{"id":17273,"date":"2021-11-11T14:42:22","date_gmt":"2021-11-11T22:42:22","guid":{"rendered":"https:\/\/ameripharmaspe.wpengine.com\/?p=17273"},"modified":"2026-03-20T14:52:59","modified_gmt":"2026-03-20T21:52:59","slug":"lenvatinib-lenvima","status":"publish","type":"post","link":"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/lenvatinib-lenvima\/","title":{"rendered":"Lenvatinib (Lenvima)"},"content":{"rendered":"\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/lenvatinib-lenvima\/#What_Is_Lenvatinib\" >What Is Lenvatinib?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/lenvatinib-lenvima\/#What_Is_Targeted_Therapy\" >What Is Targeted Therapy?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/lenvatinib-lenvima\/#Safe_Handling_and_Exposure_Precautions\" >Safe Handling and Exposure Precautions<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/lenvatinib-lenvima\/#How_Is_Lenvatinib_Used\" >How Is Lenvatinib Used?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/lenvatinib-lenvima\/#Available_Formulations\" >Available Formulations<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/lenvatinib-lenvima\/#Directions_for_Use\" >Directions for Use<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/lenvatinib-lenvima\/#Missed_Dose\" >Missed Dose<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/lenvatinib-lenvima\/#Storage\" >Storage<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/lenvatinib-lenvima\/#What_To_Avoid_While_Taking_Lenvatinib\" >What To Avoid While Taking Lenvatinib?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/lenvatinib-lenvima\/#Pregnancy_and_Lenvima\" >Pregnancy and Lenvima<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/lenvatinib-lenvima\/#Side_Effects\" >Side Effects<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/lenvatinib-lenvima\/#Hair_Loss\" >Hair Loss<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/lenvatinib-lenvima\/#Nausea_and_Vomiting\" >Nausea and Vomiting<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/lenvatinib-lenvima\/#Cardiac_Complications\" >Cardiac Complications<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/lenvatinib-lenvima\/#Hand-and-Foot_Syndrome\" >Hand-and-Foot Syndrome<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/lenvatinib-lenvima\/#Diarrhea_or_Abdominal_Pain\" >Diarrhea or Abdominal Pain<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/lenvatinib-lenvima\/#BoneJoint_Pain\" >Bone\/Joint Pain<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/lenvatinib-lenvima\/#Osteonecrosis_of_the_Jaw_ONJ\" >Osteonecrosis of the Jaw (ONJ)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/lenvatinib-lenvima\/#Thyroid_Problems\" >Thyroid Problems<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/lenvatinib-lenvima\/#Reversible_Posterior_Encephalopathy_Syndrome_PRES\" >Reversible Posterior Encephalopathy Syndrome (PRES)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/lenvatinib-lenvima\/#Liver_or_Kidney_Complications\" >Liver or Kidney Complications<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/lenvatinib-lenvima\/#Other_common_side_effects_may_include\" >Other common side effects may include:<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/lenvatinib-lenvima\/#Precautions\" >Precautions<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/lenvatinib-lenvima\/#FAQs\" >FAQs<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_Is_Lenvatinib\"><\/span>What Is Lenvatinib?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Lenvatinib (pronounced [len VA ti nib]) is also known by the brand name, Lenvima. It is an antineoplastic (anti-cancer) drug that belongs to a class called tyrosine kinase inhibitors (TKI) of vascular endothelial growth factor (VEGF) receptors. TKIs work by inhibiting the enzyme tyrosine kinase, thus blocking cell growth and division. Lenvima is a targeted therapy (a tyrosine kinase inhibitor). It is not traditional cytotoxic <a href=\"https:\/\/ameripharmaspecialty.com\/oral-chemotherapy-cancer-drugs\/\">chemotherapy<\/a>, but it is still an anti-cancer medication.<br><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_Is_Targeted_Therapy\"><\/span><strong>What Is Targeted Therapy?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Targeted therapy uses drugs designed to block specific signals that help cancer cells grow and survive. Lenvatinib is a targeted therapy that inhibits certain tyrosine kinases (including VEGF receptors), which can slow tumor growth and reduce tumor blood supply.<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Safe_Handling_and_Exposure_Precautions\"><\/span><strong>Safe Handling and Exposure Precautions<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Lenvatinib is considered a hazardous medication. Capsules are designed to be swallowed whole. Do not open, crush, or chew the capsules. If a capsule is broken or leaking, avoid direct contact with the contents.<\/p>\n\n\n\n<p>If you need to handle the capsule (especially if one is damaged), wear disposable gloves and wash hands afterward. If a capsule is damaged, contact your pharmacist for instructions on what to do next.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_Is_Lenvatinib_Used\"><\/span>How Is Lenvatinib Used?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Lenvatinib is FDA-approved for several cancers, including thyroid cancer, renal cell carcinoma (kidney cancer),\u00a0 hepatocellular carcinoma (liver cancer), and endometrial cancer. Lenvatinib can be prescribed in combination with other anti-cancer medicines, such as pembrolizumab (<a href=\"https:\/\/ameripharmaspecialty.com\/discontinued\/keytruda-empowering-the-immune-system-to-fight-cancer\/\">Keytruda<\/a>) or everolimus (Afinitor), depending on the cancer type, prior treatments, and your overall health.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">For example, for endometrial carcinoma, it is typically given in combination with pembrolizumab, and for renal cell carcinoma, it is typically given with either everolimus or pembrolizumab.<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Available_Formulations\"><\/span>Available Formulations<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Lenvatinib is only available in the form of capsules as a therapy pack and must be administered orally. The capsules are available in two different strengths: 4 mg and 10 mg. The 4 mg capsules are red and imprinted with \u201cE LENV 4 mg\u201d on one side. The 10 mg capsules are red and yellow and imprinted with \u201cE LENV 10 mg&#8221; on one side. <\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Directions_for_Use\"><\/span>Directions for Use<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Lenvatinib may be taken with or without food. While taking the capsule, swallow it whole; do not break, crush, chew, or allow it to be dissolved in your mouth. Lenvatinib may also be dissolved in a small glass (15 ml) of water or apple juice. (Put the entire capsule in liquid and leave for 10 minutes and stir for an additional 3 minutes.) Following the ingestion of the liquid, add another small amount (15 ml) of water or apple juice into the glass, swirl, and repeat a few times to ensure all contents of the capsule have been ingested. <\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Lenvatinib is typically dosed once a day, and the dose depends on the cancer type, your liver\/kidney function, and how well you tolerate treatment.<\/span> <span style=\"font-weight: 400;\">You should verify the correct dose and frequency with your provider. <\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Missed_Dose\"><\/span><b>Missed Dose<\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">If you have accidentally missed a dose, do not take a missed dose within 12 hours of the next dose. If within 12 hours, skip the missed dose and return to regular administration. <\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Storage\"><\/span><b>Storage<\/b><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Store capsules in a cool, dry place at room temperature and ensure the bottle is tightly closed.<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_To_Avoid_While_Taking_Lenvatinib\"><\/span>What To Avoid While Taking Lenvatinib?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">While on lenvatinib therapy, you must follow some precautions. Always tell your physician about any medication you are already taking. <\/span><b>Do not take any drug or medicine (even herbals or over-the-counter medications) without prior consent from your physician or pharmacist, as they may have significant interactions with lenvatinib<\/b><span style=\"font-weight: 400;\">. Talk with your oncology team before getting any vaccines. Some vaccines may be recommended, while others, such as live vaccines, may not be appropriate during treatment.<br><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Pregnancy_and_Lenvima\"><\/span>Pregnancy and Lenvima<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Pregnancy status must be checked prior to starting chemotherapy in women of childbearing age. Effective contraception must be used during treatment and for 1 month after the last dose. Lenvatinib may cause fetal harm and therefore, breastfeeding must be avoided during treatment and for at least 1 week after the last dose.<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-left\"><span class=\"ez-toc-section\" id=\"Side_Effects\"><\/span>Side Effects<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">As with any other medication, you may encounter side effects while taking lenvatinib. A few things to keep in mind are:<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">You may not have all the side effects listed below. Many people may experience little to no side effects.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">The severity of side effects may vary from person to person, so don\u2019t compare your side effects with other people\u2019s experiences.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Most of the side effects will improve when therapy is discontinued.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">These side effects are easily manageable most of the time either by readjusting the dose of lenvatinib or by using additional medications to treat the symptoms. Consult with your physician or pharmacist to explore the available options.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Do not hide any symptoms; when you feel any discomfort, do not hesitate to tell your physician or pharmacist about it.<\/span><\/li>\n<\/ul>\n\n\n\n<p><b>Note<\/b><span style=\"font-weight: 400;\">: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions. <\/span><\/p>\n\n\n\n<p><strong>Get urgent help right away if you have:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Chest pain<\/li>\n\n\n\n<li>Sudden shortness of breath<\/li>\n\n\n\n<li>Coughing up blood<\/li>\n\n\n\n<li>One-sided weakness&nbsp;<\/li>\n\n\n\n<li>Trouble speaking<\/li>\n\n\n\n<li>Severe headache\/vision changes<\/li>\n\n\n\n<li>Fainting<\/li>\n\n\n\n<li>Severe or persistent diarrhea<\/li>\n\n\n\n<li>Signs of severe bleeding<\/li>\n\n\n\n<li>Yellowing of the eyes\/skin<\/li>\n\n\n\n<li>Greatly reduced urination<\/li>\n<\/ul>\n\n\n\n<p><span style=\"font-weight: 400;\">Some of the most common side effects of lenvatinib are:<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Hair_Loss\"><\/span><span style=\"font-weight: 400;\">Hair Loss<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Hair thinning or changes in hair texture may occur, but complete hair loss is less common with lenvatinib than with many traditional chemotherapy drugs. Hair changes often improve after treatment is adjusted or stopped.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Nausea_and_Vomiting\"><\/span><span style=\"font-weight: 400;\">Nausea and Vomiting<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">You may exhibit acute or delayed nausea and vomiting once you start treatment. These symptoms usually disappear after a few hours or days after starting therapy. If nausea or vomiting is severe, contact your physician to see if they can add an <a href=\"https:\/\/www.healthline.com\/health\/antiemetic-drugs-list\">antiemetic medication<\/a> to the regimen.&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Eating habits should consist of small amounts of food four to six times a day. Try to avoid eating too much at once. Maintain proper body hydration by drinking fluids throughout the day. Nausea and vomiting may result in abdominal pain and can also cause a decrease in appetite, leading to weight loss. This <\/span><span style=\"font-weight: 400;\">may help reduce nausea or vomiting frequency and severity.<\/span><span style=\"font-weight: 400;\"> Patients 60 years and older may experience a greater incidence of these side effects.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Cardiac_Complications\"><\/span><span style=\"font-weight: 400;\">Cardiac Complications<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">There is a risk that lenvatinib may cause high or low blood pressure. It may typically present as a very bad headache or dizziness, passing out, or a change in eyesight. Less commonly, however, it can potentially lead to blood clots, heart attacks, strokes, <a href=\"https:\/\/www.nhlbi.nih.gov\/health-topics\/venous-thromboembolism\">venous thromboembolism (VTE)<\/a> or <a href=\"https:\/\/www.webmd.com\/lung\/what-is-a-pulmonary-embolism\">pulmonary embolism<\/a> (PE) if left uncontrolled. <\/span><span style=\"font-weight: 400;\">Clots may present as chest pain or pressure, coughing up blood, shortness of breath, swelling, warmth, numbness, change of color or pain in a leg or arm, trouble speaking, or trouble swallowing.<\/span><span style=\"font-weight: 400;\"> Typically these side effects are controlled with medications to treat high blood pressure.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Hand-and-Foot_Syndrome\"><\/span><span style=\"font-weight: 400;\">Hand-and-Foot Syndrome<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Another very conspicuous side effect of lenvatinib is hand-and-foot syndrome, also known as palmar-plantar syndrome or <a href=\"https:\/\/www.mdanderson.org\/cancerwise\/chemotherapy-side-effect--hand-foot-syndrome.h00-159459267.html\">palmar-plantar erythrodysesthesia<\/a>. This syndrome may cause redness, swelling, skin rash, or pain typically on the palms of the hands and the soles of the feet. More severe cases may be characterized by numbness, tingling, swelling, blistering, and peeling skin resulting in fingerprint loss. If you feel any of these symptoms, inform your doctor or pharmacist immediately, as a dose reduction may be required. Patients 60 years and older may experience a greater incidence of this side effect.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Diarrhea_or_Abdominal_Pain\"><\/span><span style=\"font-weight: 400;\">Diarrhea or Abdominal Pain<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">If you have watery stools more than four times a day or frequent loose, watery stools, you may have diarrhea. This is one of the most common side effects of lenvatinib. Abdominal pain may be associated with diarrhea. Keep hydrated and take plenty of fluids to maintain water balance in your body. Try to avoid eating raw foods, fruits, vegetables, whole-grain bread, cereals, seeds, and any other foods that may exacerbate diarrhea. Foods that will help reduce diarrheal risk include boiled or baked chicken (white meat) and white rice. In rare cases, diarrhea may become severe. If that happens, consult your doctor immediately. Patients 60 years and older may experience a greater incidence of these side effects.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"BoneJoint_Pain\"><\/span><span style=\"font-weight: 400;\">Bone\/Joint Pain<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Another common side effect includes bone or joint pain or even back pain. This may also be a result of anemia or other side effects mentioned previously. Adequate rest and hydration may help reduce potential bone, joint, or back pain. Get a doctor\u2019s approval prior to taking any over-the-counter medications such as Advil, Motrin, ibuprofen, and acetaminophen. These medications may interact with lenvatinib absorption.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Osteonecrosis_of_the_Jaw_ONJ\"><\/span><span style=\"font-weight: 400;\">Osteonecrosis of the Jaw (ONJ)<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">ONJ is an uncommon but serious condition. Symptoms can include jaw pain, swelling, loose teeth, gum sores, numbness\/heaviness in the jaw, or poor healing after dental work. Inform your health care team of any medications used for bone health, and before any invasive dental procedure. Report any mouth\/jaw symptoms promptly.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Thyroid_Problems\"><\/span><span style=\"font-weight: 400;\">Thyroid Problems<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Problems with the thyroid may occur, especially the underactivity of the thyroid gland (called <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/hypothyroidism\/symptoms-causes\/syc-20350284\">hypothyroidism<\/a>). This may result in changes in weight, feelings of tiredness or weakness, hair thinning, depression, neck or face swelling, menstrual changes, dry skin, hoarseness, muscle weakness, or sensitivity to cold.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Reversible_Posterior_Encephalopathy_Syndrome_PRES\"><\/span><span style=\"font-weight: 400;\">Reversible Posterior Encephalopathy Syndrome (PRES)<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">This condition is reversible, and usually subsides within one week of discontinuation of therapy. Presentation of this condition includes feelings of confusion, lowered alertness, change in eyesight, loss of eyesight, seizures, or a very bad headache.<\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Liver_or_Kidney_Complications\"><\/span><span style=\"font-weight: 400;\">Liver or Kidney Complications<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><span style=\"font-weight: 400;\">Kidney problems can be indicated with the inability to pass urine, changes in how much urine is passed, blood in the urine, or excessive weight gain. Liver problems can be indicated by the darkening of the urine, feelings of tiredness, lack of appetite, upset stomach or stomach pain, light-colored stools, or yellowing of the skin or eyes. If any of these signs or symptoms are present, contact your physician immediately. <\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Other_common_side_effects_may_include\"><\/span>Other common side effects may include:<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Weight loss<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Tiredness or insomnia<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Decreased appetite<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Breathing difficulty<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Mouth irritation or mouth sores<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Change in voice<\/span><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Precautions\"><\/span>Precautions<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Unless approved by your physician, lenvatinib is generally not recommended for:&nbsp;<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">Patients with risk of high blood pressure. Blood pressure should be monitored regularly.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Patients with severe kidney or liver impairment. If either occurs, dose reduction of lenvatinib is required, and if severe, then permanent discontinuation is recommended.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Patients at high risk of GI perforations and fistulas or severe diarrhea. If any of these GI events occur, immediate and permanent discontinuation of lenvatinib is recommended.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Patients with bleeding problems, blood clots, or a deficiency of calcium or potassium in the blood. Bleeding and clotting problems may include: bruising; black, tarry, or bloody stools; bleeding gums; blood in the urine; coughing up blood; cuts that take a long time to stop bleeding; nosebleeds; throwing up blood; or vomit that looks like coffee grounds.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Patients at high risk of thrombotic events.&nbsp;<\/span>\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">Thrombotic events include heart attacks, ischemic stroke, venous thromboembolism (VTE), and pulmonary embolism (PE).<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">If any of these thrombotic events occur, immediate discontinuation of lenvatinib may be recommended.<\/span><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Patients with risk of osteonecrosis of the jaw (ONJ). Lenvima therapy should be withheld before any invasive dental procedures and restarted at least 2 weeks later or once adequate healing has occurred.&nbsp;<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Patients undergoing elective surgery or procedures. Therapy may be suspended for at least 21 days before a surgery or procedure and may be restarted afterwards. Contact your physician regarding any scheduled surgeries or procedures.<\/span><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"FAQs\"><\/span>FAQs<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Is lenvatinib a chemo agent?<\/h4>\n\n\n\n<p><span style=\"font-weight: 400;\">Lenvatinib is a targeted therapy (a tyrosine kinase inhibitor), not traditional cytotoxic <a href=\"https:\/\/ameripharmaspecialty.com\/oral-chemotherapy-cancer-drugs\/\">chemotherapy<\/a>. It is still an anti-cancer medication used to treat certain cancers, sometimes in combination with other anti-cancer drugs.&nbsp;<\/span><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">How should lenvatinib be taken?<\/h4>\n\n\n\n<p><span style=\"font-weight: 400;\">Lenvatinib can be taken with or without food. The capsule can be swallowed whole or can be dissolved in 15 ml of water or apple juice. Allow the entire capsule (do not crush, break, or open) to dissolve in the liquid for 10 minutes and then mix for an additional 3 minutes. After drinking, add another 15 ml of liquid into the same cup, swirl, and drink again. Repeat a few more times to ensure all of the capsule\u2019s contents have been ingested.<\/span><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Can you lose your hair with lenvatinib?<\/h4>\n\n\n\n<p><span style=\"font-weight: 400;\">Hair thinning or changes can happen, but complete hair loss is less common with lenvatinib than with many traditional chemotherapy drugs. Risk can increase depending on combination treatments and individual factors.<\/span><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Can you touch lenvatinib?<\/h4>\n\n\n\n<p><span style=\"font-weight: 400;\">Swallow capsules whole and avoid opening\/crushing them. If a capsule is <strong>broken or leaking<\/strong>, avoid contact with the contents; wear gloves if needed and wash hands afterward. Ask your pharmacist what to do if a capsule is damaged.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lenvatinib (pronounced [len VA ti nib]) is also known by the brand name, Lenvima. It is an antineoplastic (anti-cancer) drug that belongs to a class called tyrosine kinase inhibitors (TKI) of vascular endothelial growth factor (VEGF) receptors.<\/p>\n","protected":false},"author":11,"featured_media":17615,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[64],"tags":[11],"class_list":["post-17273","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-discontinued","tag-dr-dania-jaradat"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Lenvatinib (Lenvima) - AmeriPharma\u00ae Specialty Care<\/title>\n<meta name=\"description\" content=\"Lenvatinib (Lenvima) is an antineoplastic (anti-cancer) drug that belongs to a class called tyrosine kinase inhibitors (TKI) of vascular endothelial growth factor (VEGF) receptors.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ameripharmaspecialty.com\/vi\/discontinued\/lenvatinib-lenvima\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lenvatinib (Lenvima) - 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