{"id":19123,"date":"2022-03-10T10:23:16","date_gmt":"2022-03-10T18:23:16","guid":{"rendered":"https:\/\/ameripharmaspe.wpengine.com\/staging\/?p=18711"},"modified":"2026-03-19T14:38:30","modified_gmt":"2026-03-19T21:38:30","slug":"jakafi-ruxolitinib","status":"publish","type":"post","link":"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/jakafi-ruxolitinib\/","title":{"rendered":"Jakafi (Ruxolitinib)"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Chuy\u1ec3n \u0111\u1ed5i m\u1ee5c l\u1ee5c\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Chuy\u1ec3n \u0111\u1ed5i<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/jakafi-ruxolitinib\/#How_Does_Jakafi_Work\" >Jakafi ho\u1ea1t \u0111\u1ed9ng nh\u01b0 th\u1ebf n\u00e0o?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/jakafi-ruxolitinib\/#Benefits_of_Treatment\" >L\u1ee3i \u00edch c\u1ee7a \u0111i\u1ec1u tr\u1ecb<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/jakafi-ruxolitinib\/#What_Is_Jakafi_Used_For\" >Jakafi \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 l\u00e0m g\u00ec?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/jakafi-ruxolitinib\/#How_To_Take_Jakafi\" >C\u00e1ch s\u1eed d\u1ee5ng Jakafi<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/jakafi-ruxolitinib\/#Dosage\" >Li\u1ec1u d\u00f9ng<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/jakafi-ruxolitinib\/#Myelofibrosis\" >X\u01a1 t\u1ee7y<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/jakafi-ruxolitinib\/#Polycythemia_Vera\" >B\u1ec7nh \u0111a h\u1ed3ng c\u1ea7u nguy\u00ean ph\u00e1t<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/jakafi-ruxolitinib\/#Acute_Graft-Versus-Host_Disease\" >B\u1ec7nh gh\u00e9p ch\u1ed1ng v\u1eadt ch\u1ee7 c\u1ea5p t\u00ednh<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/jakafi-ruxolitinib\/#Chronic_Graft-Versus-Host_Disease\" >B\u1ec7nh gh\u00e9p ch\u1ed1ng v\u1eadt ch\u1ee7 m\u1ea1n t\u00ednh<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/jakafi-ruxolitinib\/#Jakafi_Dose_Modifications\" >\u0110i\u1ec1u ch\u1ec9nh li\u1ec1u l\u01b0\u1ee3ng Jakafi<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/jakafi-ruxolitinib\/#Concomitant_Use_With_Strong_CYP3A4_Inhibitors\" >S\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf CYP3A4 m\u1ea1nh<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/jakafi-ruxolitinib\/#Concomitant_Use_With_Strong_CYP3A4_Inducers\" >S\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c ch\u1ea5t c\u1ea3m \u1ee9ng CYP3A4 m\u1ea1nh<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/jakafi-ruxolitinib\/#Kidney_Dysfunction\" >R\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng th\u1eadn<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/jakafi-ruxolitinib\/#Liver_Dysfunction\" >R\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng gan<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/jakafi-ruxolitinib\/#Duration_of_Therapy\" >Th\u1eddi gian tr\u1ecb li\u1ec7u<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/jakafi-ruxolitinib\/#Drug_Interactions\" >T\u01b0\u01a1ng t\u00e1c thu\u1ed1c<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/jakafi-ruxolitinib\/#Monitoring_and_Follow-Up\" >Gi\u00e1m s\u00e1t v\u00e0 theo d\u00f5i<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/jakafi-ruxolitinib\/#Side_Effects\" >T\u00e1c d\u1ee5ng ph\u1ee5<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/jakafi-ruxolitinib\/#Jakafi_for_Specific_Populations\" >Jakafi d\u00e0nh cho c\u00e1c nh\u00f3m d\u00e2n s\u1ed1 c\u1ee5 th\u1ec3<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/jakafi-ruxolitinib\/#Pregnant_Women\" >Ph\u1ee5 n\u1eef mang thai<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/jakafi-ruxolitinib\/#Breastfeeding_Women\" >Ph\u1ee5 n\u1eef cho con b\u00fa<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_Does_Jakafi_Work\"><\/span>Jakafi ho\u1ea1t \u0111\u1ed9ng nh\u01b0 th\u1ebf n\u00e0o?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Jakafi (ruxolitinib) l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf protein kinase \u1ee9c ch\u1ebf m\u1ed9t s\u1ed1 enzyme \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 <a href=\"https:\/\/www.sciencedirect.com\/topics\/neuroscience\/janus-kinase\">Janus kinase<\/a> (JAK), tham gia v\u00e0o qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t t\u1ebf b\u00e0o m\u00e1u v\u00e0 truy\u1ec1n t\u00edn hi\u1ec7u mi\u1ec5n d\u1ecbch. Trong b\u1ec7nh x\u01a1 t\u1ee7y (ung th\u01b0 t\u1ee7y x\u01b0\u01a1ng) ho\u1eb7c b\u1ec7nh \u0111a h\u1ed3ng c\u1ea7u nguy\u00ean ph\u00e1t (m\u1ed9t r\u1ed1i lo\u1ea1n m\u00e1u hi\u1ebfm g\u1eb7p), c\u00e1c kinase Janus ho\u1ea1t \u0111\u1ed9ng qu\u00e1 m\u1ee9c, d\u1eabn \u0111\u1ebfn s\u1ea3n xu\u1ea5t t\u1ebf b\u00e0o m\u00e1u kh\u00f4ng ki\u1ec3m so\u00e1t, c\u00f3 th\u1ec3 t\u00edch t\u1ee5 \u1edf c\u00e1c c\u01a1 quan kh\u00e1c, ch\u1eb3ng h\u1ea1n nh\u01b0 l\u00e1 l\u00e1ch, g\u00e2y ph\u00ec \u0111\u1ea1i. Ruxolitinib \u1ee9c ch\u1ebf c\u00e1c con \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u c\u1ee5 th\u1ec3 v\u00e0 do \u0111\u00f3 ng\u0103n ch\u1eb7n s\u1ef1 s\u1ea3n xu\u1ea5t qu\u00e1 m\u1ee9c t\u1ebf b\u00e0o m\u00e1u n\u00e0y.<\/span><\/p>\n\n\n\n<p>C\u00e1c kinase Janus l\u00e0 m\u1ed9t ph\u1ea7n c\u1ee7a con \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 con \u0111\u01b0\u1eddng JAK-STAT, gi\u00fap \u0111i\u1ec1u ch\u1ec9nh qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t t\u1ebf b\u00e0o m\u00e1u, vi\u00eam nhi\u1ec5m v\u00e0 ch\u1ee9c n\u0103ng mi\u1ec5n d\u1ecbch. Khi con \u0111\u01b0\u1eddng n\u00e0y ho\u1ea1t \u0111\u1ed9ng qu\u00e1 m\u1ee9c, n\u00f3 c\u00f3 th\u1ec3 g\u00e2y ra s\u1ea3n xu\u1ea5t t\u1ebf b\u00e0o m\u00e1u v\u00e0 vi\u00eam nhi\u1ec5m qu\u00e1 m\u1ee9c, g\u00f3p ph\u1ea7n g\u00e2y ra c\u00e1c tri\u1ec7u ch\u1ee9ng b\u1ec7nh.<\/p>\n\n\n\n<p>B\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf c\u00e1c enzyme JAK1 v\u00e0 JAK2, Jakafi gi\u00fap gi\u1ea3m t\u00edn hi\u1ec7u b\u1ea5t th\u01b0\u1eddng, t\u1eeb \u0111\u00f3 c\u00f3 th\u1ec3 c\u1ea3i thi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng nh\u01b0 l\u00e1ch to, m\u1ec7t m\u1ecfi, \u0111\u1ed5 m\u1ed3 h\u00f4i \u0111\u00eam v\u00e0 ng\u1ee9a. V\u00ec t\u00edn hi\u1ec7u JAK c\u0169ng \u0111\u00f3ng vai tr\u00f2 trong ch\u1ee9c n\u0103ng mi\u1ec5n d\u1ecbch, vi\u1ec7c \u0111i\u1ec1u tr\u1ecb c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o m\u00e1u v\u00e0 l\u00e0m t\u0103ng nguy c\u01a1 nhi\u1ec5m tr\u00f9ng, \u0111\u00f3 l\u00e0 l\u00fd do t\u1ea1i sao c\u1ea7n theo d\u00f5i th\u01b0\u1eddng xuy\u00ean.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Benefits_of_Treatment\"><\/span><strong>L\u1ee3i \u00edch c\u1ee7a \u0111i\u1ec1u tr\u1ecb<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Jakafi c\u00f3 th\u1ec3 mang l\u1ea1i m\u1ed9t s\u1ed1 l\u1ee3i \u00edch cho b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh x\u01a1 t\u1ee7y, b\u1ec7nh \u0111a h\u1ed3ng c\u1ea7u ho\u1eb7c b\u1ec7nh gh\u00e9p ch\u1ed1ng ch\u1ee7, bao g\u1ed3m:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Gi\u1ea3m k\u00edch th\u01b0\u1edbc l\u00e1 l\u00e1ch<\/li>\n\n\n\n<li>C\u1ea3i thi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng li\u00ean quan \u0111\u1ebfn b\u1ec7nh nh\u01b0 m\u1ec7t m\u1ecfi, \u0111\u1ed5 m\u1ed3 h\u00f4i ban \u0111\u00eam, \u0111au x\u01b0\u01a1ng v\u00e0 ng\u1ee9a.<\/li>\n\n\n\n<li>Ki\u1ec3m so\u00e1t b\u1ec7nh t\u1ed1t h\u01a1n khi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c kh\u00f4ng hi\u1ec7u qu\u1ea3 ho\u1eb7c kh\u00f4ng dung n\u1ea1p t\u1ed1t.<\/li>\n\n\n\n<li>M\u1ed9t l\u1ef1a ch\u1ecdn \u0111i\u1ec1u tr\u1ecb kh\u00f4ng s\u1eed d\u1ee5ng steroid cho b\u1ec7nh gh\u00e9p ch\u1ed1ng ch\u1ee7 \u1edf m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n<\/li>\n<\/ul>\n\n\n\n<p>K\u1ebft qu\u1ea3 c\u00f3 th\u1ec3 kh\u00e1c nhau \u1edf m\u1ed7i ng\u01b0\u1eddi, v\u00e0 c\u00f3 th\u1ec3 m\u1ea5t v\u00e0i tu\u1ea7n ho\u1eb7c v\u00e0i th\u00e1ng \u0111\u1ec3 th\u1ea5y \u0111\u01b0\u1ee3c \u0111\u1ea7y \u0111\u1ee7 l\u1ee3i \u00edch.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_Is_Jakafi_Used_For\"><\/span>Jakafi \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 l\u00e0m g\u00ec?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><b>X\u01a1 t\u1ee7y: <\/b><span data-preserver-spaces=\"true\">Jakafi \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb x\u01a1 t\u1ee7y (MF) trung b\u00ecnh ho\u1eb7c nguy c\u01a1 cao, bao g\u1ed3m MF nguy\u00ean ph\u00e1t, MF sau \u0111a h\u1ed3ng c\u1ea7u nguy\u00ean ph\u00e1t v\u00e0 MF sau t\u0103ng ti\u1ec3u c\u1ea7u nguy\u00ean ph\u00e1t \u1edf ng\u01b0\u1eddi l\u1edbn.<\/span><span style=\"font-weight: 400;\">&nbsp;<\/span><\/li>\n\n\n\n<li><b>B\u1ec7nh \u0111a h\u1ed3ng c\u1ea7u nguy\u00ean ph\u00e1t:<\/b> <span data-preserver-spaces=\"true\">Jakafi \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh \u0111a h\u1ed3ng c\u1ea7u nguy\u00ean ph\u00e1t (PV) cho ng\u01b0\u1eddi l\u1edbn kh\u00f4ng \u0111\u00e1p \u1ee9ng \u0111\u1ea7y \u0111\u1ee7 ho\u1eb7c kh\u00f4ng dung n\u1ea1p hydroxyurea.<\/span><\/li>\n\n\n\n<li><b>B\u1ec7nh gh\u00e9p ch\u1ed1ng v\u1eadt ch\u1ee7 c\u1ea5p t\u00ednh:<\/b> <span data-preserver-spaces=\"true\">Jakafi \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh gh\u00e9p ch\u1ed1ng v\u1eadt ch\u1ee7 c\u1ea5p t\u00ednh kh\u00e1ng steroid (aGVHD) \u1edf ng\u01b0\u1eddi l\u1edbn v\u00e0 b\u1ec7nh nhi tr\u00ean 12 tu\u1ed5i.&nbsp;<\/span><\/li>\n\n\n\n<li><b>B\u1ec7nh gh\u00e9p ch\u1ed1ng v\u1eadt ch\u1ee7 m\u1ea1n t\u00ednh: <\/b><span data-preserver-spaces=\"true\">Jakafi \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh gh\u00e9p ch\u1ed1ng v\u1eadt ch\u1ee7 m\u1ea1n t\u00ednh (cGVHD) \u1edf ng\u01b0\u1eddi l\u1edbn v\u00e0 b\u1ec7nh nhi (tr\u00ean 12 tu\u1ed5i) sau khi th\u1ea5t b\u1ea1i v\u1edbi m\u1ed9t ho\u1eb7c hai li\u1ec7u ph\u00e1p to\u00e0n th\u00e2n.<\/span><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_To_Take_Jakafi\"><\/span>C\u00e1ch s\u1eed d\u1ee5ng Jakafi<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Jakafi \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng, th\u01b0\u1eddng l\u00e0 hai l\u1ea7n m\u1ed7i ng\u00e0y, theo ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Jakafi c\u00f3 th\u1ec3 u\u1ed1ng c\u00f9ng ho\u1eb7c kh\u00f4ng c\u00f9ng th\u1ee9c \u0103n.<br><\/li>\n\n\n\n<li>U\u1ed1ng thu\u1ed1c v\u00e0o c\u00f9ng m\u1ed9t th\u1eddi \u0111i\u1ec3m m\u1ed7i ng\u00e0y.<br><\/li>\n\n\n\n<li>Nu\u1ed1t c\u1ea3 vi\u00ean thu\u1ed1c tr\u1eeb khi b\u00e1c s\u0129 c\u1ee7a b\u1ea1n h\u01b0\u1edbng d\u1eabn kh\u00e1c.<br><\/li>\n\n\n\n<li>N\u1ebfu b\u1ea1n qu\u00ean u\u1ed1ng m\u1ed9t li\u1ec1u, h\u00e3y b\u1ecf qua li\u1ec1u \u0111\u00f3 v\u00e0 u\u1ed1ng li\u1ec1u ti\u1ebfp theo v\u00e0o \u0111\u00fang gi\u1edd quy \u0111\u1ecbnh.<br><\/li>\n\n\n\n<li>Kh\u00f4ng \u0111\u01b0\u1ee3c u\u1ed1ng hai li\u1ec1u c\u00f9ng m\u1ed9t l\u00fac \u0111\u1ec3 b\u00f9 cho li\u1ec1u \u0111\u00e3 b\u1ecf l\u1ee1.<br><\/li>\n<\/ul>\n\n\n\n<p>Lu\u00f4n tu\u00e2n theo h\u01b0\u1edbng d\u1eabn c\u1ee7a b\u00e1c s\u0129 khi d\u00f9ng Jakafi.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dosage\"><\/span>Li\u1ec1u d\u00f9ng<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Myelofibrosis\"><\/span>X\u01a1 t\u1ee7y<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Li\u1ec1u kh\u1edfi \u0111\u1ea7u \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o d\u1ef1a tr\u00ean s\u1ed1 l\u01b0\u1ee3ng ti\u1ec3u c\u1ea7u:&nbsp;&nbsp;<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">\u0110\u1ed1i v\u1edbi ti\u1ec3u c\u1ea7u t\u1eeb 50.000\/mm\u00b3 \u0111\u1ebfn 100.000\/mm\u00b3: 5 mg x 2 l\u1ea7n\/ng\u00e0y<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u0110\u1ed1i v\u1edbi ti\u1ec3u c\u1ea7u t\u1eeb 100.000\/mm\u00b3 \u0111\u1ebfn 200.000\/mm\u00b3: 15 mg x 2 l\u1ea7n\/ng\u00e0y<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u0110\u1ed1i v\u1edbi ti\u1ec3u c\u1ea7u &gt; 200.000\/mm\u00b3: 20 mg x 2 l\u1ea7n\/ng\u00e0y<\/span><\/li>\n<\/ul>\n\n\n\n<p><span style=\"font-weight: 400;\">X\u00e9t nghi\u1ec7m m\u00e1u \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb, c\u1ee9 sau 2 \u0111\u1ebfn 4 tu\u1ea7n cho \u0111\u1ebfn khi li\u1ec1u l\u01b0\u1ee3ng \u1ed5n \u0111\u1ecbnh v\u00e0 sau \u0111\u00f3 theo ch\u1ec9 \u0111\u1ecbnh l\u00e2m s\u00e0ng.&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Li\u1ec1u l\u01b0\u1ee3ng s\u1ebd \u0111\u01b0\u1ee3c b\u00e1c s\u0129 x\u00e1c \u0111\u1ecbnh v\u00e0 \u0111i\u1ec1u ch\u1ec9nh d\u1ef1a tr\u00ean t\u00ednh an to\u00e0n, hi\u1ec7u qu\u1ea3 v\u00e0 s\u1ed1 l\u01b0\u1ee3ng ti\u1ec3u c\u1ea7u hi\u1ec7n t\u1ea1i.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Polycythemia_Vera\"><\/span>B\u1ec7nh \u0111a h\u1ed3ng c\u1ea7u nguy\u00ean ph\u00e1t<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">\u0110\u1ed1i v\u1edbi b\u1ec7nh \u0111a h\u1ed3ng c\u1ea7u nguy\u00ean ph\u00e1t, li\u1ec1u khuy\u1ebfn c\u00e1o l\u00e0<\/span> <span style=\"font-weight: 400;\">10 mg, ng\u00e0y 2 l\u1ea7n.<\/span><\/p>\n\n\n\n<p>Vi\u1ec7c x\u00e9t nghi\u1ec7m m\u00e1u \u0111\u01b0\u1ee3c theo d\u00f5i th\u01b0\u1eddng xuy\u00ean khi c\u00f3 ch\u1ec9 \u0111\u1ecbnh l\u00e2m s\u00e0ng.<\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Li\u1ec1u l\u01b0\u1ee3ng s\u1ebd \u0111\u01b0\u1ee3c b\u00e1c s\u0129 x\u00e1c \u0111\u1ecbnh v\u00e0 \u0111i\u1ec1u ch\u1ec9nh d\u1ef1a tr\u00ean t\u00ednh an to\u00e0n, hi\u1ec7u qu\u1ea3 v\u00e0 s\u1ed1 l\u01b0\u1ee3ng hemoglobin v\u00e0 ti\u1ec3u c\u1ea7u hi\u1ec7n t\u1ea1i.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Acute_Graft-Versus-Host_Disease\"><\/span>B\u1ec7nh gh\u00e9p ch\u1ed1ng v\u1eadt ch\u1ee7 c\u1ea5p t\u00ednh<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">\u0110\u1ed1i v\u1edbi b\u1ec7nh gh\u00e9p ch\u1ed1ng v\u1eadt ch\u1ee7 c\u1ea5p t\u00ednh, li\u1ec1u khuy\u1ebfn c\u00e1o l\u00e0<\/span> <span style=\"font-weight: 400;\">U\u1ed1ng 5 mg, ng\u00e0y 2 l\u1ea7n.<\/span><\/p>\n\n\n\n<p>Vi\u1ec7c x\u00e9t nghi\u1ec7m m\u00e1u \u0111\u01b0\u1ee3c theo d\u00f5i th\u01b0\u1eddng xuy\u00ean khi c\u00f3 ch\u1ec9 \u0111\u1ecbnh l\u00e2m s\u00e0ng.<\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Li\u1ec1u l\u01b0\u1ee3ng s\u1ebd \u0111\u01b0\u1ee3c b\u00e1c s\u0129 x\u00e1c \u0111\u1ecbnh v\u00e0 \u0111i\u1ec1u ch\u1ec9nh d\u1ef1a tr\u00ean t\u00ednh an to\u00e0n, hi\u1ec7u qu\u1ea3 v\u00e0 s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u trung t\u00ednh tuy\u1ec7t \u0111\u1ed1i (ANC) v\u00e0 m\u1ee9c bilirubin hi\u1ec7n t\u1ea1i.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Chronic_Graft-Versus-Host_Disease\"><\/span>B\u1ec7nh gh\u00e9p ch\u1ed1ng v\u1eadt ch\u1ee7 m\u1ea1n t\u00ednh<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">\u0110\u1ed1i v\u1edbi b\u1ec7nh gh\u00e9p ch\u1ed1ng v\u1eadt ch\u1ee7 m\u1ea1n t\u00ednh, li\u1ec1u khuy\u1ebfn c\u00e1o l\u00e0 10 mg u\u1ed1ng hai l\u1ea7n m\u1ed7i ng\u00e0y.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Vi\u1ec7c x\u00e9t nghi\u1ec7m m\u00e1u \u0111\u01b0\u1ee3c theo d\u00f5i th\u01b0\u1eddng xuy\u00ean khi c\u00f3 ch\u1ec9 \u0111\u1ecbnh l\u00e2m s\u00e0ng.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Li\u1ec1u l\u01b0\u1ee3ng s\u1ebd \u0111\u01b0\u1ee3c b\u00e1c s\u0129 \u0111i\u1ec1u ch\u1ec9nh d\u1ef1a tr\u00ean t\u00ednh an to\u00e0n, hi\u1ec7u qu\u1ea3 v\u00e0 m\u1ee9c ANC v\u00e0 bilirubin hi\u1ec7n t\u1ea1i.<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Jakafi_Dose_Modifications\"><\/span>\u0110i\u1ec1u ch\u1ec9nh li\u1ec1u l\u01b0\u1ee3ng Jakafi<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Concomitant_Use_With_Strong_CYP3A4_Inhibitors\"><\/span>S\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf CYP3A4 m\u1ea1nh<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">M\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c nh\u1ea5t \u0111\u1ecbnh <\/span><a href=\"https:\/\/www.uptodate.com\/contents\/image?imageKey=CARD%2F76992\"><span style=\"font-weight: 400;\">Ch\u1ea5t \u1ee9c ch\u1ebf CYP3A4<\/span><\/a><span style=\"font-weight: 400;\">, ch\u1eb3ng h\u1ea1n nh\u01b0 fluconazole, l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 Jakafi trong m\u00e1u. Do \u0111\u00f3, \u0111i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i. H\u00e3y cho b\u00e1c s\u0129 bi\u1ebft v\u1ec1 t\u1ea5t c\u1ea3 c\u00e1c lo\u1ea1i thu\u1ed1c b\u1ea1n \u0111ang d\u00f9ng tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u d\u00f9ng Jakafi v\u00ec c\u00f3 th\u1ec3 c\u1ea7n gi\u1ea3m li\u1ec1u n\u1ebfu d\u00f9ng chung v\u1edbi b\u1ea5t k\u1ef3 ch\u1ea5t \u1ee9c ch\u1ebf CYP3A4 n\u00e0o.&nbsp;<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Concomitant_Use_With_Strong_CYP3A4_Inducers\"><\/span>S\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c ch\u1ea5t c\u1ea3m \u1ee9ng CYP3A4 m\u1ea1nh<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">M\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c c\u1ea3m \u1ee9ng CYP3A4 l\u00e0m gi\u1ea3m l\u01b0\u1ee3ng Jakafi trong m\u00e1u. Do \u0111\u00f3, \u0111i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3. H\u00e3y cho b\u00e1c s\u0129 bi\u1ebft v\u1ec1 t\u1ea5t c\u1ea3 c\u00e1c lo\u1ea1i thu\u1ed1c b\u1ea1n \u0111ang d\u00f9ng tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u d\u00f9ng Jakafi v\u00ec c\u00f3 th\u1ec3 c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u n\u1ebfu d\u00f9ng chung v\u1edbi b\u1ea5t k\u1ef3 thu\u1ed1c c\u1ea3m \u1ee9ng CYP3A4 n\u00e0o.&nbsp;<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Kidney_Dysfunction\"><\/span>R\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng th\u1eadn<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">N\u1ebfu b\u1ea1n b\u1ecb suy th\u1eadn, li\u1ec1u d\u00f9ng c\u1ee7a b\u1ea1n s\u1ebd c\u1ea7n \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh. N\u1ebfu b\u1ea1n b\u1ecb suy th\u1eadn<\/span><span style=\"font-weight: 400;\">b\u1ec7nh th\u1eadn giai \u0111o\u1ea1n 2<\/span> <span style=\"font-weight: 400;\">(<\/span><span style=\"font-weight: 400;\">ESRD) kh\u00f4ng c\u1ea7n l\u1ecdc m\u00e1u, n\u00ean tr\u00e1nh d\u00f9ng Jakafi. H\u00e3y cho b\u00e1c s\u0129 bi\u1ebft n\u1ebfu b\u1ea1n b\u1ecb b\u1ea5t k\u1ef3 lo\u1ea1i suy th\u1eadn n\u00e0o.&nbsp;<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Liver_Dysfunction\"><\/span>R\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng gan<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">N\u1ebfu b\u1ea1n b\u1ecb suy gan, c\u1ea7n ph\u1ea3i \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u. H\u00e3y cho b\u00e1c s\u0129 bi\u1ebft n\u1ebfu b\u1ea1n b\u1ecb b\u1ea5t k\u1ef3 lo\u1ea1i suy gan n\u00e0o.&nbsp;<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Duration_of_Therapy\"><\/span>Th\u1eddi gian tr\u1ecb li\u1ec7u<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">B\u00e1c s\u0129 c\u00f3 th\u1ec3 cho b\u1ea1n d\u00f9ng thu\u1ed1c Jakafi trong v\u00f2ng 6 th\u00e1ng \u0111\u1ec3 xem li\u1ec7u thu\u1ed1c n\u00e0y c\u00f3 hi\u1ec7u qu\u1ea3 v\u1edbi b\u1ea1n hay kh\u00f4ng. N\u1ebfu kh\u00f4ng th\u1ea5y c\u1ea3i thi\u1ec7n sau 6 th\u00e1ng \u0111i\u1ec1u tr\u1ecb, b\u00e1c s\u0129 c\u00f3 th\u1ec3 y\u00eau c\u1ea7u b\u1ea1n ng\u1eebng d\u00f9ng thu\u1ed1c.&nbsp;&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">\u0110i\u1ec1u quan tr\u1ecdng l\u00e0 b\u1ea1n ph\u1ea3i d\u00f9ng Jakafi \u0111\u00fang theo ch\u1ec9 \u0111\u1ecbnh. Kh\u00f4ng \u0111\u01b0\u1ee3c ng\u1eebng d\u00f9ng thu\u1ed1c m\u00e0 kh\u00f4ng h\u1ecfi \u00fd ki\u1ebfn b\u00e1c s\u0129 tr\u01b0\u1edbc. Ngo\u1ea1i tr\u1eeb tr\u01b0\u1eddng h\u1ee3p b\u1ea1n b\u1ecb ch\u1ea3y m\u00e1u nghi\u00eam tr\u1ecdng. N\u1ebfu \u0111i\u1ec1u n\u00e0y x\u1ea3y ra, h\u00e3y ng\u1eebng d\u00f9ng Jakafi v\u00e0 g\u1ecdi ngay cho b\u00e1c s\u0129.<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Drug_Interactions\"><\/span>T\u01b0\u01a1ng t\u00e1c thu\u1ed1c<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Jakafi c\u00f3 th\u1ec3 t\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c v\u00e0 th\u1ef1c ph\u1ea9m ch\u1ee9c n\u0103ng kh\u00e1c.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>C\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf ho\u1eb7c c\u1ea3m \u1ee9ng CYP3A4 m\u1ea1nh c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn n\u1ed3ng \u0111\u1ed9 Jakafi.<\/li>\n\n\n\n<li>C\u00e1c lo\u1ea1i thu\u1ed1c \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch kh\u00e1c c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 nhi\u1ec5m tr\u00f9ng.<\/li>\n\n\n\n<li>N\u00f3i chung, n\u00ean tr\u00e1nh s\u1eed d\u1ee5ng v\u1eafc-xin s\u1ed1ng trong su\u1ed1t qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<\/li>\n\n\n\n<li>C\u00e1c lo\u1ea1i th\u1ef1c ph\u1ea9m ch\u1ee9c n\u0103ng t\u1eeb th\u1ea3o d\u01b0\u1ee3c, ch\u1eb3ng h\u1ea1n nh\u01b0 c\u00e2y Hypericum perforatum (c\u00e2y St. John&#039;s wort), c\u00f3 th\u1ec3 g\u00e2y c\u1ea3n tr\u1edf qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<\/li>\n<\/ul>\n\n\n\n<p>Lu\u00f4n th\u00f4ng b\u00e1o cho b\u00e1c s\u0129 v\u1ec1 t\u1ea5t c\u1ea3 c\u00e1c lo\u1ea1i thu\u1ed1c, th\u1ef1c ph\u1ea9m ch\u1ee9c n\u0103ng v\u00e0 v\u1eafc xin b\u1ea1n \u0111ang d\u00f9ng tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u s\u1eed d\u1ee5ng Jakafi.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Monitoring_and_Follow-Up\"><\/span>Gi\u00e1m s\u00e1t v\u00e0 theo d\u00f5i<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Theo d\u00f5i th\u01b0\u1eddng xuy\u00ean l\u00e0 m\u1ed9t ph\u1ea7n quan tr\u1ecdng c\u1ee7a qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Jakafi.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>X\u00e9t nghi\u1ec7m c\u00f4ng th\u1ee9c m\u00e1u nh\u1eb1m theo d\u00f5i s\u1ed1 l\u01b0\u1ee3ng h\u1ed3ng c\u1ea7u, b\u1ea1ch c\u1ea7u v\u00e0 ti\u1ec3u c\u1ea7u.<\/li>\n\n\n\n<li>Ch\u1ee9c n\u0103ng gan v\u00e0 th\u1eadn c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c theo d\u00f5i.<\/li>\n\n\n\n<li>Vi\u1ec7c \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u l\u01b0\u1ee3ng l\u00e0 ph\u1ed5 bi\u1ebfn v\u00e0 d\u1ef1a tr\u00ean k\u1ebft qu\u1ea3 x\u00e9t nghi\u1ec7m v\u00e0 t\u00e1c d\u1ee5ng ph\u1ee5.<\/li>\n<\/ul>\n\n\n\n<p>L\u1ecbch theo d\u00f5i c\u00f3 th\u1ec3 thay \u0111\u1ed5i theo th\u1eddi gian t\u00f9y thu\u1ed9c v\u00e0o ph\u1ea3n \u1ee9ng c\u1ee7a b\u1ea1n v\u1edbi \u0111i\u1ec1u tr\u1ecb.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Side_Effects\"><\/span>T\u00e1c d\u1ee5ng ph\u1ee5<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 ph\u1ed5 bi\u1ebfn nh\u1ea5t l\u00e0:&nbsp;<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/my.clevelandclinic.org\/health\/diseases\/14430-thrombocytopenia\"><span style=\"font-weight: 400;\">Gi\u1ea3m ti\u1ec3u c\u1ea7u<\/span><\/a><span style=\"font-weight: 400;\"> (ti\u1ec3u c\u1ea7u th\u1ea5p)<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Thi\u1ebfu m\u00e1u (s\u1ed1 l\u01b0\u1ee3ng h\u1ed3ng c\u1ea7u th\u1ea5p)&nbsp;<\/span><\/li>\n\n\n\n<li><a href=\"https:\/\/my.clevelandclinic.org\/health\/diseases\/21058-neutropenia\"><span style=\"font-weight: 400;\">Gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh<\/span><\/a><span style=\"font-weight: 400;\"> (s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u th\u1ea5p)<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Nguy c\u01a1 nhi\u1ec5m tr\u00f9ng (v\u00ed d\u1ee5: b\u1ec7nh lao, b\u1ec7nh n\u00e3o ch\u1ea5t tr\u1eafng \u0111a \u1ed5 ti\u1ebfn tri\u1ec3n, b\u1ec7nh zona v\u00e0 vi\u00eam gan B)&nbsp;<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">B\u1ea7m t\u00edm<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Ch\u00f3ng m\u1eb7t<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">\u0110au \u0111\u1ea7u<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Ti\u00eau ch\u1ea3y<\/span><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Jakafi_for_Specific_Populations\"><\/span>Jakafi d\u00e0nh cho c\u00e1c nh\u00f3m d\u00e2n s\u1ed1 c\u1ee5 th\u1ec3<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Pregnant_Women\"><\/span>Ph\u1ee5 n\u1eef mang thai<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng Jakafi trong th\u1eddi k\u1ef3 mang thai ho\u1eb7c khi \u0111ang c\u00f3 k\u1ebf ho\u1ea1ch mang thai. Ch\u01b0a r\u00f5 li\u1ec7u Jakafi c\u00f3 g\u00e2y h\u1ea1i cho thai nhi hay kh\u00f4ng.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Breastfeeding_Women\"><\/span>Ph\u1ee5 n\u1eef cho con b\u00fa<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Kh\u00f4ng cho con b\u00fa trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb ho\u1eb7c trong v\u00f2ng 2 tu\u1ea7n sau li\u1ec1u cu\u1ed1i c\u00f9ng. Ch\u01b0a r\u00f5 thu\u1ed1c Jakafi c\u00f3 b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9 hay kh\u00f4ng.&nbsp;<\/span><\/p>","protected":false},"excerpt":{"rendered":"<p>Jakafi (ruxolitinib) l\u00e0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf protein kinase, \u1ee9c ch\u1ebf m\u1ed9t s\u1ed1 enzyme g\u1ecdi l\u00e0 Janus kinase (JAK), tham gia v\u00e0o qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t t\u1ebf b\u00e0o m\u00e1u v\u00e0 truy\u1ec1n t\u00edn hi\u1ec7u mi\u1ec5n d\u1ecbch. Trong b\u1ec7nh x\u01a1 t\u1ee7y (ung th\u01b0 t\u1ee7y x\u01b0\u01a1ng) ho\u1eb7c b\u1ec7nh \u0111a h\u1ed3ng c\u1ea7u nguy\u00ean ph\u00e1t (m\u1ed9t r\u1ed1i lo\u1ea1n m\u00e1u hi\u1ebfm g\u1eb7p), c\u00e1c Janus kinase ho\u1ea1t \u0111\u1ed9ng qu\u00e1 m\u1ee9c, d\u1eabn \u0111\u1ebfn s\u1ea3n xu\u1ea5t t\u1ebf b\u00e0o m\u00e1u kh\u00f4ng ki\u1ec3m so\u00e1t, c\u00f3 th\u1ec3 t\u00edch t\u1ee5 \u1edf c\u00e1c c\u01a1 quan kh\u00e1c, ch\u1eb3ng h\u1ea1n nh\u01b0 l\u00e1 l\u00e1ch, g\u00e2y ph\u00ec \u0111\u1ea1i.<\/p>","protected":false},"author":9,"featured_media":19124,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[64],"tags":[9],"class_list":["post-19123","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-discontinued","tag-dr-stephanie-shieh"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - 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She attended the Western University of Health Sciences and has been a practicing pharmacist for 7 years. The most rewarding part of her job is seeing her patients happy - whether it\u2019s helping them understand their medication, catching a drug interaction, or being able to communicate with their doctor to improve their therapy. She is currently precepting students from Marshall B. Ketchum University. In her free time, she enjoys spending quality time with her husband and 2 daughters. 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