{"id":23840,"date":"2024-01-30T11:39:31","date_gmt":"2024-01-30T19:39:31","guid":{"rendered":"https:\/\/ameripharmaspecialty.com\/ivig-for-rheumatoid-arthritis-does-it-really-work\/"},"modified":"2026-03-20T15:14:34","modified_gmt":"2026-03-20T22:14:34","slug":"ivig-for-rheumatoid-arthritis-does-it-really-work","status":"publish","type":"post","link":"https:\/\/ameripharmaspecialty.com\/vi\/ivig\/ivig-for-rheumatoid-arthritis-does-it-really-work\/","title":{"rendered":"IVIG \u0111i\u1ec1u tr\u1ecb vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p: Li\u1ec7u c\u00f3 th\u1ef1c s\u1ef1 hi\u1ec7u qu\u1ea3?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">High-dose IVIG for rheumatoid arthritis (RA) is promising, but its use is still considered investigational.\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n\n\n<div  id=\"call-to-action-b14b83aeb78906c0b2402e3d399503e6\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tConsult an IVIG Specialist\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"cta__sub__heading\">\n\t\t\t\t\t\t\tThe Best IVIG Home Infusion\u00a0|\u00a0Get IVIG Treatment Assistance\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"tel:8777780318\">(877) 778-0318<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<p><span style=\"font-weight: 400;\">It is well established that IVIG regulates your immune response. Moreover, serious toxicity is infrequent with <a href=\"https:\/\/ameripharmaspecialty.com\/conditions-treatments\/immune-globulin-ig\/\">IVIG therapy<\/a>. Both these factors make it an attractive alternative to corticosteroids or other medications used to treat rheumatoid arthritis.&nbsp;&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">IVIG therapy has been shown to be effective in several diseases, including [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4334686\/\"><span style=\"font-weight: 400;\">1<\/span><\/a><span style=\"font-weight: 400;\">]:<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">Kawasaki disease<\/span><\/li>\n\n\n\n<li><a href=\"https:\/\/ameripharmaspecialty.com\/ivig\/ivig-for-cidp\/\"><span style=\"font-weight: 400;\">Chronic inflammatory demyelinating polyneuropathy (CIDP)<\/span><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/ameripharmaspecialty.com\/guillain-barre-syndrome\/gbs-guillain-barre-syndrome\/\"><span style=\"font-weight: 400;\">Guillain\u2013Barr\u00e9 syndrome (GBS)<\/span><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/ameripharmaspecialty.com\/ivig\/ivig-for-hemolytic-anemia-is-this-treatment-right-for-you\/\"><span style=\"font-weight: 400;\">Autoimmune hemolytic anemia<\/span><\/a><\/li>\n<\/ul>\n\n\n\n<p><span style=\"font-weight: 400;\">Individuals with immunoglobulin deficiencies may be at risk for developing rheumatoid arthritis, and IVIG appears to be a potential treatment for rheumatoid arthritis [<\/span><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00296-021-04871-x\"><span style=\"font-weight: 400;\">2<\/span><\/a><span style=\"font-weight: 400;\">].<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">But does it really work? This article explores the evidence, potential mechanism of action, and the limitations of use.&nbsp;<\/span><\/p>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/ivig\/ivig-for-rheumatoid-arthritis-does-it-really-work\/#A_Quick_Overview_of_the_Prevalence_and_Treatment_Options_for_Rheumatoid_Arthritis\" >A Quick Overview of the Prevalence and Treatment Options for Rheumatoid Arthritis<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/ivig\/ivig-for-rheumatoid-arthritis-does-it-really-work\/#IVIG_for_Rheumatoid_Arthritis_A_Closer_Look_at_the_Evidence\" >IVIG for Rheumatoid Arthritis: A Closer Look at the Evidence<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/ivig\/ivig-for-rheumatoid-arthritis-does-it-really-work\/#Potential_Mechanism_of_IVIG_for_Rheumatoid_Arthritis\" >Potential Mechanism of IVIG for Rheumatoid Arthritis<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/ivig\/ivig-for-rheumatoid-arthritis-does-it-really-work\/#The_Limitations_of_IVIG_for_Rheumatoid_Arthritis\" >The Limitations of IVIG for Rheumatoid Arthritis<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/ivig\/ivig-for-rheumatoid-arthritis-does-it-really-work\/#Key_Takeaways\" >Key Takeaways<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"A_Quick_Overview_of_the_Prevalence_and_Treatment_Options_for_Rheumatoid_Arthritis\"><\/span>A Quick Overview of the Prevalence and Treatment Options for Rheumatoid Arthritis<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Rheumatoid arthritis is an autoimmune disorder that affects your joints. It occurs when your immune system attacks the tissues of your joints. This leads to joint pain, swelling, and stiffness. Approximately 1.3 million U.S. adults live with this condition [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8348893\/\"><span style=\"font-weight: 400;\">3<\/span><\/a><span style=\"font-weight: 400;\">].<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Medical treatments include:<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">Nonsteroidal anti-inflammatory drugs (NSAIDs) to relieve pain and reduce inflammation<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Corticosteroids to reduce inflammation and pain and slow joint damage<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Conventional disease-modifying antirheumatic drugs (DMARDs). Examples include methotrexate (Trexall), leflunomide (Arava), and hydroxychloroquine (Plaquenil).&nbsp;<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Biologic agents, such as etanercept (<a href=\"https:\/\/ameripharmaspecialty.com\/discontinued\/enbrel-etanercept-unlocking-relief-for-autoimmune-disorders\/\" type=\"link\" id=\"https:\/\/ameripharmaspecialty.com\/discontinued\/enbrel-etanercept-unlocking-relief-for-autoimmune-disorders\/\">Enbrel<\/a>), <\/span><a href=\"https:\/\/ameripharmaspecialty.com\/other-health-conditions\/what-is-inflectra-infliximab-dyyb\/\"><span style=\"font-weight: 400;\">infliximab (Inflectra)<\/span><\/a><span style=\"font-weight: 400;\">, and <\/span><a href=\"https:\/\/ameripharmaspecialty.com\/cancer\/rituximab-rituxan\/\"><span style=\"font-weight: 400;\">rituximab (Rituxan)<\/span><\/a><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Targeted synthetic DMARDs, such as baricitinib (Olumiant), tofacitinib (<a href=\"https:\/\/ameripharmaspecialty.com\/discontinued\/xeljanz-for-autoimmune-diseases-how-it-works-who-its-for-and-what-to-expect\/\" type=\"link\" id=\"https:\/\/ameripharmaspecialty.com\/discontinued\/xeljanz-for-autoimmune-diseases-how-it-works-who-its-for-and-what-to-expect\/\">Xeljanz<\/a>), and <\/span>upadacitinib (<a href=\"https:\/\/ameripharmaspecialty.com\/discontinued\/the-role-of-rinvoq-in-addressing-multiple-inflammatory-disorders\/\" type=\"link\" id=\"https:\/\/ameripharmaspecialty.com\/discontinued\/the-role-of-rinvoq-in-addressing-multiple-inflammatory-disorders\/\">Rinvoq<\/a>)<\/li>\n<\/ul>\n\n\n\n<p><span style=\"font-weight: 400;\">Lastly, surgery may be considered if medications don\u2019t resolve symptoms.<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"IVIG_for_Rheumatoid_Arthritis_A_Closer_Look_at_the_Evidence\"><\/span>IVIG for Rheumatoid Arthritis: A Closer Look at the Evidence<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Overall, there is conflicting evidence on the benefits of IVIG for RA.&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">A 1994 trial in children with active RA failed to show any significant benefit of IVIG over placebo [<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7699642\/\"><span style=\"font-weight: 400;\">4<\/span><\/a><span style=\"font-weight: 400;\">].&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">However, in a 1995 study, researchers administered 400 mg\/kg of IVIG to 10 participants with active, treatment-resistant RA for the first 3 days, followed by monthly doses for 12 months. After monthly clinical and laboratory evaluations, they concluded that IVIG can improve symptoms and functional capability [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1005599\/\"><span style=\"font-weight: 400;\">5<\/span><\/a><span style=\"font-weight: 400;\">].<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">A separate 1996 trial found no evidence of the efficacy of IVIG in RA [<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8978962\/#\"><span style=\"font-weight: 400;\">6<\/span><\/a><span style=\"font-weight: 400;\">].<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Authors of a 2015 review concluded that IVIG might be an option if you cannot take corticosteroids or other RA medications [<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25870941\/\"><span style=\"font-weight: 400;\">7<\/span><\/a><span style=\"font-weight: 400;\">].<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">In a 2021 investigation, researchers observed the potent anti-inflammatory action of IVIG in mice, suggesting the potential role of IVIG for rheumatoid arthritis in humans [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7874841\/#\"><span style=\"font-weight: 400;\">8<\/span><\/a><span style=\"font-weight: 400;\">].<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Potential_Mechanism_of_IVIG_for_Rheumatoid_Arthritis\"><\/span>Potential Mechanism of IVIG for Rheumatoid Arthritis<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">In 2023, German researchers published a paper suggesting the potential IVIG mechanism of action in RA. According to the article, IVIG suppresses the degeneration of bones and cartilage in joints at a molecular level [<\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1074761323000936?via%3Dihub\"><span style=\"font-weight: 400;\">9<\/span><\/a><span style=\"font-weight: 400;\">].<\/span><\/p>\n\n\n\n<div  id=\"call-to-action-b128eed5dfcc8d9721a4c6c177088968\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tSpeak to a Specialist About Copay Assistance\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"#form\">Schedule a Consultation<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<p>&nbsp;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"The_Limitations_of_IVIG_for_Rheumatoid_Arthritis\"><\/span>The Limitations of IVIG for Rheumatoid Arthritis<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The first limitation is that IVIG is not FDA-approved to treat RA. In addition, many professional organizations recommend against using IVIG for rheumatoid arthritis.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For instance, the \u201cCriteria for the clinical use of intravenous immunoglobulin in Australia\u201d does not support the use of IVIG for rheumatoid arthritis and recommends alternative treatments [<\/span><a href=\"https:\/\/blood.gov.au\/pubs\/ivig\/conditions-for-which-IVIg-use-is-not-supported.html#cdn-32\"><span style=\"font-weight: 400;\">10<\/span><\/a><span style=\"font-weight: 400;\">].<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Moreover, researchers have yet to discover the exact mechanism of action, optimal dosage, and long-term effects.\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Key_Takeaways\"><\/span>Key Takeaways<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">IVIG is an investigational treatment option for RA.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Many treatment options with proven efficacy are available, such as corticosteroids and DMARDs.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">There is no evidence to support the use of IVIG for rheumatoid arthritis. However, it may be considered an option if conventional treatments fail.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Large controlled trials are needed to establish the benefits of IVIG in people with RA.<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>IVIG li\u1ec1u cao cho b\u1ec7nh vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p (RA) c\u00f3 tri\u1ec3n v\u1ecdng, nh\u01b0ng vi\u1ec7c s\u1eed d\u1ee5ng v\u1eabn c\u00f2n \u0111ang trong giai \u0111o\u1ea1n nghi\u00ean c\u1ee9u. IVIG \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh r\u00f5 r\u00e0ng l\u00e0 c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u h\u00f2a \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch. H\u01a1n n\u1eefa, li\u1ec7u ph\u00e1p IVIG \u00edt khi g\u00e2y ra \u0111\u1ed9c t\u00ednh nghi\u00eam tr\u1ecdng.<\/p>","protected":false},"author":7,"featured_media":23841,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":true,"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[7,51],"tags":[8],"class_list":["post-23840","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ivig","category-rheumatoid-arthritis","tag-dr-christine-leduc"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>IVIG for Rheumatoid Arthritis: Does It Really Work?<\/title>\n<meta name=\"description\" content=\"This article explores how IVIG may help with rheumatoid arthritis. 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Ti\u1ebfn s\u0129 Leduc hi\u1ec7n \u0111ang h\u01b0\u1edbng d\u1eabn sinh vi\u00ean t\u1eeb \u0110\u1ea1i h\u1ecdc Marshall B. Ketchum, \u0110\u1ea1i h\u1ecdc Kansas v\u00e0 \u0110\u1ea1i h\u1ecdc Midwestern. Trong th\u1eddi gian r\u1ea3nh r\u1ed7i, c\u00f4 th\u00edch \u0111i du l\u1ecbch, l\u00e0m b\u00e1nh v\u00e0 l\u00e0m v\u01b0\u1eddn. 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Moreover, serious toxicity is infrequent with IVIG therapy.","_links":{"self":[{"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/posts\/23840","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/comments?post=23840"}],"version-history":[{"count":0,"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/posts\/23840\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/media\/23841"}],"wp:attachment":[{"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/media?parent=23840"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/categories?post=23840"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/tags?post=23840"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}