u5f84\u53ef\u80fd\u56e0\u9002\u5e94\u75c7\u548c\u5177\u4f53\u60c5\u51b5\u800c\u5f02\u3002\u4efb\u4f55\u65e2\u5f80\u75c5\u53f2\u4e5f\u53ef\u80fd\u5f71\u54cd\u6cbb\u7597\u65b9\u6848\u3002\u56e0\u6b64\uff0c\u5728\u5f00\u59cb\u670d\u7528\u6b64\u836f\u4e4b\u524d\uff0c\u52a1\u5fc5\u4e0e\u533b\u751f\u5766\u8bda\u8ba8\u8bba\u60a8\u7684\u5168\u90e8\u75c5\u53f2\u3002<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">\u65e0\u8bba\u5242\u91cf\u6216\u7ed9\u836f\u9014\u5f84\u5982\u4f55\uff0c\u670d\u7528\u73af\u78f7\u9170\u80fa\u671f\u95f4\u4fdd\u6301\u5145\u8db3\u7684\u6c34\u5206\u81f3\u5173\u91cd\u8981\u3002\u5982\u524d\u6240\u8ff0\uff0c\u51fa\u8840\u6027\u8180\u80f1\u708e\u662f\u8be5\u836f\u7269\u6700\u4e25\u91cd\u7684\u4e0d\u826f\u53cd\u5e94\u4e4b\u4e00\u3002 <\/span><b>\u591a\u559d\u6c34\uff0c\u901a\u5e38\u7ea6 2 <\/b><b>\u2013<\/b><b> \u6bcf\u59293\u5347<\/b><span style=\"font-weight: 400;\">\uff0c\u6709\u52a9\u4e8e\u80be\u810f\u6392\u6cc4\u836f\u7269\u53ca\u5176\u4ee3\u8c22\u7269\uff0c\u8fd9\u53ef\u80fd\u4f1a\u663e\u8457\u964d\u4f4e\u8fd9\u79cd\u98ce\u9669\u3002<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">\u670d\u7528\u73af\u78f7\u9170\u80fa\u80f6\u56ca\u6216\u7247\u5242\u65f6\uff0c <\/span><b>\u6574\u4e2a\u541e\u4e0b<\/b><span style=\"font-weight: 400;\">\u4ee5\u4efb\u4f55\u65b9\u5f0f\u6253\u5f00\u80f6\u56ca\u6216\u538b\u788e\u836f\u7247\u4e0d\u4ec5\u53ef\u80fd\u6539\u53d8\u836f\u7269\u7684\u5438\u6536\uff0c\u8fd8\u53ef\u80fd\u4f7f\u836f\u7269\u63a5\u89e6\u5230\u975e\u9884\u671f\u63a5\u89e6\u8005\u3002\u52a1\u5fc5 <\/span><b>\u6d17\u624b\u5e76\u6e05\u6d01\u4efb\u4f55\u8868\u9762<\/b><span style=\"font-weight: 400;\"> \u836f\u7269\u53ef\u80fd\u63a5\u89e6\u8fc7\u7684\u5730\u65b9\uff0c\u4ee5\u9650\u5236\u610f\u5916\u63a5\u89e6\u3002<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">\u670d\u7528\u73af\u78f7\u9170\u80fa <\/span><b>\u5b8c\u5168\u6309\u7167\u89c4\u5b9a<\/b><span style=\"font-weight: 400;\">\u3002\u672a\u7ecf\u54a8\u8be2\u4e34\u5e8a\u533b\u751f\u800c\u8fdb\u884c\u7684\u4efb\u4f55\u6539\u53d8\u90fd\u53ef\u80fd\u589e\u52a0\u51fa\u73b0\u4e25\u91cd\u526f\u4f5c\u7528\u4ee5\u53ca\u6cbb\u7597\u5931\u8d25\u7684\u98ce\u9669\u3002<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Missed_Doses\"><\/span><b>\u6f0f\u670d\u5242\u91cf<\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">\u5982\u9700\u73af\u78f7\u9170\u80fa\u6ce8\u5c04\uff0c\u8bf7\u7acb\u5373\u8054\u7cfb\u5904\u65b9\u533b\u751f\u3002\u77eb\u6b63\u65b9\u6848\u53ef\u80fd\u56e0\u60a3\u8005\u800c\u5f02\u3002<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">\u5bf9\u4e8e\u6240\u6709\u53e3\u670d\u73af\u78f7\u9170\u80fa\u4ea7\u54c1\uff08\u80f6\u56ca\u548c\u7247\u5242\uff09\uff0c\u4e00\u65e6\u8bb0\u8d77\uff0c\u5e94\u7acb\u5373\u670d\u7528\u6f0f\u670d\u5242\u91cf\u3002\u4f46\u662f\uff0c\u5982\u679c\u4e0b\u4e00\u5242\u5e94\u57288\u5c0f\u65f6\u5185\u670d\u7528\uff0c\u5219\u8df3\u8fc7\u6f0f\u670d\u5242\u91cf\uff0c\u6062\u590d\u6b63\u5e38\u670d\u836f\u65f6\u95f4\u3002\u8bf7\u52ff\u540c\u65f6\u670d\u7528\u4e24\u5242\u6216\u670d\u7528\u4efb\u4f55\u989d\u5916\u5242\u91cf\u3002<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Treatment_Monitoring\"><\/span><b>\u6cbb\u7597\u76d1\u6d4b&nbsp;<\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK553087\/#:~:text=Cyclophosphamide%20is%20a%20medication%20primarily,anti%2Dneoplastic%20effects%20through%20alkylation.\"><span style=\"font-weight: 400;\">\u8840\u6db2\u68c0\u67e5\u3001\u5c3f\u6db2\u5206\u6790\u548c\u5404\u79cd\u626b\u63cf<\/span><\/a><span style=\"font-weight: 400;\"> \uff08\u89c1\u4e0b\u6587\uff09\u5c06\u5b9a\u671f\u8fdb\u884c<\/span><span style=\"font-weight: 400;\"> \u76d1\u6d4b\u8be5\u836f\u7269\u7684\u6709\u6548\u6027\u4ee5\u53ca\u53ef\u80fd\u56e0\u4f7f\u7528\u800c\u4ea7\u751f\u7684\u4efb\u4f55\u6bd2\u6027\uff1a<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">\u5c3f\u6db2\u68c0\u67e5<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u5168\u8840\u7ec6\u80de\u8ba1\u6570\uff08CBC\uff09\u53ca\u5206\u7c7b\u8ba1\u6570\uff0c\u7528\u4e8e\u76d1\u6d4b\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u8d2b\u8840\u548c\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3002<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u809d\u529f\u80fd\u68c0\u67e5<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u80be\u529f\u80fd\u68c0\u67e5<\/span><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Cyclophosphamide \u662f\u4e00\u79cd\u5316\u7597\u836f\u7269\uff0c\u76ee\u524d\u6709\u4eff\u5236\u836f\u548c\u6ce8\u518c\u54c1\u724c\u836f Cytoxan \u548c Neosar\u3002\u8be5\u836f\u7269\u6709\u53e3\u670d\u7247\u5242\u6216\u80f6\u56ca\u5242\u578b\uff08\u9700\u6574\u7247\u541e\u670d\uff09\u548c\u9759\u8109\u6ce8\u5c04\u5242\u578b\u3002<\/p>","protected":false},"author":10,"featured_media":20175,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[64],"tags":[14],"class_list":["post-20173","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-discontinued","tag-dr-james-lee"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cyclophosphamide - AmeriPharma\u00ae Specialty Care<\/title>\n<meta name=\"description\" content=\"Cyclophosphamide is a chemotherapy medication currently available as a generic and as the trademarked brand names, 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