{"id":18546,"date":"2022-02-07T11:36:23","date_gmt":"2022-02-07T19:36:23","guid":{"rendered":"https:\/\/ameripharmaspe.wpengine.com\/?p=18546"},"modified":"2026-01-22T11:30:57","modified_gmt":"2026-01-22T18:30:57","slug":"sorafenib-nexavar","status":"publish","type":"post","link":"https:\/\/ameripharmaspecialty.com\/vi\/cancer\/sorafenib-nexavar\/","title":{"rendered":"Nexavar (Sorafenib): C\u00f4ng d\u1ee5ng, li\u1ec1u d\u00f9ng, t\u00e1c d\u1ee5ng ph\u1ee5 v\u00e0 th\u00f4ng tin an to\u00e0n"},"content":{"rendered":"\n<p><span style=\"font-weight: 400;\">Sorafenib (pronounced [sor AF e nib]) is also known by the brand name, Nexavar. Sorafenib is available under the brand name Nexavar and as generic sorafenib. It is an antineoplastic (anti-cancer) medicine and a kinase inhibitor (a type of targeted therapy) that blocks multiple enzymes involved in tumor growth and tumor blood vessel formation. It is used to treat certain types of cancer, including liver, kidney, and thyroid cancers. Nexavar can slow cancer growth by blocking signals that help tumor cells grow and by reducing the growth of blood vessels that supply tumors.<\/span><\/p>\n\n\n\n<div  id=\"call-to-action-00851d827dcc6d426de20420019066a3\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tSpeak to a Chemo Specialist\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"tel:8777780318\">(877) 778-0318<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/cancer\/sorafenib-nexavar\/#Safe_Handling\" >Safe Handling<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/cancer\/sorafenib-nexavar\/#How_Is_Nexavar_Used\" >How Is Nexavar Used?<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/cancer\/sorafenib-nexavar\/#Available_Formulations\" >Available Formulations<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/cancer\/sorafenib-nexavar\/#Directions_for_Use\" >Directions for Use<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/cancer\/sorafenib-nexavar\/#Missed_Dose\" >Missed Dose<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/cancer\/sorafenib-nexavar\/#Storage\" >Storage<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/cancer\/sorafenib-nexavar\/#What_To_Avoid_While_Taking_Nexavar\" >What To Avoid While Taking Nexavar?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/cancer\/sorafenib-nexavar\/#Pregnancy_and_Nexavar\" >Pregnancy and Nexavar<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/cancer\/sorafenib-nexavar\/#Side_Effects\" >Side Effects<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/cancer\/sorafenib-nexavar\/#Cardiac_Complications\" >Cardiac Complications&nbsp;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/cancer\/sorafenib-nexavar\/#Bleeding_or_GI_Complications\" >Bleeding or GI Complications<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/cancer\/sorafenib-nexavar\/#Hand-and-Foot_Syndrome\" >Hand-and-Foot Syndrome<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/cancer\/sorafenib-nexavar\/#Skin_Rash\" >Skin Rash<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/cancer\/sorafenib-nexavar\/#Impaired_Wound_Healing\" >Impaired Wound Healing&nbsp;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/cancer\/sorafenib-nexavar\/#Thyroid_Impairment\" >Thyroid Impairment<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/cancer\/sorafenib-nexavar\/#Liver_Complications\" >Liver Complications&nbsp;<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/cancer\/sorafenib-nexavar\/#Precautions\" >Precautions<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/cancer\/sorafenib-nexavar\/#FAQs\" >FAQs<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Safe_Handling\"><\/span><strong>Safe Handling<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Sorafenib is considered a hazardous drug; avoid crushing\/breaking tablets and minimize direct contact. Avoid contact during pregnancy or while nursing. If a tablet is damaged, follow your pharmacy\u2019s handling instructions and consider wearing gloves.<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_Is_Nexavar_Used\"><\/span>How Is Nexavar Used?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Nexavar has been approved by the <a href=\"https:\/\/www.fda.gov\/\">Food and Drug Administration (FDA)<\/a> to treat different types of cancers, including hepatocellular, renal cell, and thyroid cancers. Your provider may prescribe Nexavar alone or with other cancer treatments, depending on your diagnosis and treatment plan. The recommended dose is 400 mg (two 200 mg tablets) taken twice daily without food (at least 1 hour before or 2 hours after a meal), unless your provider adjusts it. The dose should not be more or less than what is prescribed.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Available_Formulations\"><\/span><b>Available Formulations<\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Nexavar tablets are taken by mouth and are supplied as 200 mg oral tablets. The 200mg Nexavar brand-name tablets are round, biconvex, red, film-coated tablets debossed with the \u201cBayer cross\u201d on one side and \u201c200\u201d on the other side. However, as there are several FDA-approved generic formulations available, the tablets may look different. Consult your healthcare provider or pharmacist with any questions you may have regarding the appearance of your tablets.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Directions_for_Use\"><\/span><b>Directions for Use<\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Administer Nexavar on an empty stomach (at least 1 hour before or 2 hours after a meal). If you cannot swallow the tablets, do not crush or dissolve Nexavar unless your oncology team\/pharmacist specifically instructs you to. Ask your pharmacist for the safest preparation method to reduce dosing errors and caregiver exposure.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Missed_Dose\"><\/span><b>Missed Dose<\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">If you have accidentally missed a dose, skip the missed dose and go back to your regular schedule. Do not double dose. Do not take more than your prescribed dose of Nexavar each day.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Storage\"><\/span><b>Storage<\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Store tablets in a cool, dry place at room temperature and ensure the bottle is tightly closed.<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_To_Avoid_While_Taking_Nexavar\"><\/span>What To Avoid While Taking Nexavar?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">While taking Nexavar therapy, you must follow some precautions. Always tell your physician about any medications you are already taking. <\/span><b>Do not take any drug or medicine (even herbals, vitamins, or over-the-counter medications) without prior consent from your physician or pharmacist<\/b><span style=\"font-weight: 400;\">. They may have some significant interactions with Nexavar.<\/span><\/p>\n\n\n\n<div  id=\"call-to-action-94acfed68ff3e6872f15600d499bffff\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tSpeak to a Specialist About Copay Assistance\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"#form\">Consult a Chemo Specialist<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Pregnancy_and_Nexavar\"><\/span>Pregnancy and Nexavar<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Pregnancy status must be checked prior to starting Nexavar therapy in women of childbearing age, and effective contraception must be used during treatment and for 6 months after the last dose. Males with female partners of reproductive potential should use effective contraception during treatment and for 3 months after the last dose. Nexavar may cause fetal harm and is therefore not recommended for women who are breastfeeding during therapy. Breastfeeding should also be avoided for at least 2 weeks after the last dose.&nbsp;<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Side_Effects\"><\/span>Side Effects<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">As with any other medication, you may encounter side effects while taking Nexavar. A few things to remember are:<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">You may not have all the side effects listed below. Many people may experience little to no side effects.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">The severity of side effects may vary from person to person, so don\u2019t compare your side effects with other people\u2019s experiences.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Most of the side effects will improve when therapy is discontinued.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">These side effects are easily manageable most of the time, either by readjusting the dose of <\/span><span style=\"font-weight: 400;\">Nexavar <\/span><span style=\"font-weight: 400;\">or using additional medications to treat the symptoms. Consult with your physician or pharmacist to explore available options.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Do not hide any symptoms; if you feel any discomfort, do not hesitate to tell your physician or pharmacist about it.<\/span><\/li>\n<\/ul>\n\n\n\n<p><b>Note<\/b><span style=\"font-weight: 400;\">: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Some of the more serious side effects of Nexavar are listed below:<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Cardiac_Complications\"><\/span><span style=\"font-weight: 400;\">Cardiac Complications<\/span><span style=\"font-weight: 400;\">&nbsp;<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright\"><img loading=\"lazy\" decoding=\"async\" width=\"420\" height=\"280\" src=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/Sorafenib.jpg\" alt=\"Sorafenib\" class=\"wp-image-18548\" srcset=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/Sorafenib.jpg 420w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/Sorafenib-300x200.jpg 300w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/Sorafenib-330x220.jpg 330w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/Sorafenib-86x57.jpg 86w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/Sorafenib-167x111.jpg 167w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/Sorafenib-280x187.jpg 280w, https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/Sorafenib-370x247.jpg 370w\" sizes=\"auto, (max-width: 420px) 100vw, 420px\" \/><\/figure>\n<\/div>\n\n\n<p><span style=\"font-weight: 400;\">Nexavar may worsen any preexisting cardiac conditions and could potentially cause cardiac complications like high blood pressure, ventricular arrhythmias, heart attack, or heart failure. Blood pressure should be monitored during the first 6 weeks of treatment. If hypertension arises, it can be managed with antihypertensive therapy, and Nexavar interruption may be warranted.&nbsp;<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Bleeding_or_GI_Complications\"><\/span><span style=\"font-weight: 400;\">Bleeding or GI Complications<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Bleeding can vary from mild to serious. More serious hemorrhage can include GI bleeding, vomiting blood, bleeding from the brain, nose bleeds, or vaginal bleeding. GI complications like <a href=\"https:\/\/www.mountsinai.org\/health-library\/diseases-conditions\/gastrointestinal-perforation\">GI perforation<\/a>, although rare, may occur with Nexavar use.&nbsp;<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Hand-and-Foot_Syndrome\"><\/span><span style=\"font-weight: 400;\">Hand-and-Foot Syndrome<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Another side-effect of Nexavar is hand-and-foot syndrome. This syndrome may cause redness, swelling, skin rash, or pain, typically on the palms of the hands and the soles of the feet. More severe cases may be characterized by numbness, tingling, swelling, blistering, and peeling skin, resulting in fingerprint loss. If you experience any of these symptoms, inform your doctor or pharmacist immediately; a dose reduction may be required. This side effect typically appears within 6 weeks of treatment. To reduce hand-foot symptoms, minimize exposure to hot water, avoid constrictive footwear, and avoid excessive skin friction. It may also be advisable to wear thick cotton gloves or socks and shoes with padded insoles.<\/span><\/p>\n\n\n\n<div  id=\"call-to-action-d4c95e79e1faa67915b7c3e529703c1e\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tGet Chemotherapy Copay Assistance\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"cta__sub__heading\">\n\t\t\t\t\t\t\tChemotherapy\u00a0Financial Assistance\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"tel:8777780318\">(877) 778-0318<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Skin_Rash\"><\/span><span style=\"font-weight: 400;\">Skin Rash<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">On rare occasions, Nexavar may cause a serious skin reaction called <\/span><span style=\"font-weight: 400;\"><a href=\"https:\/\/rarediseases.org\/rare-diseases\/stevens-johnson-syndrome-and-toxic-epidermal-necrolysis\/\">Stevens-Johnson syndrome<\/a> (SJS) or toxic epidermal necrolysis (TEN). These rashes may appear as red, swollen, hives; itching, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in the mouth, throat, nose, or eyes. Notify your physician or pharmacist immediately of any signs of a rash or allergic reaction, including wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Discontinuation of Nexavar should be warranted if SJS or TEN is suspected.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Impaired_Wound_Healing\"><\/span><span style=\"font-weight: 400;\">Impaired Wound Healing<\/span><span style=\"font-weight: 400;\">&nbsp;<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Wound healing complications can be dangerous when undergoing surgery. It is recommended to withhold Nexavar for at least 10 days prior to elective surgery and avoid its use until at least 2 weeks after any surgery and until the wound is fully healed. Contact your physician immediately if you experience vomiting or coughing blood; vomit that looks like coffee grounds; blood in urine; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding; bruises without a reason or that get bigger; or any severe or persistent bleeding. These may be signs of impaired wound healing.&nbsp;<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Thyroid_Impairment\"><\/span><span style=\"font-weight: 400;\">Thyroid Impairment<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Nexavar may affect thyroid levels and can be managed with the use of thyroid replacement therapies as needed. Contact your physician immediately if you experience any abnormal changes in weight, anxiety, agitation, feelings of weakness, hair thinning, depression, neck swelling, trouble focusing, inability to handle heat or cold, menstrual changes, tremors, or sweating. These may be signs of thyroid complications.&nbsp;<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Liver_Complications\"><\/span><span style=\"font-weight: 400;\">Liver Complications<\/span><span style=\"font-weight: 400;\">&nbsp;<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Nexavar may affect the liver and cause a condition called <a href=\"https:\/\/www.who.int\/health-topics\/hepatitis#tab=tab_1\">hepatitis<\/a> (liver infection) in certain cases. This condition is identified with blood tests that are able to detect liver function. Contact your physician immediately if you experience liver problems like dark urine, fatigue,&nbsp; nausea, lack of appetite, abdominal pain, light-colored stools, vomiting, or yellow skin or eyes. These may be indications of liver complications.<\/span><\/p>\n\n\n\n<p><b>Other common side effects may include:<\/b><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">Constipation or diarrhea<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Abdominal pain or nausea<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Vomiting or upset stomach<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Fatigue<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Weight loss<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Muscle or joint pain<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Mouth irritation or mouth sores<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Change in taste<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Acne or dry skin<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Itching<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Hair loss<\/span><\/li>\n<\/ul>\n\n\n\n<div  id=\"call-to-action-4a487dc35074b43fdf70d1e6163f2b4d\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tConsult a Chemotherapy Specialist\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"cta__sub__heading\">\n\t\t\t\t\t\t\tGet Chemotherapy Treatment Assistance\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"#form\">Schedule a Consultation<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Precautions\"><\/span>Precautions<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Unless approved by your physician, Nexavar is generally not recommended in:&nbsp;<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Patients at risk of cardiovascular events. <\/strong>These events can include a history of heart disease, high blood pressure, high amounts of fat or cholesterol in the blood (<a href=\"https:\/\/my.clevelandclinic.org\/health\/diseases\/21656-hyperlipidemia\">dyslipidemia<\/a>), a history of heart attack, stroke, or arrhythmias, etc. Nexavar is known for potentially increasing blood pressure, leading to an increased risk of cardiovascular events taking place. If any of these events occur, discontinuation or a decrease in dose may be warranted. Consult with your physician for further guidance.\u00a0<\/li>\n\n\n\n<li><b>Patients with a history of serious GI perforation or hemorrhage.<\/b><span style=\"font-weight: 400;\"> If GI perforation or hemorrhage occurs during treatment, it may be recommended to withhold or discontinue Nexavar.<\/span><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"FAQs\"><\/span>FAQs<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Is Nexavar a chemo agent?<\/h4>\n\n\n\n<p><span style=\"font-weight: 400;\">Nexavar is a targeted cancer therapy (a kinase inhibitor). It works by blocking signals involved in tumor growth and tumor blood vessel formation.<\/span><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">How should Nexavar be taken?<\/h4>\n\n\n\n<p><span style=\"font-weight: 400;\">Take Nexavar twice daily on an empty stomach (at least 1 hour before or 2 hours after a meal), unless your provider instructs otherwise. If you have trouble swallowing tablets, do not crush or dissolve them unless your oncology team\/pharmacist gives you specific instructions.<br><\/span><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Can you touch Nexavar?<\/h4>\n\n\n\n<p><span style=\"font-weight: 400;\">Sorafenib is considered a hazardous drug, so avoid direct contact and do not crush or break the tablets. If you must handle them, consider wearing gloves or pour the tablet directly into your mouth without touching it.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sorafenib (pronounced [sor AF e nib]) is also known by the brand name, Nexavar. Sorafenib is available under the brand name Nexavar and as generic sorafenib. It is an antineoplastic (anti-cancer) medicine and a kinase inhibitor (a type of targeted therapy) that blocks multiple enzymes involved in tumor growth and tumor blood vessel formation.<\/p>\n","protected":false},"author":11,"featured_media":18547,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[13],"tags":[11],"class_list":["post-18546","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer","tag-dr-dania-jaradat"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Nexavar (Sorafenib): Uses, Dosing, Side Effects, and Safety Information - AmeriPharma\u00ae Specialty Care<\/title>\n<meta name=\"description\" content=\"Sorafenib (Nexavar) is an antineoplastic (anti-cancer) drug that belongs to a class called vascular endothelial growth factor (VEGF) inhibitors (or tyrosine kinase inhibitor), also known as an \u201canti-androgen treatment.\u201d\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/cancer\/sorafenib-nexavar\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nexavar (Sorafenib): Uses, Dosing, Side Effects, and Safety Information - 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C\u00f4 t\u1ed1t nghi\u1ec7p \u0110\u1ea1i h\u1ecdc Marshall B. Ketchum. \u0110i\u1ec1u b\u1ed5 \u00edch nh\u1ea5t trong c\u00f4ng vi\u1ec7c c\u1ee7a c\u00f4 l\u00e0 duy tr\u00ec m\u1ed1i quan h\u1ec7 c\u1edfi m\u1edf gi\u1eefa d\u01b0\u1ee3c s\u0129 v\u00e0 b\u1ec7nh nh\u00e2n, \u0111\u1ed3ng th\u1eddi h\u01b0\u1edbng d\u1eabn b\u1ec7nh nh\u00e2n v\u1ec1 c\u00e1ch qu\u1ea3n l\u00fd thu\u1ed1c. Trong th\u1eddi gian r\u1ea3nh r\u1ed7i, c\u00f4 th\u00edch \u0111i du l\u1ecbch \u0111\u1ebfn nhi\u1ec1u qu\u1ed1c gia kh\u00e1c nhau, d\u00e0nh th\u1eddi gian cho ch\u1ed3ng v\u00e0 con trai, v\u00e0 \u0111\u1ecdc s\u00e1ch. Xem Ti\u1ec3u s\u1eed T\u00e1c gi\u1ea3","url":"https:\/\/ameripharmaspecialty.com\/vi\/author\/dania-jaradat\/"}]}},"uagb_featured_image_src":{"full":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar.jpg",1280,853,false],"thumbnail":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar-150x150.jpg",150,150,true],"medium":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar-300x200.jpg",300,200,true],"medium_large":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar-768x512.jpg",768,512,true],"large":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar-1024x682.jpg",1024,682,true],"1536x1536":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar.jpg",1280,853,false],"2048x2048":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar.jpg",1280,853,false],"trp-custom-language-flag":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar.jpg",18,12,false],"block-image-html-large":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar.jpg",600,400,false],"ct-gallery":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar-330x220.jpg",330,220,true],"ct-section-header":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar-1146x380.jpg",1146,380,true],"ct-thumb":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar-86x57.jpg",86,57,true],"ct-thumb-large":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar-167x111.jpg",167,111,true],"ct-small":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar-280x187.jpg",280,187,true],"ct-medium":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar-370x247.jpg",370,247,true],"ct-xmedium":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar-960x640.jpg",960,640,true],"ct-large":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar.jpg",1280,853,false]},"uagb_author_info":{"display_name":"Dr. Dania Jaradat, PharmD","author_link":"https:\/\/ameripharmaspecialty.com\/vi\/author\/dania-jaradat\/"},"uagb_comment_info":0,"uagb_excerpt":"Sorafenib (pronounced [sor AF e nib]) is also known by the brand name, Nexavar. Sorafenib is available under the brand name Nexavar and as generic sorafenib. It is an antineoplastic (anti-cancer) medicine and a kinase inhibitor (a type of targeted therapy) that blocks multiple enzymes involved in tumor growth and tumor blood vessel formation.","rttpg_featured_image_url":{"full":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar.jpg",1280,853,false],"landscape":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar.jpg",1280,853,false],"portraits":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar.jpg",1280,853,false],"thumbnail":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar-150x150.jpg",150,150,true],"medium":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar-300x200.jpg",300,200,true],"large":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar-1024x682.jpg",1024,682,true],"1536x1536":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar.jpg",1280,853,false],"2048x2048":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar.jpg",1280,853,false],"trp-custom-language-flag":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar.jpg",18,12,false],"block-image-html-large":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar.jpg",600,400,false],"ct-gallery":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar-330x220.jpg",330,220,true],"ct-section-header":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar-1146x380.jpg",1146,380,true],"ct-thumb":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar-86x57.jpg",86,57,true],"ct-thumb-large":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar-167x111.jpg",167,111,true],"ct-small":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar-280x187.jpg",280,187,true],"ct-medium":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar-370x247.jpg",370,247,true],"ct-xmedium":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar-960x640.jpg",960,640,true],"ct-large":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2022\/02\/nexavar.jpg",1280,853,false]},"rttpg_author":{"display_name":"Dr. Dania Jaradat, PharmD","author_link":"https:\/\/ameripharmaspecialty.com\/vi\/author\/dania-jaradat\/"},"rttpg_comment":0,"rttpg_category":"<a href=\"https:\/\/ameripharmaspecialty.com\/vi\/category\/cancer\/\" rel=\"category tag\">Cancer<\/a>","rttpg_excerpt":"Sorafenib (pronounced [sor AF e nib]) is also known by the brand name, Nexavar. Sorafenib is available under the brand name Nexavar and as generic sorafenib. It is an antineoplastic (anti-cancer) medicine and a kinase inhibitor (a type of targeted therapy) that blocks multiple enzymes involved in tumor growth and tumor blood vessel formation.","_links":{"self":[{"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/posts\/18546","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/comments?post=18546"}],"version-history":[{"count":0,"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/posts\/18546\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/media\/18547"}],"wp:attachment":[{"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/media?parent=18546"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/categories?post=18546"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ameripharmaspecialty.com\/vi\/wp-json\/wp\/v2\/tags?post=18546"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}