{"id":26018,"date":"2024-04-08T15:10:36","date_gmt":"2024-04-08T22:10:36","guid":{"rendered":"https:\/\/ameripharmaspecialty.com\/toxic-epidermal-necrolysis-ten-causes-symptoms-treatment-and-survival-rate\/"},"modified":"2024-07-09T16:02:30","modified_gmt":"2024-07-09T23:02:30","slug":"toxic-epidermal-necrolysis-ten-causes-symptoms-treatment-and-survival-rate","status":"publish","type":"post","link":"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/toxic-epidermal-necrolysis-ten-causes-symptoms-treatment-and-survival-rate\/","title":{"rendered":"Ho\u1ea1i t\u1eed th\u01b0\u1ee3ng b\u00ec nhi\u1ec5m \u0111\u1ed9c (TEN): Nguy\u00ean nh\u00e2n, tri\u1ec7u ch\u1ee9ng, \u0111i\u1ec1u tr\u1ecb v\u00e0 t\u1ef7 l\u1ec7 s\u1ed1ng s\u00f3t"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Toxic epidermal necrolysis (TEN) is a rare, life-threatening skin reaction. It is most commonly triggered by certain medications. However, in rare cases, it can be caused by infections or vaccinations.\u00a0<\/span><\/p>\n\n\n<div  id=\"call-to-action-4b52422bed32c475aa98d82575ad9c38\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tSpeak to a Specialist About Copay Assistance\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"#form\">Schedule a Consultation<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<p><span style=\"font-weight: 400;\">A severe form of <\/span><a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/stevens-johnson-syndrome\/symptoms-causes\/syc-20355936\"><span style=\"font-weight: 400;\">Steven-Johnson\u2019s syndrome<\/span><\/a><span style=\"font-weight: 400;\"> (SJS), TEN is diagnosed when you have large areas of blistering and peeling skin on more than 30% of your body. TEN also causes extensive damage to the moist linings (mucous membranes) in the mouth, nose, throat, eyes, and genitals.<\/span><br \/><span style=\"font-weight: 400;\">In SJS, you have small areas of peeling skin, affecting less than 10% of your body. SJS-TEN overlap disease is when 10% to 30% of the body is affected.\u00a0<\/span>\u00a0<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/toxic-epidermal-necrolysis-ten-causes-symptoms-treatment-and-survival-rate\/#How_Common_Is_Toxic_Epidermal_Necrolysis\" >How Common Is Toxic Epidermal Necrolysis?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/toxic-epidermal-necrolysis-ten-causes-symptoms-treatment-and-survival-rate\/#What_Causes_Toxic_Epidermal_Necrolysis\" >What Causes Toxic Epidermal Necrolysis?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/toxic-epidermal-necrolysis-ten-causes-symptoms-treatment-and-survival-rate\/#Risk_Factors\" >Risk Factors<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/toxic-epidermal-necrolysis-ten-causes-symptoms-treatment-and-survival-rate\/#Symptoms\" >Symptoms<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/toxic-epidermal-necrolysis-ten-causes-symptoms-treatment-and-survival-rate\/#Toxic_Epidermal_Necrolysis_Treatment\" >Toxic Epidermal Necrolysis Treatment<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/toxic-epidermal-necrolysis-ten-causes-symptoms-treatment-and-survival-rate\/#Intravenous_Immunoglobulin_IVIG\" >Intravenous Immunoglobulin (IVIG)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/toxic-epidermal-necrolysis-ten-causes-symptoms-treatment-and-survival-rate\/#Systemic_steroids\" >Systemic steroids<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/toxic-epidermal-necrolysis-ten-causes-symptoms-treatment-and-survival-rate\/#IVIG_With_Steroids\" >IVIG With Steroids<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/toxic-epidermal-necrolysis-ten-causes-symptoms-treatment-and-survival-rate\/#Plasmapheresis_Plasma_Exchange\" >Plasmapheresis (Plasma Exchange)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/toxic-epidermal-necrolysis-ten-causes-symptoms-treatment-and-survival-rate\/#Tumor_Necrosis_Factor-Alpha_TNF-Alpha_Inhibitors\" >Tumor Necrosis Factor-Alpha (TNF-Alpha) Inhibitors<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/toxic-epidermal-necrolysis-ten-causes-symptoms-treatment-and-survival-rate\/#Toxic_Epidermal_Necrolysis_Survival_Rate\" >Toxic Epidermal Necrolysis Survival Rate<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/toxic-epidermal-necrolysis-ten-causes-symptoms-treatment-and-survival-rate\/#Complications\" >Complications<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/toxic-epidermal-necrolysis-ten-causes-symptoms-treatment-and-survival-rate\/#Sepsis\" >Sepsis<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/toxic-epidermal-necrolysis-ten-causes-symptoms-treatment-and-survival-rate\/#Breathing_Problems\" >Breathing Problems<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/toxic-epidermal-necrolysis-ten-causes-symptoms-treatment-and-survival-rate\/#Eye_Problems\" >Eye Problems<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/toxic-epidermal-necrolysis-ten-causes-symptoms-treatment-and-survival-rate\/#Toxic_Epidermal_Necrolysis_Long-Term_Effects\" >Toxic Epidermal Necrolysis Long-Term Effects<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/toxic-epidermal-necrolysis-ten-causes-symptoms-treatment-and-survival-rate\/#Toxic_Epidermal_Necrolysis_TEN_vs_Steven-Johnsons_Syndrome_SJS\" >Toxic Epidermal Necrolysis (TEN) vs Steven-Johnson\u2019s Syndrome (SJS)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/toxic-epidermal-necrolysis-ten-causes-symptoms-treatment-and-survival-rate\/#Frequently_Asked_Questions\" >Frequently Asked Questions<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"How_Common_Is_Toxic_Epidermal_Necrolysis\"><\/span>How Common Is Toxic Epidermal Necrolysis?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">TEN is a rare condition, affecting 1.9 people per million U.S. adults each year [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK574530\/#\"><span style=\"font-weight: 400;\">1<\/span><\/a><span style=\"font-weight: 400;\">].<\/span>\u00a0<\/p>\n<h2><span class=\"ez-toc-section\" id=\"What_Causes_Toxic_Epidermal_Necrolysis\"><\/span>What Causes Toxic Epidermal Necrolysis?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">In some cases, the exact cause is not known. In others, several factors can induce TEN, including:<\/span><\/p>\n<ul>\n<li><b>Antiseizure medications<\/b><span style=\"font-weight: 400;\">: Phenobarbital, phenytoin, carbamazepine, valproic acid, and lamotrigine<\/span><\/li>\n<li aria-level=\"1\"><b>Antibacterial drugs<\/b><span style=\"font-weight: 400;\">: Sulfonamides (trimethoprim-sulfamethoxazole), chloramphenicol, penicillins, and ciprofloxacin<\/span><\/li>\n<li aria-level=\"1\"><b>Non-steroidal anti-inflammatory drugs (NSAIDs)<\/b><span style=\"font-weight: 400;\">: Piroxicam, meloxicam<\/span><\/li>\n<li aria-level=\"1\"><b>Antigout agents<\/b><span style=\"font-weight: 400;\">: Allopurinol<\/span><\/li>\n<li aria-level=\"1\"><b>Anti-HIV medications<\/b><span style=\"font-weight: 400;\">: Nevirapine and abacavir<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Rare triggers can include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Bacterial infections<\/b><span style=\"font-weight: 400;\">: Mycoplasma pneumoniae infections<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Viral infections<\/b><span style=\"font-weight: 400;\">: Herpes and hepatitis A<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Vaccines<\/b><span style=\"font-weight: 400;\">: Meningococcal B and MMR vaccines\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/ameripharmaspecialty.com\/?s=Graft-versus-host\"><b>Graft-versus-host disease<\/b><\/a> <span style=\"font-weight: 400;\">\u00a0<\/span><\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Risk_Factors\"><\/span>Risk Factors<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The following factors can increase your risk of TEN:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">HIV infection\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weak immune system (such as in HIV\/AIDS and autoimmune disorders)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Personal or family history of TEN<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Genetic factors<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cancer (specifically blood cancers)<\/span><\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Symptoms\"><\/span>Symptoms<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-24020 size-full\" src=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/04\/body-ache.jpg\" alt=\"Mature woman suffering body aches from Toxic Epidermal Necrolysis\" width=\"420\" height=\"280\" srcset=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/04\/body-ache.jpg 420w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/04\/body-ache-300x200.jpg 300w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/04\/body-ache-330x220.jpg 330w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/04\/body-ache-86x57.jpg 86w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/04\/body-ache-167x111.jpg 167w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/04\/body-ache-280x187.jpg 280w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/04\/body-ache-370x247.jpg 370w\" sizes=\"auto, (max-width: 420px) 100vw, 420px\" \/>Symptoms may appear a few weeks after you start taking a drug. Initially, you may have flu-like symptoms, such as:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Body aches<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cough\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fever\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chills<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Red and swollen eyes<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">As the disease progresses, you may have:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Widespread skin pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A rapidly spreading rash affecting more than 30% of your body<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blisters and peeling skin\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sores and swelling on the mucous membranes, including the mouth, eyes, respiratory tract, and genitals<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">These signs and symptoms may resemble other skin diseases. Because TEN is life-threatening, seek immediate medical care if you think you have symptoms of TEN.<\/span>\u00a0<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Toxic_Epidermal_Necrolysis_Treatment\"><\/span>Toxic Epidermal Necrolysis Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">People with TEN need emergency care at a hospital, preferably in an intensive care unit (ICU) or burn center. Treatment is mainly supportive and includes [<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32151629\/\"><span style=\"font-weight: 400;\">2<\/span><\/a><span style=\"font-weight: 400;\">]:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stopping all potential triggers<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Isolation to prevent infection<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Administering IV fluids and nutrition<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Protective dressings and antibacterial creams or ointments to prevent skin infection<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antibiotic therapy if signs of infection are present<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Medications to reduce pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Eye and oral cavity examination\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oxygen via a face mask (if needed)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Medications to prevent blood clots<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">No specific treatment for TEN exists. However, your provider may consider the following based on your age, symptom severity, expectations, and preferences:<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Intravenous_Immunoglobulin_IVIG\"><\/span><span style=\"font-weight: 400;\">Intravenous Immunoglobulin (IVIG)<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><a href=\"https:\/\/ameripharmaspecialty.com\/ivig\/ivig\/\/ivig\/\"><span style=\"font-weight: 400;\">IVIG<\/span><\/a><span style=\"font-weight: 400;\"> is a sterile liquid that contains disease-fighting proteins (<\/span><a href=\"https:\/\/ameripharmaspecialty.com\/ivig\/ivig\/\/immunoglobulins-ig\/\"><span style=\"font-weight: 400;\">immunoglobulins<\/span><\/a><span style=\"font-weight: 400;\"> or antibodies). Some studies show that early treatment with high-dose IVIG can improve survival and speed recovery [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2958184\/\"><span style=\"font-weight: 400;\">3<\/span><\/a><span style=\"font-weight: 400;\">].<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Systemic_steroids\"><\/span><span style=\"font-weight: 400;\">Systemic steroids<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Your provider may give you a steroid to halt the progression of TEN. Nonetheless, the use of steroids is highly controversial. Some studies suggest that steroids may increase the risk of death.\u00a0<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"IVIG_With_Steroids\"><\/span><span style=\"font-weight: 400;\">IVIG With Steroids<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"font-weight: 400;\">According to a recent review published in the <a href=\"https:\/\/www.jaad.org\/\">Journal of the American Academy of Dermatology,<\/a> clinicians should consider combination therapy with IVIG and steroids to treat TEN [<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32898587\/\"><span style=\"font-weight: 400;\">4<\/span><\/a><span style=\"font-weight: 400;\">]. The authors of the review conclude that this combination may reduce death risk in individuals with TEN.\u00a0<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Plasmapheresis_Plasma_Exchange\"><\/span><span style=\"font-weight: 400;\">Plasmapheresis (Plasma Exchange)<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Plasmapheresis separates the liquid part of the blood (plasma) from blood cells. Following separation, the blood cells are mixed with a liquid and infused back into the body.\u00a0<\/span><br \/><span style=\"font-weight: 400;\">Daily plasmapheresis for 3 days can help remove the causative drug, its byproducts, and other inflammatory substances from the body.\u00a0<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Tumor_Necrosis_Factor-Alpha_TNF-Alpha_Inhibitors\"><\/span><span style=\"font-weight: 400;\">Tumor Necrosis Factor-Alpha (TNF-Alpha) Inhibitors<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"font-weight: 400;\">TNF-alpha inhibitors, such as <\/span><a href=\"https:\/\/ameripharmaspecialty.com\/other-health-conditions\/renflexis-infliximab\/\"><span style=\"font-weight: 400;\">infliximab<\/span><\/a><span style=\"font-weight: 400;\"> and etanercept, may help resolve skin lesions in toxic epidermal necrolysis. They may be used alone or as a second-line medication.\u00a0<\/span>\u00a0<\/p>\n\n\n<div  id=\"call-to-action-2e063152ee06f781fd407c8a62316c61\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tCan IVIG help?\u00a0|\u00a0Free IVIG Treatment Info\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"tel:8777780318\">(877) 778-0318<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<p>&nbsp;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Toxic_Epidermal_Necrolysis_Survival_Rate\"><\/span>Toxic Epidermal Necrolysis Survival Rate<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Toxic epidermal necrolysis causes death in about 25% of the cases, and the death rate is lower in children (less than 10%). The death rate is higher if you [<\/span><a href=\"https:\/\/www.msdmanuals.com\/home\/skin-disorders\/hypersensitivity-and-reactive-skin-disorders\/stevens-johnson-syndrome-sjs-and-toxic-epidermal-necrolysis-ten\"><span style=\"font-weight: 400;\">5<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.jaadinternational.org\/article\/S2666-3287(23)00106-2\/fulltext#\"><span style=\"font-weight: 400;\">6<\/span><\/a><span style=\"font-weight: 400;\">]:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Are over 40\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have high blood sugar<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have a fast heart rate<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have chronic kidney disease<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Complications\"><\/span>Complications<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">People older than 70 years are most likely to develop complications. Likewise, the risk of complications is higher in people with liver cirrhosis (scarring of the liver) or cancer.\u00a0<\/span><br \/>\n<span style=\"font-weight: 400;\">Complications of TEN include:<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Sepsis\"><\/span><span style=\"font-weight: 400;\">Sepsis<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Sepsis or blood infection is a life-threatening condition. It happens when the immune response to an infection damages your body\u2019s vital organs, putting you into shock and causing organ failure.\u00a0<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Breathing_Problems\"><\/span><span style=\"font-weight: 400;\">Breathing Problems<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"font-weight: 400;\">If your lungs are involved, you may find it difficult to breathe. In severe cases, your lungs may be too weak, causing an excess of carbon dioxide and a deficiency of oxygen in your blood.\u00a0<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Eye_Problems\"><\/span><span style=\"font-weight: 400;\">Eye Problems<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Eye problems associated with TEN are dry eye, ingrown eyelashes, corneal scarring, and, in rare cases, blindness.<\/span><br \/>\n&nbsp;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Toxic_Epidermal_Necrolysis_Long-Term_Effects\"><\/span>Toxic Epidermal Necrolysis Long-Term Effects<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Some long-term effects among TEN survivors are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry itchy skin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hair or nail loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Excessive sweating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry eyes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sensitivity to light\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lung damage<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">In a recent survey of 121 TEN\/SJS survivors, more than half screened positive for depression, and over 40% screened positive for anxiety [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8100906\/#\"><span style=\"font-weight: 400;\">7<\/span><\/a><span style=\"font-weight: 400;\">].<\/span><br \/>\n&nbsp;<\/p>\n\n\n<div  id=\"call-to-action-f3c54cf672b25350040a1e9994bc9567\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tGet Financial Assistance\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"#form\">Schedule a Consultation<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<p>&nbsp;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Toxic_Epidermal_Necrolysis_TEN_vs_Steven-Johnsons_Syndrome_SJS\"><\/span>Toxic Epidermal Necrolysis (TEN) vs Steven-Johnson\u2019s Syndrome (SJS)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The major differences between TEN and SJS are as follows:<\/span><\/p>\n<table>\n<tbody>\n<tr>\n<td>\n<p style=\"text-align: center;\"><b>Features<\/b><\/p>\n<\/td>\n<td style=\"text-align: center;\">\n<p style=\"text-align: center;\"><b>TEN<\/b><\/p>\n<\/td>\n<td>\n<p style=\"text-align: center;\"><b>SJS<\/b><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<p style=\"text-align: center;\"><b>Severity<\/b><\/p>\n<\/td>\n<td style=\"text-align: center;\">\n<p style=\"text-align: center;\">More severe<\/p>\n<\/td>\n<td style=\"text-align: center;\">\n<p style=\"text-align: center;\">Less severe<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<p style=\"text-align: center;\"><b>Affected body surface<\/b><\/p>\n<\/td>\n<td>\n<p style=\"text-align: center;\">More than 30%<\/p>\n<\/td>\n<td>\n<p style=\"text-align: center;\">Less than 10%<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<p style=\"text-align: center;\"><b>Occurrence in the US<\/b><\/p>\n<\/td>\n<td>\n<p style=\"text-align: center;\">1.9 per million people each year<\/p>\n<\/td>\n<td>\n<p style=\"text-align: center;\">9.3 per million people each year<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\">\n<p style=\"text-align: center;\"><b>Death rate<\/b><\/p>\n<\/td>\n<td style=\"text-align: center;\">\n<p style=\"text-align: center;\">About 25% in adults<\/p>\n<\/td>\n<td>\n<p style=\"text-align: center;\">About 10%<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Frequently_Asked_Questions\"><\/span>Frequently Asked Questions<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h4>Which drug causes toxic epidermal necrolysis?<\/h4>\n<p><span style=\"font-weight: 400;\">Medications commonly associated with toxic epidermal necrolysis are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antiseizure medications: Phenobarbital, phenytoin, carbamazepine, valproic acid, and lamotrigine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antibacterial drugs: Sulfonamides (trimethoprim-sulfamethoxazole), chloramphenicol,\u00a0 penicillins, and ciprofloxacin<\/span><\/li>\n<\/ul>\n<h4>What causes epidermal necrolysis?<\/h4>\n<p><span style=\"font-weight: 400;\">Medications are the primary causes of TEN in adults, whereas infections are the main causes in children.\u00a0\u00a0<\/span><\/p>\n<h4>Which layer of skin is affected by toxic epidermal necrolysis?<\/h4>\n<p><span style=\"font-weight: 400;\">Toxic epidermal necrolysis causes the top layer of your skin (epidermis) to detach from the lower layers of skin (dermis).\u00a0<\/span><\/p>\n<h4>What are the clinical features of toxic epidermal necrolysis?<\/h4>\n<p><span style=\"font-weight: 400;\">TEN causes peeling skin on more than 30% of your body. It also causes extensive damage to the moist linings (mucous membranes) in the mouth, nose, throat, eyes, and genitals.<\/span><br \/>\n&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>Ho\u1ea1i t\u1eed th\u01b0\u1ee3ng b\u00ec nhi\u1ec5m \u0111\u1ed9c (TEN) l\u00e0 m\u1ed9t ph\u1ea3n \u1ee9ng da hi\u1ebfm g\u1eb7p, \u0111e d\u1ecda t\u00ednh m\u1ea1ng. N\u00f3 th\u01b0\u1eddng \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t b\u1edfi m\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c nh\u1ea5t \u0111\u1ecbnh. Tuy nhi\u00ean, trong nh\u1eefng tr\u01b0\u1eddng h\u1ee3p hi\u1ebfm hoi, n\u00f3 c\u00f3 th\u1ec3 do nhi\u1ec5m tr\u00f9ng ho\u1eb7c ti\u00eam ch\u1ee7ng g\u00e2y ra. L\u00e0 m\u1ed9t d\u1ea1ng nghi\u00eam tr\u1ecdng c\u1ee7a h\u1ed9i ch\u1ee9ng Stevens-Johnson (SJS), TEN \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n khi b\u1ea1n c\u00f3 nh\u1eefng v\u00f9ng da ph\u1ed3ng r\u1ed9p v\u00e0 bong tr\u00f3c l\u1edbn tr\u00ean h\u01a1n 30% di\u1ec7n t\u00edch c\u01a1 th\u1ec3.<\/p>","protected":false},"author":27,"featured_media":25924,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":true,"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[4],"tags":[33],"class_list":["post-26018","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-other-health-conditions","tag-dr-samantha-kaeberlein"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Toxic Epidermal Necrolysis (TEN): Causes, Symptoms, Treatment, and 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