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Myositis

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Myositis

Myositis

Myositis originates from two words, “myo,” meaning muscle, and “itis,” meaning inflammation. Thus, myositis refers to a group of diseases that cause inflammation of muscles 

Myositis presents with symptoms like pain, swelling, and overall weakness. 

 

What triggers myositis? 

Many people have experienced delayed onset muscle soreness (DOMS) after strenuous exercise, but this condition is temporary and subsides with rest.  Other conditions that cause myositis include infection, muscle injury from medications, genetic diseases, autoimmune conditions, electrolyte imbalances, thyroid disease, and drug side effects. 

Myositis is commonly used to refer to chronic inflammation that mainly results from autoimmune conditions in which the body’s immune system starts attacking its own tissues. Myositis resulting from autoimmune diseases is also known as Idiopathic Inflammatory Myositis (IIM). In contrast to other kinds of myopathies, IIM is more serious and associated with severe complications. 

 

Types of Myositis 

While there are several types of myositis, It can be classified into four sub-types

  • Polymyositis (PM) 
  • Dermatomyositis (DM) 
  • Immune-mediated necrotizing myopathy (IMNM)
  • Sporadic Inclusion Body Myositis (sIBM)
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Polymyositis (PM)

Polymyositis most commonly affects adults in their 30s to 50s and is more common in women than in men. It affects many groups of muscles (poly=many, myositis=muscle inflammation), the most common ones being closer to the trunk of the body  (ie shoulders, upper arms, neck, upper back, thighs, and, hips, and thigh areas.  Muscle weakness will begin with these muscles and may spread to other parts of the body. PM patients may also experience breathing problems and trouble swallowing if muscles in the chest wall or neck are affected. 

Dermatomyositis (DM)

Dermatomyositis can affect people of any age or sex but is more common in women than in men. DM may occur in children, in which case it is referred to as Juvenile Dermatomyositis. Like polymyositis, dermatomyositis causes muscles to become inflamed in several areas, but it starts with a body rash and dry, scaly skin. The rash is predominantly on the eyelids, nose, cheeks, back, upper chest, elbows, knees, and knuckles.

Immune-mediated necrotizing myopathy (IMNM)

IMNM is characterized by signs of necrosis,  or cell death, in muscles which leads to severe weakness and fatigue. People with necrotizing myopathy experience weakness around the trunk of the body(ie forearms, thighs, hips, shoulders, neck, and back) 

Sporadic Inclusion Body Myositis (sIBM)

sIBM is the most common myopathy in people above 50 years of age and is more common in men than in women. Unlike other types of myositis, symptoms of sIBM develop gradually over several years. For this reason, patients may experience symptoms for many years before they are diagnosed. People with this condition find difficulty performing day-to-day activities, such as walking and climbing stairs, Muscles most often affected are those at the front of the thighs and those that elevate the feet and those in the hips, fingers, wrists, upper arms, shoulders, neck, and back. Many patients will notice shrinking (atrophy) in the arms and thighs as the muscles become weaker.

 

Myositis Symptoms

Since the condition primarily involves muscle tissue, muscle weakness is the most common symptom of myositis. Other symptoms include muscle swelling and pain.

Almost all symptoms of myositis worsen gradually over time. People with myositis may or may not feel pain initially, but weakness and fatigue adversely impact the quality of life. Large groups of muscles, particularly those supporting shoulders, hips, thighs, back, and neck are significantly affected over time, the weakness in muscles becomes so severe that it disrupts normal movement resulting in falls, difficulty getting up after a fall, climbing stairs, and getting up from a chair.

 

Causes of Myositis 

Infections

The most common infectious cause of myositis is viral infections. Rarely other organisms like bacteria and fungi can cause myositis as well. Viruses or bacteria directly invade muscle tissue or release substances that damage muscles.

Injuries

Vigorous exercise can lead to muscle pain, swelling, and weakness for up to days after a workout. Inflammation contributes to these symptoms, making it a form of myositis. Myositis symptoms and injury after exercise usually resolves completely with rest. 

Drugs

Certain medications can cause temporary muscle damage.  These include:

Statins: Statins is a group of cholesterol-lowering medications. Potentially serious side effects include myositis and rhabdomyolysis. People on statins are advised to avoid grapefruit juice as it can interfere with the body’s ability to break down statin medications, which increases the level of statins in the blood and therefore increases the possibility of side effects. 

Colchicine: Colchicine is commonly used to prevent or treat gout flareups. One of the rare side effects of taking colchicine is myopathy, symptoms of which are similar to those of myositis. 

Plaquenil: Plaquenil is used to prevent or treat malaria caused by mosquito bites. It is also used to treat lupus or rheumatoid arthritis. A possible side effect is myopathy (including paralysis or neuromyopathy). 

Alpha-interferon: Alpha-interferons are used to treat various cancers and virus infections such as Hepatitis B. Possible side effects include myositis and myopathy (including cardiomyopathy)

Alcohol: Heavy drinking s associated with myopathy, causing symptoms of muscle pain and weakness. It can either be acute, after a person has binged on alcohol or chronic, developing over time with heavy alcohol use

Cocaine: Cocaine is a highly addictive substance that affects the central nervous system. It adversely affects muscle cells and is known to cause myopathy and rhabdomyolysis

Myopathy can occur right after starting one of these medications or may occur after months to years of use. Most are reversible upon drug discontinuation if recognized early.

 

Myositis Diagnosis

There are a series of different tests that can help diagnose myositis. These include: 

Blood Tests

Muscles contain several proteins that are continuously released into the blood as our body makes new cells and fixes damaged cells. When there is an increase in muscle cell damage, the levels of these proteins increase in the blood as well. An elevated level of muscle proteins can help diagnose myositis. The most prominent ones that are tested for in myositis are Creatine kinase (CK), and aldolase,. Other blood tests, such as antinuclear antibodies (ANA), check for abnormal antibodies that help identify if an autoimmune condition is present. 

Electromyography (EMG)

EMG studies test the specific response of muscles to electrical nerve signals.  By doing so, EMG identifies muscles that are weak or damanged by myositis. 

Muscle Biopsy and Skin Biopsy

These two tests are the most accurate test for diagnosing myositis.  A small incision is made and a small sample is removed for testing. Muscle and skin biopsies are often the most definitive way to diagnose myositis. 

MRI

MRI is non-invasive and uses a scanner to create images of muscles.  An MRI scan can help identify areas of myositis and changes in muscles over time.

 

Is Myositis Curable?

Currently, there is no cure for myositis, but the disease can be managed to reduce inflammation and prevent muscle weakness from progressing.  Certain medications and lifestyle changes can slow down its progression.

 

Treatment of Myositis

Medical Treatment

Myositis varies widely from one patient to another, so no single treatment will work for everyone. There are a number of medications available that may be used individually or in combination. 

Immunosuppressants

Immunosuppressants are drugs that inhibit the activity of the immune system and prevent immune cells from attacking healthy tissue. Immunosuppressants used in treating myositis include Methotrexate, Azathioprine, Mycophenolate Mofetil, Cyclosporine, Tacrolimus, Cyclophosphamide, and Hydroxychloroquine. 

Corticosteroids

Corticosteroids include Prednisone, Methylprednisolone, and other steroids.

Anti-Inflammatory Drugs

Non-steroidal anti-inflammatory drugs (NSAIDs), such as Aspirin and Ibuprofen, help fight inflammation and provide pain relief in myositis.  

Intravenous Immunoglobulin (IVIg)

Biological therapies have earned significant popularity over the last couple of years. IVIg is a blood product derived from human plasma that contains antibodies to help control inflammation It’s considered an effective therapy in controlled trials in patients with polymyositis, dermatomyositis, and infectious myositis.

 

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What is the life expectancy of someone with myositis? 

The prognosis for different forms of myositis varies greatly and can depend on the presence of other conditions. While Sporadic Inclusion Body Myositis is a progressive disease, life expectancy is usually the same as for those without the disease. However, for Dermatomyositis, Polymyositis, and Necrotizing Myopathy, the progression of the disease is more complicated and harder to predict. According to The Myositis Association, more than 95% of these patients are still alive more than five years after diagnosis. Many experiences only one period of acute illness in their lifetime while others struggle with symptoms for years.

 

How do I know if I have myositis?

Muscle weakness is the main symptom of myositis. In inflammatory myositis, weakness worsens over weeks and months andthe weakness affects large muscle groups, including the neck, shoulders, hips, and back. Muscles on both sides are usually affected. People with myositis often face difficulty in getting up from a chair or climbing stairs If you experience progressive weakness, with or without muscle pain, it’s best you consult your health care provider right away.

 

Can myositis go away on its own?

Like other inflammatory and autoimmune diseases, myositis does not go away on its own. Therefore, its management focuses on preserving muscle tissue by slowing down disease progression, mitigating muscle pain, and improving quality of life.

 

Can myositis be fatal?

Myositis is a progressive disease, meaning it worsens with time unless it is treated aggressively. Without the right treatment, it can lead to disability, and eventually, death. Therefore timely therapy is key so that progression can be slowed and quality of life can be improved. 

 

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Is myositis associated with covid?

Recent findings have indicated covid-19 can be associated with viral myositis. COVID19 induced myositis may vary in presentation, from dermatomyositis to rhabdomyolysis. 

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