{"id":24729,"date":"2023-12-08T10:46:00","date_gmt":"2023-12-08T10:46:00","guid":{"rendered":"https:\/\/ameripharmaspecialty.com\/?p=24729"},"modified":"2024-07-09T12:19:08","modified_gmt":"2024-07-09T19:19:08","slug":"ivig-mechanism-of-action-unraveling-the-enigma-of-this-potent-therapy","status":"publish","type":"post","link":"https:\/\/ameripharmaspecialty.com\/es\/ivig\/ivig-mechanism-of-action-unraveling-the-enigma-of-this-potent-therapy\/","title":{"rendered":"Mecanismo de acci\u00f3n de la IgIV: desentra\u00f1ando el enigma de esta potente terapia"},"content":{"rendered":"\r\n<p>The mechanism of action of intravenous immunoglobulin, or IVIG, to treat several inflammatory problems is complex and involves multiple processes that work synergistically.<\/p>\r\n\r\n\r\n\n<div  id=\"call-to-action-e392870f6a974f780ba64fa118d37416\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tGet Your IVIG Dose\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"cta__sub__heading\">\n\t\t\t\t\t\t\tAt-Home Infusion\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"tel:8777780318\">(877) 778-0318<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\r\n\r\n\r\n<p>This increasingly popular therapy is nothing less than a miracle for a myriad of inflammatory and autoimmune medical conditions. But how it exactly works in the body is still a mystery for the most part. In this article, you will learn about the potential mechanisms for how IVIG works.\u00a0<\/p>\r\n\r\n\r\n\r\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ameripharmaspecialty.com\/es\/ivig\/ivig-mechanism-of-action-unraveling-the-enigma-of-this-potent-therapy\/#A_Quick_Overview_of_IVIG\" >A Quick Overview of IVIG<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ameripharmaspecialty.com\/es\/ivig\/ivig-mechanism-of-action-unraveling-the-enigma-of-this-potent-therapy\/#General_IVIG_Mechanism_of_Action\" >General IVIG Mechanism of Action<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ameripharmaspecialty.com\/es\/ivig\/ivig-mechanism-of-action-unraveling-the-enigma-of-this-potent-therapy\/#Substitution\" >Substitution<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/ameripharmaspecialty.com\/es\/ivig\/ivig-mechanism-of-action-unraveling-the-enigma-of-this-potent-therapy\/#Immunomodulation\" >Immunomodulation<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/ameripharmaspecialty.com\/es\/ivig\/ivig-mechanism-of-action-unraveling-the-enigma-of-this-potent-therapy\/#Mechanism_of_Action_in_Autoimmune_and_Inflammatory_Diseases\" >Mechanism of Action in Autoimmune and Inflammatory Diseases<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/ameripharmaspecialty.com\/es\/ivig\/ivig-mechanism-of-action-unraveling-the-enigma-of-this-potent-therapy\/#IVIG_Mechanism_of_Action_in_Neurological_Disorders\" >IVIG Mechanism of Action in Neurological Disorders<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/ameripharmaspecialty.com\/es\/ivig\/ivig-mechanism-of-action-unraveling-the-enigma-of-this-potent-therapy\/#Mechanism_of_Action_in_Skin_Diseases\" >Mechanism of Action in Skin Diseases<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/ameripharmaspecialty.com\/es\/ivig\/ivig-mechanism-of-action-unraveling-the-enigma-of-this-potent-therapy\/#IVIG_Mechanism_of_Action_in_Infectious_Diseases\" >IVIG Mechanism of Action in Infectious Diseases<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/ameripharmaspecialty.com\/es\/ivig\/ivig-mechanism-of-action-unraveling-the-enigma-of-this-potent-therapy\/#IVIG_Mechanism_of_Action_in_Hematology\" >IVIG Mechanism of Action in Hematology<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"A_Quick_Overview_of_IVIG\"><\/span>A Quick Overview of IVIG<span class=\"ez-toc-section-end\"><\/span><\/h2>\r\n\r\n\r\n\r\n<p>IVIG contains antibodies obtained from healthy donors. Antibodies are proteins of the immune system that recognize and attack foreign material in your body. IVIG is used to treat many different inflammatory and autoimmune disorders, such as:<\/p>\r\n\r\n\r\n\r\n<ul class=\"wp-block-list\">\r\n<li><a href=\"https:\/\/ameripharmaspecialty.com\/guillain-barre-syndrome\/gbs-guillain-barre-syndrome\/\">Guillain-Barre syndrome&nbsp;<\/a>(GBS)<\/li>\r\n\r\n\r\n\r\n<li><a href=\"https:\/\/ameripharmaspecialty.com\/other-health-conditions\/what-is-multifocal-motor-neuropathy-mmn\/#\">Multifocal motor neuropathy<\/a>&nbsp;(MMN)<\/li>\r\n\r\n\r\n\r\n<li><a href=\"https:\/\/ameripharmaspecialty.com\/cidp\/what-is-cidp\/#\">Chronic inflammatory demyelinating polyneuropathy<\/a>&nbsp;(CIDP)<\/li>\r\n\r\n\r\n\r\n<li>Toxic epidermal necrolysis<\/li>\r\n\r\n\r\n\r\n<li>Hematological cancers<\/li>\r\n\r\n\r\n\r\n<li>Primary\/secondary immunoglobulin deficiencies&nbsp;<\/li>\r\n\r\n\r\n\r\n<li>Systemic lupus erythematosus (SLE)<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"General_IVIG_Mechanism_of_Action\"><\/span>General IVIG Mechanism of Action<span class=\"ez-toc-section-end\"><\/span><\/h2>\r\n\r\n\r\n\r\n<p>The exact IVIG mechanism of action is unclear. However, it is thought to work by the following mechanisms [<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1473050216302038\">1<\/a>]:<\/p>\r\n\r\n\r\n\r\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Substitution\"><\/span>Substitution<span class=\"ez-toc-section-end\"><\/span><\/h3>\r\n\r\n\r\n\r\n<p>IVIG strengthens your immune system by providing antibodies that can fight off infectious material from bacteria and viruses.\u00a0<\/p>\r\n\r\n\r\n\r\n<p>In addition, it also activates your body\u2019s second line of defense\u2014adaptive immunity. The adaptive immune response is pathogen-specific and long-lasting. For example, adaptive immunity provides life-long protection against measles to a person who recovers from measles.<\/p>\r\n\r\n\r\n\r\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Immunomodulation\"><\/span>Immunomodulation<span class=\"ez-toc-section-end\"><\/span><\/h3>\r\n\r\n\r\n\r\n<p>Immunomodulation by IVIG involves numerous complex and intertwined processes, such as:<\/p>\r\n\r\n\r\n\r\n<ul class=\"wp-block-list\">\r\n<li>Neutralization of autoantibodies<\/li>\r\n\r\n\r\n\r\n<li>Decrease in pro-inflammatory effects of specialized white blood cells (WBC)<\/li>\r\n\r\n\r\n\r\n<li>Expansion of T cells that suppress the immune response<\/li>\r\n\r\n\r\n\r\n<li>Neutralization of proteins that signal the movement of WBCs<\/li>\r\n\r\n\r\n\r\n<li>Suppression of programmed cell death<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Mechanism_of_Action_in_Autoimmune_and_Inflammatory_Diseases\"><\/span>Mechanism of Action in Autoimmune and Inflammatory Diseases<span class=\"ez-toc-section-end\"><\/span><\/h2>\r\n\r\n\r\n\r\n<p><strong>Autoimmune disorders<\/strong>\u00a0occur when your immune system produces autoantibodies, which are antibodies that attack healthy tissues. Examples of autoimmune diseases include\u00a0Guillain-Barre syndrome,\u00a0chronic inflammatory demyelinating polyneuropathy,\u00a0<a href=\"https:\/\/ameripharmaspecialty.com\/conditions-treatments\/multiple-sclerosis\/\">multiple sclerosis<\/a>, and others. IVIG helps treat autoimmune disease by neutralizing the autoantibodies, which helps control associated signs and symptoms.\u00a0<\/p>\r\n\r\n\r\n\r\n<p><strong>Inflammatory disorders<\/strong>\u00a0happen when your immune system attacks healthy tissues, causing inflammation. Examples include\u00a0<a href=\"https:\/\/ameripharmaspecialty.com\/ivig\/ivig-and-inflammatory-bowel-disease-ibd\/\">inflammatory bowel disease<\/a>, systemic lupus erythematosus, and gout. IVIG helps improve symptoms of inflammatory diseases by decreasing inflammation and activating anti-inflammatory chemicals.\u00a0<\/p>\r\n\r\n\r\n\n<div  id=\"call-to-action-8052ce26f5b651dbe5ef530f0038e574\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tSpeak to a Specialist About\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"cta__sub__heading\">\n\t\t\t\t\t\t\tCopay Assistance\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"#form\">Consult an IVIG Specialist<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\r\n\r\n\r\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"IVIG_Mechanism_of_Action_in_Neurological_Disorders\"><\/span>IVIG Mechanism of Action in Neurological Disorders<span class=\"ez-toc-section-end\"><\/span><\/h2>\r\n\r\n\r\n\r\n<p>Neurological disorders affect your brain, spinal cord, peripheral nerves, nerve roots, neuromuscular junction, and muscles.\u00a0<\/p>\r\n\r\n\r\n\r\n<p>IVIG is FDA-approved to treat:<\/p>\r\n\r\n\r\n\r\n<ul class=\"wp-block-list\">\r\n<li>Guillain-Barre syndrome<\/li>\r\n\r\n\r\n\r\n<li>Multifocal motor neuropathy<\/li>\r\n\r\n\r\n\r\n<li>Chronic inflammatory demyelinating polyneuropathy<\/li>\r\n\r\n\r\n\r\n<li>Dermatomyositis<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<p>Though IVIG doesn\u2019t help with all neurological disorders, there\u2019s clinical evidence to support using IVIG to treat the following:<\/p>\r\n\r\n\r\n\r\n<ul class=\"wp-block-list\">\r\n<li>Myasthenia gravis<\/li>\r\n\r\n\r\n\r\n<li>Autoimmune epilepsy<\/li>\r\n\r\n\r\n\r\n<li>Neuromyelitis&nbsp;<\/li>\r\n\r\n\r\n\r\n<li>Autoimmune encephalitis<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<p>Antibodies, specialized immune cells, or infection-fighting proteins mediate almost all neurological disorders that respond to IVIG therapy [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8585501\/\">2<\/a>]. IVIG targets one or more of these mediators to help improve symptoms. Moreover, IVIG suppresses autoantibody-producing cells and B cells.<\/p>\r\n\r\n\r\n\r\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Mechanism_of_Action_in_Skin_Diseases\"><\/span>Mechanism of Action in Skin Diseases<span class=\"ez-toc-section-end\"><\/span><\/h2>\r\n\r\n\r\n\n<div  id=\"image-with-text-3b73abdc689bb10ae5cf2e597640311f\" style=\"\" class=\"ct_image_with_text\">\n        <div class=\"container\">\n        <div class=\"block-spacing block-wrap image_with_text \">\n                            <div class=\"image_with_text_content\">\n                    <p>High-dose IVIG may be used to treat skin diseases that don\u2019t respond to conventional treatments [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2800881\/#\">3<\/a>]. Examples include:<\/p>\n<ul>\n<li aria-level=\"1\">Chronic hives<\/li>\n<li aria-level=\"1\">Eczema<\/li>\n<li aria-level=\"1\">Toxic epidermal necrolysis<\/li>\n<li aria-level=\"1\">Herpes gestationis (intensely itchy rashes during the second or third trimester)<\/li>\n<li aria-level=\"1\"><a href=\"https:\/\/ameripharmaspecialty.com\/other-health-conditions\/what-is-amyopathic-dermatomyositis-adm\/\">Dermatomyositis<\/a><\/li>\n<\/ul>\n                <\/div>\n                                        <div class=\"image_with_text_media\">\n                    <picture>\n                                                <source loading=\"lazy\" media=\"(min-width:768px)\" srcset=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/12\/skin-condition.jpg\">\n                        <img decoding=\"async\" loading=\"lazy\" src=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/12\/skin-condition.jpg\" alt=\"https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2023\/12\/skin-condition.jpg\" style=\"width:auto;\">\n                    <\/picture>\n                <\/div>\n                    <\/div>\n    <\/div>\n<\/div>\r\n\r\n\r\n<p>The exact mechanism of action is unclear. However, researchers believe IVIG works by suppressing B and T cells, blocking the death of skin cells, and decreasing inflammation [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4739470\/\">4<\/a>].<\/p>\r\n\r\n\r\n\r\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"IVIG_Mechanism_of_Action_in_Infectious_Diseases\"><\/span>IVIG Mechanism of Action in Infectious Diseases<span class=\"ez-toc-section-end\"><\/span><\/h2>\r\n\r\n\r\n\r\n<p>IVIG may be used with antimicrobials to treat several bacterial and viral infections, such as [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7127229\/\">5<\/a>]:<\/p>\r\n\r\n\r\n\r\n<ul class=\"wp-block-list\">\r\n<li>Childhood HIV<\/li>\r\n\r\n\r\n\r\n<li>Bacterial infections of the digestive tract<\/li>\r\n\r\n\r\n\r\n<li>Cytomegalovirus (CMV) infection<\/li>\r\n\r\n\r\n\r\n<li>Chickenpox<\/li>\r\n\r\n\r\n\r\n<li>Genital herpes<\/li>\r\n\r\n\r\n\r\n<li>Parvovirus infection<\/li>\r\n\r\n\r\n\r\n<li>Clostridium difficile<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n<p>IVIG is thought to neutralize bacterial toxins and enhance phagocytosis (ingesting and eliminating bacterial cells). Likewise, IVIG neutralizes viruses and activates immune cells that remove virus-infected cells from the body [<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.987231\/full\">6<\/a>].<\/p>\r\n\r\n\r\n\n<div  id=\"call-to-action-179228bbf431355ce046d62813cb389f\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tGet IVIG Copay Assistance\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"cta__sub__heading\">\n\t\t\t\t\t\t\tSpeak to a Specialist\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"tel:8777780318\">(877) 778-0318<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\r\n\r\n\r\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"IVIG_Mechanism_of_Action_in_Hematology\"><\/span>IVIG Mechanism of Action in Hematology<span class=\"ez-toc-section-end\"><\/span><\/h2>\r\n\r\n\r\n\r\n<p>IVIG may be used to treat blood problems, like immune thrombocytopenia (a condition of low platelet levels, which leads to easy bruising and bleeding) [<a href=\"https:\/\/cdn.amegroups.cn\/journals\/vats\/files\/journals\/29\/articles\/6137\/public\/6137-PB5-2485-R3.pdf\">7<\/a>].<\/p>\r\n\r\n\r\n\r\n<p>However, its mechanism is unclear and needs further research.\u00a0<\/p>\r\n","protected":false},"excerpt":{"rendered":"<p>El mecanismo de acci\u00f3n de la inmunoglobulina intravenosa, o IgIV, para tratar varios problemas inflamatorios es complejo e involucra m\u00faltiples procesos que trabajan sin\u00e9rgicamente.<br \/>\nEsta terapia cada vez m\u00e1s popular no es menos que un milagro para una gran variedad de afecciones m\u00e9dicas inflamatorias y autoinmunes.<\/p>","protected":false},"author":26,"featured_media":24730,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":true,"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[7],"tags":[],"class_list":["post-24729","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ivig"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>IVIG Mechanism of Action: Unraveling the Enigma of This Potent Therapy<\/title>\n<meta name=\"description\" content=\"Learn about the IVIG mechanism of action for various conditions. 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