{"id":23387,"date":"2023-10-05T12:01:19","date_gmt":"2023-10-05T19:01:19","guid":{"rendered":"https:\/\/ameripharmaspecialty.com\/?p=23387"},"modified":"2026-04-07T10:43:13","modified_gmt":"2026-04-07T17:43:13","slug":"ivig-premedication-essential-things-to-know","status":"publish","type":"post","link":"https:\/\/ameripharmaspecialty.com\/vi\/ivig\/ivig-premedication-essential-things-to-know\/","title":{"rendered":"Chu\u1ea9n b\u1ecb tr\u01b0\u1edbc khi truy\u1ec1n IVIG: M\u1ecdi \u0111i\u1ec1u b\u1ea1n c\u1ea7n bi\u1ebft"},"content":{"rendered":"\n<p><span style=\"font-weight: 400;\">Intravenous immunoglobulin (IVIG) premedication is one of the ways to minimize infusion-related side effects.&nbsp;<\/span><\/p>\n\n\n\n<div  id=\"call-to-action-d1a260575612d9b9d08eb7cf6c0afcf9\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tGet IVIG Copay Assistance\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"cta__sub__heading\">\n\t\t\t\t\t\t\tIVIG Financial Assistance\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"tel:8777780318\">(877) 778-0318<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<p><span style=\"font-weight: 400;\">Though <a href=\"https:\/\/ameripharmaspecialty.com\/ivig\/ivig\/\/ivig\/\">intravenous immunoglobulin (IVIG)<\/a> is well tolerated, some users may experience side effects such as flushing, headache, malaise, fever, chills, and fatigue. Rare and serious side effects can include:<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">Renal impairment<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Thrombosis (blood clot inside a blood vessel)<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Arrhythmia (irregular heartbeat)<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Aseptic meningitis (swelling of the brain linings)<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Hemolytic anemia (a disorder of the blood cells)<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Transfusion-related acute lung injury (TRALI)<\/span><\/li>\n<\/ul>\n\n\n\n<p><span style=\"font-weight: 400;\">Some strategies to reduce the risk of side effects include:<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">Slowing the infusion rate or lowering the dose<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Switching from <a href=\"https:\/\/ameripharmaspecialty.com\/ivig\/scig-vs-ivig\/\">IVIG to SCIG<\/a> (subcutaneous immunoglobulin)<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Switching to other immunoglobulin preparations<br><\/span><\/li>\n<\/ul>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/ivig\/ivig-premedication-essential-things-to-know\/#What_Is_IVIG_Premedication\" >What Is IVIG Premedication?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/ivig\/ivig-premedication-essential-things-to-know\/#What_Are_the_Most_Frequently_Used_IVIG_Premedications\" >What Are the Most Frequently Used IVIG Premedications?<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/ivig\/ivig-premedication-essential-things-to-know\/#Analgesics\" >Analgesics<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/ivig\/ivig-premedication-essential-things-to-know\/#Antihistamines\" >Antihistamines<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/ivig\/ivig-premedication-essential-things-to-know\/#Corticosteroids\" >Corticosteroids<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/ivig\/ivig-premedication-essential-things-to-know\/#How_Effective_Is_IVIG_Premedication\" >How Effective Is IVIG Premedication?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/ivig\/ivig-premedication-essential-things-to-know\/#Do_All_Patients_Need_IVIG_Premedication\" >Do All Patients Need IVIG Premedication?<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_Is_IVIG_Premedication\"><\/span>What Is IVIG Premedication?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">IVIG premedication involves the administration of one or more medications roughly 30 minutes before starting IVIG therapy. This is done to reduce the likelihood of side effects during your IVIG infusion.&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">You may also receive premedication if you experience side effects during therapy.&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Before giving you premedication, your doctor will ask about any previous adverse events from IVIG therapy and assess for current risk of potential side effects.&nbsp;&nbsp;<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_Are_the_Most_Frequently_Used_IVIG_Premedications\"><\/span>What Are the Most Frequently Used IVIG Premedications?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">The following medicines are commonly used:&nbsp;<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Analgesics\"><\/span><span style=\"font-weight: 400;\">Analgesics<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Also called painkillers, these medicines relieve pain. Acetaminophen (Tylenol) is the most frequently used analgesic for IVIG premedication. The usual adult dose is 650 mg orally once. The oral dose for children depends on their body weight.&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Anti-inflammatory medicines called <a href=\"https:\/\/my.clevelandclinic.org\/health\/treatments\/11086-non-steroidal-anti-inflammatory-medicines-nsaids\">NSAIDs<\/a> (non-steroidal anti-inflammatory drugs) may also be necessary. Examples include ibuprofen (Advil, Motrin) and naproxen (Aleve).<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Antihistamines\"><\/span><span style=\"font-weight: 400;\">Antihistamines<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">These medicines treat symptoms of allergic reactions, such as rashes, swelling, or itching. Examples include:<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><b>Diphenhydramine (Benadryl)<\/b><span style=\"font-weight: 400;\">: The usual adult dose is 25 mg to 50 mg orally or through IV once. This is the most commonly prescribed antihistamine for premedication.<\/span><\/li>\n\n\n\n<li><b>Loratadine (Claritin)<\/b><span style=\"font-weight: 400;\">: 10 mg orally once.&nbsp;<\/span><\/li>\n\n\n\n<li><b>Cetirizine (Zyrtec)<\/b><span style=\"font-weight: 400;\">: 10 mg orally once.<\/span><\/li>\n\n\n\n<li><b>Fexofenadine (Allegra)<\/b><span style=\"font-weight: 400;\">: 180 mg orally once.<\/span><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Corticosteroids\"><\/span><span style=\"font-weight: 400;\">Corticosteroids<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Also called steroids, these medicines help to reduce inflammation and swelling. The frequently used corticosteroids for IVIG premedication are:<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><b><a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a682792.html\">Dexamethasone<\/a> (Decadron)<\/b><span style=\"font-weight: 400;\">: The usual adult dose is 4 mg orally or through IV once.<\/span><\/li>\n\n\n\n<li><b>Methylprednisolone (Medrol)<\/b><span style=\"font-weight: 400;\">: 20 mg to 60 mg IV once.&nbsp;<\/span><\/li>\n\n\n\n<li><b>Hydrocortisone (Hydrocort)<\/b><span style=\"font-weight: 400;\">: 50 mg to 200 mg IV once.&nbsp;<\/span><\/li>\n<\/ul>\n\n\n\n<p><b>Note:<\/b> These steroids are not the same as the ones that some athletes abuse, which are referred to as anabolic steroids.<br><b><\/b><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">The choice of a drug and premedication protocol can vary according to your specific need, the co-occurrence of other medical conditions, and the medicines you take. It is also possible that your doctor may continue using the premedication at lower doses after your treatment if a side effect does occur during treatment.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">In addition to premedication, staying well hydrated before IVIG therapy is crucial to preventing side effects. Your doctor may pre-hydrate you with normal saline (NS) which can help reduce the occurrence of headaches, renal impairment (kidney problems), and hemolysis (red blood cell destruction).<\/span><\/p>\n\n\n\n<div  id=\"call-to-action-c0e94ca3f37858a3bb4a93f37533c102\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tAsk About IVIG Home Infusion\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"#form\">Schedule a Consultation<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_Effective_Is_IVIG_Premedication\"><\/span>How Effective Is IVIG Premedication?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright\"><img loading=\"lazy\" decoding=\"async\" width=\"420\" height=\"236\" src=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/10\/ivig-bottle.jpg\" alt=\"IVIG bottle handing on IV pole\" class=\"wp-image-23393\" srcset=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/10\/ivig-bottle.jpg 420w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/10\/ivig-bottle-300x169.jpg 300w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/10\/ivig-bottle-86x48.jpg 86w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/10\/ivig-bottle-167x94.jpg 167w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/10\/ivig-bottle-280x157.jpg 280w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/10\/ivig-bottle-370x208.jpg 370w\" sizes=\"auto, (max-width: 420px) 100vw, 420px\" \/><\/figure>\n<\/div>\n\n\n<p><span style=\"font-weight: 400;\">Appropriate premedication greatly reduces the frequency and severity of side effects [<\/span><a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2018.01299\/full\"><span style=\"font-weight: 400;\">1].<\/span><\/a><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">In a 2016 review, authors noted that premedication with acetaminophen, diphenhydramine, or dexamethasone significantly reduced the occurrence of IVIG side effects [<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26384525\/\"><span style=\"font-weight: 400;\">2<\/span><\/a><span style=\"font-weight: 400;\">].\u00a0<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Moreover, several international guidelines recommend the use of IVIG premedication. However, premedication is effective only in controlling mild-to-moderate symptoms. In severe cases, your doctor may decide to stop IVIG therapy.&nbsp;<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Do_All_Patients_Need_IVIG_Premedication\"><\/span>Do All Patients Need IVIG Premedication?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">No, not all patients require premedication. However, while all patients do not require IVIG premedication, many are able to tolerate IVIG better with premedication.&nbsp;&nbsp;<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>S\u1eed d\u1ee5ng globulin mi\u1ec5n d\u1ecbch ti\u00eam t\u0129nh m\u1ea1ch (IVIG) tr\u01b0\u1edbc khi truy\u1ec1n d\u1ecbch l\u00e0 m\u1ed9t trong nh\u1eefng c\u00e1ch \u0111\u1ec3 gi\u1ea3m thi\u1ec3u c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 li\u00ean quan \u0111\u1ebfn truy\u1ec1n d\u1ecbch. M\u1eb7c d\u00f9 globulin mi\u1ec5n d\u1ecbch ti\u00eam t\u0129nh m\u1ea1ch (IVIG) \u0111\u01b0\u1ee3c dung n\u1ea1p t\u1ed1t, m\u1ed9t s\u1ed1 ng\u01b0\u1eddi d\u00f9ng c\u00f3 th\u1ec3 g\u1eb7p c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nh\u01b0 \u0111\u1ecf m\u1eb7t, \u0111au \u0111\u1ea7u, kh\u00f3 ch\u1ecbu, s\u1ed1t, \u1edbn l\u1ea1nh v\u00e0 m\u1ec7t m\u1ecfi.<\/p>","protected":false},"author":27,"featured_media":23391,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[7],"tags":[33],"class_list":["post-23387","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ivig","tag-dr-samantha-kaeberlein"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>IVIG Premedication: Everything You Need to Know | AmeriPharma<\/title>\n<meta name=\"description\" content=\"Learn about IVIG premedication and how it can reduce side effects. 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