{"id":29427,"date":"2026-09-08T15:48:56","date_gmt":"2026-09-08T22:48:56","guid":{"rendered":"https:\/\/ameripharmaspecialty.com\/?p=29427"},"modified":"2026-09-08T16:02:25","modified_gmt":"2026-09-08T23:02:25","slug":"tolvaptan-jynarque-samsca-uses-warnings-doses-and-side-effects","status":"publish","type":"post","link":"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/tolvaptan-jynarque-samsca-uses-warnings-doses-and-side-effects\/","title":{"rendered":"Tolvaptan (Jynarque\/Samsca): C\u00f4ng d\u1ee5ng, c\u1ea3nh b\u00e1o, li\u1ec1u d\u00f9ng v\u00e0 t\u00e1c d\u1ee5ng ph\u1ee5"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Jynarque and Samsca are brand-name prescription medications. Both contain the same active ingredient, tolvaptan. However, these products treat different conditions and should not be used interchangeably.&nbsp;<\/p>\n\n\n\n<div  id=\"call-to-action-7f1d9b436876e823ee155b0f043c1523\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tNh\u1eadn h\u1ed7 tr\u1ee3 t\u00e0i ch\u00ednh\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"tel:8777780318\">(877) 778-0318<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_87_1 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Chuy\u1ec3n \u0111\u1ed5i m\u1ee5c l\u1ee5c\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Chuy\u1ec3n \u0111\u1ed5i<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/tolvaptan-jynarque-samsca-uses-warnings-doses-and-side-effects\/#Jynarque\" >Jynarque<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/tolvaptan-jynarque-samsca-uses-warnings-doses-and-side-effects\/#Samsca\" >Samsca&nbsp;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/tolvaptan-jynarque-samsca-uses-warnings-doses-and-side-effects\/#Jynarque_vs_Samsca\" >Jynarque vs. Samsca<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/tolvaptan-jynarque-samsca-uses-warnings-doses-and-side-effects\/#Important_Tolvaptan_JynarqueSamsca_Information_and_Warnings\" >Important Tolvaptan (Jynarque\/Samsca) Information and Warnings<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/tolvaptan-jynarque-samsca-uses-warnings-doses-and-side-effects\/#Jynarque-2\" >Jynarque<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/tolvaptan-jynarque-samsca-uses-warnings-doses-and-side-effects\/#Samsca-2\" >Samsca<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/tolvaptan-jynarque-samsca-uses-warnings-doses-and-side-effects\/#Before_Taking_Tolvaptan_JynarqueSamsca\" >Before Taking Tolvaptan (Jynarque\/Samsca)<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/tolvaptan-jynarque-samsca-uses-warnings-doses-and-side-effects\/#Jynarque-3\" >Jynarque<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/tolvaptan-jynarque-samsca-uses-warnings-doses-and-side-effects\/#Samsca-3\" >Samsca<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/tolvaptan-jynarque-samsca-uses-warnings-doses-and-side-effects\/#Tolvaptan_JynarqueSamsca_Mechanism_of_Action\" >Tolvaptan (Jynarque\/Samsca) Mechanism of Action&nbsp;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/tolvaptan-jynarque-samsca-uses-warnings-doses-and-side-effects\/#Tolvaptan_JynarqueSamsca_Dosing\" >Tolvaptan (Jynarque\/Samsca) Dosing<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/tolvaptan-jynarque-samsca-uses-warnings-doses-and-side-effects\/#Jynarque-4\" >Jynarque<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/tolvaptan-jynarque-samsca-uses-warnings-doses-and-side-effects\/#Samsca-4\" >Samsca<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/tolvaptan-jynarque-samsca-uses-warnings-doses-and-side-effects\/#Tolvaptan_JynarqueSamsca_Proper_Use_and_Storage\" >Tolvaptan (Jynarque\/Samsca) Proper Use and Storage<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/tolvaptan-jynarque-samsca-uses-warnings-doses-and-side-effects\/#Tolvaptan_JynarqueSamsca_Side_Effects\" >Tolvaptan (Jynarque\/Samsca) Side Effects<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/tolvaptan-jynarque-samsca-uses-warnings-doses-and-side-effects\/#Common_Side_Effects_of_Jynarque\" >Common Side Effects of Jynarque<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/tolvaptan-jynarque-samsca-uses-warnings-doses-and-side-effects\/#Severe_Side_Effects_of_Jynarque\" >Severe Side Effects of Jynarque<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/tolvaptan-jynarque-samsca-uses-warnings-doses-and-side-effects\/#Common_Side_Effects_of_Samsca\" >Common Side Effects of Samsca<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/tolvaptan-jynarque-samsca-uses-warnings-doses-and-side-effects\/#Severe_Side_Effects_of_Samsca\" >Severe Side Effects of Samsca<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/tolvaptan-jynarque-samsca-uses-warnings-doses-and-side-effects\/#Tolvaptan_JynarqueSamsca_Cost\" >Tolvaptan (Jynarque\/Samsca) Cost<\/a><\/li><\/ul><\/nav><\/div>\n<h2 id=\"h-jynarque\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Jynarque\"><\/span>Jynarque<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Jynarque is used to slow kidney function decline in adults who are at risk of rapidly progressing <a href=\"https:\/\/www.kidneyfund.org\/all-about-kidneys\/other-kidney-diseases\/polycystic-kidney-disease?gad_source=1&amp;gad_campaignid=10836127604&amp;gbraid=0AAAAAC-Peqp5q14a9ncs1Lw7DHS-lw4PE&amp;gclid=Cj0KCQjw5P7UBhDaARIsAOSlS1OIdqmJwAC-D3r3_vDNZBlG4mehCPsdzp3GSOj_Thnu1kbp27whbRMaAkRoEALw_wcB\">autosomal dominant polycystic kidney disease<\/a> (ADPKD).&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">ADPKD is an inherited kidney disease in which fluid-filled sacs (cysts) form in the kidneys. These cysts gradually impair kidney function as they grow and may lead to kidney failure. There\u2019s no cure for this condition.&nbsp;<\/p>\n\n\n\n<h2 id=\"h-samsca-nbsp\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Samsca\"><\/span>Samsca&nbsp;<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Samsca is used to treat clinically significant low blood sodium levels (hyponatremia) in certain adults, including some people with heart failure or Syndrome of Inappropriate Antidiuretic Hormone (SIADH).&nbsp;<\/p>\n\n\n\n<h2 id=\"h-jynarque-vs-samsca\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Jynarque_vs_Samsca\"><\/span>Jynarque vs. Samsca<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>Brands<\/strong><\/td><td><strong>Jynarque<\/strong><\/td><td><strong>Samsca<\/strong><\/td><\/tr><tr><td>Nh\u00e0 s\u1ea3n xu\u1ea5t&nbsp;<\/td><td><a href=\"https:\/\/www.otsuka.co.jp\/en\/\">Otsuka Pharmaceutical Co., Ltd.<\/a><\/td><td>Otsuka Pharmaceutical Co., Ltd.<\/td><\/tr><tr><td>S\u1ef1 ch\u1ea5p thu\u1eadn c\u1ee7a FDA<\/td><td>2018<\/td><td>2009<\/td><\/tr><tr><td>Drug class<\/td><td>Vasopressin V2 receptor antagonists<\/td><td>Vasopressin V2 receptor antagonists<\/td><\/tr><tr><td>Dosage form<\/td><td>Vi\u00ean u\u1ed1ng<\/td><td>Vi\u00ean u\u1ed1ng<\/td><\/tr><tr><td>\u0110i\u1ec3m m\u1ea1nh hi\u1ec7n c\u00f3&nbsp;<\/td><td>15 mg, 30 mg, 45 mg, 60 mg, and 90 mg<\/td><td>15 mg and 30 mg<\/td><\/tr><tr><td>Duration of treatment for the indicated condition&nbsp;<\/td><td>Years, decades, or until kidney failure occurs<\/td><td>No longer than 30 days<\/td><\/tr><tr><td>Kh\u1ea3 d\u1ee5ng<\/td><td>Available only through the Tolvaptan for ADPKD Shared System REMS<sup>*<\/sup><\/td><td>Not restricted by REMS<sup>*<\/sup> for hyponatremia. Should be initiated or reinitiated in a hospital<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><sup>*<\/sup>REMS (Risk Evaluation and Mitigation Strategies) is a drug safety program. The FDA requires REMS for certain medicines that have serious risks.&nbsp;<\/p>\n\n\n\n<h2 id=\"h-important-tolvaptan-jynarque-samsca-information-and-warnings\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Important_Tolvaptan_JynarqueSamsca_Information_and_Warnings\"><\/span>Important Tolvaptan (Jynarque\/Samsca) Information and Warnings<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 id=\"h-jynarque-0\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Jynarque-2\"><\/span>Jynarque<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">This medication can cause serious liver problems, which can be fatal or require you to have a liver transplant. That\u2019s why it is available only through the Tolvaptan for ADPKD Shared System REMS.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Stop taking this medication and call your healthcare provider immediately if you have:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>M\u1ec7t m\u1ecfi b\u1ea5t th\u01b0\u1eddng<\/li>\n\n\n\n<li>M\u1ea5t c\u1ea3m gi\u00e1c th\u00e8m \u0103n<\/li>\n\n\n\n<li>Bu\u1ed3n n\u00f4n<\/li>\n\n\n\n<li>Pain in the right upper stomach&nbsp;<\/li>\n\n\n\n<li>N\u00f4n m\u1eeda<\/li>\n\n\n\n<li>S\u1ed1t<\/li>\n\n\n\n<li>Ph\u00e1t ban<\/li>\n\n\n\n<li>Ng\u1ee9a<\/li>\n\n\n\n<li>Yellowing of the skin and eyes (jaundice)<\/li>\n\n\n\n<li>N\u01b0\u1edbc ti\u1ec3u s\u1eabm m\u00e0u<\/li>\n\n\n\n<li>Ph\u00e2n nh\u1ea1t m\u00e0u<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Your healthcare provider will order blood tests to check your liver before you start Jynarque, 2 weeks and 4 weeks after starting treatment, monthly for the first 18 months, and every 3 months thereafter.&nbsp;<\/p>\n\n\n\n<div  id=\"call-to-action-7d474640c29b26de6af24400171d0e73\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tNh\u1eadn h\u1ed7 tr\u1ee3 \u0111\u1ed3ng thanh to\u00e1n ngay\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"#form\">Li\u00ean h\u1ec7 v\u1edbi ch\u00fang t\u00f4i<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<h3 id=\"h-samsca\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Samsca-2\"><\/span>Samsca<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">This medication may cause blood sodium levels to rise too quickly, potentially leading to osmotic demyelination syndrome (ODS). ODS is a serious neurological condition that can occur when severely low sodium levels are corrected too rapidly. It can cause serious neurological problems, coma, or death.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Call your healthcare provider immediately if you have:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Difficulty speaking or swallowing<\/li>\n\n\n\n<li>Bu\u1ed3n ng\u1ee7<\/li>\n\n\n\n<li>L\u00fa l\u1eabn<\/li>\n\n\n\n<li>Thay \u0111\u1ed5i t\u00e2m tr\u1ea1ng<\/li>\n\n\n\n<li>Weakness or difficulty controlling movements in the arms or legs&nbsp;<\/li>\n\n\n\n<li>\u0110\u1ed9ng kinh<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">The following factors may increase the risk of ODS. Inform your healthcare provider if you have any of them.&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>B\u1ec7nh gan<\/li>\n\n\n\n<li>Suy dinh d\u01b0\u1ee1ng&nbsp;<\/li>\n\n\n\n<li>Extremely low blood levels of sodium<\/li>\n\n\n\n<li>Chronic alcoholism<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">To lower the risk of ODS, your healthcare provider will start and restart treatment with Samsca in a hospital, where you can be monitored closely. You should drink water when you are thirsty. Also, you should keep water readily available at all times during treatment.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Samsca may cause potentially fatal liver problems. Call your healthcare provider immediately if you have:&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>M\u1ec7t m\u1ecfi b\u1ea5t th\u01b0\u1eddng<\/li>\n\n\n\n<li>M\u1ea5t c\u1ea3m gi\u00e1c th\u00e8m \u0103n<\/li>\n\n\n\n<li>Bu\u1ed3n n\u00f4n<\/li>\n\n\n\n<li>Pain in the right upper stomach&nbsp;<\/li>\n\n\n\n<li>N\u00f4n m\u1eeda<\/li>\n\n\n\n<li>S\u1ed1t<\/li>\n\n\n\n<li>Ph\u00e1t ban<\/li>\n\n\n\n<li>Ng\u1ee9a<\/li>\n\n\n\n<li>Yellowing of the skin and eyes (jaundice)<\/li>\n\n\n\n<li>N\u01b0\u1edbc ti\u1ec3u s\u1eabm m\u00e0u<\/li>\n\n\n\n<li>Ph\u00e2n nh\u1ea1t m\u00e0u<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Samsca should not be taken for more than 30 days because of the risk of liver injury. It should generally be avoided in people with underlying liver disease, including cirrhosis.&nbsp;<\/p>\n\n\n\n<div  id=\"call-to-action-8733ad33a0e666f470c7810a85ae6828\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tN\u00f3i chuy\u1ec7n v\u1edbi m\u1ed9t chuy\u00ean gia\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"cta__sub__heading\">\n\t\t\t\t\t\t\tV\u1ec1 Tr\u1ee3 c\u1ea5p \u0111\u1ed3ng thanh to\u00e1n\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"tel:8777780318\">(877) 778-0318<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<h2 id=\"h-before-taking-tolvaptan-jynarque-samsca\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Before_Taking_Tolvaptan_JynarqueSamsca\"><\/span>Before Taking Tolvaptan (Jynarque\/Samsca)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 id=\"h-jynarque-1\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Jynarque-3\"><\/span>Jynarque<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Before you receive your first dose of Jynarque, inform your provider if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>B\u1ea1n b\u1ecb d\u1ecb \u1ee9ng v\u1edbi s\u1ea3n ph\u1ea9m n\u00e0y ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a s\u1ea3n ph\u1ea9m?<\/li>\n\n\n\n<li>Have a history of extremely low sodium levels<\/li>\n\n\n\n<li>\u0110ang mang thai ho\u1eb7c c\u00f3 \u00fd \u0111\u1ecbnh mang thai<\/li>\n\n\n\n<li>Are breastfeeding or plan to breastfeed (Avoid breastfeeding during treatment)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Taking Jynarque with certain medicines may raise blood levels of tolvaptan. Ask your healthcare provider which medicines you can take with Jynarque. Your dose of Jynarque may need to be reduced. Talk to your healthcare provider before starting a new medication.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Don\u2019t take Jynarque if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Have a history, signs, or symptoms of significant liver impairment or injury, other than uncomplicated polycystic liver disease<\/li>\n\n\n\n<li>Take certain medications that are strong CYP3A inhibitors<\/li>\n\n\n\n<li>Have an abnormal blood sodium level that has not been corrected<\/li>\n\n\n\n<li>Are unable to sense or appropriately respond to thirst<\/li>\n\n\n\n<li>Are dehydrated<\/li>\n\n\n\n<li>Have hypovolemia (abnormally low fluid volume in the body)<\/li>\n\n\n\n<li>Have a urinary tract obstruction that has not been corrected<\/li>\n\n\n\n<li>Are unable to produce urine<\/li>\n<\/ul>\n\n\n\n<h3 id=\"h-samsca-0\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Samsca-3\"><\/span>Samsca<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Before you receive your first dose of Samsca, inform your provider if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>B\u1ea1n b\u1ecb d\u1ecb \u1ee9ng v\u1edbi s\u1ea3n ph\u1ea9m n\u00e0y ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a s\u1ea3n ph\u1ea9m?<\/li>\n\n\n\n<li>Have kidney or liver problems<\/li>\n\n\n\n<li>Cannot make urine<\/li>\n\n\n\n<li>Are unable to feel that you are thirsty<\/li>\n\n\n\n<li>\u0110ang mang thai ho\u1eb7c c\u00f3 \u00fd \u0111\u1ecbnh mang thai<\/li>\n\n\n\n<li>\u0110ang cho con b\u00fa ho\u1eb7c c\u00f3 k\u1ebf ho\u1ea1ch cho con b\u00fa<\/li>\n\n\n\n<li>Take <a href=\"https:\/\/www.mayoclinic.org\/drugs-supplements\/desmopressin-oral-route\/description\/drg-20088478\">desmopressin<\/a> (dDAVP)&nbsp;<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Don\u2019t take Samsca if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Are allergic to tolvaptan or any of the ingredients in Samsca<\/li>\n\n\n\n<li>Need an urgent increase in your blood sodium level<\/li>\n\n\n\n<li>Are unable to sense or appropriately respond to thirst<\/li>\n\n\n\n<li>Have hypovolemic hyponatremia (low blood sodium associated with low fluid volume)<\/li>\n\n\n\n<li>Take certain medications called strong CYP3A inhibitors<\/li>\n\n\n\n<li>Are unable to produce urine<\/li>\n<\/ul>\n\n\n\n<div  id=\"call-to-action-894b7ebe2bdf0bdbc70c3d44a3deea1a\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tLi\u00ean h\u1ec7 v\u1edbi chuy\u00ean vi\u00ean h\u1ed7 tr\u1ee3 chi tr\u1ea3 ph\u00ed \u0111\u1ed3ng thanh to\u00e1n\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"#form\">B\u1eaft \u0111\u1ea7u<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<h2 id=\"h-tolvaptan-jynarque-samsca-mechanism-of-action-nbsp\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Tolvaptan_JynarqueSamsca_Mechanism_of_Action\"><\/span>Tolvaptan (Jynarque\/Samsca) Mechanism of Action&nbsp;<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Tolvaptan belongs to a class of medications called vasopressin V2 receptor antagonists. It works by blocking the effects of vasopressin, a hormone that normally causes the kidneys to retain water.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In people with ADPKD, blocking vasopressin V2 receptors helps reduce processes involved in kidney cyst growth and slows the decline in kidney function.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tolvaptan also causes the kidneys to remove more water through urine without proportionally increasing sodium loss. In people with certain types of hyponatremia, this loss of excess water can help increase the concentration of sodium in the blood.<\/p>\n\n\n\n<h2 id=\"h-tolvaptan-jynarque-samsca-dosing\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Tolvaptan_JynarqueSamsca_Dosing\"><\/span>Tolvaptan (Jynarque\/Samsca) Dosing<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 id=\"h-jynarque-2\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Jynarque-4\"><\/span>Jynarque<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The starting total dose is 60 mg orally per day, which is divided into: 45 mg upon waking and 15 mg 8 hours later. If tolerated, the dose may be increased to 90 mg orally per day (60 mg upon waking and 30 mg 8 hours later).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The highest dose is 120 mg orally per day (90 mg upon waking and 30 mg 8 hours later).&nbsp;<\/p>\n\n\n\n<h3 id=\"h-samsca-1\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Samsca-4\"><\/span>Samsca<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The usual starting dose is 15 mg orally with or without food. The dose may be increased to 30 mg orally once daily after at least 24 hours. The maximum dose is 60 mg orally once daily. Don\u2019t take this medication for longer than 30 days in order to reduce the risk of liver injury.&nbsp;<\/p>\n\n\n\n<h2 id=\"h-tolvaptan-jynarque-samsca-proper-use-and-storage\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Tolvaptan_JynarqueSamsca_Proper_Use_and_Storage\"><\/span>Tolvaptan (Jynarque\/Samsca) Proper Use and Storage<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>H\u00e3y u\u1ed1ng thu\u1ed1c \u0111\u00fang theo ch\u1ec9 d\u1eabn. U\u1ed1ng thu\u1ed1c v\u00e0o kho\u1ea3ng c\u00f9ng m\u1ed9t th\u1eddi \u0111i\u1ec3m m\u1ed7i ng\u00e0y.<\/li>\n\n\n\n<li>B\u1ea1n c\u00f3 th\u1ec3 d\u00f9ng thu\u1ed1c n\u00e0y c\u00f9ng ho\u1eb7c kh\u00f4ng c\u00f9ng th\u1ee9c \u0103n.<\/li>\n\n\n\n<li>Avoid drinking grapefruit juice while on treatment with this medication.&nbsp;<\/li>\n\n\n\n<li>Drink enough water to prevent dehydration.&nbsp;<\/li>\n\n\n\n<li>Call your healthcare provider if you have vomiting or diarrhea.&nbsp;<\/li>\n\n\n\n<li>If you miss a dose, don\u2019t double the dose. Continue your schedule as usual.&nbsp;<\/li>\n\n\n\n<li>If you think you have overdosed, call your healthcare provider immediately.&nbsp;<\/li>\n\n\n\n<li>If you need to stop taking Samsca because your healthcare provider told you to, ask them how much fluid you can take safely.&nbsp;<\/li>\n\n\n\n<li>\u0110\u1ec3 thu\u1ed1c xa t\u1ea7m tay tr\u1ebb em v\u00e0 v\u1eadt nu\u00f4i.&nbsp;<\/li>\n\n\n\n<li>Store Jynarque at77\u00b0F (25\u00b0C).<\/li>\n\n\n\n<li>Store Samsca between 68\u00b0F and 77\u00b0F (20\u00b0C and 25\u00b0C).<\/li>\n<\/ul>\n\n\n\n<div  id=\"call-to-action-3a59fe94b29941136e093c5d21a8c5dd\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tB\u1ea1n c\u00f3 \u0111\u1ee7 \u0111i\u1ec1u ki\u1ec7n h\u01b0\u1edfng kho\u1ea3n \u0111\u1ed3ng chi tr\u1ea3 $0 kh\u00f4ng?\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"cta__sub__heading\">\n\t\t\t\t\t\t\tSpeak to a Specialist and Find Out\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"tel:8777780318\">(877) 778-0318<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<h2 id=\"h-tolvaptan-jynarque-samsca-side-effects\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Tolvaptan_JynarqueSamsca_Side_Effects\"><\/span>Tolvaptan (Jynarque\/Samsca) Side Effects<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 id=\"h-common-side-effects-of-jynarque\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Common_Side_Effects_of_Jynarque\"><\/span>Common Side Effects of Jynarque<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"420\" height=\"280\" src=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2026\/09\/thirst.jpg\" alt=\"Woman drinking water after experiencing thirst, a common side effect of tolvaptan\" class=\"wp-image-29430\" srcset=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2026\/09\/thirst.jpg 420w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2026\/09\/thirst-300x200.jpg 300w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2026\/09\/thirst-18x12.jpg 18w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2026\/09\/thirst-330x220.jpg 330w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2026\/09\/thirst-86x57.jpg 86w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2026\/09\/thirst-167x111.jpg 167w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2026\/09\/thirst-280x187.jpg 280w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2026\/09\/thirst-370x247.jpg 370w\" sizes=\"auto, (max-width: 420px) 100vw, 420px\" \/><\/figure>\n<\/div>\n\n\n<ul class=\"wp-block-list\">\n<li>Kh\u00e1t n\u01b0\u1edbc&nbsp;<\/li>\n\n\n\n<li>Drinking more fluid than normal<\/li>\n\n\n\n<li>\u0110i ti\u1ec3u th\u01b0\u1eddng xuy\u00ean<\/li>\n\n\n\n<li>T\u0103ng l\u01b0\u1ee3ng n\u01b0\u1edbc ti\u1ec3u<\/li>\n\n\n\n<li>Urinating at night<\/li>\n<\/ul>\n\n\n\n<h3 id=\"h-severe-side-effects-of-jynarque\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Severe_Side_Effects_of_Jynarque\"><\/span>Severe Side Effects of Jynarque<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.healthline.com\/health\/hypernatremia\">Hypernatremia<\/a> (elevated blood sodium levels)<\/li>\n\n\n\n<li>Dehydration and hypovolemia (loss of too much fluid from the body)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Jynarque increases water loss through urination and can cause dehydration and hypovolemia (abnormally low fluid volume). Drink enough water throughout the day and night to avoid becoming thirsty or dehydrated. If you cannot drink enough water for any reason, stop taking Jynarque and contact your healthcare provider.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Call your healthcare provider if you experience any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Ch\u00f3ng m\u1eb7t<\/li>\n\n\n\n<li>Ng\u1ea5t x\u1ec9u<\/li>\n\n\n\n<li>Gi\u1ea3m c\u00e2n<\/li>\n\n\n\n<li>Changes in heart rhythm&nbsp;<\/li>\n\n\n\n<li>L\u00fa l\u1eabn<\/li>\n\n\n\n<li>C\u1ef1c k\u1ef3 y\u1ebfu \u0111u\u1ed1i<\/li>\n<\/ul>\n\n\n\n<h3 id=\"h-common-side-effects-of-samsca\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Common_Side_Effects_of_Samsca\"><\/span>Common Side Effects of Samsca<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Kh\u00e1t n\u01b0\u1edbc<\/li>\n\n\n\n<li>Kh\u00f4 mi\u1ec7ng<\/li>\n\n\n\n<li>\u0110i\u1ec3m y\u1ebfu<\/li>\n\n\n\n<li>T\u00e1o b\u00f3n<\/li>\n\n\n\n<li>\u0110i ti\u1ec3u th\u01b0\u1eddng xuy\u00ean<\/li>\n\n\n\n<li>T\u0103ng l\u01b0\u1ee3ng n\u01b0\u1edbc ti\u1ec3u<\/li>\n\n\n\n<li>Elevated blood glucose levels<\/li>\n<\/ul>\n\n\n\n<h3 id=\"h-severe-side-effects-of-samsca\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Severe_Side_Effects_of_Samsca\"><\/span>Severe Side Effects of Samsca<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Call your healthcare provider immediately if you have signs of dehydration, such as dizziness or feeling like you are going to pass out. Tell your healthcare provider if you have vomiting or diarrhea and difficulty drinking fluids.<\/p>\n\n\n\n<h2 id=\"h-tolvaptan-jynarque-samsca-cost\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Tolvaptan_JynarqueSamsca_Cost\"><\/span>Tolvaptan (Jynarque\/Samsca) Cost<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Chi ph\u00ed c\u00f3 th\u1ec3 thay \u0111\u1ed5i t\u00f9y thu\u1ed9c v\u00e0o g\u00f3i b\u1ea3o hi\u1ec3m, \u0111\u1ecba \u0111i\u1ec3m v\u00e0 hi\u1ec7u thu\u1ed1c c\u1ee7a b\u1ea1n. H\u00e3y h\u1ecfi nh\u00e0 cung c\u1ea5p b\u1ea3o hi\u1ec3m xem g\u00f3i b\u1ea3o hi\u1ec3m c\u1ee7a b\u1ea1n c\u00f3 chi tr\u1ea3 cho lo\u1ea1i thu\u1ed1c n\u00e0y kh\u00f4ng ho\u1eb7c b\u1ea1n c\u00f3 c\u1ea7n ph\u1ea3i xin ph\u00e9p tr\u01b0\u1edbc kh\u00f4ng.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Otsuka offers copay assistance for eligible patients who have been prescribed Jynarque. <a href=\"https:\/\/ameripharmaspecialty.com\/vi\/ho-tro-tai-chinh\/\">Li\u00ean h\u1ec7 v\u1edbi ch\u00fang t\u00f4i<\/a> if you are interested in getting <a href=\"https:\/\/ameripharmaspecialty.com\/vi\/tolvaptan-copay-assistance\/\" data-type=\"link\" data-id=\"https:\/\/ameripharmaspecialty.com\/tolvaptan-copay-assistance\/\">copay assistance for tolvaptan<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>Jynarque and Samsca are brand-name prescription medications. Both contain the same active ingredient, tolvaptan. However, these products treat different conditions and should not be used interchangeably.\u00a0<\/p>","protected":false},"author":27,"featured_media":29429,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[4],"tags":[33],"class_list":["post-29427","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-other-health-conditions","tag-dr-samantha-kaeberlein"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.4 (Yoast SEO v28.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Tolvaptan (Jynarque\/Samsca): Uses, Warnings, Doses, and Side Effects - AmeriPharma\u00ae Specialty Care<\/title>\n<meta name=\"description\" content=\"Tolvaptan (Jynarque and Samsca) treats ADPKD and certain cases of hyponatremia. 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Both contain the same active ingredient, tolvaptan. 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