{"id":26009,"date":"2024-05-08T13:59:20","date_gmt":"2024-05-08T20:59:20","guid":{"rendered":"https:\/\/ameripharmaspecialty.com\/what-to-do-when-ivig-doesnt-work\/"},"modified":"2026-04-07T10:40:59","modified_gmt":"2026-04-07T17:40:59","slug":"what-to-do-when-ivig-doesnt-work","status":"publish","type":"post","link":"https:\/\/ameripharmaspecialty.com\/es\/ivig\/what-to-do-when-ivig-doesnt-work\/","title":{"rendered":"Qu\u00e9 hacer cuando la inmunoglobulina intravenosa (IVIG) no funciona: Tratamientos alternativos a la IVIG"},"content":{"rendered":"\n<p>Worried about what to do when intravenous immune globulin (IVIG) doesn\u2019t work or fails to work as expected? Take a breath. You have several treatment options with comparable or even better outcomes.&nbsp;<\/p>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ameripharmaspecialty.com\/es\/ivig\/what-to-do-when-ivig-doesnt-work\/#Highlights\" >Highlights<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ameripharmaspecialty.com\/es\/ivig\/what-to-do-when-ivig-doesnt-work\/#IVIG_Alternatives_in_Chronic_Inflammatory_Demyelinating_Polyneuropathy_CIDP\" >IVIG Alternatives in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ameripharmaspecialty.com\/es\/ivig\/what-to-do-when-ivig-doesnt-work\/#IVIG_Alternatives_in_Guillain_Barre_Syndrome_GBS\" >IVIG Alternatives in Guillain Barre Syndrome (GBS)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/ameripharmaspecialty.com\/es\/ivig\/what-to-do-when-ivig-doesnt-work\/#IVIG_Alternatives_in_Kawasaki_Disease_KD\" >IVIG Alternatives in Kawasaki Disease (KD)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/ameripharmaspecialty.com\/es\/ivig\/what-to-do-when-ivig-doesnt-work\/#IVIG_Alternatives_in_Bleeding_Disorders\" >IVIG Alternatives in Bleeding Disorders<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/ameripharmaspecialty.com\/es\/ivig\/what-to-do-when-ivig-doesnt-work\/#IVIG_Alternatives_in_Immune_Deficiency\" >IVIG Alternatives in Immune Deficiency<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/ameripharmaspecialty.com\/es\/ivig\/what-to-do-when-ivig-doesnt-work\/#What_Can_Be_Used_Instead_of_IVIG\" >What Can Be Used Instead of IVIG?<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Highlights\"><\/span>Highlights<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">When IVIG doesn\u2019t work, your provider may recommend alternative treatments, such as plasmapheresis, corticosteroids, and immunosuppressive agents.\u00a0<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">The choice of an alternative treatment is highly individualized.<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Alternative treatments depend on co-existing medical conditions, age, potential risks, and availability\/cost.<\/span><\/li>\n<\/ul>\n\n\n\n<p><span style=\"font-weight: 400;\"><a href=\"https:\/\/ameripharmaspecialty.com\/ivig\/what-to-expect-during-your-ivig-infusion-treatment\/\">IVIG is an effective treatment<\/a> for numerous autoimmune, inflammatory, and infectious conditions. But, like all medications, not everyone responds to IVIG equally, and some may not respond at all.&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Several factors may determine the success or failure of <a href=\"https:\/\/ameripharmaspecialty.com\/conditions-treatments\/immune-globulin-ig\/\">IVIG therapy<\/a>, such as:<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">Individual patient factors<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Age\u00a0<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">Adherence to treatment plan\u00a0<\/span><\/li>\n<\/ul>\n\n\n\n<p><span style=\"font-weight: 400;\">Likewise, studies show that the percentage of responders can vary depending on the condition being treated. In this article, we discuss the alternatives to IVIG specific for various medical conditions.&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Also Read: <\/span><a href=\"https:\/\/ameripharmaspecialty.com\/ivig\/how-to-tell-if-ivig-is-working\/\"><span style=\"font-weight: 400;\">How To Tell if IVIG Is Working<\/span><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"IVIG_Alternatives_in_Chronic_Inflammatory_Demyelinating_Polyneuropathy_CIDP\"><\/span>IVIG Alternatives in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Though IVIG is a first-line treatment for CIDP, about 1 in 4 people with CIDP don\u2019t respond to it. When IVIG doesn\u2019t work, your provider may prescribe immunosuppressive agents or monoclonal antibodies (mAbs) [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3105635\/#\"><span style=\"font-weight: 400;\">1<\/span><\/a><span style=\"font-weight: 400;\">]. Additionally, some experts recommend switching from IVIG to <\/span><a href=\"https:\/\/ameripharmaspecialty.com\/ivig\/what-is-scig\/\"><span style=\"font-weight: 400;\">SCIG<\/span><\/a><span style=\"font-weight: 400;\"> (subcutaneous immunoglobulin).&nbsp;&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Immunosuppressive agents work by preventing the immune system from attacking the protective covering around nerve cells. Examples of immunosuppressives include azathioprine, mycophenolate mofetil, methotrexate, cyclosporine, and <a href=\"https:\/\/ameripharmaspecialty.com\/discontinued\/cyclophosphamide\/\">cyclophosphamide<\/a>.\u00a0<\/span><\/p>\n\n\n\n<p><a href=\"https:\/\/ameripharmaspecialty.com\/cancer\/rituximab-rituxan\/\"><span style=\"font-weight: 400;\">Rituximab<\/span><\/a><span style=\"font-weight: 400;\">, a monoclonal antibody, improves CIDP symptoms in treatment-resistant cases according to a 2022 review [<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34120208\/\"><span style=\"font-weight: 400;\">2<\/span><\/a><span style=\"font-weight: 400;\">].<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"IVIG_Alternatives_in_Guillain_Barre_Syndrome_GBS\"><\/span>IVIG Alternatives in Guillain Barre Syndrome (GBS)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">IVIG is the primary treatment for GBS. Yet, about 25% of people who don\u2019t respond to it need mechanical ventilation, and 20% of people cannot walk without support after 6 months [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2883091\/#\"><span style=\"font-weight: 400;\">3<\/span><\/a><span style=\"font-weight: 400;\">].<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">When IVIG doesn\u2019t work, your provider may switch you to <\/span><a href=\"https:\/\/ameripharmaspecialty.com\/guillain-barre-syndrome\/plasmapheresis-for-guillain-barre-syndrome-benefits-risks-and-dose\/\"><span style=\"font-weight: 400;\">plasmapheresis<\/span><\/a><span style=\"font-weight: 400;\"> (plasma exchange) [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK594395\/#\"><span style=\"font-weight: 400;\">4<\/span><\/a><span style=\"font-weight: 400;\">]. Plasmapheresis helps by removing the antibodies that attack your nerves.&nbsp;<\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"IVIG_Alternatives_in_Kawasaki_Disease_KD\"><\/span>IVIG Alternatives in Kawasaki Disease (KD)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">Though universal treatment guidelines are not available for KD, alternative treatments for IVIG-resistant KD include [<\/span><a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2023.1149519\/full#\"><span style=\"font-weight: 400;\">4<\/span><\/a><span style=\"font-weight: 400;\">]:<\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"font-weight: 400;\">A corticosteroid called methylprednisolone<\/span><\/li>\n\n\n\n<li><span style=\"font-weight: 400;\">A monoclonal antibody called infliximab (often considered the drug of choice)<\/span><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"IVIG_Alternatives_in_Bleeding_Disorders\"><\/span>IVIG Alternatives in Bleeding Disorders<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><span style=\"font-weight: 400;\">If you have a bleeding disorder called immune thrombocytopenia (ITP), you are at risk of blood loss, especially during surgery. IVIG is commonly used before surgery to reduce the risk.&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">A 2020 trial shows that an oral drug\u2014eltrombopag\u2014can be as effective as IVIG in people with ITP [<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32853584\/\"><span style=\"font-weight: 400;\">5<\/span><\/a><span style=\"font-weight: 400;\">].<\/span><\/p>\n\n\n\n<div  id=\"call-to-action-002bfe8622f5eac94abaefd9329d32f1\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tConsult an IVIG Specialist\u00a0|\u00a0The Best IVIG Home Infusion\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"tel:8777780318\">(877) 778-0318<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<p>&nbsp;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"IVIG_Alternatives_in_Immune_Deficiency\"><\/span>IVIG Alternatives in Immune Deficiency<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Emerging evidence suggests that SCIG (subcutaneous immunoglobulin) may be a better option for people with immune deficiency.\u00a0<\/span><br \/>\n<span style=\"font-weight: 400;\">Unlike IVIG, SCIG results in the slow release of antibodies from the subcutaneous tissues into the blood. This allows antibody levels in the blood to remain steady. However, with IVIG, the antibody levels in the blood are more erratic.<\/span><br \/>\n<span style=\"font-weight: 400;\">Moreover, SCIG is more convenient because you can inject your dose at home or anywhere else at any time of day after some training. Additionally, side effects are less common with SCIG compared to IVIG.\u00a0<\/span><br \/>\n&nbsp;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"What_Can_Be_Used_Instead_of_IVIG\"><\/span>What Can Be Used Instead of IVIG?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">In general, SCIG causes fewer side effects than IVIG. You may choose SCIG over IVIG if you:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cannot tolerate IVIG side effects<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have poor venous access<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Find SCIG more compatible with your lifestyle<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Further Reading: <\/span><a href=\"https:\/\/ameripharmaspecialty.com\/ivig\/scig-vs-ivig\/\"><span style=\"font-weight: 400;\">SCIG vs. IVIG: Which Treatment Is Best for You?<\/span><\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>\u00bfLe preocupa qu\u00e9 hacer cuando la inmunoglobulina intravenosa (IVIG) no funciona o no funciona como se espera? Respire hondo. Tiene varias opciones de tratamiento con resultados comparables o incluso mejores.\u00a0<\/p>","protected":false},"author":26,"featured_media":25943,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":true,"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[7],"tags":[32],"class_list":["post-26009","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ivig","tag-dr-robert-hakim"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>What to Do When IVIG Doesn&#039;t Work: IVIG Alternatives | AmeriPharma<\/title>\n<meta name=\"description\" content=\"Explore what to do when IVIG treatment fails \u2014 including alternative therapies, second-line immunotherapies, and next steps your doctor may recommend.\" \/>\n<meta name=\"robots\" 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