{"id":19700,"date":"2022-03-29T10:03:15","date_gmt":"2022-03-29T17:03:15","guid":{"rendered":"https:\/\/ameripharmaspe.wpengine.com\/staging\/?p=18935"},"modified":"2026-03-19T14:34:07","modified_gmt":"2026-03-19T21:34:07","slug":"docetaxel-taxotere","status":"publish","type":"post","link":"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/","title":{"rendered":"Docetaxel\uff08\u591a\u897f\u4ed6\u8d5b\uff09\uff1a\u7528\u9014\u3001\u5242\u91cf\u3001\u526f\u4f5c\u7528\u548c\u5b89\u5168\u4fe1\u606f"},"content":{"rendered":"\n<p><span style=\"font-weight: 400;\">Docetaxel (pronounced [dos se TAKS el]) is also known by the brand name Taxotere. It is an antineoplastic (anti-cancer) drug that belongs to a class called antimicrotubular or <\/span><a href=\"https:\/\/go.drugbank.com\/categories\/DBCAT002720\"><span style=\"font-weight: 400;\">taxane derivatives<\/span><\/a><span style=\"font-weight: 400;\">. It is a type of chemotherapy that prevents cancer cells from multiplying and restricts their growth.&nbsp;<\/span><\/p>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/#What_Is_Chemotherapy\" >What Is Chemotherapy?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/#Protection_From_Chemotherapy\" >Protection From Chemotherapy<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/#How_Is_Docetaxel_Used\" >How Is Docetaxel Used?<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/#Available_Formulations\" >Available Formulations<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/#Injectable_solution\" >Injectable solution:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/#Alcohol-free_solution_for_injection\" >Alcohol-free solution for injection:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/#Directions_for_Use\" >Directions for Use&nbsp;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/#One-Vial_Formulations\" >One-Vial Formulations&nbsp;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/#Two-Vial_Formulation\" >Two-Vial Formulation&nbsp;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/#Missed_Dose\" >Missed Dose<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/#Storage\" >Storage<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/#What_To_Avoid_While_Taking_Docetaxel\" >What To Avoid While Taking Docetaxel?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/#Pregnancy_and_Docetaxel\" >Pregnancy and Docetaxel<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/#Side_Effects\" >Side Effects<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/#Bone_Marrow_Suppression_BMS\" >Bone Marrow Suppression (BMS)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/#Skin_Rash\" >Skin Rash<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/#Extravasation\" >Extravasation<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/#Fluid_Retention\" >Fluid Retention<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/#Allergic_ReactionHypersensitivity\" >Allergic Reaction\/Hypersensitivity<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/#Tumor_Lysis_Syndrome_TLS\" >Tumor Lysis Syndrome (TLS)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/#FatigueWeakness\" >Fatigue\/Weakness<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/#Secondary_Malignancies\" >Secondary Malignancies<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/#Visual_Impairment\" >Visual Impairment<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/#Neurosensory_Symptoms\" >Neurosensory Symptoms<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/#Monitoring\" >Monitoring<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-26\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/#Docetaxel_FAQs\" >Docetaxel FAQs<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_Is_Chemotherapy\"><\/span>What Is Chemotherapy?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\"><a href=\"https:\/\/ameripharmaspecialty.com\/oral-chemotherapy-cancer-drugs\/\">Chemotherapy<\/a> is a cancer treatment that uses cytotoxic medications to destroy rapidly dividing cells. These agents inhibit cellular growth and division, ultimately leading to cancer cell death.<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Protection_From_Chemotherapy\"><\/span>Protection From Chemotherapy<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Docetaxel is classified as a hazardous antineoplastic agent. Appropriate precautions must be followed during preparation, handling, administration, storage, and disposal in accordance with institutional hazardous drug handling guidelines (e.g., USP 800). Personal protective equipment (PPE), including chemotherapy-rated gloves, should be used.<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_Is_Docetaxel_Used\"><\/span>How Is Docetaxel Used?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Docetaxel has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of various malignancies, including breast cancer, non\u2013small cell lung cancer, prostate cancer, gastric cancer, and head and neck cancers. It may also be used in other oncologic indications based on clinical judgment and treatment guidelines. It can be prescribed alone or with other medications simultaneously.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Available_Formulations\"><\/span><b>Available Formulations<\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Docetaxel is only available as a solution for intravenous injection. It is available in different concentrations including 10 mg\/ml and 20 mg\/ml, and some formulations may contain alcohol. The solution for injection may be available in a one-vial or two-vial formulation.&nbsp;<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Injectable_solution\"><\/span><b>Injectable solution:<\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">10 mg\/ml (2 ml, 8 ml, or 16 ml)<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">20 mg\/ml (1 ml or 4 ml)<\/span><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Alcohol-free_solution_for_injection\"><\/span><b>Alcohol-free solution for injection:<\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">20 mg\/ml<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">80 mg\/4 ml<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">160 mg\/8 ml<\/span><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Directions_for_Use\"><\/span><b>Directions for Use&nbsp;<\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">The dose of docetaxel is determined using patient weight, height, body surface area (BSA), cancer type, general health, and other medical conditions. It should be infused over 1 hour using nonsorbing polyethylene-lined (non-DHP like glass, polypropylene, polyolefin) tubing. Gently rotate and invert manually to mix the solution thoroughly before administration. Avoid vigorous agitation of solutions. Dilute docetaxel with 250 to 500 ml of normal saline (NS) or <\/span><a href=\"https:\/\/www.webmd.com\/drugs\/2\/drug-32881\/dextrose-5-in-water-d5w-intravenous\/details\"><span style=\"font-weight: 400;\">dextrose 5% in water<\/span><\/a><span style=\"font-weight: 400;\"> (D5W) to a final concentration of 0.3 to 0.74 mg\/ml.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">If intact vials were refrigerated, allow them to sit at room temperature for 5 minutes prior to dilution. Inspect vials as the solution is supersaturated and may crystallize over time. Do not use if crystallized. IV filters are not recommended for use with docetaxel. Assure proper needle or catheter position before administration.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"One-Vial_Formulations\"><\/span><b>One-Vial Formulations&nbsp;<\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">For the non-alcohol formulation, use a 20-gauge needle to withdraw docetaxel from the vial, then dilute with the appropriate solution.&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">For the Taxotere formulation, a 21-gauge needle should be used to withdraw docetaxel from the vial.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Two-Vial_Formulation\"><\/span><b>Two-Vial Formulation&nbsp;<\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Vials should be diluted with <\/span><a href=\"https:\/\/www.drugs.com\/inactive\/polyethylene-glycol-400-272.html\"><span style=\"font-weight: 400;\">polyethylene glycol 400<\/span><\/a><span style=\"font-weight: 400;\">\/water (provided with the drug).<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Missed_Dose\"><\/span><b>Missed Dose<\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">This medicine needs to be administered on a fixed schedule. <\/span><span style=\"font-weight: 400;\">If you miss a dose, notify your doctor, home health caregiver, or treatment clinic.&nbsp;<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Storage\"><\/span><b>Storage<\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Storage and stability may vary by manufacturer; refer to specific prescribing and manufacturer information. Under certain situations, docetaxel may be stored at room temperature or in the refrigerator. Docetaxel should be stored away from direct sunlight. Solutions diluted for infusion should be used within a short period of time after mixing. Please refer to prescriber and manufacturer instructions for specific times.&nbsp;<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_To_Avoid_While_Taking_Docetaxel\"><\/span>What To Avoid While Taking Docetaxel?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">While taking docetaxel therapy, you must follow some precautions. Always tell your physician about any medications you are already taking. <\/span><b>Do not take any drug or medicine (even herbals, vitamins, or over-the-counter medications) without prior consent from your physician or pharmacist<\/b><span style=\"font-weight: 400;\">. They may have some significant interactions with docetaxel. <\/span><span style=\"font-weight: 400;\">Avoid grapefruit, grapefruit juice, and any foods or supplements containing grapefruit or grapefruit juice throughout therapy as they may interact with the medication as well.<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Pregnancy_and_Docetaxel\"><\/span>Pregnancy and Docetaxel<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Pregnancy status must be checked prior to starting docetaxel therapy in women of childbearing age, and effective contraception must be used during treatment and for 6 months after the last dose. Males with female partners of reproductive potential should also use effective contraception during therapy and for 3 months after the last docetaxel dose. Docetaxel may cause fetal harm and is therefore not recommended for women who are breastfeeding during therapy. Breastfeeding should be avoided for at least 1 week after the last dose.&nbsp;<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Side_Effects\"><\/span>Side Effects<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright\"><img loading=\"lazy\" decoding=\"async\" width=\"420\" height=\"280\" src=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/03\/docetaxel-patient.jpg\" alt=\"Docetaxel and taxotere patient\" class=\"wp-image-22246\" srcset=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/03\/docetaxel-patient.jpg 420w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/03\/docetaxel-patient-300x200.jpg 300w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/03\/docetaxel-patient-330x220.jpg 330w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/03\/docetaxel-patient-86x57.jpg 86w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/03\/docetaxel-patient-167x111.jpg 167w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/03\/docetaxel-patient-280x187.jpg 280w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/03\/docetaxel-patient-370x247.jpg 370w\" sizes=\"auto, (max-width: 420px) 100vw, 420px\" \/><\/figure>\n<\/div>\n\n\n<p><span style=\"font-weight: 400;\">As with any other medication, you may encounter side effects while taking docetaxel. A few things to remember are:<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">You may not have all the side effects listed below. Many people may experience little to no side effects.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">The severity of side effects may vary from person to person, so don&#8217;t compare your side effects with other people\u2019s experiences.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Most of the side effects will improve when therapy is discontinued.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">These side effects are easily manageable most of the time either by readjusting the dose of docetaxel or using additional medications to treat the symptoms. Consult with your physician or pharmacist to explore available options.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Patients should promptly report any new or worsening symptoms to their healthcare provider.<\/span><\/li>\n<\/ul>\n\n\n\n<p><b>Note<\/b><span style=\"font-weight: 400;\">: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Some of the more serious side effects of docetaxel are listed below:<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Bone_Marrow_Suppression_BMS\"><\/span><span style=\"font-weight: 400;\">Bone Marrow Suppression (BMS)<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">It is essential to keep up with regular blood tests, especially the complete blood count test (CBC). The CBC blood test is capable of detecting potential BMS, including <\/span><a href=\"https:\/\/www.cancer.net\/coping-with-cancer\/physical-emotional-and-social-effects-cancer\/managing-physical-side-effects\/neutropenia\"><span style=\"font-weight: 400;\">neutropenia<\/span><\/a><span style=\"font-weight: 400;\"> (low neutrophils, a type of white blood cell), thrombocytopenia (low platelet count), and anemia (low red blood cells), all of which are potential side effects of using docetaxel.&nbsp;<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Skin_Rash\"><\/span><span style=\"font-weight: 400;\">Skin Rash<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">On rare occasions, docetaxel may cause a serious skin reaction called <\/span><a href=\"https:\/\/my.clevelandclinic.org\/health\/diseases\/17656-stevens-johnson-syndrome\"><span style=\"font-weight: 400;\">Stevens-Johnson syndrome<\/span><\/a><span style=\"font-weight: 400;\"> (SJS) or toxic epidermal necrolysis (TEN). These rashes may appear as red, swollen hives; itching, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in the mouth, throat, nose, or eyes. Notify your physician or pharmacist immediately of any signs of a rash or allergic reaction, including wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Discontinuation of docetaxel may be warranted if SJS or TEN is suspected.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Extravasation\"><\/span><span style=\"font-weight: 400;\">Extravasation<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Docetaxel is an irritant with vesicant-like properties. Proper needle or catheter placement should be ensured before and during infusion; avoid extravasation. Extravasation is the leakage of the drug from a blood vessel or tube into the tissue around it. If extravasation occurs, stop the infusion immediately and disconnect (leave the needle in place). Aspirate the extravasated solution gently (do NOT flush the line) and remove the needle. Elevate the part of the body that has experienced the extravasation and apply a warm compress to the area.<br><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Fluid_Retention\"><\/span><span style=\"font-weight: 400;\">Fluid Retention<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Docetaxel can commonly cause fluid retention (also known as edema) and weight gain. Edema may lead to significant complications, including liver or heart complications and edema in the lungs. In certain cases, the fluid may need to be drained. Rapid weight gain or swelling of the abdomen, legs, feet, or arms can all be signs of fluid retention. Contact your physician if you experience any of these symptoms. Fluid retention only occurs during docetaxel use and on average subsides within 16 weeks after discontinuation of treatment.&nbsp;<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Allergic_ReactionHypersensitivity\"><\/span><span style=\"font-weight: 400;\">Allergic Reaction\/Hypersensitivity<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">There have been cases reported of patients with allergic reactions to the docetaxel injection or any of its components. In addition, worsening asthma has been reported with therapy in patients with a history of asthma, sinusitis, or allergies. Signs of an allergic reaction can include rash; hives; itching; wheezing; red, swollen, blistered, or peeling skin with or without fever; trouble breathing, swallowing, or talking; tightness in the chest or throat; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. If you are experiencing any of these symptoms, seek emergency medical attention immediately. Hypersensitivity with docetaxel most typically occurs within the first 2 infusions.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Tumor_Lysis_Syndrome_TLS\"><\/span><span style=\"font-weight: 400;\">Tumor Lysis Syndrome (TLS)<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">TLS is caused by the fast breakdown of cancer cells (bursting of the cells). TLS can lead to kidney failure and the need for dialysis treatment, or an abnormal heart rhythm. Certain types of conditions are at higher risk for TLS. Consult with your physician to learn more. Tell your healthcare provider right away if you have any of the following signs or symptoms of TLS: trouble passing urine, abnormal heartbeat, passing out, muscle weakness or cramping, constant fatigue, diarrhea, or inability to eat.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"FatigueWeakness\"><\/span><span style=\"font-weight: 400;\">Fatigue\/Weakness<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Docetaxel may cause fatigue, dizziness, drowsiness, and visual disturbances. These symptoms may persist for several days to weeks following infusion. Driving or operating heavy machinery immediately after docetaxel infusion is not advised.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Secondary_Malignancies\"><\/span><span style=\"font-weight: 400;\">Secondary Malignancies<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Although rare, docetaxel can potentially give rise to a secondary type of cancer during treatments, including <\/span><a href=\"https:\/\/www.cancer.org\/cancer\/acute-myeloid-leukemia\/about\/what-is-aml.html\"><span style=\"font-weight: 400;\">myeloid leukemia<\/span><\/a><span style=\"font-weight: 400;\">. Continuous monitoring during treatment for new malignancies may be necessary.&nbsp;<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Visual_Impairment\"><\/span><span style=\"font-weight: 400;\">Visual Impairment<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">A condition called <\/span><a href=\"https:\/\/www.umkelloggeye.org\/conditions-treatments\/cystoid-macular-edema-cme#:~:text=Cystoid%20macular%20edema%20or%20CME,cause%20retinal%20swelling%20or%20edema.\"><span style=\"font-weight: 400;\">cystoid macular edema<\/span><\/a><span style=\"font-weight: 400;\"> (CME) may occur with docetaxel use. If vision impairment occurs, a prompt comprehensive ophthalmic exam is recommended. If CME is diagnosed, initiate appropriate CME management and discontinue docetaxel (consider non-taxane treatments). This condition typically appears after the first cycle but subsides in most patients within 4 months after therapy completion.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Neurosensory_Symptoms\"><\/span><span style=\"font-weight: 400;\">Neurosensory Symptoms<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Severe neurosensory symptoms like paresthesia, dysesthesia, or pain have been observed. These are sensations, especially in the hands and feet, similar to \u201cpins and needles\u201d or tingling and prickling. After discontinuation, symptoms may take some time to disappear.<\/span><\/p>\n\n\n\n<p><b>Other common side effects<\/b> <b>may include:<\/b><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">Nausea\/vomiting<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Mouth sores<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Hair loss<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Nail changes<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Changes in taste<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Weight loss<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Eye redness<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Joint\/muscle pain<\/span><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Monitoring\"><\/span>Monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Due to its many side effects, monitoring is an important part of managing d<\/span><span style=\"font-weight: 400;\">ocetaxel therapy. The following includes what you can expect with docetaxel use:<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">Monitoring for hypersensitivity and fluid retention. <\/span><span style=\"font-weight: 400;\">Patients should be premedicated with corticosteroids for 3 days, beginning the day before docetaxel administration, to help reduce the incidence and severity of hypersensitivity reactions and fluid retention.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Monitoring of liver function, especially in patients with preexisting liver complications&nbsp;<\/span>\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">Certain docetaxel formulations contain ethanol and should be used with caution in patients with hepatic impairment, alcohol sensitivity, or those in whom alcohol exposure should be minimized.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Docetaxel may not be recommended in patients with severe liver impairment.<\/span><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Frequent blood tests to monitor bone marrow suppression.<\/span><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Docetaxel_FAQs\"><\/span>Docetaxel FAQs<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h4 class=\"wp-block-heading\"><b>Is <\/b><b>docetaxel <\/b><b>a chemo agent?<\/b><\/h4>\n\n\n\n<p><span style=\"font-weight: 400;\">Chemotherapy agents are medications used in the treatment of malignant diseases. Docetaxel works by blocking certain structures in the cancer cell which are essential for the replication and growth of cancer and normal cells. Inhibition of these structures leads to cellular death. Thus, docetaxel is a chemo agent that is used as a treatment option for various cancer patients.<\/span><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><b>How should docetaxel be taken?<\/b><\/h4>\n\n\n\n<p><span style=\"font-weight: 400;\">Docetaxel is administered as an intravenous infusion by a trained healthcare professional in an oncology setting. Dosing is individualized based on body surface area (BSA), cancer type, and patient-specific factors. Refer to the \u201cDirections for Use\u201d section above for detailed preparation and administration guidance.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Docetaxel (pronounced [dos se TAKS el]) is also known by the brand name Taxotere. It is an antineoplastic (anti-cancer) drug that belongs to a class called antimicrotubular or taxane derivatives. It is a type of chemotherapy that prevents cancer cells from multiplying and restricts their growth.\u00a0<\/p>\n","protected":false},"author":11,"featured_media":19704,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[64],"tags":[11],"class_list":["post-19700","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-discontinued","tag-dr-dania-jaradat"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Docetaxel (Taxotere): Uses, Dosing, Side Effects, and Safety Information - AmeriPharma\u00ae Specialty Care<\/title>\n<meta name=\"description\" content=\"Docetaxel (Taxotere) is an antineoplastic (anti-cancer) drug that belongs to a class called antimicrotubular or taxane derivatives.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/docetaxel-taxotere\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Docetaxel (Taxotere): Uses, Dosing, Side Effects, and Safety Information - 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