Hyqvia Subq Infusion: Administration & Cost

Brand name: Hyqvia
Manufacturer: Baxter Healthcare Corporation, Baxter BioScience
Alternatives: Immune globulin infusion 10% with recombinant human hyaluronidase

Hyqvia څه شی دی؟

Hyqvia یو انجیکشن وړ درمل دی چې په جینیاتي ډول ډیزاین شوی پروټین لري. دا د دوه ګوني وایل واحد دی چې د وایل سره د معافیت ګلوبولین انفیوژن 10% (Ig) او د بیا ترکیب شوي انساني هایالورونیدیس (Hy) یو بل بوتل، کوم چې ستاسو بدن سره د انجیکشن وړ درملو جذبولو کې مرسته کوي.

برخې یو په بل پسې (لومړی های، دوهم Ig) د ستنې سیټ له لارې اچول کیږي.

درملنه/درملنه

Hyqvia is an immune globulin infusion. It is a sterilized solution made up of human plasma containing antibodies that help your body protect itself against different infectious diseases. It is used for:

• Treating primary immunodeficiency in adults and pediatric patients aged two years and older 
• Maintenance therapy for adults with chronic inflammatory demyelinating polyneuropathy (CIDP).

انفیوژن

Hyqvia د پوستکي لاندې د پوستکي لاندې انفیوژن په بڼه ورکول کیږي. دا لري انعطاف منونکې اداره انتخابونه، او د روغتیا پاملرنې چمتو کوونکی کولی شي تاسو ته درس درکړي چې څنګه د خپل کور په آرامۍ کې پخپله اداره وکړئ. 

It is essential that you receive proper training from a healthcare professional and understand the instructions thoroughly before self-administration. Do not self-administer the medication if you do not understand all of the instructions.

The infusion can also be administered at an infusion center.

ذخیره کول

• Hyqvia can be stored in a refrigerator at 36°F to 46°F for up to 3 years (do not freeze the medication).
• It may be stored at room temperature (up to 77°F) for up to 3 months, but only during the first 24 months from the date of manufacture printed on the carton. 
• Do not return Hyqvia to the refrigerator if you take it out to store at room temperature. 
• Store Hyqvia in its original carton to protect it from light.
• The refrigerated product should be allowed to reach room temperature before use. 
• Do not heat or microwave the product.

اداره

For infusion, an infusion pump is needed to titrate the appropriate flow rate. To prevent leakage at the infusion site while administering Hyqvia, a longer needle (12 or 14 mm) and the use of multiple infusion sites should be considered.

• Before infusing, inspect the vials for any cloudy precipitates, and do not shake the vials. 
• Do not use the medication if the solution is not clear. 
• Each vial is single-use and should not be used more than once.
• Suggested infusion sites are the thighs or abdomen. 
• When infusing, do not mix the two medications given in the Hyqvia kit.

Sequential Infusion

Both of the components of Hyqvia are infused sequentially, starting first with Hyaluronidase, then Ig 10% within 10 minutes through the same subcutaneous needle. 

د entire contents of the Hyaluronidase vial are used for each full or partial vial of Ig.   

Local infusion-site reactions such as mild to moderate pain, temporary soft pancake-like swelling, itching, and skin redness are common. 

Swelling may last 1 to 3 days, and infusion-related reactions should go away in a few hours.

مخنیوی

Do not use Hyqvia If you ever had an allergic reaction to immune globulin, human albumin, and hyaluronidase or if you are immunoglobulin A deficient.

خبرداری او احتیاطي تدابیر

Hyqvia کولی شي د وینې د ټوټې کیدو لامل شي، په ځانګړې توګه که تاسو 65 کاله یا ډیر عمر لرئ، د زړه ناروغي، د دوران ناروغي، یا د وینې د ټوټې کیدو تاریخ ولرئ. 

که تاسو د سینې ناڅاپي درد، بې حسي، د خبرو کولو کمزورتیا، د لید اختلال، د ساه لنډۍ یا درد، تودوخه، یا په پښه یا لاس کې پړسوب تجربه کړئ نو سمدلاسه خپل چمتو کونکي سره اړیکه ونیسئ. 

که تاسو کوم بل روغتیايي حالت لکه شکر، د پښتورګو ناروغي، امیندوارۍ، یا د اوبو کمښت لرئ، د انفیوژن ورکولو دمخه خپل روغتیا پال ته خبر ورکړئ. په اخته شوې سیمه کې یا شاوخوا مه انفیوژن کوئ ځکه چې دا ممکن د انتان د خپریدو لامل شي.

د درملو تعامل

Hyqvia may interact and interfere with the immune responses to live virus vaccines, such as those for measles, mumps, rubella (MMR), and chickenpox.

Therefore, you should inform your healthcare provider about your Hyqvia treatment before receiving any vaccinations.

جانبي عوارض

According to clinical trials, more than 5% of the subjects experienced some common side effects, including headache, fever, vomiting, nausea, fatigue, antibody formation against hyaluronidase, and symptoms of allergy such as swelling, itching, pain, and skin rash. There is no evidence of skin damage from Hyqvia so far.

Hyqvia can cause blood clots or thrombosis. Get immediate medical assistance if you experience any of the following adverse effects:

• د خبرو او لید ستونزې
• ناڅاپه بې حسي او سستي
• د سینې درد
• په ټوخي کې وینه
• تیاره پیشاب
• د ادرار کموالی
• ژیړی
• انتان
• د زړه چټک ټکان
• په لاس یا پښه کې د وینې ټوټې کېدل
• د سږو ناروغۍ لکه د انتقال پورې اړوند د سږو حاد ټپ (TRALI)

خوراک

د dosing of Hyqvia is on an individualized basis.

د Hyqvia خوراک توپیرونه لاندې بحث شوي دي:

• که چیرې ناروغ دمخه د Ig انفیوژن اخلي، نو درملنه باید د وروستي Ig انفیوژن څخه یوه اونۍ وروسته پیل شي.
• په تدریجي ډول دوز او فریکونسي د 1 اونۍ دوز څخه 3 یا 4 اونۍ دوز ته لوړه کړئ.
• The initial dose is 7.5 g on week 1, 15 g on week 2,  22.5 g on week 4, then 30 g on week 7 (full information is available in the Hyqvia package insert).
• که چیرې ناروغ د IVIG درملنې څخه تیر شوی وي، نو د لومړني دوز زیاتوالي وروسته Hyqvia په ورته دوز او فریکونسۍ کې د پخوانۍ IV درملنې په څیر تطبیق کړئ.
• If the patient has switched from SCIG treatment or is IgG-naïve, then administer at 300 – 600 mg/kg at 3 to 4 week intervals after initial ramp-up.
• که چیرې ناروغ د پښتورګو د ناکامۍ یا ترومبوسس لوړ خطر سره مخ وي، نو Hyqvia په لږترلږه دوز او د انفیوژن په کچه چې عملي وي، تطبیق کړئ.

د هر سایټ حجم:

هغه ناروغانو ته چې وزن یې ۴۰ کیلوګرامه یا ډیر وي، تر ۶۰۰ ملی لیتره پورې په هر ځای کې ورکول کیدی شي او هغه کسانو ته چې وزن یې له ۴۰ کیلوګرامه څخه کم وي، تر ۳۰۰ ملی لیتره پورې ورکول کیدی شي. 

Rate of Infusion:

Administer the hyaluronidase of Hyqvia (HY) at an initial rate per site of approximately 1 to 2 ml per minute or as tolerated.

Administer the immune globulin 10% (IG) component of Hyqvia at the rates shown below for the initial infusions. Based on tolerability, these rates may be adjusted by the pharmacist. 

Uses

Hyqvia is mainly indicated for treating primary immunodeficiency (PI) in adults and children 2 years of age and over. It is also used as maintenance therapy for chronic inflammatory demyelinating polyneuropathy (CIDP) in adults. ​ 

Immunodeficiency conditions may include common variable immunodeficiency, Wiskott-Aldrich syndrome, congenital or X-linked agammaglobulinemia, and severe combined immunodeficiencies.

Hyqvia Cost

The average cost for Hyqvia subcutaneous solution (160 units/ml–10%) is approximately $665 for a supply of 26.25 ml ($25.33/unit). This price may vary depending on the pharmacy you visit or the coverage you have through your health insurance provider.

د شریک تادیې مرسته

Certain programs offer assistance with the cost of Hyqvia. Offers may be in different forms, including a printable coupon, rebate, trial offer, savings card, or free samples. Some offers may be printed directly from a website. Others require proper enrollment, completing a questionnaire, or obtaining a sample from the provider’s office. 

Copay assistance programs include:

• Hyqvia OnePath Copay Assistance Program
• Hyqvia HelloHyqvia Free Trial Offer
• HealthWell Foundation Copay Program
• Patient Access Network Foundation (PAN)
• OnePath Patient Assistance Program (Hyqvia)

یادونه: All the above-mentioned programs have different eligibility requirements.

If you would like help in applying for any of these programs, please contact us for financial assistance.

Hyqvia vs. Hizentra

Like Hyqvia, د Hizentra معرفي کول is indicated for primary immunodeficiency syndrome and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).

د Hizentra معرفي کول is used as replacement therapy for primary humoral immunodeficiency (PI) in adults and pediatric patients 2 years and older.

Hizentra may also be used for other diagnoses. Hizentra subcutaneous injection is approximately $209.01 for a supply of 5 ml ($41.80/unit). 

This price may vary depending on the pharmacy. 

Pros of Hyqvia vs. Hizentra:

• Lower cost per ml – However it is important to note that Hyqvia is less concentrated than Hizentra (10% vs. 20% IgG), and larger volumes are necessary for treatment. Because of this, the total cost of Hyqvia is often comparable to the cost of Hizentra in many cases despite having a lower cost per ml. 
• Less frequent dosing (monthly vs. biweekly)
• 1 to 2 infusion sites

Cons of Hyqvia vs. Hizentra:

• Must infuse two components: Hy and Ig
• More fluid to infuse
• Longer infusion time