Hyqvia Subq Infusion: Administration & Cost

Brand name: Hyqvia
제조사: Baxter Healthcare Corporation, Baxter BioScience
Alternatives: Immune globulin infusion 10% with recombinant human hyaluronidase

What Is Hyqvia?

Hyqvia is an injectable drug containing a genetically designed protein. It is a dual vial unit with a vial of immune globulin infusion 10% (Ig) and another vial of recombinant human hyaluronidase (Hy), which assists your body in the absorption of injectable medicines.

The parts are infused one after the other (Hy first, Ig second) through a needle set.

Treatment/Therapy

Hyqvia is an immune globulin infusion. It is a sterilized solution made up of human plasma containing antibodies that help your body protect itself against different infectious diseases. It is used for:

• Treating primary immunodeficiency in adults and pediatric patients aged two years and older 
• Maintenance therapy for adults with chronic inflammatory demyelinating polyneuropathy (CIDP).

Infusion

Hyqvia is administered in the form of a subcutaneous infusion, given under the skin. It has flexible administration options, and a healthcare provider can teach you how to self-administer in the comfort of your own home. 

It is essential that you receive proper training from a healthcare professional and understand the instructions thoroughly before self-administration. Do not self-administer the medication if you do not understand all of the instructions.

The infusion can also be administered at an infusion center.

저장

• Hyqvia can be stored in a refrigerator at 36°F to 46°F for up to 3 years (do not freeze the medication).
• It may be stored at room temperature (up to 77°F) for up to 3 months, but only during the first 24 months from the date of manufacture printed on the carton. 
• Do not return Hyqvia to the refrigerator if you take it out to store at room temperature. 
• Store Hyqvia in its original carton to protect it from light.
• The refrigerated product should be allowed to reach room temperature before use. 
• Do not heat or microwave the product.

관리

For infusion, an infusion pump is needed to titrate the appropriate flow rate. To prevent leakage at the infusion site while administering Hyqvia, a longer needle (12 or 14 mm) and the use of multiple infusion sites should be considered.

• Before infusing, inspect the vials for any cloudy precipitates, and do not shake the vials. 
• Do not use the medication if the solution is not clear. 
• Each vial is single-use and should not be used more than once.
• Suggested infusion sites are the thighs or abdomen. 
• When infusing, do not mix the two medications given in the Hyqvia kit.

Sequential Infusion

Both of the components of Hyqvia are infused sequentially, starting first with Hyaluronidase, then Ig 10% within 10 minutes through the same subcutaneous needle. 

그만큼 entire contents of the Hyaluronidase vial are used for each full or partial vial of Ig.   

Local infusion-site reactions such as mild to moderate pain, temporary soft pancake-like swelling, itching, and skin redness are common. 

Swelling may last 1 to 3 days, and infusion-related reactions should go away in a few hours.

Contraindications

Do not use Hyqvia If you ever had an allergic reaction to immune globulin, human albumin, and hyaluronidase or if you are immunoglobulin A deficient.

Warnings and Precautions

Hyqvia can cause blood clots, especially if you are 65 years or older, have heart disease, circulation disease, or a history of blood clots. 

Immediately contact your provider if you experience sudden chest pain, numbness, slurred speech, vision disorder, shortness of breath or pain, warmth, or swelling in the leg or arm. 

Inform your health care professional before administering infusion if you have any other health conditions such as diabetes, kidney disease, pregnancy, or dehydration. Do not infuse into or around an infected area as it may cause the infection to spread.

Drug Interactions

Hyqvia may interact and interfere with the immune responses to live virus vaccines, such as those for measles, mumps, rubella (MMR), and chickenpox.

Therefore, you should inform your healthcare provider about your Hyqvia treatment before receiving any vaccinations.

부작용

According to clinical trials, more than 5% of the subjects experienced some common side effects, including headache, fever, vomiting, nausea, fatigue, antibody formation against hyaluronidase, and symptoms of allergy such as swelling, itching, pain, and skin rash. There is no evidence of skin damage from Hyqvia so far.

Hyqvia can cause blood clots or thrombosis. Get immediate medical assistance if you experience any of the following adverse effects:

• Speech and vision problems
• Sudden numbness and lethargy
• 가슴 통증
• Blood in cough
• 진한 소변
• Decreased urination
• 황달
• 전염병
• Fast heartbeat
• Blood clotting in arm or leg
• Pulmonary disease such as transfusion-related acute lung injury (TRALI)

투여량

그만큼 dosing of Hyqvia is on an individualized basis.

Hyqvia dosing variations are discussed below:

• If the patient already takes Ig infusions, the treatment should be initiated 1 week after the last Ig infusion.
• Gradually increase dosage and frequency from a 1-week dose to a 3 or 4-week dose.
• The initial dose is 7.5 g on week 1, 15 g on week 2,  22.5 g on week 4, then 30 g on week 7 (full information is available in the Hyqvia package insert).
• If the patient has switched from IVIG treatment, then administer Hyqvia at the same dose and frequency as the previous IV treatment after initial dose ramp-up.
• If the patient has switched from SCIG treatment or is IgG-naïve, then administer at 300 – 600 mg/kg at 3 to 4 week intervals after initial ramp-up.
• If the patient is at high risk of renal failure or thrombosis, then administer Hyqvia at the minimum dose and infusion rate practicable.

Volume Per Site:

Up to 600 ml per site can be administered for patients who weigh 40 kg or more and up to 300 ml per site can be administered for those who weigh less than 40 kg. 

Rate of Infusion:

Administer the hyaluronidase of Hyqvia (HY) at an initial rate per site of approximately 1 to 2 ml per minute or as tolerated.

Administer the immune globulin 10% (IG) component of Hyqvia at the rates shown below for the initial infusions. Based on tolerability, these rates may be adjusted by the pharmacist. 

Uses

Hyqvia is mainly indicated for treating primary immunodeficiency (PI) in adults and children 2 years of age and over. It is also used as maintenance therapy for chronic inflammatory demyelinating polyneuropathy (CIDP) in adults. ​ 

Immunodeficiency conditions may include common variable immunodeficiency, Wiskott-Aldrich syndrome, congenital or X연관 무감마글로불린혈증, and severe combined immunodeficiencies.

Hyqvia Cost

The average cost for Hyqvia subcutaneous solution (160 units/ml–10%) is approximately $665 for a supply of 26.25 ml ($25.33/unit). This price may vary depending on the pharmacy you visit or the coverage you have through your health insurance provider.

공제금 지원

Certain programs offer assistance with the cost of Hyqvia. Offers may be in different forms, including a printable coupon, rebate, trial offer, savings card, or free samples. Some offers may be printed directly from a website. Others require proper enrollment, completing a questionnaire, or obtaining a sample from the provider’s office. 

Copay assistance programs include:

• Hyqvia OnePath Copay Assistance Program
• Hyqvia HelloHyqvia Free Trial Offer
• HealthWell Foundation Copay Program
• Patient Access Network Foundation (PAN)
• OnePath Patient Assistance Program (Hyqvia)

메모: All the above-mentioned programs have different eligibility requirements.

If you would like help in applying for any of these programs, please contact us for financial assistance.

Hyqvia vs. Hizentra

Like Hyqvia, Hizentra is indicated for primary immunodeficiency syndrome and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).

Hizentra is used as replacement therapy for primary humoral immunodeficiency (PI) in adults and pediatric patients 2 years and older.

Hizentra may also be used for other diagnoses. Hizentra subcutaneous injection is approximately $209.01 for a supply of 5 ml ($41.80/unit). 

This price may vary depending on the pharmacy. 

Pros of Hyqvia vs. Hizentra:

• Lower cost per ml – However it is important to note that Hyqvia is less concentrated than Hizentra (10% vs. 20% IgG), and larger volumes are necessary for treatment. Because of this, the total cost of Hyqvia is often comparable to the cost of Hizentra in many cases despite having a lower cost per ml. 
• Less frequent dosing (monthly vs. biweekly)
• 1 to 2 infusion sites

Cons of Hyqvia vs. Hizentra:

• Must infuse two components: Hy and Ig
• More fluid to infuse
• Longer infusion time