{"id":20173,"date":"2022-05-11T11:58:51","date_gmt":"2022-05-11T18:58:51","guid":{"rendered":"https:\/\/ameripharmaspe.wpengine.com\/staging\/?p=19120"},"modified":"2026-03-26T14:16:10","modified_gmt":"2026-03-26T21:16:10","slug":"cyclophosphamide","status":"publish","type":"post","link":"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/cyclophosphamide\/","title":{"rendered":"Cyclophosphamide"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Cyclophosphamide<\/span><span style=\"font-weight: 400;\"> l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c h\u00f3a tr\u1ecb hi\u1ec7n c\u00f3 s\u1eb5n d\u01b0\u1edbi d\u1ea1ng thu\u1ed1c g\u1ed1c v\u00e0 d\u01b0\u1edbi d\u1ea1ng t\u00ean th\u01b0\u01a1ng m\u1ea1i \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111\u0103ng k\u00fd, Cytoxan v\u00e0 Neosar.<\/span> <span style=\"font-weight: 400;\">Thu\u1ed1c n\u00e0y c\u00f3 d\u1ea1ng vi\u00ean n\u00e9n ho\u1eb7c vi\u00ean nang u\u1ed1ng ph\u1ea3i nu\u1ed1t c\u1ea3 vi\u00ean v\u00e0 d\u1ea1ng dung d\u1ecbch ti\u00eam t\u0129nh m\u1ea1ch.<\/span> <span style=\"font-weight: 400;\">Cyclophosphamide \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb m\u1ed9t <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=cef038cc-efab-46d9-99c2-95bb11d6c9bc#leftmenu\"><span style=\"font-weight: 400;\">nhi\u1ec1u lo\u1ea1i ung th\u01b0<\/span><\/a><span style=\"font-weight: 400;\">ch\u1eb3ng h\u1ea1n nh\u01b0 ung th\u01b0 v\u00fa v\u00e0 b\u1ec7nh b\u1ea1ch c\u1ea7u. Vi\u1ec7c truy\u1ec1n d\u1ecbch th\u01b0\u1eddng \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n b\u1edfi c\u00e1c chuy\u00ean gia ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe \u0111\u01b0\u1ee3c \u0111\u00e0o t\u1ea1o t\u1ea1i ph\u00f2ng kh\u00e1m\/ph\u00f2ng m\u1ea1ch b\u00e1c s\u0129 ho\u1eb7c b\u1ec7nh vi\u1ec7n. C\u00f3 th\u1ec3 s\u1eed d\u1ee5ng thu\u1ed1c n\u00e0y trong <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK553087\/#:~:text=Cyclophosphamide%20is%20a%20medication%20primarily,anti%2Dneoplastic%20effects%20through%20alkylation.\"><span style=\"font-weight: 400;\">k\u1ebft h\u1ee3p v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c kh\u00e1c<\/span><\/a><span style=\"font-weight: 400;\">, t\u00f9y thu\u1ed9c v\u00e0o ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb.<\/span><\/p>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Chuy\u1ec3n \u0111\u1ed5i m\u1ee5c l\u1ee5c\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Chuy\u1ec3n \u0111\u1ed5i<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/cyclophosphamide\/#Cyclophosphamide_Uses\" >C\u00f4ng d\u1ee5ng c\u1ee7a Cyclophosphamide<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/cyclophosphamide\/#How_It_Works\" >N\u00f3 ho\u1ea1t \u0111\u1ed9ng nh\u01b0 th\u1ebf n\u00e0o<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/cyclophosphamide\/#Cyclophosphamide_Side_Effects\" >T\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a Cyclophosphamide<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/cyclophosphamide\/#Serious_Side_Effects\" >T\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/cyclophosphamide\/#Warnings\" >C\u1ea3nh b\u00e1o<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/cyclophosphamide\/#Infertility_and_Birth_Defects_Warning\" >C\u1ea3nh b\u00e1o v\u1ec1 v\u00f4 sinh v\u00e0 d\u1ecb t\u1eadt b\u1ea9m sinh<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/cyclophosphamide\/#Blood_in_the_Urine_Warning\" >C\u1ea3nh b\u00e1o c\u00f3 m\u00e1u trong n\u01b0\u1edbc ti\u1ec3u<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/cyclophosphamide\/#Infections\" >Nhi\u1ec5m tr\u00f9ng<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/cyclophosphamide\/#Secondary_Malignancy_Risk\" >Nguy c\u01a1 m\u1eafc b\u1ec7nh \u00e1c t\u00ednh th\u1ee9 ph\u00e1t<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/cyclophosphamide\/#Allergy_Warning\" >C\u1ea3nh b\u00e1o d\u1ecb \u1ee9ng<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/cyclophosphamide\/#Disease-specific_Considerations\" >Nh\u1eefng c\u00e2n nh\u1eafc c\u1ee5 th\u1ec3 v\u1ec1 b\u1ec7nh<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/cyclophosphamide\/#For_Patients_With_Kidney_Disease\" >\u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh th\u1eadn:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/cyclophosphamide\/#For_Patients_With_Liver_Disease\" >\u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh gan:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/cyclophosphamide\/#Individuals_With_Urinary_Outflow_Obstruction\" >Nh\u1eefng ng\u01b0\u1eddi b\u1ecb t\u1eafc ngh\u1ebdn \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u:<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/cyclophosphamide\/#Cyclophosphamide_Drug_Interactions\" >T\u01b0\u01a1ng t\u00e1c thu\u1ed1c Cyclophosphamide<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/cyclophosphamide\/#How_To_Take_Cyclophosphamide\" >C\u00e1ch d\u00f9ng Cyclophosphamide<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/cyclophosphamide\/#Missed_Doses\" >Li\u1ec1u b\u1ecb qu\u00ean<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/cyclophosphamide\/#Treatment_Monitoring\" >Theo d\u00f5i \u0111i\u1ec1u tr\u1ecb&nbsp;<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Cyclophosphamide_Uses\"><\/span>C\u00f4ng d\u1ee5ng c\u1ee7a Cyclophosphamide<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">C\u00f4ng d\u1ee5ng li\u00ean quan \u0111\u1ebfn ung th\u01b0:<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">Ung th\u01b0 bu\u1ed3ng tr\u1ee9ng<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Ung th\u01b0 v\u00fa<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">B\u1ec7nh b\u1ea1ch c\u1ea7u<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">U lympho t\u1ebf b\u00e0o T \u1edf da<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">U lympho Hodgkin v\u00e0 u lympho kh\u00f4ng Hodgkin<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">B\u1ec7nh \u0111a u t\u1ee7y<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">U nguy\u00ean b\u00e0o th\u1ea7n kinh<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">U nguy\u00ean b\u00e0o v\u00f5ng m\u1ea1c<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Ung th\u01b0 ph\u1ed5i t\u1ebf b\u00e0o nh\u1ecf (kh\u00f4ng theo ch\u1ec9 \u0111\u1ecbnh)<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">U c\u01a1 v\u00e2n (kh\u00f4ng theo ch\u1ec9 \u0111\u1ecbnh)<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">U nguy\u00ean b\u00e0o Ewing (kh\u00f4ng theo ch\u1ec9 \u0111\u1ecbnh)<\/span><\/li>\n<\/ul>\n\n\n\n<p><span style=\"font-weight: 400;\">C\u00f4ng d\u1ee5ng kh\u00e1c (kh\u00f4ng ghi tr\u00ean nh\u00e3n):<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">H\u1ed9i ch\u1ee9ng th\u1eadn h\u01b0<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Vi\u00eam th\u1eadn lupus<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Vi\u00eam da c\u01a1\/<a href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/polymyositis\/\">vi\u00eam \u0111a c\u01a1<\/a><\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Ph\u00f2ng ng\u1eeba b\u1ec7nh gh\u00e9p ch\u1ed1ng v\u1eadt ch\u1ee7<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Gh\u00e9p t\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u ho\u1eb7c gh\u00e9p t\u1ee7y<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Thi\u1ebfu m\u00e1u tan m\u00e1u t\u1ef1 mi\u1ec5n<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Vi\u00eam \u0111a \u0111\u1ed9ng m\u1ea1ch d\u1ea1ng n\u00fat<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Vi\u00eam ph\u1ed5i k\u1ebd<\/span><\/li>\n<\/ul>\n\n\n\n<p><span style=\"font-weight: 400;\">Li\u1ec1u l\u01b0\u1ee3ng v\u00e0 \u0111\u01b0\u1eddng d\u00f9ng cyclophosphamide \u0111\u01b0\u1ee3c \u01b0u ti\u00ean thay \u0111\u1ed5i t\u00f9y theo ch\u1ea9n \u0111o\u00e1n. Khi \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh, h\u00e3y th\u1ea3o lu\u1eadn chi ti\u1ebft v\u1ec1 k\u1ebf ho\u1ea1ch \u0111i\u1ec1u tr\u1ecb v\u1edbi b\u00e1c s\u0129 k\u00ea \u0111\u01a1n. <\/span><b>Vi\u1ec7c tu\u00e2n th\u1ee7 \u0111i\u1ec1u tr\u1ecb l\u00e0 r\u1ea5t quan tr\u1ecdng v\u1edbi lo\u1ea1i thu\u1ed1c n\u00e0y<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_It_Works\"><\/span>N\u00f3 ho\u1ea1t \u0111\u1ed9ng nh\u01b0 th\u1ebf n\u00e0o<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Cyclophosphamide thu\u1ed9c nh\u00f3m thu\u1ed1c \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 t\u00e1c nh\u00e2n alkyl h\u00f3a. Thu\u1ed1c \u0111i\u1ec1u tr\u1ecb ung th\u01b0 b\u1eb1ng c\u00e1ch ph\u00e1 v\u1ee1 qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p DNA trong qu\u00e1 tr\u00ecnh ph\u00e2n chia t\u1ebf b\u00e0o, t\u1eeb \u0111\u00f3 ng\u0103n ch\u1eb7n qu\u00e1 tr\u00ecnh n\u00e0y. \u0110i\u1ec1u n\u00e0y d\u1eabn \u0111\u1ebfn <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK304336\/\"><span style=\"font-weight: 400;\">\u1ee9c ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a nhi\u1ec1u lo\u1ea1i t\u1ebf b\u00e0o ung th\u01b0<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Cyclophosphamide kh\u00f4ng ch\u1ecdn l\u1ecdc tr\u00ean t\u1ebf b\u00e0o ung th\u01b0. Do \u0111\u00f3, t\u00e1c d\u1ee5ng c\u1ee7a n\u00f3 c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn m\u1ed9t s\u1ed1 t\u1ebf b\u00e0o kh\u1ecfe m\u1ea1nh c\u1ee7a c\u01a1 th\u1ec3, \u0111\u1eb7c bi\u1ec7t l\u00e0 nh\u1eefng t\u1ebf b\u00e0o li\u00ean quan \u0111\u1ebfn h\u1ec7 mi\u1ec5n d\u1ecbch. Do \u0111\u00f3, n\u00f3 c\u00f3 ho\u1ea1t t\u00ednh \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch m\u1ea1nh m\u1ebd, c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng cho c\u00e1c r\u1ed1i lo\u1ea1n t\u1ef1 mi\u1ec5n.<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Cyclophosphamide_Side_Effects\"><\/span>T\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a Cyclophosphamide<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 th\u01b0\u1eddng g\u1eb7p bao g\u1ed3m <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=cef038cc-efab-46d9-99c2-95bb11d6c9bc#leftmenu\"><span style=\"font-weight: 400;\">bu\u1ed3n n\u00f4n, n\u00f4n m\u1eeda, m\u1edd m\u1eaft, ch\u00f3ng m\u1eb7t v\u00e0 ch\u00e1n \u0103n<\/span><\/a><span style=\"font-weight: 400;\">. V\u00ec cyclophosphamide c\u00f3 th\u1ec3 l\u00e0m suy gi\u1ea3m th\u1ecb l\u1ef1c v\u00e0 s\u1ef1 nh\u1ea1y b\u00e9n v\u1ec1 tinh th\u1ea7n, <\/span><b>tr\u00e1nh l\u00e1i xe ho\u1eb7c s\u1eed d\u1ee5ng m\u00e1y m\u00f3c h\u1ea1ng n\u1eb7ng khi \u0111ang ch\u1ecbu t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n\n\n\n<p>\u0110\u1ed9t bi\u1ebfn Cyclophosphamide th\u01b0\u1eddng g\u00e2y \u1ee9c ch\u1ebf t\u1ee7y x\u01b0\u01a1ng, c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u th\u1ea5p (gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh), thi\u1ebfu m\u00e1u v\u00e0 s\u1ed1 l\u01b0\u1ee3ng ti\u1ec3u c\u1ea7u th\u1ea5p (gi\u1ea3m ti\u1ec3u c\u1ea7u). \u0110i\u1ec1u n\u00e0y l\u00e0m t\u0103ng nguy c\u01a1 nhi\u1ec5m tr\u00f9ng, m\u1ec7t m\u1ecfi v\u00e0 ch\u1ea3y m\u00e1u.<\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">D\u01b0\u1edbi \u0111\u00e2y l\u00e0 m\u1ed9t s\u1ed1 kh\u00e1c <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9104732\/\"><span style=\"font-weight: 400;\">t\u00e1c d\u1ee5ng ph\u1ee5 c\u00f3 th\u1ec3 x\u1ea3y ra<\/span><\/a><span style=\"font-weight: 400;\"> c\u00f3 li\u00ean quan \u0111\u1ebfn cyclophosphamide:<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">Nhi\u1ec5m tr\u00f9ng<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">S\u1ef1 thay \u0111\u1ed5i m\u00e0u s\u1eafc c\u1ee7a m\u00f3ng tay<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">S\u1ef1 thay \u0111\u1ed5i m\u00e0u s\u1eafc c\u1ee7a da<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Ph\u00e1t ban da<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">R\u1ee5ng t\u00f3c<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Lo\u00e9t mi\u1ec7ng<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Ti\u00eau ch\u1ea3y<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u0110au d\u1ea1 d\u00e0y<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u0110au nh\u1ee9c c\u01a1 th\u1ec3<\/span><\/li>\n<\/ul>\n\n\n\n<p><span style=\"font-weight: 400;\">Trong h\u1ea7u h\u1ebft c\u00e1c tr\u01b0\u1eddng h\u1ee3p, n\u1ebfu t\u00e1c d\u1ee5ng ph\u1ee5 nh\u1eb9, ch\u00fang c\u00f3 th\u1ec3 bi\u1ebfn m\u1ea5t trong v\u00f2ng v\u00e0i ng\u00e0y ho\u1eb7c v\u00e0i tu\u1ea7n khi c\u01a1 th\u1ec3 th\u00edch nghi v\u1edbi thu\u1ed1c. N\u1ebfu ch\u00fang k\u00e9o d\u00e0i ho\u1eb7c tr\u1edf n\u00ean nghi\u00eam tr\u1ecdng h\u01a1n, h\u00e3y li\u00ean h\u1ec7 v\u1edbi b\u00e1c s\u0129 ho\u1eb7c d\u01b0\u1ee3c s\u0129 \u0111\u1ec3 \u0111\u01b0\u1ee3c h\u01b0\u1edbng d\u1eabn th\u00eam.<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Serious_Side_Effects\"><\/span>T\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">M\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng\/nghi\u00eam tr\u1ecdng v\u00e0 c\u1ea7n \u0111\u01b0\u1ee3c ch\u0103m s\u00f3c y t\u1ebf ngay l\u1eadp t\u1ee9c. Bao g\u1ed3m:<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">Nhi\u1ec5m tr\u00f9ng (xem \u201c<\/span><a href=\"#warnings\"><span style=\"font-weight: 400;\">C\u1ea3nh b\u00e1o<\/span><\/a><span style=\"font-weight: 400;\">&quot; d\u01b0\u1edbi)<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Vi\u00eam b\u00e0ng quang xu\u1ea5t huy\u1ebft\/\u0111\u1ed9c t\u00ednh th\u1eadn (xem \u201c<\/span><a href=\"#warnings\"><span style=\"font-weight: 400;\">C\u1ea3nh b\u00e1o<\/span><\/a><span style=\"font-weight: 400;\">&quot; d\u01b0\u1edbi):<\/span>\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">\u0110au b\u00e0ng quang<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">M\u00e1u trong n\u01b0\u1edbc ti\u1ec3u<\/span><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">C\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 tim m\u1ea1ch (th\u01b0\u1eddng g\u1eb7p h\u01a1n \u1edf li\u1ec1u cao):<\/span>\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">Nh\u1ecbp tim kh\u00f4ng \u0111\u1ec1u ho\u1eb7c nh\u1ecbp \u0111i\u1ec7u<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u0110au ng\u1ef1c<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">H\u1ee5t h\u01a1i<\/span><\/li>\n\n\n\n<li>C\u00e1c d\u1ea5u hi\u1ec7u suy tim, ch\u1eb3ng h\u1ea1n nh\u01b0 ph\u00f9 ch\u00e2n ho\u1eb7c t\u0103ng c\u00e2n \u0111\u1ed9t ng\u1ed9t.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">C\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 ph\u1ed5i (bao g\u1ed3m vi\u00eam ph\u1ed5i k\u1ebd ho\u1eb7c x\u01a1 ph\u1ed5i):<\/span>\n<ul class=\"wp-block-list\">\n<li>H\u1ee5t h\u01a1i<\/li>\n\n\n\n<li>Ho dai d\u1eb3ng<\/li>\n\n\n\n<li>Kh\u00f3 th\u1edf ng\u00e0y c\u00e0ng tr\u1ea7m tr\u1ecdng<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">B\u1ec7nh gan:<\/span>\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">\u0110au b\u1ee5ng tr\u00ean<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">N\u01b0\u1edbc ti\u1ec3u s\u1eabm m\u00e0u<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Ph\u00e2n nh\u1ea1t m\u00e0u ho\u1eb7c m\u00e0u \u0111\u1ea5t s\u00e9t<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">V\u00e0ng da ho\u1eb7c v\u00e0ng l\u00f2ng tr\u1eafng m\u1eaft<\/span><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Ch\u1eadm l\u00e0nh v\u1ebft th\u01b0\u01a1ng<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">V\u00f4 sinh (xem \u201c<\/span><a href=\"#warnings\"><span style=\"font-weight: 400;\">C\u1ea3nh b\u00e1o<\/span><\/a><span style=\"font-weight: 400;\">&quot; d\u01b0\u1edbi)<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">H\u1ed9i ch\u1ee9ng hormone ch\u1ed1ng b\u00e0i ni\u1ec7u kh\u00f4ng ph\u00f9 h\u1ee3p (SIADH), l\u00e0 t\u00ecnh tr\u1ea1ng c\u01a1 th\u1ec3 gi\u1eef qu\u00e1 nhi\u1ec1u n\u01b0\u1edbc. C\u00e1c tri\u1ec7u ch\u1ee9ng c\u00f3 th\u1ec3 bao g\u1ed3m:<\/span>\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">H\u00f4n m\u00ea<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u0110\u1ed9ng kinh<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u1ea2o gi\u00e1c<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">L\u00fa l\u1eabn<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Y\u1ebfu c\u01a1<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Chu\u1ed9t r\u00fat c\u01a1 b\u1eafp<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">M\u1ea5t c\u1ea3m gi\u00e1c th\u00e8m \u0103n<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">S\u1ef1 c\u00e1u k\u1ec9nh v\u00e0 b\u1ed3n ch\u1ed3n<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><b>Ghi ch\u00fa:<\/b><span style=\"font-weight: 400;\"> M\u1ee5c ti\u00eau c\u1ee7a ch\u00fang t\u00f4i l\u00e0 cung c\u1ea5p cho b\u1ea1n th\u00f4ng tin ch\u00ednh x\u00e1c v\u00e0 c\u1eadp nh\u1eadt nh\u1ea5t c\u00f3 th\u1ec3. Tuy nhi\u00ean, do m\u1ed7i c\u00e1 nh\u00e2n l\u00e0 duy nh\u1ea5t, ch\u00fang t\u00f4i kh\u00f4ng th\u1ec3 \u0111\u1ea3m b\u1ea3o r\u1eb1ng th\u00f4ng tin n\u00e0y bao g\u1ed3m t\u1ea5t c\u1ea3 c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 ti\u1ec1m \u1ea9n. H\u00e3y lu\u00f4n t\u00ecm ki\u1ebfm l\u1eddi khuy\u00ean y t\u1ebf chuy\u00ean nghi\u1ec7p \u0111\u1ec3 x\u00e1c nh\u1eadn.<\/span><\/p>\n\n\n\n<div id=\"warnings\">\n<h2><span class=\"ez-toc-section\" id=\"Warnings\"><\/span>C\u1ea3nh b\u00e1o<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Infertility_and_Birth_Defects_Warning\"><\/span>C\u1ea3nh b\u00e1o v\u1ec1 v\u00f4 sinh v\u00e0 d\u1ecb t\u1eadt b\u1ea9m sinh<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Cyclophosphamide c\u00f3 th\u1ec3 g\u00e2y v\u00f4 sinh kh\u00f4ng th\u1ec3 h\u1ed3i ph\u1ee5c \u1edf c\u1ea3 nam v\u00e0 n\u1eef. \u1ede ph\u1ee5 n\u1eef, \u0111i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 bi\u1ec3u hi\u1ec7n d\u01b0\u1edbi d\u1ea1ng v\u00f4 kinh (kh\u00f4ng c\u00f3 kinh nguy\u1ec7t) ho\u1eb7c suy bu\u1ed3ng tr\u1ee9ng s\u1edbm. \u1ede nam gi\u1edbi, n\u00f3 c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn gi\u1ea3m s\u1ea3n xu\u1ea5t tinh tr\u00f9ng (thi\u1ec3u tinh tr\u00f9ng) ho\u1eb7c ho\u00e0n to\u00e0n kh\u00f4ng c\u00f3 tinh tr\u00f9ng (v\u00f4 tinh tr\u00f9ng), c\u00f3 th\u1ec3 l\u00e0 v\u0129nh vi\u1ec5n t\u00f9y thu\u1ed9c v\u00e0o li\u1ec1u t\u00edch l\u0169y v\u00e0 th\u1eddi gian \u0111i\u1ec1u tr\u1ecb. N\u00f3 \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 can thi\u1ec7p tr\u1ef1c ti\u1ebfp v\u00e0o s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u1ea3 t\u1ebf b\u00e0o tr\u1ee9ng v\u00e0 tinh tr\u00f9ng. Trong tr\u01b0\u1eddng h\u1ee3p mang thai th\u00e0nh c\u00f4ng, cyclophosphamide c\u0169ng \u0111\u01b0\u1ee3c bi\u1ebft l\u00e0 g\u00e2y h\u1ea1i tr\u1ef1c ti\u1ebfp cho thai nhi, bao g\u1ed3m d\u1ecb t\u1eadt b\u1ea9m sinh, s\u1ea3y thai v\u00e0 ch\u1eadm ph\u00e1t tri\u1ec3n. Do \u0111\u00f3, ph\u1ee5 n\u1eef trong \u0111\u1ed9 tu\u1ed5i sinh s\u1ea3n n\u00ean th\u1ef1c hi\u1ec7n c\u00e1c bi\u1ec7n ph\u00e1p th\u00edch h\u1ee3p \u0111\u1ec3 ph\u00f2ng ng\u1eeba. <strong>tr\u00e1nh mang thai trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb<\/strong> V\u00e0 <strong>l\u00ean \u0111\u1ebfn 1 n\u0103m sau khi ng\u1eebng thu\u1ed1c<\/strong>. N\u1ebfu kh\u00f4ng th\u1ec3 tr\u00e1nh kh\u1ecfi vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c trong th\u1eddi k\u1ef3 mang thai, ng\u01b0\u1eddi k\u00ea \u0111\u01a1n c\u1ea7n c\u00e2n nh\u1eafc c\u1ea9n th\u1eadn t\u1ea5t c\u1ea3 c\u00e1c r\u1ee7i ro v\u00e0 l\u1ee3i \u00edch ti\u1ec1m \u1ea9n c\u1ee7a thu\u1ed1c.<\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Ng\u01b0\u1eddi ta bi\u1ebft r\u1eb1ng Cyclophosphamide c\u0169ng c\u00f3 trong s\u1eefa m\u1eb9. Do \u0111\u00f3,<\/span><b> c\u00e1c b\u00e0 m\u1eb9 \u0111ang cho con b\u00fa n\u00ean tr\u00e1nh cho con b\u00fa<\/b><span style=\"font-weight: 400;\"> n\u1ebfu \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng trong nh\u1eefng tr\u01b0\u1eddng h\u1ee3p nh\u01b0 v\u1eady. Tr\u1ebb s\u01a1 sinh ti\u1ebfp x\u00fac v\u1edbi cyclophosphamide c\u00f3 th\u1ec3 b\u1ecb ch\u1eadm ph\u00e1t tri\u1ec3n ho\u1eb7c khuy\u1ebft t\u1eadt v\u0129nh vi\u1ec5n v\u1ec1 th\u1ec3 ch\u1ea5t v\u00e0 tinh th\u1ea7n.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Blood_in_the_Urine_Warning\"><\/span>C\u1ea3nh b\u00e1o c\u00f3 m\u00e1u trong n\u01b0\u1edbc ti\u1ec3u<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Cyclophosphamide \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a th\u00e0nh m\u1ed9t h\u1ee3p ch\u1ea5t g\u1ecdi l\u00e0 acrolein, c\u00f3 th\u1ec3 g\u00e2y k\u00edch \u1ee9ng v\u00e0 l\u00e0m t\u1ed5n th\u01b0\u01a1ng ni\u00eam m\u1ea1c b\u00e0ng quang v\u00e0 \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u. Ti\u1ebfp x\u00fac th\u01b0\u1eddng xuy\u00ean c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn m\u1ed9t t\u00ecnh tr\u1ea1ng \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2938536\/#:~:text=Hemorrhagic%20cystitis%20is%20defined%20as,usually%20responds%20promptly%20to%20treatment.\">vi\u00eam b\u00e0ng quang xu\u1ea5t huy\u1ebft<\/a>, \u0111\u1eb7c tr\u01b0ng b\u1edfi \u0111au nh\u00f3i \u1edf m\u1ed9t b\u00ean l\u01b0ng d\u01b0\u1edbi, \u0111au b\u00e0ng quang ho\u1eb7c ti\u1ec3u ra m\u00e1u. Khi nghi ng\u1edd m\u1ed9t ho\u1eb7c nhi\u1ec1u tri\u1ec7u ch\u1ee9ng n\u00e0y, h\u00e3y li\u00ean h\u1ec7 ngay v\u1edbi b\u00e1c s\u0129.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Nguy c\u01a1 ph\u00e1t tri\u1ec3n vi\u00eam b\u00e0ng quang xu\u1ea5t huy\u1ebft c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c gi\u1ea3m b\u1eb1ng c\u00e1ch t\u0103ng l\u01b0\u1ee3ng ch\u1ea5t l\u1ecfng \u0111\u01b0a v\u00e0o, th\u01b0\u1eddng l\u00ean \u0111\u1ebfn 2 <\/span><span style=\"font-weight: 400;\">\u2013<\/span><span style=\"font-weight: 400;\"> 3 l\u00edt m\u1ed7i ng\u00e0y cho h\u1ea7u h\u1ebft m\u1ecdi ng\u01b0\u1eddi. B\u1ea1n c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c k\u00ea \u0111\u01a1n m\u1ed9t lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 <\/span><a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a613013.html\"><span style=\"font-weight: 400;\">Mesna<\/span><\/a><span style=\"font-weight: 400;\">, c\u00f3 th\u1ec3 d\u00f9ng trong v\u00f2ng 4 ng\u00e0y sau li\u1ec1u cyclophosphamide. Li\u1ec1u \u0111\u1ea7u ti\u00ean th\u01b0\u1eddng \u0111\u01b0\u1ee3c ti\u00eam t\u0129nh m\u1ea1ch, v\u00e0 c\u00e1c li\u1ec1u ti\u1ebfp theo c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c d\u00f9ng d\u01b0\u1edbi d\u1ea1ng vi\u00ean n\u00e9n. Vi\u1ec7c duy tr\u00ec \u0111\u1ee7 l\u01b0\u1ee3ng n\u01b0\u1edbc u\u1ed1ng trong khi d\u00f9ng Mesna l\u00e0 r\u1ea5t quan tr\u1ecdng \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o hi\u1ec7u qu\u1ea3 trung h\u00f2a \u0111\u1ed9c t\u00ednh tr\u00ean th\u1eadn c\u1ee7a cyclophosphamide.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Infections\"><\/span>Nhi\u1ec5m tr\u00f9ng<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Cyclophosphamide \u1ee9c ch\u1ebf ch\u1ee9c n\u0103ng t\u1ee7y x\u01b0\u01a1ng v\u00e0 l\u00e0m suy y\u1ebfu h\u1ec7 mi\u1ec5n d\u1ecbch. Do \u0111\u00f3, b\u1ec7nh nh\u00e2n d\u00f9ng thu\u1ed1c n\u00e0y c\u00f3 th\u1ec3 d\u1ec5 b\u1ecb m\u1eafc c\u00e1c b\u1ec7nh l\u00fd kh\u00e1c h\u01a1n. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25455720\/\">nhi\u1ec5m tr\u00f9ng nghi\u00eam tr\u1ecdng ho\u1eb7c th\u1eadm ch\u00ed t\u1eed vong<\/a>. Ng\u01b0\u1eddi \u0111ang b\u1ecb nhi\u1ec5m tr\u00f9ng \u0111ang ho\u1ea1t \u0111\u1ed9ng n\u00ean tr\u00e1nh d\u00f9ng cyclophosphamide cho \u0111\u1ebfn khi t\u00ecnh tr\u1ea1ng b\u1ec7nh \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb \u0111\u1ea7y \u0111\u1ee7. H\u00e3y b\u00e1o ngay cho b\u00e1c s\u0129 n\u1ebfu b\u1ea1n g\u1eb7p b\u1ea5t k\u1ef3 d\u1ea5u hi\u1ec7u n\u00e0o sau \u0111\u00e2y:<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">\u0110au nh\u1ee9c c\u01a1 th\u1ec3<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u1edan l\u1ea1nh<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">S\u1ed1t t\u1eeb 100,4\u00b0F (38\u00b0C) tr\u1edf l\u00ean<\/span><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Secondary_Malignancy_Risk\"><\/span><strong>Nguy c\u01a1 m\u1eafc b\u1ec7nh \u00e1c t\u00ednh th\u1ee9 ph\u00e1t<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>S\u1eed d\u1ee5ng cyclophosphamide l\u00e2u d\u00e0i c\u00f3 li\u00ean quan \u0111\u1ebfn t\u0103ng nguy c\u01a1 m\u1eafc c\u00e1c b\u1ec7nh ung th\u01b0 th\u1ee9 ph\u00e1t, \u0111\u1eb7c bi\u1ec7t l\u00e0 ung th\u01b0 b\u00e0ng quang, b\u1ec7nh b\u1ea1ch c\u1ea7u c\u1ea5p t\u00ednh v\u00e0 c\u00e1c b\u1ec7nh \u00e1c t\u00ednh v\u1ec1 huy\u1ebft h\u1ecdc kh\u00e1c. Nguy c\u01a1 n\u00e0y ph\u1ee5 thu\u1ed9c v\u00e0o li\u1ec1u l\u01b0\u1ee3ng v\u00e0 t\u0103ng l\u00ean khi ti\u1ebfp x\u00fac k\u00e9o d\u00e0i. H\u00e3y b\u00e1o ngay cho b\u00e1c s\u0129 n\u1ebfu ph\u00e1t hi\u1ec7n c\u00f3 m\u00e1u trong n\u01b0\u1edbc ti\u1ec3u ho\u1eb7c c\u00e1c tri\u1ec7u ch\u1ee9ng b\u1ea5t th\u01b0\u1eddng kh\u00e1c.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Allergy_Warning\"><\/span>C\u1ea3nh b\u00e1o d\u1ecb \u1ee9ng<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Nh\u01b0 v\u1edbi b\u1ea5t k\u1ef3 ch\u1ea5t n\u00e0o, cyclophosphamide c\u00f3 th\u1ec3 g\u00e2y ra <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK553087\/#:~:text=Cyclophosphamide%20is%20a%20medication%20primarily,anti%2Dneoplastic%20effects%20through%20alkylation.\"><span style=\"font-weight: 400;\">\u0111e d\u1ecda t\u00ednh m\u1ea1ng<\/span> <span style=\"font-weight: 400;\">ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng<\/span><\/a><span style=\"font-weight: 400;\"> \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n nh\u1ea1y c\u1ea3m. M\u1ed9t s\u1ed1 d\u1ea5u hi\u1ec7u v\u00e0 tri\u1ec7u ch\u1ee9ng ti\u1ec1m \u1ea9n bao g\u1ed3m:<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">S\u1ed1c<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">N\u00f4n m\u1eeda<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Ch\u00f3ng m\u1eb7t<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Th\u1edf kh\u00f2 kh\u00e8<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">S\u01b0ng m\u1eb7t ho\u1eb7c c\u1ed5 h\u1ecdng<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">N\u1ed5i m\u1ec1 \u0111ay<\/span><\/li>\n<\/ul>\n\n\n\n<p><span style=\"font-weight: 400;\">N\u1ebfu b\u1ea5t k\u1ef3 tri\u1ec7u ch\u1ee9ng n\u00e0o trong s\u1ed1 n\u00e0y xu\u1ea5t hi\u1ec7n khi b\u1eaft \u0111\u1ea7u d\u00f9ng cyclophosphamide, h\u00e3y ng\u1eebng thu\u1ed1c ngay l\u1eadp t\u1ee9c v\u00e0 t\u00ecm ki\u1ebfm s\u1ef1 ch\u0103m s\u00f3c y t\u1ebf kh\u1ea9n c\u1ea5p. S\u1ef1 m\u1eabn c\u1ea3m nh\u01b0 v\u1eady ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c v\u00e0 kh\u00f4ng bao gi\u1edd \u0111\u01b0\u1ee3c th\u1eed l\u1ea1i.<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Disease-specific_Considerations\"><\/span>Nh\u1eefng c\u00e2n nh\u1eafc c\u1ee5 th\u1ec3 v\u1ec1 b\u1ec7nh<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"For_Patients_With_Kidney_Disease\"><\/span>\u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh th\u1eadn:<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Cyclophosphamide c\u00f3 th\u1ec3 t\u00edch t\u1ee5 \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn. Do \u0111\u00f3, \u0111i\u1ec1u quan tr\u1ecdng l\u00e0 ph\u1ea3i ki\u1ec3m tra ch\u1ee9c n\u0103ng th\u1eadn tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u d\u00f9ng thu\u1ed1c n\u00e0y v\u00e0 th\u01b0\u1eddng xuy\u00ean trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb. T\u00f9y thu\u1ed9c v\u00e0o m\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng, b\u00e1c s\u0129 c\u00f3 th\u1ec3 c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u \u0111\u1ec3 ng\u0103n ng\u1eeba \u0111\u1ed9c t\u00ednh ph\u00e1t tri\u1ec3n.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"For_Patients_With_Liver_Disease\"><\/span>\u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh gan:<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Gan ch\u1ecbu tr\u00e1ch nhi\u1ec7m ho\u1ea1t h\u00f3a v\u00e0 chuy\u1ec3n h\u00f3a cyclophosphamide. Do \u0111\u00f3, b\u1ec7nh gan c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c n\u00e0y v\u00e0 t\u0103ng nguy c\u01a1 \u0111\u1ed9c t\u00ednh. \u0110\u1ed1i v\u1edbi suy gan nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh, th\u01b0\u1eddng kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u. Tuy nhi\u00ean, trong tr\u01b0\u1eddng h\u1ee3p suy gan n\u1eb7ng, vi\u1ec7c s\u1eed d\u1ee5ng c\u00f3 th\u1ec3 b\u1ecb ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh do nguy c\u01a1 gi\u1ea3m hi\u1ec7u qu\u1ea3.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Individuals_With_Urinary_Outflow_Obstruction\"><\/span>Nh\u1eefng ng\u01b0\u1eddi b\u1ecb t\u1eafc ngh\u1ebdn \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u:<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">C\u00e1 nh\u00e2n v\u1edbi <\/span><a href=\"https:\/\/medlineplus.gov\/ency\/article\/000507.htm#:~:text=Obstructive%20uropathy%20is%20a%20condition,injure%20one%20or%20both%20kidneys.\"><span style=\"font-weight: 400;\">b\u1ec7nh l\u00fd t\u1eafc ngh\u1ebdn \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u<\/span><\/a><span style=\"font-weight: 400;\"> n\u00ean tr\u00e1nh d\u00f9ng cyclophosphamide. V\u00ec thu\u1ed1c n\u00e0y ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua n\u01b0\u1edbc ti\u1ec3u, n\u00ean t\u00ecnh tr\u1ea1ng n\u00e0y c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m kh\u1ea3 n\u0103ng \u0111\u00e0o th\u1ea3i thu\u1ed1c c\u1ee7a c\u01a1 th\u1ec3 n\u1ebfu kh\u00f4ng b\u1ecb suy th\u1eadn.<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Cyclophosphamide_Drug_Interactions\"><\/span>T\u01b0\u01a1ng t\u00e1c thu\u1ed1c Cyclophosphamide<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Cyclophosphamide c\u00f3 th\u1ec3 t\u01b0\u01a1ng t\u00e1c v\u1edbi nhi\u1ec1u lo\u1ea1i thu\u1ed1c, th\u1ef1c ph\u1ea9m ch\u1ee9c n\u0103ng th\u1ea3o d\u01b0\u1ee3c v\u00e0 vitamin kh\u00e1c khi d\u00f9ng \u0111\u1ed3ng th\u1eddi. \u0110i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 g\u00e2y ra s\u1ef1 thay \u0111\u1ed5i n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft thanh c\u1ee7a t\u1ea5t c\u1ea3 c\u00e1c ch\u1ea5t li\u00ean quan, d\u1eabn \u0111\u1ebfn nguy c\u01a1 \u0111\u1ed9c t\u00ednh. H\u00e3y duy tr\u00ec danh s\u00e1ch c\u1eadp nh\u1eadt t\u1ea5t c\u1ea3 c\u00e1c lo\u1ea1i thu\u1ed1c b\u1ea1n \u0111ang d\u00f9ng. Tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u d\u00f9ng cyclophosphamide, ho\u1eb7c b\u1ea5t k\u1ef3 lo\u1ea1i thu\u1ed1c n\u00e0o kh\u00e1c, h\u00e3y nh\u1edb tr\u00ecnh danh s\u00e1ch n\u00e0y cho b\u00e1c s\u0129 v\u00e0 d\u01b0\u1ee3c s\u0129 \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 b\u1ea5t k\u1ef3 v\u1ea5n \u0111\u1ec1 n\u00e0o. <\/span><span style=\"font-weight: 400;\">Kh\u00f4ng \u0111\u01b0\u1ee3c b\u1eaft \u0111\u1ea7u, ng\u1eebng ho\u1eb7c thay \u0111\u1ed5i li\u1ec1u l\u01b0\u1ee3ng c\u1ee7a b\u1ea5t k\u1ef3 lo\u1ea1i thu\u1ed1c n\u00e0o m\u00e0 kh\u00f4ng tham kh\u1ea3o \u00fd ki\u1ebfn b\u00e1c s\u0129 tr\u01b0\u1edbc.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">B\u1ea5t k\u1ef3 lo\u1ea1i thu\u1ed1c n\u00e0o \u1ee9c ch\u1ebf ch\u1ee9c n\u0103ng t\u1ee7y x\u01b0\u01a1ng \u0111\u1ec1u c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh nghi\u00eam tr\u1ecdng, thi\u1ebfu m\u00e1u ho\u1eb7c gi\u1ea3m ti\u1ec3u c\u1ea7u khi d\u00f9ng k\u1ebft h\u1ee3p v\u1edbi cyclophosphamide. Sau \u0111\u00e2y l\u00e0 m\u1ed9t s\u1ed1 ch\u1ea5t c\u00f3 th\u1ec3 t\u01b0\u01a1ng t\u00e1c v\u1edbi cyclophosphamide:<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><b>Allopurinol: <\/b><span style=\"font-weight: 400;\">\u1ee9c ch\u1ebf t\u1ee7y x\u01b0\u01a1ng t\u0103ng c\u01b0\u1eddng<\/span><\/li>\n\n\n\n<li><b>Amiodarone: <\/b><span style=\"font-weight: 400;\">t\u0103ng kh\u1ea3 n\u0103ng g\u00e2y \u0111\u1ed9c t\u00ednh cho ph\u1ed5i<\/span><\/li>\n\n\n\n<li><b>Anthracycline (t\u1ee9c l\u00e0 doxorubicin, idarubicin):<\/b><span style=\"font-weight: 400;\"> t\u00e1c d\u1ee5ng t\u0103ng c\u01b0\u1eddng \u0111\u1ed9c t\u00ednh tim<\/span><\/li>\n\n\n\n<li><b>Azathioprine:<\/b><span style=\"font-weight: 400;\"> c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 \u0111\u1ed9c t\u00ednh v\u1edbi gan<\/span><\/li>\n\n\n\n<li><b>Thu\u1ed1c sinh h\u1ecdc (abrocitinib, baricitinib, denosumab, etanercept, natalizumab, ocrelizumab, ofatumumab, ruxolitinib, tofacitinib, upadacitinib, v.v.):<\/b><span style=\"font-weight: 400;\"> t\u0103ng c\u01b0\u1eddng \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch<\/span><\/li>\n\n\n\n<li><b>Thu\u1ed1c ch\u1ed1ng n\u1ea5m nh\u00f3m azole (v\u00ed d\u1ee5: itraconazole, ketoconazole):<\/b><span style=\"font-weight: 400;\"> c\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng \u0111\u1ed9c h\u1ea1i c\u1ee7a cyclophosphamide<\/span><\/li>\n\n\n\n<li><b>Chlorpromazine:<\/b><span style=\"font-weight: 400;\"> t\u0103ng c\u01b0\u1eddng \u1ee9c ch\u1ebf t\u1ee7y x\u01b0\u01a1ng<\/span><\/li>\n\n\n\n<li><b>Cladribine:<\/b><span style=\"font-weight: 400;\"> t\u0103ng c\u01b0\u1eddng \u1ee9c ch\u1ebf t\u1ee7y x\u01b0\u01a1ng v\u00e0 \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch<\/span><\/li>\n\n\n\n<li><b>Clozapin:<\/b><span style=\"font-weight: 400;\"> t\u0103ng nguy c\u01a1 gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh<\/span><\/li>\n\n\n\n<li><b>Cyclosporin:<\/b><span style=\"font-weight: 400;\"> gi\u1ea3m hi\u1ec7u qu\u1ea3<\/span><\/li>\n\n\n\n<li><b>Deferiprone:<\/b><span style=\"font-weight: 400;\"> t\u0103ng nguy c\u01a1 gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh<\/span><\/li>\n\n\n\n<li><b>C\u00e2y c\u00fac t\u00edm:<\/b><span style=\"font-weight: 400;\"> c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb c\u1ee7a cyclophosphamide<\/span><\/li>\n\n\n\n<li><b>Fexinidazol:<\/b><span style=\"font-weight: 400;\"> t\u0103ng c\u01b0\u1eddng \u1ee9c ch\u1ebf t\u1ee7y x\u01b0\u01a1ng<\/span><\/li>\n\n\n\n<li><b><a href=\"https:\/\/ameripharmaspecialty.com\/vi\/other-health-conditions\/filgrastim-zarxio\/\">Filgrastim<\/a>:<\/b><span style=\"font-weight: 400;\"> t\u0103ng nguy c\u01a1 nhi\u1ec5m \u0111\u1ed9c ph\u1ed5i<\/span><\/li>\n\n\n\n<li><b>Leflunomide:<\/b><span style=\"font-weight: 400;\"> t\u0103ng c\u01b0\u1eddng \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch<\/span><\/li>\n\n\n\n<li><b>Thu\u1ed1c \u1ee9c ch\u1ebf protease (v\u00ed d\u1ee5 ritonavir, darunavir, saquinavir, indinavir, lopinavir, atazanavir, v.v.):<\/b><span style=\"font-weight: 400;\"> c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 ng\u1ed9 \u0111\u1ed9c cyclophosphamide<\/span><\/li>\n\n\n\n<li><b>Succinylcholine:<\/b><span style=\"font-weight: 400;\"> n\u1ed3ng \u0111\u1ed9 succinylcholine trong huy\u1ebft thanh c\u00f3 th\u1ec3 t\u0103ng l\u00ean<\/span><\/li>\n\n\n\n<li><b>Tacrolimus:<\/b><span style=\"font-weight: 400;\"> t\u0103ng nguy c\u01a1 nhi\u1ec5m tr\u00f9ng<\/span><\/li>\n\n\n\n<li><b>Thu\u1ed1c l\u1ee3i ti\u1ec3u thiazide (t\u1ee9c l\u00e0 hydrochlorothiazide, metolazone, indapamide, v.v.):<\/b><span style=\"font-weight: 400;\"> t\u0103ng nguy c\u01a1 gi\u1ea3m b\u1ea1ch c\u1ea7u h\u1ea1t<\/span><\/li>\n\n\n\n<li><b>V\u1eafc-xin (b\u1ea5t ho\u1ea1t): <\/b><span style=\"font-weight: 400;\">gi\u1ea3m hi\u1ec7u qu\u1ea3<\/span><\/li>\n\n\n\n<li><b>V\u1eafc-xin (tr\u1ef1c ti\u1ebfp): <\/b><span style=\"font-weight: 400;\">nguy c\u01a1 nhi\u1ec5m tr\u00f9ng li\u00ean quan \u0111\u1ebfn v\u1eafc-xin<\/span><\/li>\n\n\n\n<li><b>Vasopressin:<\/b><span style=\"font-weight: 400;\"> nguy c\u01a1 t\u0103ng t\u00e1c d\u1ee5ng ch\u1ed1ng b\u00e0i ni\u1ec7u<\/span><\/li>\n<\/ul>\n\n\n\n<p><b>Ghi ch\u00fa:<\/b><span style=\"font-weight: 400;\"> Xin l\u01b0u \u00fd r\u1eb1ng danh s\u00e1ch tr\u00ean kh\u00f4ng \u0111\u1ea7y \u0111\u1ee7. H\u00e3y lu\u00f4n tham kh\u1ea3o \u00fd ki\u1ebfn b\u00e1c s\u0129 ho\u1eb7c d\u01b0\u1ee3c s\u0129 \u0111\u1ec3 c\u00f3 \u0111\u00e1nh gi\u00e1 \u0111\u1ea7y \u0111\u1ee7 v\u1ec1 danh s\u00e1ch thu\u1ed1c c\u1ee7a b\u1ea1n.<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_To_Take_Cyclophosphamide\"><\/span>C\u00e1ch d\u00f9ng Cyclophosphamide<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Cyclophosphamide c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c d\u00f9ng qua \u0111\u01b0\u1eddng t\u0129nh m\u1ea1ch (IV) ho\u1eb7c \u0111\u01b0\u1eddng u\u1ed1ng (PO). Li\u1ec1u l\u01b0\u1ee3ng v\u00e0 \u0111\u01b0\u1eddng d\u00f9ng c\u00f3 th\u1ec3 thay \u0111\u1ed5i t\u00f9y theo ch\u1ec9 \u0111\u1ecbnh v\u00e0 t\u00ecnh tr\u1ea1ng b\u1ec7nh. B\u1ea5t k\u1ef3 t\u00ecnh tr\u1ea1ng b\u1ec7nh l\u00fd n\u00e0o c\u00f3 t\u1eeb tr\u01b0\u1edbc c\u0169ng c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn quy\u1ebft \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb. Do \u0111\u00f3, \u0111i\u1ec1u r\u1ea5t quan tr\u1ecdng l\u00e0 ph\u1ea3i th\u1ea3o lu\u1eadn c\u1edfi m\u1edf to\u00e0n b\u1ed9 ti\u1ec1n s\u1eed b\u1ec7nh c\u1ee7a b\u1ea1n v\u1edbi b\u00e1c s\u0129 tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u d\u00f9ng thu\u1ed1c n\u00e0y.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">B\u1ea5t k\u1ec3 li\u1ec1u l\u01b0\u1ee3ng hay \u0111\u01b0\u1eddng d\u00f9ng, vi\u1ec7c gi\u1eef \u0111\u1ee7 n\u01b0\u1edbc l\u00e0 r\u1ea5t quan tr\u1ecdng khi d\u00f9ng cyclophosphamide. Nh\u01b0 \u0111\u00e3 \u0111\u1ec1 c\u1eadp tr\u01b0\u1edbc \u0111\u00f3, vi\u00eam b\u00e0ng quang xu\u1ea5t huy\u1ebft l\u00e0 m\u1ed9t trong nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng nh\u1ea5t c\u1ee7a thu\u1ed1c n\u00e0y. <\/span><b>U\u1ed1ng nhi\u1ec1u n\u01b0\u1edbc, th\u01b0\u1eddng l\u00e0 kho\u1ea3ng 2 <\/b><b>\u2013<\/b><b> 3 l\u00edt m\u1ed7i ng\u00e0y<\/b><span style=\"font-weight: 400;\">, gi\u00fap th\u1eadn b\u00e0i ti\u1ebft thu\u1ed1c v\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a n\u00f3, c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 nguy c\u01a1 n\u00e0y.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Khi d\u00f9ng vi\u00ean nang ho\u1eb7c vi\u00ean n\u00e9n cyclophosphamide, <\/span><b>nu\u1ed1t tr\u1ecdn ch\u00fang<\/b><span style=\"font-weight: 400;\">Vi\u1ec7c m\u1edf vi\u00ean nang ho\u1eb7c nghi\u1ec1n n\u00e1t vi\u00ean thu\u1ed1c theo b\u1ea5t k\u1ef3 c\u00e1ch n\u00e0o kh\u00f4ng ch\u1ec9 c\u00f3 th\u1ec3 l\u00e0m thay \u0111\u1ed5i kh\u1ea3 n\u0103ng h\u1ea5p th\u1ee5 thu\u1ed1c khi d\u00f9ng m\u00e0 c\u00f2n c\u00f3 th\u1ec3 khi\u1ebfn thu\u1ed1c ti\u1ebfp x\u00fac v\u1edbi ng\u01b0\u1eddi kh\u00f4ng mong mu\u1ed1n. H\u00e3y \u0111\u1ea3m b\u1ea3o <\/span><b>r\u1eeda tay v\u00e0 lau s\u1ea1ch m\u1ecdi b\u1ec1 m\u1eb7t<\/b><span style=\"font-weight: 400;\"> thu\u1ed1c c\u00f3 th\u1ec3 ti\u1ebfp x\u00fac v\u1edbi thu\u1ed1c \u0111\u1ec3 h\u1ea1n ch\u1ebf ti\u1ebfp x\u00fac ngo\u00e0i \u00fd mu\u1ed1n.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">D\u00f9ng cyclophosphamide <\/span><b>ch\u00ednh x\u00e1c nh\u01b0 \u0111\u00e3 quy \u0111\u1ecbnh<\/b><span style=\"font-weight: 400;\">. B\u1ea5t k\u1ef3 thay \u0111\u1ed5i n\u00e0o m\u00e0 kh\u00f4ng tham kh\u1ea3o \u00fd ki\u1ebfn b\u00e1c s\u0129 l\u00e2m s\u00e0ng \u0111\u1ec1u c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 g\u1eb7p ph\u1ea3i c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng c\u0169ng nh\u01b0 th\u1ea5t b\u1ea1i trong \u0111i\u1ec1u tr\u1ecb.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Missed_Doses\"><\/span><b>Li\u1ec1u b\u1ecb qu\u00ean<\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">\u0110\u1ed1i v\u1edbi ti\u00eam cyclophosphamide, h\u00e3y li\u00ean h\u1ec7 ngay v\u1edbi b\u00e1c s\u0129 k\u00ea \u0111\u01a1n. K\u1ebf ho\u1ea1ch \u0111i\u1ec1u ch\u1ec9nh c\u00f3 th\u1ec3 kh\u00e1c nhau t\u00f9y t\u1eebng b\u1ec7nh nh\u00e2n.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">\u0110\u1ed1i v\u1edbi t\u1ea5t c\u1ea3 c\u00e1c s\u1ea3n ph\u1ea9m cyclophosphamide \u0111\u01b0\u1eddng u\u1ed1ng (vi\u00ean nang v\u00e0 vi\u00ean n\u00e9n), h\u00e3y u\u1ed1ng li\u1ec1u \u0111\u00e3 qu\u00ean ngay khi nh\u1edb ra. Tuy nhi\u00ean, n\u1ebfu li\u1ec1u ti\u1ebfp theo ph\u1ea3i u\u1ed1ng trong v\u00f2ng 8 gi\u1edd, h\u00e3y b\u1ecf qua li\u1ec1u \u0111\u00e3 qu\u00ean v\u00e0 ti\u1ebfp t\u1ee5c l\u1ecbch u\u1ed1ng thu\u1ed1c th\u00f4ng th\u01b0\u1eddng. Kh\u00f4ng u\u1ed1ng hai li\u1ec1u c\u00f9ng l\u00fac ho\u1eb7c u\u1ed1ng th\u00eam b\u1ea5t k\u1ef3 li\u1ec1u n\u00e0o.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Treatment_Monitoring\"><\/span><b>Theo d\u00f5i \u0111i\u1ec1u tr\u1ecb&nbsp;<\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK553087\/#:~:text=Cyclophosphamide%20is%20a%20medication%20primarily,anti%2Dneoplastic%20effects%20through%20alkylation.\"><span style=\"font-weight: 400;\">X\u00e9t nghi\u1ec7m m\u00e1u, x\u00e9t nghi\u1ec7m n\u01b0\u1edbc ti\u1ec3u v\u00e0 c\u00e1c lo\u1ea1i qu\u00e9t kh\u00e1c nhau<\/span><\/a><span style=\"font-weight: 400;\"> (xem b\u00ean d\u01b0\u1edbi) s\u1ebd \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n th\u01b0\u1eddng xuy\u00ean<\/span><span style=\"font-weight: 400;\"> \u0111\u1ec3 theo d\u00f5i hi\u1ec7u qu\u1ea3 v\u00e0 b\u1ea5t k\u1ef3 \u0111\u1ed9c t\u00ednh n\u00e0o c\u00f3 th\u1ec3 ph\u00e1t sinh khi s\u1eed d\u1ee5ng thu\u1ed1c n\u00e0y:<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">X\u00e9t nghi\u1ec7m n\u01b0\u1edbc ti\u1ec3u<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">X\u00e9t nghi\u1ec7m c\u00f4ng th\u1ee9c m\u00e1u to\u00e0n ph\u1ea7n (CBC) k\u00e8m ph\u00e2n t\u00edch t\u1ebf b\u00e0o m\u00e1u \u0111\u1ec3 theo d\u00f5i t\u00ecnh tr\u1ea1ng gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh, thi\u1ebfu m\u00e1u v\u00e0 gi\u1ea3m ti\u1ec3u c\u1ea7u.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">X\u00e9t nghi\u1ec7m ch\u1ee9c n\u0103ng gan<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">X\u00e9t nghi\u1ec7m ch\u1ee9c n\u0103ng th\u1eadn<\/span><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Cyclophosphamide l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c h\u00f3a tr\u1ecb hi\u1ec7n c\u00f3 s\u1eb5n d\u01b0\u1edbi d\u1ea1ng thu\u1ed1c generic v\u00e0 d\u01b0\u1edbi c\u00e1c t\u00ean th\u01b0\u01a1ng m\u1ea1i \u0111\u00e3 \u0111\u0103ng k\u00fd nh\u00e3n hi\u1ec7u, Cytoxan v\u00e0 Neosar. Thu\u1ed1c n\u00e0y c\u00f3 s\u1eb5n d\u01b0\u1edbi d\u1ea1ng vi\u00ean n\u00e9n ho\u1eb7c vi\u00ean nang u\u1ed1ng (ph\u1ea3i nu\u1ed1t c\u1ea3 vi\u00ean) v\u00e0 d\u1ea1ng dung d\u1ecbch ti\u00eam t\u0129nh m\u1ea1ch.<\/p>","protected":false},"author":10,"featured_media":20175,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[64],"tags":[14],"class_list":["post-20173","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-discontinued","tag-dr-james-lee"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cyclophosphamide - AmeriPharma\u00ae Specialty Care<\/title>\n<meta name=\"description\" content=\"Cyclophosphamide is a chemotherapy medication currently available as a generic and as the trademarked brand names, Cytoxan and Neosar. 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This medication is available as oral tablets or capsules that must be swallowed whole and as injectable solutions that are administered intravenously.","rttpg_featured_image_url":{"full":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/05\/Cyclophosphamide-1.jpeg",1280,853,false],"landscape":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/05\/Cyclophosphamide-1.jpeg",1280,853,false],"portraits":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/05\/Cyclophosphamide-1.jpeg",1280,853,false],"thumbnail":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/05\/Cyclophosphamide-1-150x150.jpeg",150,150,true],"medium":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/05\/Cyclophosphamide-1-300x200.jpeg",300,200,true],"large":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/05\/Cyclophosphamide-1-1024x682.jpeg",1024,682,true],"1536x1536":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/05\/Cyclophosphamide-1.jpeg",1280,853,false],"2048x2048":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/05\/Cyclophosphamide-1.jpeg",1280,853,false],"trp-custom-language-flag":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/05\/Cyclophosphamide-1.jpeg",18,12,false],"block-image-html-large":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/05\/Cyclophosphamide-1.jpeg",600,400,false],"ct-gallery":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/05\/Cyclophosphamide-1-330x220.jpeg",330,220,true],"ct-section-header":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/05\/Cyclophosphamide-1-1146x380.jpeg",1146,380,true],"ct-thumb":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/05\/Cyclophosphamide-1-86x57.jpeg",86,57,true],"ct-thumb-large":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/05\/Cyclophosphamide-1-167x111.jpeg",167,111,true],"ct-small":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/05\/Cyclophosphamide-1-280x187.jpeg",280,187,true],"ct-medium":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/05\/Cyclophosphamide-1-370x247.jpeg",370,247,true],"ct-xmedium":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/05\/Cyclophosphamide-1-960x640.jpeg",960,640,true],"ct-large":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/05\/Cyclophosphamide-1.jpeg",1280,853,false]},"rttpg_author":{"display_name":"Dr. James Lee, PharmD, BCPS","author_link":"https:\/\/ameripharmaspecialty.com\/vi\/author\/james-lee\/"},"rttpg_comment":0,"rttpg_category":"<a href=\"https:\/\/ameripharmaspecialty.com\/vi\/category\/discontinued\/\" rel=\"category tag\">Discontinued<\/a>","rttpg_excerpt":"Cyclophosphamide is a chemotherapy medication currently available as a generic and as the trademarked brand names, Cytoxan and Neosar. This medication is available as oral tablets or capsules that must be swallowed whole and as injectable solutions that are administered intravenously.","_links":{"self":[{"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/posts\/20173","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/comments?post=20173"}],"version-history":[{"count":0,"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/posts\/20173\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/media\/20175"}],"wp:attachment":[{"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/media?parent=20173"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/categories?post=20173"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/tags?post=20173"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}