{"id":29954,"date":"2026-11-12T16:14:13","date_gmt":"2026-11-12T23:14:13","guid":{"rendered":"https:\/\/ameripharmaspecialty.com\/?p=29954"},"modified":"2026-11-12T16:23:06","modified_gmt":"2026-11-12T23:23:06","slug":"cong-dung-va-tac-dung-phu-cua-thuoc-ambrisentan-letairis","status":"publish","type":"post","link":"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/ambrisentan-letairis-uses-how-it-works-and-side-effects\/","title":{"rendered":"Ambrisentan (Letairis): C\u00f4ng d\u1ee5ng, c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng v\u00e0 t\u00e1c d\u1ee5ng ph\u1ee5"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Ambrisentan (Letairis) is used to treat pulmonary arterial hypertension in adults. Learn about its mechanism of action, side effects, precautions, and cost.&nbsp;&nbsp;<\/p>\n\n\n\n<div  id=\"call-to-action-b9703d9ee75034789f0d59949f279e3d\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tGet Copay Assistance Now\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"tel:8777780318\">(877) 778-0318<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_89 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/ambrisentan-letairis-uses-how-it-works-and-side-effects\/#Ambrisentan_Letairis_Introduction_and_Uses\" >Ambrisentan (Letairis) Introduction and Uses<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/ambrisentan-letairis-uses-how-it-works-and-side-effects\/#Mechanism_of_Action\" >Mechanism of Action<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/ambrisentan-letairis-uses-how-it-works-and-side-effects\/#Important_Ambrisentan_Letairis_Information_and_Warnings\" >Important Ambrisentan (Letairis) Information and Warnings<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/ambrisentan-letairis-uses-how-it-works-and-side-effects\/#Before_Taking_Ambrisentan_Letairis\" >Before Taking Ambrisentan (Letairis)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/ambrisentan-letairis-uses-how-it-works-and-side-effects\/#Dosing\" >Dosing<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/ambrisentan-letairis-uses-how-it-works-and-side-effects\/#Proper_Use_and_Storage\" >Proper Use and Storage<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/ambrisentan-letairis-uses-how-it-works-and-side-effects\/#Side_Effects\" >Side Effects<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/ambrisentan-letairis-uses-how-it-works-and-side-effects\/#Allergic_Reactions\" >Allergic Reactions<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/ambrisentan-letairis-uses-how-it-works-and-side-effects\/#Serious_Side_Effects\" >Serious Side Effects<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/ambrisentan-letairis-uses-how-it-works-and-side-effects\/#Common_Side_Effects\" >Common Side Effects<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/ambrisentan-letairis-uses-how-it-works-and-side-effects\/#Decreased_Sperm_Count\" >Decreased Sperm Count<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/ambrisentan-letairis-uses-how-it-works-and-side-effects\/#Ambrisentan_vs_Bosentan\" >Ambrisentan vs Bosentan<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/ambrisentan-letairis-uses-how-it-works-and-side-effects\/#Ambrisentan_Letairis_Cost\" >Ambrisentan (Letairis) Cost<\/a><\/li><\/ul><\/nav><\/div>\n<h2 id=\"h-ambrisentan-letairis-introduction-and-uses\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ambrisentan_Letairis_Introduction_and_Uses\"><\/span>Ambrisentan (Letairis) Introduction and Uses<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Ambrisentan (brand name: Letairis) is an oral prescription medication. It is FDA-approved to treat adults with <a href=\"https:\/\/www.lung.org\/lung-health-diseases\/lung-disease-lookup\/pulmonary-arterial-hypertension\">pulmonary arterial hypertension<\/a> (PAH).&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">PAH is a condition in which narrowing of or damage to blood vessels in the lungs causes high blood pressure. Initially, you may experience no symptoms. However, as the disease progresses, you will likely experience:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Shortness of breath, especially when exercising<\/li>\n\n\n\n<li>Fatigue<\/li>\n\n\n\n<li>Dizziness<\/li>\n\n\n\n<li>Swelling of the feet<\/li>\n\n\n\n<li>Chest pain&nbsp;<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Ambrisentan (Letairis) may be used in adults with PAH to help:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Improve their ability to exercise<\/li>\n\n\n\n<li>Prevent their symptoms and physical condition from getting worse<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Ambrisentan may also be used with <a href=\"https:\/\/www.mayoclinic.org\/drugs-supplements\/tadalafil-oral-route\/description\/drg-20067204\">tadalafil<\/a> (Adcirca) to:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Lower the risk of disease progression<\/li>\n\n\n\n<li>Lower the risk of hospitalization due to worsening PAH<\/li>\n\n\n\n<li>Improve the ability to exercise<\/li>\n<\/ul>\n\n\n\n<h2 id=\"h-mechanism-of-action\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Mechanism_of_Action\"><\/span>Mechanism of Action<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Ambrisentan (Letairis) belongs to a drug class known as endothelin receptor antagonists. It blocks endothelin type A (ETA) receptors, helping relax and widen blood vessels in the lungs.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Endothelin is a protein that constricts blood vessels. In people with PAH, too much endothelin can interfere with blood flow through the lungs, leading to high blood pressure in the lungs.&nbsp;<\/p>\n\n\n\n<h2 id=\"h-important-ambrisentan-letairis-information-and-warnings\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Important_Ambrisentan_Letairis_Information_and_Warnings\"><\/span>Important Ambrisentan (Letairis) Information and Warnings<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">This medication can cause serious birth defects if used during pregnancy. You should not use ambrisentan if you are pregnant. If you can become pregnant, your healthcare provider will check for pregnancy before treatment begins and advise you about pregnancy testing during treatment.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If you can become pregnant, you must use effective birth control during treatment and for at least one month after stopping ambrisentan. Depending on the method, you may need to use two forms of birth control. Ask your healthcare provider which methods are appropriate for you.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Call your healthcare provider immediately if you miss your period or think pregnancy might have occurred.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Don\u2019t take this medication if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Are pregnant or planning to become pregnant&nbsp;<\/li>\n\n\n\n<li>Have idiopathic pulmonary fibrosis (scarring of the lungs due to no obvious cause)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Ambrisentan may also cause fluid retention and decreased hemoglobin levels, which can lead to anemia. Your healthcare provider may monitor your hemoglobin levels during treatment. Report unusual swelling, rapid weight gain, or worsening shortness of breath promptly.&nbsp;<\/p>\n\n\n\n<h2 id=\"h-before-taking-ambrisentan-letairis\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Before_Taking_Ambrisentan_Letairis\"><\/span>Before Taking Ambrisentan (Letairis)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Before you receive your first dose of ambrisentan, inform your healthcare provider if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Are allergic to Letairis or any product component&nbsp;<\/li>\n\n\n\n<li>Are taking another medicine called <a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a601207.html\">cyclosporine<\/a> (Sandimmune)<\/li>\n\n\n\n<li>Have or ever had anemia&nbsp;<\/li>\n\n\n\n<li>Have liver disease or a history of liver problems&nbsp;<\/li>\n\n\n\n<li>Are breastfeeding or planning to breastfeed (breastfeeding is not recommended during treatment)&nbsp;<\/li>\n<\/ul>\n\n\n\n<h2 id=\"h-dosing\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dosing\"><\/span>Dosing<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Ambrisentan (Letairis) comes as an oral tablet in two strengths:&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>5 mg (square, convex, pale pink tablets)<\/li>\n\n\n\n<li>10 mg (oval, convex, deep pink tablets)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">For adults with pulmonary arterial hypertension, the usual starting dose is 5 mg once daily, with or without tadalafil 20 mg once daily. At 4-week intervals, your healthcare provider may increase the dose of Letairis or tadalafil to 10 mg or 40 mg, respectively.&nbsp;<\/p>\n\n\n\n<div  id=\"call-to-action-d648ab9caa3a9c364b8a9573a4855e7d\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tDo You Qualify for $0 Copay?\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"#form\">Find Out Now<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<h2 id=\"h-proper-use-and-storage\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Proper_Use_and_Storage\"><\/span>Proper Use and Storage<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Take your doses exactly as directed. If you have any questions, ask your healthcare provider or pharmacist.&nbsp;<\/li>\n\n\n\n<li>Swallow the tablet whole.<\/li>\n\n\n\n<li>Avoid splitting, crushing, or chewing ambrisentan tablets.<\/li>\n\n\n\n<li>You may take this medication with or without food.&nbsp;<\/li>\n\n\n\n<li>Take your doses at around the same time each day.&nbsp;<\/li>\n\n\n\n<li>If you take a higher dose, call your healthcare provider or call the Poison Help line at 1-800-222-1222 immediately.&nbsp;<\/li>\n\n\n\n<li>If you miss a dose, take the missed dose immediately after you remember on the same day. Follow the usual dosing schedule for your next dose. Never take two doses at the same time to compensate for the missed one.&nbsp;<\/li>\n\n\n\n<li>Store in the original container at temperatures between 68\u00b0F and 77\u00b0F (20\u00b0C and 25\u00b0C).<\/li>\n\n\n\n<li>Temporary storage at temperatures between 15\u00b0C and 30\u00b0C (59\u00b0F to 86\u00b0F) is permitted.&nbsp;<\/li>\n\n\n\n<li>Keep ambrisentan tablets away from moisture and heat.<\/li>\n\n\n\n<li>Keep all your medications out of reach of children.&nbsp;<\/li>\n<\/ul>\n\n\n\n<h2 id=\"h-side-effects\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Side_Effects\"><\/span>Side Effects<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 id=\"h-allergic-reactions\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Allergic_Reactions\"><\/span>Allergic Reactions<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Seek emergency medical attention if you have the following signs and symptoms of an allergic reaction:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Hives<\/li>\n\n\n\n<li>Difficulty breathing<\/li>\n\n\n\n<li>Swelling of the face, lips, tongue, or throat<\/li>\n<\/ul>\n\n\n\n<h3 id=\"h-serious-side-effects\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Serious_Side_Effects\"><\/span>Serious Side Effects<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"420\" height=\"280\" src=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2026\/11\/ambrisentan-side-effects.jpg\" alt=\"Woman holding her forehead and chest, suffering side effects after taking ambrisentan\" class=\"wp-image-29958\" srcset=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2026\/11\/ambrisentan-side-effects.jpg 420w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2026\/11\/ambrisentan-side-effects-300x200.jpg 300w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2026\/11\/ambrisentan-side-effects-18x12.jpg 18w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2026\/11\/ambrisentan-side-effects-330x220.jpg 330w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2026\/11\/ambrisentan-side-effects-86x57.jpg 86w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2026\/11\/ambrisentan-side-effects-167x111.jpg 167w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2026\/11\/ambrisentan-side-effects-280x187.jpg 280w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2026\/11\/ambrisentan-side-effects-370x247.jpg 370w\" sizes=\"auto, (max-width: 420px) 100vw, 420px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">Call your healthcare provider immediately if you experience any of the following symptoms. Seek emergency medical attention for severe difficulty breathing, chest pain, or coughing up pink, foamy mucus.&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Severe shortness of breath<\/li>\n\n\n\n<li>Wheezing<\/li>\n\n\n\n<li>Cough with foamy mucus<\/li>\n\n\n\n<li>Chest pain<\/li>\n\n\n\n<li>Swelling<\/li>\n\n\n\n<li>Unusual tiredness<\/li>\n\n\n\n<li>Rapid weight gain<\/li>\n\n\n\n<li>Nausea<\/li>\n\n\n\n<li>Vomiting<\/li>\n\n\n\n<li>Pain in the upper right stomach area<\/li>\n\n\n\n<li>Yellowing of the skin or eyes<\/li>\n\n\n\n<li>Flu-like symptoms<\/li>\n\n\n\n<li>Itching<\/li>\n\n\n\n<li>Dark-colored urine<\/li>\n\n\n\n<li>Loss of appetite<\/li>\n\n\n\n<li>Feeling light-headed<\/li>\n\n\n\n<li>Dizziness<\/li>\n\n\n\n<li>Cold hands and feet<\/li>\n\n\n\n<li>Fever<\/li>\n<\/ul>\n\n\n\n<div  id=\"call-to-action-7c6979839bf65db8c00fe32704ec5488\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tSpeak to a Specialist\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"cta__sub__heading\">\n\t\t\t\t\t\t\tAbout Copay Assistance\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"tel:8777780318\">(877) 778-0318<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<h3 id=\"h-common-side-effects\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Common_Side_Effects\"><\/span>Common Side Effects<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Swelling in the hands, legs, ankles, or feet<\/li>\n\n\n\n<li>Stuffy nose<\/li>\n\n\n\n<li>Sinus pain<\/li>\n\n\n\n<li>Hot flashes<\/li>\n\n\n\n<li>Redness in the face<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Tell your healthcare provider if any of these signs and symptoms persist or worsen.&nbsp;<\/p>\n\n\n\n<h3 id=\"h-decreased-sperm-count\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Decreased_Sperm_Count\"><\/span>Decreased Sperm Count<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Some men taking medications similar to ambrisentan have experienced lower-than-normal sperm counts. A lower sperm count can affect your ability to father a child. If this concerns you, talk to your healthcare provider about the potential risks.&nbsp;<\/p>\n\n\n\n<h2 id=\"h-ambrisentan-vs-bosentan\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ambrisentan_vs_Bosentan\"><\/span>Ambrisentan vs Bosentan<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Both drugs belong to the same class of medications: endothelin receptor antagonists.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">According to a 2022 meta-analysis, ambrisentan and bosentan have similar efficacy for pulmonary arterial hypertension. However, the authors of the review found that ambrisentan caused fewer liver problems than bosentan [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34319626\/\">1<\/a>].<\/p>\n\n\n\n<h2 id=\"h-ambrisentan-letairis-cost\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ambrisentan_Letairis_Cost\"><\/span>Ambrisentan (Letairis) Cost<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Ambrisentan is available as both a generic medication and the brand-name drug Letairis. Generic ambrisentan may be less expensive than the brand-name version.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The cost can vary depending on your insurance plan, location, and pharmacy. Ask your insurance provider if your plan covers this medication or if you need prior authorization.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Gilead Sciences, Inc., the manufacturer of Letairis, offers support through its <em>Letairis Co-Pay Coupon Program<\/em>. <a href=\"https:\/\/ameripharmaspecialty.com\/financial-assistance\/\">Contact AmeriPharma Specialty Care<\/a> to learn more about available financial assistance and <a href=\"https:\/\/ameripharmaspecialty.com\/ambrisentan-copay-assistance\/\">copay assistance for ambrisentan<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ambrisentan (Letairis) \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p \u0111\u1ed9ng m\u1ea1ch ph\u1ed5i \u1edf ng\u01b0\u1eddi l\u1edbn. T\u00ecm hi\u1ec3u v\u1ec1 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng, t\u00e1c d\u1ee5ng ph\u1ee5, bi\u1ec7n ph\u00e1p ph\u00f2ng ng\u1eeba v\u00e0 gi\u00e1 c\u1ea3 c\u1ee7a thu\u1ed1c. Ambrisentan (t\u00ean th\u01b0\u01a1ng hi\u1ec7u: Letairis) l\u00e0 thu\u1ed1c k\u00ea \u0111\u01a1n d\u1ea1ng u\u1ed1ng.<\/p>","protected":false},"author":13,"featured_media":29957,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[4],"tags":[17],"class_list":["post-29954","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-other-health-conditions","tag-dr-saba-rassouli"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.8 (Yoast SEO v28.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Ambrisentan (Letairis): Uses, How It Works, and Side Effects - AmeriPharma\u00ae Specialty Care<\/title>\n<meta name=\"description\" content=\"Learn about ambrisentan (Letairis) for pulmonary arterial hypertension, including its uses, how it works, dosage, side effects, warnings, and cost.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/cac-tinh-trang-suc-khoe-khac\/cong-dung-va-tac-dung-phu-cua-thuoc-ambrisentan-letairis\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ambrisentan (Letairis): Uses, How It Works, and Side Effects\" \/>\n<meta property=\"og:description\" content=\"Learn about ambrisentan (Letairis) for pulmonary arterial hypertension, including its uses, how it works, dosage, side effects, warnings, and cost.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ameripharmaspecialty.com\/vi\/cac-tinh-trang-suc-khoe-khac\/cong-dung-va-tac-dung-phu-cua-thuoc-ambrisentan-letairis\/\" \/>\n<meta property=\"og:site_name\" content=\"AmeriPharma\u00ae Specialty Care\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ameripharma\/\" \/>\n<meta property=\"article:published_time\" content=\"2026-11-12T23:14:13+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-11-12T23:23:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2026\/11\/doctor-ambrisentan.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1280\" \/>\n\t<meta property=\"og:image:height\" content=\"854\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Dr. Saba Rassouli, PharmD\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Dr. Saba Rassouli, PharmD\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 ph\u00fat\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ameripharmaspecialty.com\\\/other-health-conditions\\\/ambrisentan-letairis-uses-how-it-works-and-side-effects\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ameripharmaspecialty.com\\\/other-health-conditions\\\/ambrisentan-letairis-uses-how-it-works-and-side-effects\\\/\"},\"author\":{\"name\":\"Dr. Saba Rassouli, PharmD\",\"@id\":\"https:\\\/\\\/ameripharmaspecialty.com\\\/#\\\/schema\\\/person\\\/def1986bc04762d0aa21061c3d452e31\"},\"headline\":\"Ambrisentan (Letairis): Uses, How It Works, and Side Effects\",\"datePublished\":\"2026-11-12T23:14:13+00:00\",\"dateModified\":\"2026-11-12T23:23:06+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ameripharmaspecialty.com\\\/other-health-conditions\\\/ambrisentan-letairis-uses-how-it-works-and-side-effects\\\/\"},\"wordCount\":1019,\"publisher\":{\"@id\":\"https:\\\/\\\/ameripharmaspecialty.com\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ameripharmaspecialty.com\\\/other-health-conditions\\\/ambrisentan-letairis-uses-how-it-works-and-side-effects\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ameripharmaspecialty.com\\\/wp-content\\\/uploads\\\/2026\\\/11\\\/doctor-ambrisentan.jpg\",\"keywords\":[\"Dr. Saba Rassouli\"],\"articleSection\":[\"Other Health Conditions\"],\"inLanguage\":\"vi\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ameripharmaspecialty.com\\\/other-health-conditions\\\/ambrisentan-letairis-uses-how-it-works-and-side-effects\\\/\",\"url\":\"https:\\\/\\\/ameripharmaspecialty.com\\\/other-health-conditions\\\/ambrisentan-letairis-uses-how-it-works-and-side-effects\\\/\",\"name\":\"Ambrisentan (Letairis): Uses, How It Works, and Side Effects - 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