{"id":18503,"date":"2022-02-04T09:56:30","date_gmt":"2022-02-04T17:56:30","guid":{"rendered":"https:\/\/ameripharmaspe.wpengine.com\/?p=18503"},"modified":"2026-03-19T14:31:11","modified_gmt":"2026-03-19T21:31:11","slug":"bevacizumab-avastin","status":"publish","type":"post","link":"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/bevacizumab-avastin\/","title":{"rendered":"\u4e86\u89e3\u8d1d\u4f10\u73e0\u5355\u6297\uff08Avastin\uff09\uff1a\u4e00\u79cd\u9776\u5411\u6297\u764c\u7597\u6cd5\u7684\u8be6\u89e3"},"content":{"rendered":"\n<p><span style=\"font-weight: 400;\">Bevacizumab (pronounced [be vuh SIZ uh mab]) is also known by the brand name Avastin. Bevacizumab is a monoclonal antibody; therefore, it does not have traditional \u201cgeneric\u201d formulations as a biologic agent. \u00a0However, there are multiple FDA-approved biosimilars, including Mvasi, Zirabev, Alymsys, Vegzelma, Avzivi, and Jobevne. Bevacizumab is an antineoplastic (anti-cancer) targeted therapy thatworks on vascular endothelial growth factor (VEGF) inhibitors (an anti-angiogenic therapy), and it is often used with chemotherapy depending on the cancer type and regimen. Avastin may slow tumor growth by reducing the formation of new blood vessels that supply tumors, which can decrease the tumor\u2019s access to oxygen and nutrients.<\/span><\/p>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/bevacizumab-avastin\/#What_Is_Chemotherapy\" >What Is Chemotherapy?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/bevacizumab-avastin\/#How_Is_Avastin_Used\" >How Is Avastin Used?<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/bevacizumab-avastin\/#Available_Formulations\" >Available Formulations<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/bevacizumab-avastin\/#Directions_for_Use\" >Directions for Use<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/bevacizumab-avastin\/#Missed_Dose\" >Missed Dose<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/bevacizumab-avastin\/#Storage\" >Storage<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/bevacizumab-avastin\/#What_To_Avoid_While_Taking_Avastin\" >What To Avoid While Taking Avastin<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/bevacizumab-avastin\/#Pregnancy_and_Avastin\" >Pregnancy and Avastin<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/bevacizumab-avastin\/#Side_Effects\" >Side Effects<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/bevacizumab-avastin\/#Cardiac_Complications\" >Cardiac Complications<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/bevacizumab-avastin\/#Hemorrhage_Bleeding_or_GI_Effects\" >Hemorrhage (Bleeding) or GI Effects&nbsp;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/bevacizumab-avastin\/#Kidney_Complications\" >Kidney Complications<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/bevacizumab-avastin\/#Vision_Complications\" >Vision Complications<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/bevacizumab-avastin\/#Injection_Site_Reactions\" >Injection Site Reactions<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/bevacizumab-avastin\/#Dizziness_Fatigue_or_Headache\" >Dizziness, Fatigue, or Headache<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/bevacizumab-avastin\/#Bone_Joint_Back_and_Muscle_Pain\" >Bone, Joint, Back, and Muscle Pain&nbsp;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/bevacizumab-avastin\/#Posterior_Reversible_Encephalopathy_Syndrome_PRES\" >Posterior Reversible Encephalopathy Syndrome (PRES)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/bevacizumab-avastin\/#Osteonecrosis_of_the_Jaw_ONJ\" >Osteonecrosis of the Jaw (ONJ)&nbsp;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/bevacizumab-avastin\/#Impaired_Wound_Healing\" >Impaired Wound Healing<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/bevacizumab-avastin\/#Infertility\" >Infertility&nbsp;<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/bevacizumab-avastin\/#Precautions\" >Precautions<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/bevacizumab-avastin\/#FAQs\" >FAQs<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_Is_Chemotherapy\"><\/span>What Is Chemotherapy?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Chemotherapy is a cancer treatment that uses cytotoxic drugs to damage or kill rapidly dividing cells.<\/p>\n\n\n\n<p>Avastin (bevacizumab) is not a classic cytotoxic chemotherapy drug \u2014 it is a targeted therapy that blocks VEGF and helps slow tumor blood-vessel growth (angiogenesis). It is often prescribed in combination with chemotherapy for certain cancers.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_Is_Avastin_Used\"><\/span>How Is Avastin Used?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Avastin has been approved by the Food and Drug Administration (FDA) to treat different types of cancers. It can be prescribed in combination with other <\/span><a href=\"https:\/\/ameripharmaspecialty.com\/cancer\/enzalutamide-xtandi\/\"><span style=\"font-weight: 400;\">chemotherapy agents<\/span><\/a><span style=\"font-weight: 400;\">, depending on the severity and type of cancer.&nbsp;<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Available_Formulations\"><\/span><b>Available Formulations<\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Avastin is supplied as a solution for intravenous infusion. Intravitreal (eye) use is an off-label use and is not an FDA-approved indication. Avastin solution contains polysorbate 80 and is available as single-use vials in two different strengths: 100 mg\/4 ml or 400 mg\/16 ml.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Directions_for_Use\"><\/span><b>Directions for Use<\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Avastin should be diluted in normal saline per clinic protocol. Do not use and discard if the solution in the vial appears cloudy, discolored, or contains particulate matter. Do not administer or mix with dextrose-containing solutions. Avastin is typically administered once every 2 or 3 weeks, depending on the reason for use.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">The initial dose of the intravenous infusion should be infused over 90 minutes, and the second infusion can be administered over 60 minutes if the initial dose is well tolerated. The third and any subsequent infusions may be administered over 30 minutes if the 60-minute infusion is well tolerated. Infusion time should not be less than 30 minutes. If Avastin is administered with other medications, consult with your provider on which medication should be administered first and how the infusions should be sequenced. In some cases, premedication may be required to prevent a side effect from happening.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Missed_Dose\"><\/span><b>Missed Dose<\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">If a dose is missed, contact your physician immediately to reschedule.&nbsp;<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Storage\"><\/span><b>Storage<\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Store intact vials in their original cartons in the refrigerator. Do not freeze or shake, and protect from light. Discard any unused portion of the vial after administration.&nbsp;<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_To_Avoid_While_Taking_Avastin\"><\/span>What To Avoid While Taking Avastin<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">While taking Avastin therapy, you must follow some precautions. Always tell your physician about any medications you are already taking. <\/span><b>Do not take any drug or medicine (even herbals, vitamins, or over-the-counter medications) without prior consent from your physician or pharmacist<\/b><span style=\"font-weight: 400;\">. They may have some significant interactions with Avastin.<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Pregnancy_and_Avastin\"><\/span>Pregnancy and Avastin<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Pregnancy status must be checked prior to starting Avastin therapy in women of childbearing age. Effective contraception must be used during treatment and for 6 months after the last dose. Avastin may cause fetal harm and is therefore not recommended for women who are breastfeeding during therapy. Breastfeeding should also be avoided for at least 6 months after the last dose.<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Side_Effects\"><\/span>Side Effects<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright\"><img loading=\"lazy\" decoding=\"async\" width=\"420\" height=\"228\" src=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/avastin-appointment-1.jpg\" alt=\"Avastin appointment\" class=\"wp-image-18511\" srcset=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/avastin-appointment-1.jpg 420w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/avastin-appointment-1-300x163.jpg 300w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/avastin-appointment-1-86x47.jpg 86w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/avastin-appointment-1-167x91.jpg 167w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/avastin-appointment-1-280x152.jpg 280w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/avastin-appointment-1-370x201.jpg 370w\" sizes=\"auto, (max-width: 420px) 100vw, 420px\" \/><\/figure>\n<\/div>\n\n\n<p><span style=\"font-weight: 400;\">As with any other medication, you may encounter side effects while taking Avastin. A few things to remember are:<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">You may not have all the side effects listed below. Many people may experience little to no side effects.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">The severity of side effects may vary from person to person, so don\u2019t compare your side effects with other people\u2019s experiences.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Most of the side effects will improve when therapy is discontinued.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">These side effects are easily manageable most of the time, either by readjusting the dose of Avastin or using additional medications to treat the symptoms. Consult with your physician or pharmacist to explore available options.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Do not hide any symptoms; if you feel any discomfort, do not hesitate to tell your physician or pharmacist about it.<\/span><\/li>\n<\/ul>\n\n\n\n<p><b>Note<\/b><span style=\"font-weight: 400;\">: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Some of the more serious side effects of Avastin are listed below:<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Cardiac_Complications\"><\/span><span style=\"font-weight: 400;\">Cardiac Complications<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">There may be cardiac complications with the use of Avastin like hypertension, left ventricular heart failure (LVHF), or <\/span><a href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/thromboembolism\"><span style=\"font-weight: 400;\">thromboembolism<\/span><\/a><span style=\"font-weight: 400;\"> (can include heart attack or stroke). Hypertension can be managed with antihypertensive therapy. LVHF most commonly will be prevalent within the first 6 months of Avastin use but may be resolved after discontinuation of therapy.&nbsp;<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Hemorrhage_Bleeding_or_GI_Effects\"><\/span><span style=\"font-weight: 400;\">Hemorrhage (Bleeding) or GI Effects<\/span><span style=\"font-weight: 400;\">&nbsp;<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Bleeding can vary from mild or serious. More serious hemorrhage can include GI bleeding, vomiting blood, bleeding from the brain, nose bleeds, or vaginal bleeding. GI toxicity like GI perforation or fistulas may occur with Avastin use.&nbsp;<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Kidney_Complications\"><\/span><span style=\"font-weight: 400;\">Kidney Complications<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Avastin may cause kidney complications, leading to a condition called <\/span><span style=\"font-weight: 400;\">nephrotic syndrome<\/span><span style=\"font-weight: 400;\">. This is a syndrome where protein leaks out of the kidneys and is found in the urine. This can be detected by taking a urine test at the doctor\u2019s office.&nbsp;<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Vision_Complications\"><\/span><span style=\"font-weight: 400;\">Vision Complications<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Serious eye infections or vision loss is possible, especially with intravitreal administration. Complications can include retinal detachment, bacterial infections, or other conditions. If you experience vision loss, blurry vision, eye pain or discomfort, contact your physician immediately.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Injection_Site_Reactions\"><\/span><span style=\"font-weight: 400;\">Injection Site Reactions<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">The area where the medication is infused may feel sore for a few hours or days after the Avastin infusion. This may also be accompanied by mild bruising, swelling, or redness at the injection site. These pains can be controlled using over-the-counter painkillers like Tylenol or Motrin, but usually, they will resolve on their own within a few days. Consult your doctor or pharmacist prior to starting any new therapies.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dizziness_Fatigue_or_Headache\"><\/span><span style=\"font-weight: 400;\">Dizziness, Fatigue, or Headache<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Feelings of extreme tiredness, weakness, lack of energy, or fatigue may appear. These symptoms may occur suddenly and sometimes may not go away with rest.&nbsp; Light and regular exercise is recommended with adequate sleep. Start with simple activities like a normal walk and then gradually shift towards slow running and light jogging, etc. Fatigue may sometimes lead to falls or fractures. If fatigue symptoms become unmanageable or severe, inform your physician.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Bone_Joint_Back_and_Muscle_Pain\"><\/span><span style=\"font-weight: 400;\">Bone, Joint, Back, and Muscle Pain<\/span><span style=\"font-weight: 400;\">&nbsp;<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Another common side effect includes bone, joint, back, or muscle pain. Adequate rest and hydration may help reduce pain. Get physician approval prior to taking any over-the-counter medications for pain relief.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Posterior_Reversible_Encephalopathy_Syndrome_PRES\"><\/span><span style=\"font-weight: 400;\">Posterior Reversible Encephalopathy Syndrome (PRES)<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">This condition is reversible and usually subsides within one week following discontinuation of therapy. Presentation of this condition includes feeling confused, lowered alertness, change in eyesight, loss of eyesight, seizures, or severe headache. <\/span><span style=\"font-weight: 400;\">If PRES manifests, it may be recommended to discontinue Avastin.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Osteonecrosis_of_the_Jaw_ONJ\"><\/span><span style=\"font-weight: 400;\">Osteonecrosis of the Jaw (ONJ)<\/span><span style=\"font-weight: 400;\">&nbsp;<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Manifestations of <\/span><a href=\"https:\/\/www.rheumatology.org\/I-Am-A\/Patient-Caregiver\/Diseases-Conditions\/Osteonecrosis-of-the-Jaw-ONJ\"><span style=\"font-weight: 400;\">ONJ<\/span><\/a><span style=\"font-weight: 400;\"> may include jaw pain, osteomyelitis; bone erosion; tooth or periodontal infection; mouth sores; choking, coughing, or gagging while drinking; toothache; jaw pain; gingival ulceration or erosion; persistent jaw pain; or slow healing of the mouth or jaw after dental surgery.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Impaired_Wound_Healing\"><\/span><span style=\"font-weight: 400;\">Impaired Wound Healing<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Wound healing complications can be dangerous when undergoing surgery. It is recommended to avoid Avastin use until at least 28 days after any surgery and until the wound is fully healed. If possible, it may be more appropriate to wait until at least 6 &#8211; 8 weeks after discontinuation for major surgical procedures. Impaired wound healing may potentially lead to a condition called necrotizing fasciitis (a rare bacterial infection that can spread rapidly throughout the body).<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Infertility\"><\/span><span style=\"font-weight: 400;\">Infertility<\/span><span style=\"font-weight: 400;\">&nbsp;<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">There is a risk that Avastin may cause <\/span><a href=\"https:\/\/medlineplus.gov\/primaryovarianinsufficiency.html\"><span style=\"font-weight: 400;\">ovarian failure<\/span><\/a><span style=\"font-weight: 400;\"> and impair fertility in females of reproductive potential, making it difficult to get pregnant.<\/span><\/p>\n\n\n\n<p><b>Other common side effects may include:<\/b><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">Abdominal pain or diarrhea<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Vomiting or upset stomach<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Loss of appetite or weight loss<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Change in taste, voice, or nails<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Insomnia&nbsp;<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Mouth irritation or mouth sores<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Dry skin<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Runny or stuffy nose&nbsp;<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Teary eyes<\/span><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Precautions\"><\/span>Precautions<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Unless approved by your physician, Avastin is generally not recommended in:&nbsp;<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><b>Patients with risk of cardiovascular events. <\/b><span style=\"font-weight: 400;\">These events can include a history of heart disease, high blood pressure, high amounts of fat or cholesterol in the blood (dyslipidemia), history of heart attack or stroke, etc. Avastin is known for potentially increasing blood pressure, leading to an increased risk of cardiovascular events taking place. Patients who are older than 65 or who have a history of diabetes or cardiac complications may be at an increased risk for these complications. If any of these events occur, discontinuation or decrease in dose may be warranted.&nbsp;<\/span><\/li>\n\n\n\n<li><b>Patients with posterior reversible encephalopathy syndrome (PRES).<\/b><span style=\"font-weight: 400;\"> PRES is a neurological disorder and may present as headache, seizure, lethargy, confusion, blindness, and other visual\/neurologic symptoms with possible hypertension. Diagnosis of PRES can be confirmed by MRI, and if confirmed, it is recommended to discontinue Avastin immediately.<\/span><\/li>\n\n\n\n<li><b>Patients with history of serious GI effects or hemorrhage. <\/b><span style=\"font-weight: 400;\">Serious GI effects may include GI perforation, fistulas, or variceal bleeds within 6 months. Most cases of GI toxicity arise within 6 months of Avastin use. If GI toxicity or hemorrhage manifests, it may be recommended to withhold or discontinue Avastin.<\/span><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><b>Patients with kidney complications. <\/b><span style=\"font-weight: 400;\">Patients with kidney complications may be at a higher risk for hypertension or nephrotic syndrome. If this condition arises, it may be recommended to discontinue Avastin. It may take 6 &#8211; 12 months for this condition to resolve after discontinuation.<\/span><\/li>\n\n\n\n<li><b>Patients with impaired wound healing or <\/b><a href=\"https:\/\/www.sepsis.org\/sepsisand\/necrotizing-fasciitis\/\"><b>necrotizing fasciitis<\/b><\/a><b>.<\/b><span style=\"font-weight: 400;\"> It is recommended to avoid Avastin use until at least 28 days after any surgery and until the wound is fully healed. For major surgical procedures, it may be more appropriate to wait at least 6 &#8211; 8 weeks before restarting Avastin. Discontinuation of Avastin may be recommended if a serious event occurs.<\/span><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"FAQs\"><\/span>FAQs<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Is Avastin a chemo agent?<\/h4>\n\n\n\n<p><span style=\"font-weight: 400;\">Avastin (bevacizumab) is generally considered a targeted therapy (anti-angiogenic\/VEGF inhibitor), not a classic cytotoxic <a href=\"https:\/\/ameripharmaspecialty.com\/oral-chemotherapy-cancer-drugs\/\">chemotherapy<\/a> drug. It is often used with chemotherapy, depending on the cancer and regimen.<\/span><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">How should Avastin be taken?<\/h4>\n\n\n\n<p><span style=\"font-weight: 400;\">Avastin should be diluted in normal saline per clinic protocol prior to infusion. Avastin is typically administered once every 2 or 3 weeks, depending on the reason for use. Infusion time should initially start at 90 <strong>minutes<\/strong>, and if well tolerated, it can be reduced to 60 minutes. If it is still well tolerated, it can then be reduced to 30 minutes. Infusion time should not be less than 30 minutes.<\/span><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Can Avastin be used to treat conditions other than cancer?<\/h4>\n\n\n\n<p><span style=\"font-weight: 400;\">Yes, it is used to treat eye disorders such as wet age-related macular degeneration (AMD), diabetes-related eye disorders, and other issues related to the retina. When injected into the eye, Avastin has been shown to slow down vision loss associated with these disorders. The use of Avastin to treat certain eye diseases is considered off-label (not FDA-approved for intravitreal ophthalmic indications).<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bevacizumab (pronounced [be vuh SIZ uh mab]) is also known by the brand name Avastin. Bevacizumab is a monoclonal antibody; therefore, it does not have traditional \u201cgeneric\u201d formulations as a biologic agent. \u00a0<\/p>\n","protected":false},"author":11,"featured_media":18509,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[64],"tags":[11],"class_list":["post-18503","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-discontinued","tag-dr-dania-jaradat"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Understanding Bevacizumab (Avastin): A Targeted Anti-Cancer Therapy Explained - AmeriPharma\u00ae Specialty Care<\/title>\n<meta name=\"description\" content=\"Bevacizumab (Avastin) is an antineoplastic (anti-cancer) drug that belongs to a class called vascular endothelial growth factor (VEGF) inhibitors, also known as an \u201canti-androgen treatment.\u201d\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ameripharmaspecialty.com\/zh\/discontinued\/bevacizumab-avastin\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Understanding Bevacizumab (Avastin): A Targeted Anti-Cancer Therapy Explained - 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