Apalutamide (Erleada)

Apalutamide (pronounced [a pa LOO ta mide]) is also known by the brand name Erleada. It is an 항종양제 라는 클래스에 속함 항안드로겐 요법. Erleada is a type of chemotherapy that prevents cancer cells from multiplying and restricts their growth.

화학요법이란 무엇인가?

화학요법은 특정 약물을 사용하여 암세포를 죽이는 암 치료법입니다. 이러한 약물은 일반적으로 세포독성 화학 물질로, 세포에 독성을 나타내며 세포의 성장을 제한하고 분열을 방해하여 궁극적으로 세포를 사멸시킵니다. 

화학 요법으로부터의 보호

Erleada is considered to be a hazardous agent, and normally, the pills are covered by a thin coating of material, but if this coating is damaged, removed, melted, or if the pill is broken into pieces, the chemical inside the pill can cause damage to your skin if you touch it. Therefore, it is important to take appropriate precautions for receiving, handling, storing, administering, and disposing of this medication. It is highly recommended to wear gloves if touching this medication or to avoid touching it entirely by using the cap of the bottle to scoop up the tablet and put it directly into the mouth.

Erleada는 어떻게 사용되나요?

Erleada는 다음에서 승인되었습니다. 식품의약국(FDA) 남성의 다양한 전립선암 치료에 사용됩니다. 단독으로 또는 다른 약물과 동시에 처방될 수 있습니다. 

사용 가능한 제형

현재 Erleada는 60mg 경구정으로만 판매됩니다. 

사용 방법

Erleada는 일반적으로 1일 1회 240mg을 투여합니다. 대부분의 경우 다른 지속형 약물과 병용하여 처방됩니다. 안드로겐 결핍 치료. Verify the correct dose and frequency with your provider. The dose should not be more or less than what is prescribed. Administer at the same time each day. Erleada may be taken with or without food. Swallow tablets whole with water; do not break, crush, chew, or allow the tablets to be dissolved in your mouth. If tablets are accidentally broken or damaged, avoid inhalation or contact with skin or mucous membranes. 

정제를 통째로 삼키기 어려운 경우, 정제를 부수지 않고 120ml의 애플소스에 섞어주세요. 15분간 그대로 두었다가 저어준 후, 다시 15분간 그대로 둔 후, 정제가 덩어리 없이 잘 섞일 때까지 다시 저어주세요. 잘 섞이면 숟가락을 사용하여 즉시 애플소스 혼합물을 삼키세요. 용기를 물 60ml로 헹구고 내용물을 즉시 마셔주세요. 1회 복용량을 모두 복용하기 위해 물 60ml를 한 번 더 넣어주세요. 조제 후 1시간 이내에 복용하세요. 나중에 사용하기 위해 보관하지 마세요.

복용량 누락

이 약은 정해진 일정에 따라 복용해야 합니다. 복용을 놓친 경우, 같은 날 가능한 한 빨리 복용하고 다음 날 다시 원래 복용 일정으로 돌아가십시오. 놓친 복용량을 보충하기 위해 추가 정제를 복용하지 마십시오. 2회 이상 복용을 놓친 경우 즉시 의사에게 연락하십시오. 

저장

정제는 원래 용기에 담아 서늘하고 건조한 실온에 보관하고 병뚜껑을 꼭 닫아 보관하십시오. 병은 직사광선을 피해 보관하십시오. 버리지 마십시오. 건조제 약은 습기로부터 보호되어야 하므로 병에 담아 보관하세요.

What To Avoid While Taking Erleada

While taking Erleada therapy, you must follow some precautions. Always tell your physician about any medications you are already taking. 의사 또는 약사의 사전 동의 없이 약물이나 의약품(한약, 비타민 또는 일반 의약품 포함)을 복용하지 마십시오.. They may have some significant interactions with Erleada.

Pregnancy and Erleada

Erleada is not approved for use in females. Males with female partners of reproductive potential should use effective contraception during treatment and for 3 months after the last dose. Pregnant women should wear gloves when handling tablets, especially if they are broken, crushed, or damaged, as this medication may cause fetal harm or fetal loss.

Erleada 부작용

As with any other medication, you may encounter side effects while taking Erleada. A few things to remember are:

• 아래 나열된 모든 부작용이 나타나지 않을 수도 있습니다. 많은 사람들이 부작용을 거의 또는 전혀 경험하지 않을 수도 있습니다.
• The severity of side effects may vary from person to person, so don’t compare your side effects with other people’s experiences.
• 대부분의 부작용은 치료를 중단하면 호전됩니다.
• These side effects are easily manageable most of the time either by readjusting the dose of Erleada or using additional medications to treat the symptoms. Consult with your physician or pharmacist to explore available options.
• 어떠한 증상도 숨기지 마세요. 불편함을 느끼면 주저하지 말고 의사나 약사에게 알리세요. 

메모: 이 목록은 모든 부작용을 포괄하는 것은 아닙니다. 궁금한 점이 있으면 의사와 상담하세요. 

Some of the more serious side effects of Erleada are listed below:

Cardiac Complications

Although uncommon, there is a risk for Erleada to cause an increase in the interval between when the heart contracts and relaxes, potentially increasing the risk for even more cardiac complications. 

Skin Rash

On rare occasions, Erleada may cause a serious skin rash. These rashes may appear as red, swollen hives; itching, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in the mouth, throat, nose, or eyes. Notify your physician or pharmacist immediately of any signs of a rash or allergic reaction, including wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. A rash can most typically appear within 3 months of Erleada use. Discontinuation of Erleada may be warranted if a rash is suspected. 

Fall or Fracture Risk

Patients who have a high fracture or fall risk may need to consider taking additional therapy that can help increase bone density to prevent any falls or bone fractures. This risk is potentially due to the high chance of fatigue and weakness/dizziness side effects. The risk is highest within the first 10 minutes after taking the medication. Monitoring of bone density may be warranted throughout therapy. 

발작

Although rare, it is possible that Erleada therapy may increase the risk for seizures. Patients receiving concomitant medications that may lower the seizure threshold (e.g., certain antidepressants) may be at a higher risk. If seizures occur, contact your physician immediately. 

Thyroid Impairment

Erleada may affect thyroid levels, and this can be managed with the use of thyroid replacement therapies as needed. It can typically cause a condition called hypothyroidism (lower thyroid-stimulating hormone lab value). Contact your physician immediately if you experience any abnormal changes in weight, anxiety, agitation, feeling very weak, hair thinning, depression, neck swelling, trouble focusing, inability to handle heat or cold, menstrual changes, tremors, or sweating. These may be signs of thyroid complications. 

기타 일반적인 부작용 다음을 포함할 수 있습니다.

• 피곤함이나 약함을 느낀다
• 식욕 감소
• 체중 감량
• 뜨거운 섬광
• 설사
• 속쓰림
• 관절 통증

모니터링

Due to its many side effects, monitoring is an important part of managing Erleada therapy. The following includes what you can expect with Erleada use:

• Monitoring for fall risk, especially for patients aged 65 and older.
• Frequent blood tests to monitor thyroid function.
• Regular blood pressure checks for cardiac monitoring.
• For patients with a history of heart failure, recent myocardial infarction (MI), or ventricular arrhythmia, close monitoring for other cardiac complications.
• For patients with a history of seizures, continual monitoring throughout therapy.

Erleada FAQs

Is Erleada a chemo agent?

항암제 are those that are used in the management of various cancers. Erleada works by blocking the production of the testosterone hormone, thereby slowing the growth and spread of prostate cancer. Thus, it is a chemo agent that is used as a treatment option for various cancer patients. 

How should Erleada be taken?

Erleada is only available as a 60 mg oral tablet. Most of the time, it is prescribed in combination with other medications. Verify the correct dose and frequency with your provider. Swallow tablets whole with water; do not break, crush, chew, or allow tablets to be dissolved in your mouth. Erleada can be taken with or without food. It is typically dosed at 240 mg once a day.

What can I do if I am unable to swallow tablets whole?

If unable to swallow tablets whole, mix tablets in 120 ml of applesauce without crushing them.

• Allow mixture to sit for 15 minutes, stir the mixture, then let the mixture sit another 15 minutes.
• Stir the mixture again until tablets are dispersed without any chunks remaining.
• Once dispersed, swallow the applesauce mixture immediately using a spoon.
• Rinse the container with 60 ml of water and immediately drink the contents.
• Repeat with a second 60 ml of water to ensure the entire dose is administered.
• Consume mixture within 1 hour of preparation; do not store for later use.