Kuelewa Orbactiv: Kipimo, Madhara, Gharama, na Faida za Kliniki

Some gram-positive bacteria have become resistant to currently available antibiotics. If you are fighting against such bacteria, drugs like Orbactiv can be a lifesaver for you. In this article, we will explore everything you need to know about Orbactiv, including its dosing, side effects, cost, and more.

What Is Orbactiv?

Orbactiv (oritavancin) is an antibiotic drug. The FDA approved this drug on August 6, 2014, for treating acute bacterial skin and skin structure infections (ABSSSI) in adults [1]. This drug is especially useful in treating infections caused by some specific bacteria resistant to conventional antibiotics. 

Doctors can only use Orbactiv to treat infections caused by specific gram-positive microorganisms. Otherwise, this drug can create antibiotic-resistant bacteria. Orbactiv is given via intravenous infusion, which takes about 3 hours. You only have to take a single dose for it to work.

What Is Orbactiv Used To Treat?

Orbactiv (oritavancin) is a branded prescription antibiotic. It treats adults with acute bacterial skin and skin structure infections caused by specific microorganisms. ABSSSI are serious bacterial infections that affect your skin and the tissues under your skin. These infections can be life-threatening. Symptoms of these infections include pain, redness, fever, chills, fatigue, and pus-filled bumps or sores.

Doctors can only use this medication to treat or prevent infections proven or strongly suspected to be caused by certain gram-positive microorganisms. These microorganisms include [2]:

• Staphylococcus aureus (including methicillin-susceptible and methicillin-resistant isolates)
• Streptococcus anginosus group (includes S. anginosus, S. intermedius, na S. constellatus)
• Streptococcus agalactiae
• Streptococcus pyogenes
• Enterococcus faecalis (vancomycin-susceptible isolates only)
• Streptococcus dysgalactiae

Orbactiv carries the possibility of creating drug-resistant microorganisms. So, you should only receive Orbactiv infusions to treat or prevent infections caused by the bacteria mentioned above, lower the risk of developing drug-resistant bacteria, and maintain the efficacy of Orbactiv and other medicines.

How Does Orbactiv Work?

Orbactiv is a branded antibiotic that contains the active ingredient oritavancin. It kills bacteria in three ways [2]. First, it blocks the bacteria from creating its own protective outer wall. Second, it can prevent the parts of the bacteria’s cell walls from linking together. Third, it damages the bacteria’s outer membrane, causing it to leak. Together, these three actions make this medication very effective in killing bacteria.

Madhara

Orbactiv can cause side effects ranging from mild to severe. You should immediately consult your doctor if you encounter any severe side effects. Let’s talk about some common and severe side effects of receiving Orbactiv infusions [3]:

Madhara ya Kawaida

Common side effects include:

• Maumivu ya kichwa
• Kichefuchefu
• Kutapika
• Kuhara
• Skin and soft tissue infection

Severe Side Effects

Severe side effects include the following:

Hypersensitivity Reactions: Orbactiv can cause severe allergic reactions, including anaphylaxis, which can be life-threatening. Signs of an allergic reaction include hives, difficulty breathing, and swelling of the face, lips, or tongue. If you are allergic to glycopeptides, you should be careful when using this medication. Immediately stop using Orbactiv if you experience any allergic reaction while taking it.

Clostridioides difficile Associated Disease (CDAD): This is a severe type of diarrhea that can even be fatal. Contact your doctor right away if you encounter diarrhea after taking Orbactiv.

Infusion-Related Reactions: You may experience some side effects during Orbactiv infusions. Tell your doctor right away if you feel chills, dizziness, light-headedness, chest pain, or back pain. Stopping or slowing the injection can help reduce the symptoms.

Development of Drug-Resistant Bacteria: Orbactiv is only effective in treating infections caused by certain bacteria. So, you should only use it when the presence of certain specific bacteria is proven or highly suspected. Otherwise, it can create drug-resistant bacteria.

Please note that this is not a list of all possible side effects. Consult your doctor if you encounter any other side effects after receiving this medication.

Kuweka kipimo

This drug can only be used in adult patients. Your doctor will give you Orbactiv via intravenous infusion. It will take about three hours for your infusion to complete. The recommended dosage is 1,200 mg as a single-dose intravenous infusion [2]. But remember that your doctor may modify your dose based on your situation. So, always follow your doctor’s recommendation.

Gharama

Orbactiv is available as a powder for injection, with a strength of 400 mg per vial. Each vial costs around $1,225 [4]. For a single dose, you need 3 vials. So, the total cost of treatment is around $3,675. However, the actual cost depends on your insurance coverage, location, treatment plan, and the pharmacy you visit.

Maswali Yanayoulizwa Mara kwa Mara

Here are some frequently asked questions about Orbactiv:

1. Does Orbactiv cause hair loss?

No, it does not cause hair loss. In clinical trials, patients didn’t mention hair loss (alopecia) as a side effect [2]. However, if you experience any hair loss after taking Orbactiv, consult your doctor.

2. Can I use Orbactiv if I have liver or kidney problems?

You can safely receive Orbactiv infusions if you have mild to moderate liver or kidney problems. There is no need to adjust your dosage in these cases. However, there is no clinical safety data on severe liver or kidney disease patients [2]. So, you should consult your doctor for more information.

3. Is Orbactiv safe during pregnancy or breastfeeding?

There is still no data on the safety of Orbactiv usage during pregnancy or breastfeeding [2]. You should only use it during pregnancy or breastfeeding if your doctor thinks that the benefits outweigh the potential risks. 

4. Is Orbactiv effective against all types of bacteria?

No. Orbactiv is only effective against some specific gram-positive bacteria, including resistant strains like MRSA. So, be sure to only use it according to your doctor’s recommendation.

5. Does Orbactiv interact with other medications?

Yes. It can interact with some medicines, including blood thinner drugs like heparin or warfarin. If you are already taking heparin or warfarin, then Orbactiv may increase your risk of bleeding. So, you should inform your doctor about all the medicines you take, including over-the-counter drugs, before getting Orbactiv infusions.

6. What are the clinical benefits?

According to the clinical trial data, the majority of patients treated with Orbactiv were able to stop the spread of their skin infection and recover from their fever in two to three days [2]. In another study, researchers found that Orbactiv cured 68 patients out of 75 who suffered from gram-positive infections [5].