{"id":23946,"date":"2024-03-12T13:34:24","date_gmt":"2024-03-12T20:34:24","guid":{"rendered":"https:\/\/ameripharmaspecialty.com\/are-ivig-products-interchangeable\/"},"modified":"2026-03-24T09:29:01","modified_gmt":"2026-03-24T16:29:01","slug":"are-ivig-products-interchangeable","status":"publish","type":"post","link":"https:\/\/ameripharmaspecialty.com\/es\/ivig\/are-ivig-products-interchangeable\/","title":{"rendered":"\u00bfSon intercambiables los productos IVIG?"},"content":{"rendered":"

Aunque los productos de inmunoglobulina intravenosa (IVIG) son igualmente eficaces y todos funcionan para normalizar el sistema inmunol\u00f3gico hiperactivo o comprometido, son <\/span>no intercambiables<\/span><\/a>, a diferencia de los medicamentos gen\u00e9ricos t\u00edpicos. E<\/span>muy <\/span>Marca de IgIV<\/span><\/a> es diferente en t\u00e9rminos de composici\u00f3n, purificaci\u00f3n y tratamiento aprobado para diferentes condiciones m\u00e9dicas.<\/span><\/p>\n\n\n\n

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\n\t\t\t\t\t\t\tHable con un especialista sobre la asistencia con los copagos\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t(877) 778-0318<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n

Por ejemplo, Gamunex y Privigen<\/a> Ambos son productos de IgIV que se utilizan para tratar la polineuropat\u00eda desmielinizante inflamatoria cr\u00f3nica (<\/span>PDIC<\/span><\/a>). Sin embargo, ambos productos son fabricados por diferentes compa\u00f1\u00edas farmac\u00e9uticas y tienen caracter\u00edsticas diferentes como composici\u00f3n, purificaci\u00f3n, formulaci\u00f3n y perfiles de tolerabilidad. <\/span><\/p>\n\n\n\n

Los pacientes que experimentan una reacci\u00f3n a Gamunex podr\u00edan no presentar ninguna reacci\u00f3n a Privigen con una preparaci\u00f3n diferente. Por esta raz\u00f3n, los productos de IgIV se consideran no intercambiables. <\/span> <\/p>\n\n\n\n

Este art\u00edculo destaca los factores clave que explican a\u00fan m\u00e1s por qu\u00e9 los productos IVIG no son intercambiables. <\/span><\/p>\n\n\n\n

\n
\nPalanca<\/span><\/path><\/svg><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n
  • \u00bfQu\u00e9 son los productos IVIG?<\/a><\/li>
  • \u00bfPor qu\u00e9 los productos de IgIV no son intercambiables?<\/a>
    • Composici\u00f3n<\/a><\/li>
    • Proceso de purificaci\u00f3n<\/a><\/li>
    • Formulaci\u00f3n<\/a><\/li><\/ul><\/li>
    • Conclusi\u00f3n<\/a><\/li><\/ul><\/nav><\/div>\n

      <\/span>\u00bfQu\u00e9 son los productos IVIG?<\/span><\/h2>\n\n\n\n

      Los productos de IgIV son principalmente agentes biol\u00f3gicos que consisten en una soluci\u00f3n concentrada de <\/span>inmunoglobulinas<\/span><\/a> (anticuerpos) derivados del plasma humano de miles de donantes sanos. <\/span><\/p>\n\n\n\n

      El <\/span>Administraci\u00f3n de Alimentos y Medicamentos de los Estados Unidos (FDA)<\/span><\/a> ha aprobado hasta el momento alrededor de diez productos IVIG para el tratamiento de trastornos autoinmunes y de inmunodeficiencia, que son los siguientes: <\/span><\/p>\n\n\n\n

        \n
      1. Asceniv<\/span><\/li>\n\n\n\n
      2. Vivigam<\/span><\/li>\n\n\n\n
      3. Carimune NF, nanofiltrado<\/span><\/li>\n\n\n\n
      4. Flebogamma DIF 5% y 10%<\/span><\/li>\n\n\n\n
      5. Gammagard L\u00edquido<\/span> y <\/span>Gammagard S\/D<\/span><\/li>\n\n\n\n
      6. Gammaplex 5% y 10%<\/a><\/span><\/li>\n\n\n\n
      7. Gamunex-C<\/a>, Gammaked<\/span><\/li>\n\n\n\n
      8. Octagam<\/span><\/a><\/li>\n\n\n\n
      9. Panzyga<\/span><\/a><\/li>\n\n\n\n
      10. Privigen<\/span><\/li>\n<\/ol>\n\n\n\n

        Cada producto est\u00e1 indicado para el tratamiento de diversos trastornos causados por la disfunci\u00f3n del sistema inmunitario. Diferentes compa\u00f1\u00edas farmac\u00e9uticas fabrican estos productos de IgIV seg\u00fan su protocolo de fabricaci\u00f3n est\u00e1ndar, lo que los hace universalmente no intercambiables. <\/span> <\/p>\n\n\n\n

        <\/span>\u00bfPor qu\u00e9 los productos de IgIV no son intercambiables?<\/span><\/h2>\n\n\n
        \n
        \"3D<\/figure>\n<\/div>\n\n\n


        Hay varios factores clave que hacen que los productos IVIG no sean intercambiables. <\/span><\/p>\n\n\n\n

        <\/span>Composici\u00f3n<\/span><\/h3>\n\n\n\n

        La composici\u00f3n de los productos de IgIV suele variar seg\u00fan la marca. Cada producto de IgIV puede tener un tipo y una concentraci\u00f3n de inmunoglobulina (anticuerpo) espec\u00edficos. Por ejemplo, nuestro organismo suele tener cinco tipos de inmunoglobulinas: IgG, IgA, IgE, IgM e IgD. <\/span><\/p>\n\n\n\n

        Entre las inmunoglobulinas, la IgG es el anticuerpo m\u00e1s abundante en el plasma humano y es un componente principal de todos los productos IVIG (presente en 95% de la concentraci\u00f3n).  <\/span><\/p>\n\n\n\n

        Otros anticuerpos, como IgA e IgM, est\u00e1n presentes en cantidades traza en los productos de IgIV. <\/span><\/p>\n\n\n\n

        El anticuerpo primario (IgG) tambi\u00e9n tiene cuatro subtipos (IgG1, IgG2, IgG3 e IgG4), y es posible que diferentes productos de IgIV contengan proporciones variables de las subclases de IgG, IgA e IgM. Esto tambi\u00e9n puede hacer que los productos de IgIV difieran en cuanto a su especificidad antig\u00e9nica. <\/span><\/p>\n\n\n\n

        Por ejemplo, si un paciente presenta anticuerpos IgA, se pueden recetar productos de IgIV con una baja proporci\u00f3n de IgA, como Flebogamma o Gammagard S\/D. Sin embargo, si un paciente con anticuerpos IgA tambi\u00e9n padece diabetes, el producto de IgIV Gammagard S\/D podr\u00eda ser potencialmente mortal para los pacientes diab\u00e9ticos, ya que contiene glucosa como agente estabilizador.<\/span><\/p>\n\n\n\n

        <\/span>Proceso de purificaci\u00f3n<\/span><\/h3>\n\n\n\n

        Las empresas farmac\u00e9uticas pueden utilizar m\u00e9todos de purificaci\u00f3n ligeramente diferentes (como <\/span>fraccionamiento<\/span><\/a>, precipitaci\u00f3n y cromatograf\u00eda) para purificar las inmunoglobulinas del plasma humano. Las variaciones en los m\u00e9todos de purificaci\u00f3n pueden influir en los niveles de impurezas, como agregados, anticuerpos contra ant\u00edgenos de grupos sangu\u00edneos y citocinas, lo que puede afectar la seguridad y la tolerabilidad del producto final de IgIV.<\/span> <\/p>\n\n\n\n

        \n\t
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        \n\t\t\t\t\t\t\tObtenga su dosis de IgIV: infusi\u00f3n en casa\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\tConsulte a un especialista en IgIV<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n

        <\/span>Formulaci\u00f3n<\/span><\/h3>\n\n\n\n

        La formulaci\u00f3n de los productos de IgIV tambi\u00e9n difiere en t\u00e9rminos de pH, estabilizadores y <\/span>osmolalidad<\/span><\/a>Por ejemplo, las marcas de IgIV como Gammagard S\/D contienen az\u00facar (como glucosa) como estabilizador y un mayor contenido de sodio, lo cual no se recomienda para pacientes con diabetes, enfermedades card\u00edacas o renales. En cambio, la soluci\u00f3n l\u00edquida Gammagard no contiene az\u00facar ni sodio. <\/span><\/p>\n\n\n\n

        Aunque ambos productos de IgIV tratan la inmunodeficiencia humoral primaria (IP) en pacientes adultos y pedi\u00e1tricos de 2 a\u00f1os o m\u00e1s, difieren en el contenido de az\u00facar, el contenido de sodio, los niveles de pH y la osmolalidad (ver Tabla 1). <\/span><\/p>\n\n\n\n

        Por lo tanto, estas variaciones en la formulaci\u00f3n de los productos de IgIV influyen en su estabilidad, vida \u00fatil y compatibilidad con la fisiolog\u00eda del paciente. <\/span><\/p>\n\n\n\n

        Dado que cada producto tiene una formulaci\u00f3n diferente, se recomienda consultar a su m\u00e9dico antes de cambiar entre productos de IgIV.<\/span><\/p>\n\n\n\n

        Tabla 1: Formulaciones de productos de IgIV<\/strong><\/p>\n\n\n\n

        Productos de IgIV<\/b><\/td>Contenido de IgA<\/b><\/td>Estabilizador<\/b><\/td>pH<\/b><\/td>Osmolalidad<\/b><\/td>Contenido de az\u00facar y sodio<\/b><\/td><\/tr>
        L\u00edquido Gammagard (soluci\u00f3n 10%)<\/b><\/td>Promedio 37 \u00b5g\/mL<\/span><\/td>Glicina (300 mM)<\/span><\/td>4.6-5.1<\/span><\/td>240-300 mOsmol\/kg<\/span><\/td>Sin az\u00facar
        Sin sodio<\/span><\/td><\/tr>
        Gammagard S\/D<\/b><\/td><1<\/span>\u00b5g\/mL<\/span><\/td>Glicina (250 mM)
        Glucosa (3 g\/dl)<\/span><\/td>        		6.4-7.2<\/span><\/td>636 mOsmol\/kg<\/span><\/td>Glucosa (2 g\/dL)<\/span><\/td><\/tr>
        Gammaplex 10%<\/b><\/td><20<\/span>\u00b5g\/mL<\/span><\/td>Glicina (200-300 mM)<\/span><\/td>4.9-5.2<\/span><\/td>>240 mOsmol\/kg<\/span><\/td>Sin sacarosa ni maltosa
        Sodio: <30 mEq\/L<\/span><\/td><\/tr>
        Bivigam\u00ae<\/b><\/td>\u2264200<\/span>\u00b5g\/mL<\/span><\/td>Glicina (200-290 mM)<\/span><\/td>4.0-4.6<\/span><\/td>\u2264<\/span>510 mOsmol\/kg<\/span><\/td>Sin az\u00facar
        Sodio: 100-140 mEq\/L<\/span><\/td><\/tr>
        Flebogamma 5%<\/b><\/td><50<\/span>\u00b5g\/mL<\/span><\/td>D-sorbitol (5 g\/dL)<\/span><\/td>5.0-6.0<\/span><\/td>240-370 mOsmol\/kg<\/span><\/td>D-sorbitol (5 g\/dl)
        Sodio: cantidad traza<\/span><\/td><\/tr>
        Flebogamma 10%<\/b><\/td><100<\/span>\u00b5g\/mL<\/span><\/td>D-sorbitol (5 g\/dL)<\/span><\/td>5.0-6.0<\/span><\/td>240-370 mOsmol\/kg<\/span><\/td>D-sorbitol (5 g\/dl)
        Sodio: cantidad traza<\/span><\/td><\/tr>
        Gamunex<\/b><\/td>46 \u00b5g\/mL<\/span><\/td>Glicina (160-250 mM)<\/span><\/td>4.0-4.5<\/span><\/td>258 mOsmol\/kg<\/span><\/td>Sin az\u00facar
        Sodio: Cantidad traza<\/span><\/td><\/tr>
        Octagam<\/b><\/td>\u2264200 <\/span>\u00b5g\/mL<\/span><\/td>Maltosa (10 g\/dL)<\/span><\/td>5.1-6.0<\/span><\/td>310-380 mOsmol\/k<\/span><\/td>Maltosa
        Sodio: <30 mEq\/L<\/span><\/td><\/tr>
        Panzyga<\/b><\/td>Promedio 100 \u00b5g\/mL<\/span><\/td>Glicina (200-260 mM)<\/span><\/td>4.5-5.0<\/span><\/td>240-310 mOsmol\/kg<\/span><\/td>Sin sacarosa
        Sodio: Cantidad traza<\/span><\/td><\/tr>
        Privigen<\/b><\/td>\u226425 <\/span>\u00b5g\/mL<\/span><\/td>L-prolina (250 mM)<\/span><\/td>4.6-5.0<\/span><\/td>240-440 mOsmol\/kg<\/span><\/td>Sin az\u00facar
        Sodio: Cantidad traza<\/span><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

        <\/span>Conclusi\u00f3n<\/span><\/h2>\n\n\n\n

        A diferencia de los medicamentos gen\u00e9ricos, los productos de IgIV no son intercambiables. Cada producto de IgIV tiene una composici\u00f3n diferente (concentraci\u00f3n de inmunoglobulina), se somete a un proceso de purificaci\u00f3n distinto y tiene una formulaci\u00f3n distinta (estabilizador, pH, osmolalidad o contenido de sodio). <\/span>
         <\/p>","protected":false},"excerpt":{"rendered":"

        Though intravenous immunoglobulin (IVIG) products are equally efficacious, and all work to normalize the overactive or compromised immune system, they are not interchangeable, unlike typical generic drugs. Every IVIG brand is different in terms of composition, purification, and approved treatment for different medical conditions.<\/p>","protected":false},"author":7,"featured_media":23948,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[7],"tags":[8],"class_list":["post-23946","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ivig","tag-dr-christine-leduc"],"acf":[],"yoast_head":"\nAre IVIG Products Interchangeable? | AmeriPharma<\/title>\n<meta name=\"description\" content=\"Are IVIG products interchangeable? 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Christine Leduc, PharmD","image":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/secure.gravatar.com\/avatar\/9f2e7e868ac19420a5672d88350e7e0e3c6a750140410fd606eec96984812e89?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/9f2e7e868ac19420a5672d88350e7e0e3c6a750140410fd606eec96984812e89?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/9f2e7e868ac19420a5672d88350e7e0e3c6a750140410fd606eec96984812e89?s=96&d=mm&r=g","caption":"Dr. Christine Leduc, PharmD"},"description":"La Dra. Christine Leduc, doctora en farmacia, naci\u00f3 y creci\u00f3 en Irvine, California. Curs\u00f3 estudios universitarios en la Universidad Midwestern, donde se gradu\u00f3 con honores. Lo m\u00e1s gratificante de su trabajo es sugerir cambios en el estilo de vida, educar a los pacientes sobre el funcionamiento de sus medicamentos y ser tutora de futuros farmac\u00e9uticos. Sus \u00e1reas de especializaci\u00f3n son la atenci\u00f3n al cliente y el conocimiento de medicamentos especializados. Tras haber trabajado en el sector servicios, ha adquirido las habilidades de atenci\u00f3n al cliente necesarias para comprender las necesidades de sus pacientes. Actualmente, la Dra. Leduc imparte clases a estudiantes de la Universidad Marshall B. Ketchum, la Universidad de Kansas y la Universidad Midwestern. En su tiempo libre, disfruta de viajar, la reposter\u00eda y la jardiner\u00eda. 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