{"id":26017,"date":"2024-04-11T13:58:34","date_gmt":"2024-04-11T20:58:34","guid":{"rendered":"https:\/\/ameripharmaspecialty.com\/how-is-ivig-made-the-intricate-steps-of-ivig-manufacturing-revealed\/"},"modified":"2026-03-24T09:34:47","modified_gmt":"2026-03-24T16:34:47","slug":"how-is-ivig-made-the-intricate-steps-of-ivig-manufacturing-revealed","status":"publish","type":"post","link":"https:\/\/ameripharmaspecialty.com\/vi\/ivig\/how-is-ivig-made-the-intricate-steps-of-ivig-manufacturing-revealed\/","title":{"rendered":"IVIG \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t nh\u01b0 th\u1ebf n\u00e0o? C\u00e1c b\u01b0\u1edbc ph\u1ee9c t\u1ea1p c\u1ee7a qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t IVIG \u0111\u01b0\u1ee3c ti\u1ebft l\u1ed9"},"content":{"rendered":"<p><a href=\"https:\/\/ameripharmaspecialty.com\/vi\/ivig\/ivig\/\/ivig\/\"><span style=\"font-weight: 400;\">Globulin mi\u1ec5n d\u1ecbch ti\u00eam t\u0129nh m\u1ea1ch (IVIG)<\/span><\/a><span style=\"font-weight: 400;\"> l\u00e0 m\u1ed9t s\u1ea3n ph\u1ea9m \u0111i\u1ec1u tr\u1ecb \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ebf t\u1eeb huy\u1ebft t\u01b0\u01a1ng c\u1ee7a h\u00e0ng ng\u00e0n ng\u01b0\u1eddi hi\u1ebfn t\u1eb7ng. Huy\u1ebft t\u01b0\u01a1ng ng\u01b0\u1eddi ch\u1ee9a nhi\u1ec1u th\u00e0nh ph\u1ea7n thi\u1ebft y\u1ebfu, bao g\u1ed3m immunoglobulin (Ig), c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 kh\u00e1ng th\u1ec3. <\/span><a href=\"https:\/\/ameripharmaspecialty.com\/vi\/ivig\/ivig\/\/immunoglobulins-ig\/\"><span style=\"font-weight: 400;\">Globulin mi\u1ec5n d\u1ecbch<\/span><\/a><span style=\"font-weight: 400;\"> l\u00e0 th\u00e0nh ph\u1ea7n quan tr\u1ecdng c\u1ee7a h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch v\u00e0 gi\u00fap c\u01a1 th\u1ec3 ch\u1ed1ng l\u1ea1i nhi\u1ec5m tr\u00f9ng.&nbsp;<\/span><\/p>\n\n\n\n<div  id=\"call-to-action-2ec18077b5912b2fc5afc2ff649c5b32\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tH\u1ecfi v\u1ec1 d\u1ecbch truy\u1ec1n IVIG t\u1ea1i nh\u00e0\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"tel:8777780318\">(877) 778-0318<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<p><span style=\"font-weight: 400;\">Qu\u00e1 tr\u00ecnh tinh ch\u1ebf immunoglobulin t\u1eeb huy\u1ebft t\u01b0\u01a1ng \u0111\u1ec3 t\u1ea1o ra li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb cho b\u1ec7nh nh\u00e2n r\u1ea5t ph\u1ee9c t\u1ea1p v\u00e0 t\u1ed1n th\u1eddi gian. Ph\u1ea3i m\u1ea5t kho\u1ea3ng 9 th\u00e1ng \u0111\u1ec3 s\u1ea3n xu\u1ea5t m\u1ed9t l\u00f4 s\u1ea3n ph\u1ea9m IVIG ph\u1ee5c v\u1ee5 m\u1ee5c \u0111\u00edch \u0111i\u1ec1u tr\u1ecb.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">S\u1ea3n ph\u1ea9m IVIG cu\u1ed1i c\u00f9ng bao g\u1ed3m h\u1ed7n h\u1ee3p kh\u00e1ng th\u1ec3 \u0111\u01b0\u1ee3c ti\u00eam t\u0129nh m\u1ea1ch v\u00e0o m\u00e1u c\u1ee7a b\u1ec7nh nh\u00e2n.\u00a0<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Trong b\u00e0i vi\u1ebft n\u00e0y, ch\u00fang t\u00f4i s\u1ebd th\u1ea3o lu\u1eadn v\u1ec1 m\u1ed9t lo\u1ea1t c\u00e1c b\u01b0\u1edbc m\u00e0 m\u1ecdi nh\u00e0 s\u1ea3n xu\u1ea5t \u0111\u1ec1u tu\u00e2n theo \u0111\u1ec3 t\u1ea1o ra dung d\u1ecbch IVIG v\u00f4 tr\u00f9ng cu\u1ed1i c\u00f9ng ph\u1ee5c v\u1ee5 m\u1ee5c \u0111\u00edch \u0111i\u1ec1u tr\u1ecb.\u00a0<\/span><\/p>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Chuy\u1ec3n \u0111\u1ed5i m\u1ee5c l\u1ee5c\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Chuy\u1ec3n \u0111\u1ed5i<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/ivig\/how-is-ivig-made-the-intricate-steps-of-ivig-manufacturing-revealed\/#IVIG_Production_Process\" >Quy tr\u00ecnh s\u1ea3n xu\u1ea5t IVIG<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/ivig\/how-is-ivig-made-the-intricate-steps-of-ivig-manufacturing-revealed\/#Collection_of_Plasma\" >Thu th\u1eadp huy\u1ebft t\u01b0\u01a1ng<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/ivig\/how-is-ivig-made-the-intricate-steps-of-ivig-manufacturing-revealed\/#Plasma_Fractionation\" >Ph\u00e2n \u0111o\u1ea1n huy\u1ebft t\u01b0\u01a1ng<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/ivig\/how-is-ivig-made-the-intricate-steps-of-ivig-manufacturing-revealed\/#Purification_of_IVIG\" >Thanh l\u1ecdc IVIG<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/ivig\/how-is-ivig-made-the-intricate-steps-of-ivig-manufacturing-revealed\/#Removal_of_Harmful_Pathogens\" >Lo\u1ea1i b\u1ecf c\u00e1c t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh c\u00f3 h\u1ea1i<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/ivig\/how-is-ivig-made-the-intricate-steps-of-ivig-manufacturing-revealed\/#Formulation_and_Composition_of_IVIG\" >C\u00f4ng th\u1ee9c v\u00e0 th\u00e0nh ph\u1ea7n c\u1ee7a IVIG<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/ivig\/how-is-ivig-made-the-intricate-steps-of-ivig-manufacturing-revealed\/#Final_Testing_and_Packaging_of_IVIG\" >Ki\u1ec3m tra v\u00e0 \u0111\u00f3ng g\u00f3i cu\u1ed1i c\u00f9ng c\u1ee7a IVIG<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/ivig\/how-is-ivig-made-the-intricate-steps-of-ivig-manufacturing-revealed\/#Conclusion\" >Ph\u1ea7n k\u1ebft lu\u1eadn<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"IVIG_Production_Process\"><\/span>Quy tr\u00ecnh s\u1ea3n xu\u1ea5t IVIG<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">C\u00e1c b\u01b0\u1edbc li\u00ean quan \u0111\u1ebfn qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t IVIG bao g\u1ed3m thu th\u1eadp huy\u1ebft t\u01b0\u01a1ng, ph\u00e2n \u0111o\u1ea1n, tinh ch\u1ebf, b\u00e0o ch\u1ebf, th\u1eed nghi\u1ec7m v\u00e0 \u0111\u00f3ng g\u00f3i.&nbsp;<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Collection_of_Plasma\"><\/span>Thu th\u1eadp huy\u1ebft t\u01b0\u01a1ng<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Quy tr\u00ecnh s\u1ea3n xu\u1ea5t IVIG b\u1eaft \u0111\u1ea7u b\u1eb1ng vi\u1ec7c thu th\u1eadp huy\u1ebft t\u01b0\u01a1ng t\u1eeb h\u00e0ng ng\u00e0n ng\u01b0\u1eddi hi\u1ebfn t\u1eb7ng kh\u1ecfe m\u1ea1nh. Ng\u01b0\u1eddi hi\u1ebfn t\u1eb7ng \u0111\u01b0\u1ee3c l\u1ef1a ch\u1ecdn th\u00f4ng qua s\u00e0ng l\u1ecdc nghi\u00eam ng\u1eb7t \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 \u0111\u1ed9 an to\u00e0n cao nh\u1ea5t c\u1ee7a huy\u1ebft t\u01b0\u01a1ng.\u00a0<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Huy\u1ebft t\u01b0\u01a1ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 s\u1ea3n xu\u1ea5t IVIG \u0111\u01b0\u1ee3c l\u1ea5y t\u1eeb hai ngu\u1ed3n: Kho\u1ea3ng <\/span><b>20% \u0111\u1ebfn t\u1eeb nh\u1eefng ng\u01b0\u1eddi hi\u1ebfn m\u00e1u<\/b><span style=\"font-weight: 400;\">, trong khi ph\u1ea7n c\u00f2n l\u1ea1i <\/span><b>80% c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb ng\u01b0\u1eddi hi\u1ebfn huy\u1ebft t\u01b0\u01a1ng<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">V\u00ec immunoglobulin ch\u1ec9 chi\u1ebfm m\u1ed9t ph\u1ea7n nh\u1ecf trong huy\u1ebft t\u01b0\u01a1ng, n\u00ean c\u1ea7n r\u1ea5t nhi\u1ec1u l\u1ea7n hi\u1ebfn t\u1eb7ng \u0111\u1ec3 s\u1ea3n xu\u1ea5t \u0111\u1ee7 IVIG \u0111i\u1ec1u tr\u1ecb cho b\u1ec7nh nh\u00e2n. V\u00ed d\u1ee5, \u0111\u1ec3 s\u1ea3n xu\u1ea5t \u0111\u1ee7 IG \u0111i\u1ec1u tr\u1ecb cho m\u1ed9t b\u1ec7nh nh\u00e2n suy gi\u1ea3m mi\u1ec5n d\u1ecbch trong m\u1ed9t n\u0103m, c\u1ea7n kho\u1ea3ng 130 l\u1ea7n hi\u1ebfn t\u1eb7ng t\u1eeb nh\u1eefng ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Plasma_Fractionation\"><\/span>Ph\u00e2n \u0111o\u1ea1n huy\u1ebft t\u01b0\u01a1ng<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Sau khi thu th\u1eadp huy\u1ebft t\u01b0\u01a1ng, m\u1ed9t lo\u1ea1t c\u00e1c qu\u00e1 tr\u00ecnh ph\u00e2n \u0111o\u1ea1n di\u1ec5n ra, trong \u0111\u00f3 c\u00e1c protein huy\u1ebft t\u01b0\u01a1ng nh\u01b0 globulin mi\u1ec5n d\u1ecbch, c\u00e1c y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u v\u00e0 <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459198\/#:~:text=Albumin%20is%20the%20most%20abundant,to%2015%20gm%20per%20day.\"><span style=\"font-weight: 400;\">albumin<\/span><\/a><span style=\"font-weight: 400;\"> \u0111\u01b0\u1ee3c t\u00e1ch ra kh\u1ecfi c\u00e1c th\u00e0nh ph\u1ea7n plasma kh\u00e1c.\u00a0<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">K\u1ef9 thu\u1eadt ph\u00e2n \u0111o\u1ea1n c\u1ee7a Cohn, \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n b\u1edfi <\/span><a href=\"https:\/\/en.wikipedia.org\/wiki\/Edwin_Joseph_Cohn\"><span style=\"font-weight: 400;\">Edwin J. Cohn<\/span><\/a><span style=\"font-weight: 400;\"> trong Th\u1ebf chi\u1ebfn II, ph\u01b0\u01a1ng ph\u00e1p n\u00e0y th\u01b0\u1eddng \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n, v\u1edbi m\u1ed9t s\u1ed1 c\u1ea3i ti\u1ebfn m\u1edbi h\u01a1n, \u0111\u1ec3 chi\u1ebft xu\u1ea5t dung d\u1ecbch immunoglobulin c\u00f4 \u0111\u1eb7c t\u1eeb huy\u1ebft t\u01b0\u01a1ng. Trong k\u1ef9 thu\u1eadt n\u00e0y, m\u1ed9t l\u01b0\u1ee3ng nh\u1ecf c\u1ed3n (ethanol) \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 gi\u1ea3m \u0111\u1ed9 pH v\u00e0 c\u01b0\u1eddng \u0111\u1ed9 ion nh\u1eb1m t\u00e1ch albumin v\u00e0 c\u00e1c protein huy\u1ebft t\u01b0\u01a1ng kh\u00e1c d\u1ef1a tr\u00ean \u0111\u1ed9 h\u00f2a tan c\u1ee7a ch\u00fang.\u00a0<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Trong qu\u00e1 tr\u00ecnh n\u00e0y, nhi\u1ec7t \u0111\u1ed9 \u0111\u01b0\u1ee3c gi\u1eef \u1edf m\u1ee9c th\u1ea5p \u0111\u1ec3 gi\u1ea3m kh\u1ea3 n\u0103ng nhi\u1ec5m b\u1ea9n v\u00e0 cho ph\u00e9p ph\u00e2n \u0111o\u1ea1n \u1edf quy m\u00f4 l\u1edbn.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Purification_of_IVIG\"><\/span>Thanh l\u1ecdc IVIG<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright\"><img decoding=\"async\" src=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/04\/ivig-300x200.jpg\" alt=\"IVIG fluid being administered in hospital\" class=\"wp-image-24016\"\/><\/figure>\n<\/div>\n\n\n<p><span style=\"font-weight: 400;\">Sau khi c\u00e1c globulin mi\u1ec5n d\u1ecbch \u0111\u01b0\u1ee3c t\u00e1ch b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p ph\u00e2n \u0111o\u1ea1n, qu\u00e1 tr\u00ecnh tinh ch\u1ebf nghi\u00eam ng\u1eb7t \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n \u0111\u1ec3 t\u1ea1o ra dung d\u1ecbch globulin mi\u1ec5n d\u1ecbch c\u00f4 \u0111\u1eb7c. Qu\u00e1 tr\u00ecnh tinh ch\u1ebf lo\u1ea1i b\u1ecf c\u00e1c protein kh\u00f4ng ho\u1ea1t \u0111\u1ed9ng, t\u1ea1p ch\u1ea5t v\u00e0 ch\u1ea5t g\u00e2y \u00f4 nhi\u1ec5m kh\u1ecfi dung d\u1ecbch. \u0110\u1ec3 tinh ch\u1ebf globulin mi\u1ec5n d\u1ecbch, c\u1ea7n c\u00f3 c\u00e1c ph\u01b0\u01a1ng ph\u00e1p kh\u00e1c nhau. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5206469\/#:~:text=Chromatography%20is%20an%20important%20biophysical,for%20qualitative%20and%20quantitative%20analysis.\"><span style=\"font-weight: 400;\">s\u1eafc k\u00fd<\/span><\/a><span style=\"font-weight: 400;\"> c\u00e1c ph\u01b0\u01a1ng ph\u00e1p nh\u01b0 s\u1eafc k\u00fd trao \u0111\u1ed5i ion s\u1eed d\u1ee5ng DEAE Sephadex\u00ae, s\u1eafc k\u00fd c\u1ea3m \u1ee9ng \u0111i\u1ec7n t\u00edch k\u1ef5 n\u01b0\u1edbc v\u00e0 s\u1eafc k\u00fd lo\u1ea1i tr\u1eeb k\u00edch th\u01b0\u1edbc \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng.\u00a0<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">M\u1ed7i k\u1ef9 thu\u1eadt s\u1eafc k\u00fd l\u00e0 duy nh\u1ea5t v\u00e0 mang l\u1ea1i <\/span>95% \u2013 97% c\u1ee7a IgG tinh khi\u1ebft cao<span style=\"font-weight: 400;\"> t\u1eeb th\u1ec3 t\u00edch nh\u1ecf huy\u1ebft t\u01b0\u01a1ng ng\u01b0\u1eddi trong quy tr\u00ecnh tinh ch\u1ebf m\u1ed9t b\u01b0\u1edbc. V\u00ed d\u1ee5, s\u1eafc k\u00fd c\u1ed9t DEAE Sephadex\u00ae t\u1ea1o ra dung d\u1ecbch IgG 95% c\u00f3 \u0111\u1ed9 tinh khi\u1ebft cao.\u00a0<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Ng\u01b0\u1ee3c l\u1ea1i, s\u1eafc k\u00fd lo\u1ea1i tr\u1eeb k\u00edch th\u01b0\u1edbc gi\u00fap t\u00e1ch c\u00e1c d\u1ea1ng immunoglobulin IgG kh\u00e1c nhau d\u1ef1a tr\u00ean k\u00edch th\u01b0\u1edbc t\u01b0\u01a1ng \u1ee9ng c\u1ee7a ch\u00fang kh\u1ecfi huy\u1ebft t\u01b0\u01a1ng g\u1ed9p.\u00a0<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">H\u01a1n n\u1eefa, c\u00e1c quy tr\u00ecnh s\u1eafc k\u00fd c\u00f2n gi\u00fap lo\u1ea1i b\u1ecf immunoglobulin IgA, c\u00f3 th\u1ec3 g\u00e2y s\u1ed1c ph\u1ea3n v\u1ec7 nghi\u00eam tr\u1ecdng \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n thi\u1ebfu h\u1ee5t IgA v\u00e0 c\u00f3 kh\u00e1ng th\u1ec3 anti IgA trong m\u00e1u.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Removal_of_Harmful_Pathogens\"><\/span>Lo\u1ea1i b\u1ecf c\u00e1c t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh c\u00f3 h\u1ea1i<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">V\u00ec IVIG \u0111\u01b0\u1ee3c t\u1ea1o th\u00e0nh t\u1eeb c\u00e1c nh\u00f3m huy\u1ebft t\u01b0\u01a1ng t\u1eeb h\u00e0ng ng\u00e0n ng\u01b0\u1eddi hi\u1ebfn t\u1eb7ng, n\u00ean c\u00f3 kh\u1ea3 n\u0103ng m\u1ed9t lo\u1ea1i vi-r\u00fat nh\u01b0 HIV ho\u1eb7c <a href=\"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hepatitis-c#:~:text=Hepatitis%20C%20is%20an%20inflammation,including%20liver%20cirrhosis%20and%20cancer.\">Vi\u00eam gan C<\/a> c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ch\u1ee9a trong m\u1eabu. M\u1eb7c d\u00f9 vi\u1ec7c l\u1ef1a ch\u1ecdn ng\u01b0\u1eddi hi\u1ebfn IVIG \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n r\u1ea5t c\u1ea9n th\u1eadn b\u1eb1ng c\u00e1ch s\u00e0ng l\u1ecdc ng\u01b0\u1eddi hi\u1ebfn v\u00e0 ki\u1ec3m tra m\u1eabu hi\u1ebfn \u0111\u1ec3 t\u00ecm virus ho\u1eb7c vi khu\u1ea9n, nh\u01b0ng vi\u1ec7c s\u1eed d\u1ee5ng quy tr\u00ecnh ph\u00e2n \u0111o\u1ea1n l\u00e0 r\u1ea5t quan tr\u1ecdng \u0111\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c \u0111\u1ed9 tinh khi\u1ebft cao trong m\u1eabu.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Ngo\u00e0i ra, m\u1ed9t s\u1ed1 ph\u01b0\u01a1ng ph\u00e1p \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf \u0111\u1ec3 lo\u1ea1i b\u1ecf ho\u1eb7c v\u00f4 hi\u1ec7u h\u00f3a c\u00e1c t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh do vi-r\u00fat nh\u01b0 sau:<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><b>X\u1eed l\u00fd b\u1eb1ng dung m\u00f4i\/ch\u1ea5t t\u1ea9y r\u1eeda (S\/D)<\/b><span style=\"font-weight: 400;\"> v\u00f4 hi\u1ec7u h\u00f3a vi-r\u00fat b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng c\u00e1c h\u00f3a ch\u1ea5t ph\u00e1 h\u1ee7y l\u1edbp v\u1ecf ngo\u00e0i c\u1ee7a ch\u00fang.<\/span><\/li>\n\n\n\n<li><b>Thanh tr\u00f9ng <\/b><span style=\"font-weight: 400;\">l\u00e0 qu\u00e1 tr\u00ecnh \u0111un n\u00f3ng dung d\u1ecbch IVIG \u0111\u1ebfn 60\u2103 trong 10 gi\u1edd.<\/span><\/li>\n\n\n\n<li><b>B\u1ee9c x\u1ea1 UVC v\u00e0 b\u1ee9c x\u1ea1 li\u1ec1u th\u1ea5p<\/b><span style=\"font-weight: 400;\"> ph\u01b0\u01a1ng ph\u00e1p \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ti\u00eau di\u1ec7t vi-r\u00fat b\u1eb1ng c\u00e1ch t\u1ea5n c\u00f4ng v\u00e0o c\u1ea5u tr\u00fac di truy\u1ec1n c\u1ee7a n\u00f3.\u00a0<\/span><\/li>\n\n\n\n<li><b>X\u1eed l\u00fd pH th\u1ea5p<\/b><span style=\"font-weight: 400;\"> ph\u00e1 v\u1ee1 l\u1edbp b\u1ea3o v\u1ec7 c\u1ee7a vi-r\u00fat v\u00e0 thay \u0111\u1ed5i c\u1ea5u tr\u00fac protein.\u00a0<\/span><\/li>\n\n\n\n<li><b>L\u1ecdc nano <\/b><span style=\"font-weight: 400;\">l\u00e0 m\u1ed9t lo\u1ea1i ph\u01b0\u01a1ng ph\u00e1p si\u00eau l\u1ecdc trong \u0111\u00f3 dung d\u1ecbch IVIG \u0111i qua m\u00e0ng (b\u1ed9 l\u1ecdc) c\u00f3 c\u00e1c l\u1ed7 qu\u00e1 nh\u1ecf \u0111\u1ec3 vi-r\u00fat c\u00f3 th\u1ec3 l\u1ecdt qua.\u00a0<\/span><\/li>\n<\/ul>\n\n\n\n<div  id=\"call-to-action-b6e14080588f89b773b213e5da24abd2\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tIVIG c\u00f3 th\u1ec3 gi\u00fap \u00edch g\u00ec? | Th\u00f4ng tin \u0111i\u1ec1u tr\u1ecb IVIG mi\u1ec5n ph\u00ed\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"#form\">L\u00ean l\u1ecbch t\u01b0 v\u1ea5n<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Formulation_and_Composition_of_IVIG\"><\/span>C\u00f4ng th\u1ee9c v\u00e0 th\u00e0nh ph\u1ea7n c\u1ee7a IVIG<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Sau khi IVIG \u0111\u01b0\u1ee3c tinh ch\u1ebf, n\u00f3 tr\u1ea3i qua qu\u00e1 tr\u00ecnh \u0111i\u1ec1u ch\u1ebf v\u00e0 \u1ed5n \u0111\u1ecbnh \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o hi\u1ec7u qu\u1ea3 v\u00e0 \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh. C\u00e1c nh\u00e0 s\u1ea3n xu\u1ea5t \u0111i\u1ec1u ch\u1ebf v\u00e0 \u1ed5n \u0111\u1ecbnh dung d\u1ecbch IVIG b\u1eb1ng c\u00e1ch \u0111i\u1ec1u ch\u1ec9nh \u0111\u1ed9 pH v\u00e0 th\u00eam c\u00e1c ch\u1ea5t \u1ed5n \u0111\u1ecbnh nh\u01b0 \u0111\u01b0\u1eddng ho\u1eb7c axit amin. B\u01b0\u1edbc n\u00e0y l\u00e0m cho m\u1ed7i s\u1ea3n ph\u1ea9m IVIG kh\u00e1c nhau v\u1ec1 c\u00f4ng th\u1ee9c v\u00e0 th\u00e0nh ph\u1ea7n.&nbsp;<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Final_Testing_and_Packaging_of_IVIG\"><\/span>Ki\u1ec3m tra v\u00e0 \u0111\u00f3ng g\u00f3i cu\u1ed1i c\u00f9ng c\u1ee7a IVIG<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">C\u00e1c s\u1ea3n ph\u1ea9m IVIG tr\u1ea3i qua quy tr\u00ecnh ki\u1ec3m tra v\u00e0 ki\u1ec3m so\u00e1t ch\u1ea5t l\u01b0\u1ee3ng nghi\u00eam ng\u1eb7t trong su\u1ed1t qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t. Nhi\u1ec1u x\u00e9t nghi\u1ec7m v\u00e0 ph\u00e2n t\u00edch \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n \u0111\u1ec3 lo\u1ea1i b\u1ecf c\u00e1c ch\u1ea5t g\u00e2y \u00f4 nhi\u1ec5m, m\u1ea7m b\u1ec7nh virus ho\u1eb7c prion.\u00a0<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Sau khi ho\u00e0n t\u1ea5t c\u00e1c th\u1eed nghi\u1ec7m ki\u1ec3m so\u00e1t ch\u1ea5t l\u01b0\u1ee3ng, s\u1ea3n ph\u1ea9m cu\u1ed1i c\u00f9ng \u0111\u01b0\u1ee3c chuy\u1ec3n v\u00e0o l\u1ecd trong m\u00f4i tr\u01b0\u1eddng v\u00f4 tr\u00f9ng v\u00e0 \u1ee7 trong v\u00e0i tu\u1ea7n \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 \u0111\u1ed9 an to\u00e0n cao.\u00a0<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Sau khi ki\u1ec3m tra l\u1ea7n cu\u1ed1i, IVIG \u0111\u01b0\u1ee3c d\u00e1n nh\u00e3n, \u0111\u00f3ng g\u00f3i v\u00e0 chuy\u1ec3n \u0111\u1ebfn c\u00e1c c\u01a1 s\u1edf ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe \u0111\u1ec3 s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb.\u00a0<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Conclusion\"><\/span>Ph\u1ea7n k\u1ebft lu\u1eadn<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">IVIG \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t t\u1eeb huy\u1ebft t\u01b0\u01a1ng c\u1ee7a h\u00e0ng ng\u00e0n ng\u01b0\u1eddi hi\u1ebfn t\u1eb7ng, sau \u0111\u00f3 \u0111\u01b0\u1ee3c tinh ch\u1ebf th\u00f4ng qua c\u00e1c ph\u01b0\u01a1ng ph\u00e1p tinh ch\u1ebf v\u00e0 ki\u1ec3m so\u00e1t ch\u1ea5t l\u01b0\u1ee3ng nghi\u00eam ng\u1eb7t. T\u1eeb kh\u00e2u thu th\u1eadp huy\u1ebft t\u01b0\u01a1ng \u0111\u1ebfn pha ch\u1ebf dung d\u1ecbch IVIG v\u00f4 tr\u00f9ng, quy tr\u00ecnh thu th\u1eadp \u0111\u01b0\u1ee3c tu\u00e2n th\u1ee7 nghi\u00eam ng\u1eb7t \u1edf m\u1ecdi b\u01b0\u1edbc \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o t\u00ednh an to\u00e0n, hi\u1ec7u qu\u1ea3 v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng c\u1ee7a s\u1ea3n ph\u1ea9m.&nbsp;<\/span><br>&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>Globulin mi\u1ec5n d\u1ecbch ti\u00eam t\u0129nh m\u1ea1ch (IVIG) l\u00e0 m\u1ed9t s\u1ea3n ph\u1ea9m \u0111i\u1ec1u tr\u1ecb \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ebf t\u1eeb huy\u1ebft t\u01b0\u01a1ng thu th\u1eadp t\u1eeb h\u00e0ng ngh\u00ecn ng\u01b0\u1eddi hi\u1ebfn t\u1eb7ng. Huy\u1ebft t\u01b0\u01a1ng ng\u01b0\u1eddi ch\u1ee9a m\u1ed9t s\u1ed1 th\u00e0nh ph\u1ea7n thi\u1ebft y\u1ebfu, bao g\u1ed3m globulin mi\u1ec5n d\u1ecbch (Ig), c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 kh\u00e1ng th\u1ec3. Globulin mi\u1ec5n d\u1ecbch l\u00e0 th\u00e0nh ph\u1ea7n quan tr\u1ecdng c\u1ee7a h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch v\u00e0 gi\u00fap c\u01a1 th\u1ec3 ch\u1ed1ng l\u1ea1i nhi\u1ec5m tr\u00f9ng.\u00a0<\/p>","protected":false},"author":27,"featured_media":25927,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[7],"tags":[33],"class_list":["post-26017","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ivig","tag-dr-samantha-kaeberlein"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>How is IVIG Made? The IVIG Production Process | AmeriPharma<\/title>\n<meta name=\"description\" content=\"Learn how IVIG is made, from plasma collection and fractionation to purification. Discover the intricate steps of immunoglobulin manufacturing.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/ivig\/how-is-ivig-made-the-intricate-steps-of-ivig-manufacturing-revealed\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"How is IVIG Made? The IVIG Production Process | AmeriPharma\" \/>\n<meta property=\"og:description\" content=\"Learn how IVIG is made, from plasma collection and fractionation to purification. 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