{"id":23828,"date":"2024-01-26T11:40:47","date_gmt":"2024-01-26T19:40:47","guid":{"rendered":"https:\/\/ameripharmaspecialty.com\/everything-you-need-to-know-about-neonatal-alloimmune-thrombocytopenia-2\/"},"modified":"2024-07-01T09:45:26","modified_gmt":"2024-07-01T16:45:26","slug":"everything-you-need-to-know-about-neonatal-alloimmune-thrombocytopenia-2","status":"publish","type":"post","link":"https:\/\/ameripharmaspecialty.com\/es\/other-health-conditions\/everything-you-need-to-know-about-neonatal-alloimmune-thrombocytopenia-2\/","title":{"rendered":"Todo lo que necesita saber sobre la trombocitopenia aloinmune neonatal"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Neonatal alloimmune thrombocytopenia (NAIT) is a rare but serious immune disorder that affects fetuses and newborns. According to a 2021 review, NAIT affects 1 in every 1,000 live births in the U.S. [<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32657948\/\"><span style=\"font-weight: 400;\">1<\/span><\/a><span style=\"font-weight: 400;\">]<\/span><\/p>\n\n\n<div  id=\"call-to-action-facfe5177872617df24ddc63f4962c1c\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tSpeak to a Specialist About Copay Assistance\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"tel:8777780318\">(877) 778-0318<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<p><span style=\"font-weight: 400;\">Neonatal alloimmune thrombocytopenia (NAIT) occurs when the mother\u2019s immune cells attack and destroy the baby\u2019s platelets. As a result, the baby\u2019s platelet count drops in a condition known as <\/span><a href=\"https:\/\/ameripharmaspecialty.com\/?s=thrombocytopenia\"><span style=\"font-weight: 400;\">thrombocytopenia<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><br \/><span style=\"font-weight: 400;\">Severe thrombocytopenia increases the risk of bleeding into the baby\u2019s brain (intracranial hemorrhage) and other vital organs.\u00a0<\/span><br \/><span style=\"font-weight: 400;\">NAIT is also known by other names:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fetal and neonatal alloimmune thrombocytopenia (FNAIT)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fetomaternal alloimmune thrombocytopenia (FMAIT)<\/span><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ameripharmaspecialty.com\/es\/other-health-conditions\/everything-you-need-to-know-about-neonatal-alloimmune-thrombocytopenia-2\/#What_Are_the_Symptoms_of_Neonatal_Alloimmune_Thrombocytopenia\" >What Are the Symptoms of Neonatal Alloimmune Thrombocytopenia?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ameripharmaspecialty.com\/es\/other-health-conditions\/everything-you-need-to-know-about-neonatal-alloimmune-thrombocytopenia-2\/#What_Causes_Neonatal_Alloimmune_Thrombocytopenia\" >What Causes Neonatal Alloimmune Thrombocytopenia?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ameripharmaspecialty.com\/es\/other-health-conditions\/everything-you-need-to-know-about-neonatal-alloimmune-thrombocytopenia-2\/#Diagnosis\" >Diagnosis<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/ameripharmaspecialty.com\/es\/other-health-conditions\/everything-you-need-to-know-about-neonatal-alloimmune-thrombocytopenia-2\/#HPA_testing\" >HPA testing<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/ameripharmaspecialty.com\/es\/other-health-conditions\/everything-you-need-to-know-about-neonatal-alloimmune-thrombocytopenia-2\/#Ultrasound\" >Ultrasound<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/ameripharmaspecialty.com\/es\/other-health-conditions\/everything-you-need-to-know-about-neonatal-alloimmune-thrombocytopenia-2\/#Neonatal_Alloimmune_Thrombocytopenia_What_Are_the_Treatment_Options\" >Neonatal Alloimmune Thrombocytopenia: What Are the Treatment Options?<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/ameripharmaspecialty.com\/es\/other-health-conditions\/everything-you-need-to-know-about-neonatal-alloimmune-thrombocytopenia-2\/#Prenatal_treatment_options\" >Prenatal treatment options\u00a0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/ameripharmaspecialty.com\/es\/other-health-conditions\/everything-you-need-to-know-about-neonatal-alloimmune-thrombocytopenia-2\/#Postnatal_treatment_options\" >Postnatal treatment options<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/ameripharmaspecialty.com\/es\/other-health-conditions\/everything-you-need-to-know-about-neonatal-alloimmune-thrombocytopenia-2\/#Neonatal_Alloimmune_Thrombocytopenia_FAQs\" >Neonatal Alloimmune Thrombocytopenia: FAQs<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"What_Are_the_Symptoms_of_Neonatal_Alloimmune_Thrombocytopenia\"><\/span>What Are the Symptoms of Neonatal Alloimmune Thrombocytopenia?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Symptoms can appear before birth or up to a month after, and they can vary depending on the degree of platelet drop in the baby\u2019s blood.\u00a0<\/span><br \/><span style=\"font-weight: 400;\">The most common signs are purple-colored spots in the skin (petechiae and purpura). They usually appear within a few hours following birth. Other signs can include easy bruising and excessive bleeding.\u00a0<\/span><br \/><span style=\"font-weight: 400;\">Mild symptoms typically resolve with time and after appropriate treatment. Some babies may have no signs other than a low platelet count. However, severe cases (where bleeding occurs in the brain, digestive tract, lungs, or eyes) can lead to death or long-term disability.\u00a0<\/span><br \/><span style=\"font-weight: 400;\">Some babies with severe NAIT may have a bulge on the head, which can indicate blood accumulation under the scalp (cephalohematoma) [<\/span><a href=\"https:\/\/rarediseases.org\/rare-diseases\/fetal-and-neonatal-alloimmune-thrombocytopenia\/\"><span style=\"font-weight: 400;\">2<\/span><\/a><span style=\"font-weight: 400;\">].<\/span><br \/>\u00a0<\/p>\n<h2><span class=\"ez-toc-section\" id=\"What_Causes_Neonatal_Alloimmune_Thrombocytopenia\"><\/span>What Causes Neonatal Alloimmune Thrombocytopenia?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Platelets have molecules on their surface called human platelet antigens (HPAs). A baby inherits half of these HPAs from the father and half from the mother [<\/span><a href=\"https:\/\/www.rcog.org.uk\/media\/tcga1t1e\/bjog-2019-regan-prenatal-management-of-pregnancies-at-risk-of-fet.pdf\"><span style=\"font-weight: 400;\">3<\/span><\/a><span style=\"font-weight: 400;\">].\u00a0<\/span><br \/><span style=\"font-weight: 400;\">During the course of pregnancy, the baby\u2019s platelets can cross the placental barrier and reach the mother&#8217;s bloodstream without causing any issues.\u00a0<\/span><br \/><span style=\"font-weight: 400;\">However, in NAIT, the mother\u2019s immune system fails to recognize HPAs obtained from the father. Consequently, the mother\u2019s immune cells produce antibodies (anti-HPAs) that destroy the baby\u2019s platelets. The exact reason behind this is still unknown.\u00a0<\/span><br \/>\u00a0<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Diagnosis\"><\/span>Diagnosis<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">NAIT is often underdiagnosed.\u00a0<\/span><br \/><span style=\"font-weight: 400;\">Routine screening is not practiced unless there is a family history of the condition. For NAIT occurring in the first pregnancy, diagnosis is delayed until further testing following birth.\u00a0<\/span><br \/><span style=\"font-weight: 400;\">If your child\u2019s doctor suspects this condition, they may order a complete blood count (CBC) for your newborn.\u00a0<\/span><br \/><span style=\"font-weight: 400;\">Diagnostic tests can include:<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"HPA_testing\"><\/span><span style=\"font-weight: 400;\">HPA testing<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"font-weight: 400;\">HPA testing includes a blood test to determine if the mother\u2019s blood has anti-HPA antibodies. HPA genotyping of both parents and the newborn helps determine if their respective HPAs are compatible.\u00a0<\/span><br \/><span style=\"font-weight: 400;\">If thrombocytopenia occurred in the previous pregnancy, your doctor will test the fetus. For this, they will draw a fluid sample from the amniotic sac to determine your baby\u2019s platelet antigen type.<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Ultrasound\"><\/span><span style=\"font-weight: 400;\">Ultrasound<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"font-weight: 400;\">An ultrasound uses sound waves to visualize the fetus and look for signs of bleeding.\u00a0<\/span><br \/>\u00a0<\/p>\n\n\n<div  id=\"call-to-action-2da94847369af120cc217563ac968bb7\" style=\"\" class=\"ct_call_to_action\">\n\t<div class=\"container\">\n\t\t<div class=\"block-wrap cta\">\n\t\t\t<div class=\"block-column\">\n\t\t\t\t<div class=\"cta_headings\">\n\t\t\t\t\t\t\t\t\t\t\t<h4 class=\"cta__heading\">\n\t\t\t\t\t\t\tGet IVIG Copay Assistance\u00a0|\u00a0IVIG Financial Assistance\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<span class=\"cta_btn\">\n\t\t\t\t\t\t<a href=\"#form\">Consult an IVIG Specialist<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<p>&nbsp;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Neonatal_Alloimmune_Thrombocytopenia_What_Are_the_Treatment_Options\"><\/span>Neonatal Alloimmune Thrombocytopenia: What Are the Treatment Options?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Treatment varies depending on symptom severity, the fetus&#8217;s gestational age, and the timing of diagnosis (before or after birth).\u00a0<\/span><br \/>\n<span style=\"font-weight: 400;\">Experts recommend initiating treatment in newborns with very low platelet levels, regardless of whether NAIT is confirmed.\u00a0<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Prenatal_treatment_options\"><\/span><span style=\"font-weight: 400;\">Prenatal treatment options\u00a0<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"font-weight: 400;\">For NAIT diagnosed before birth or if the fetus is at a higher risk, doctors may give the mother:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Intravenous Immunoglobulin<\/span><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/ameripharmaspecialty.com\/ivig\/ivig\/\/ivig\/\"><span style=\"font-weight: 400;\">IVIG<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Steroids<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Serial intrauterine platelet transfusions (IUPT)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">IVIG and steroids suppress the mother\u2019s immune system and prevent it from producing antibodies against the baby\u2019s platelets.\u00a0<\/span><br \/>\n<span style=\"font-weight: 400;\">IUPT is invasive and can harm the fetus. Thus, doctors typically use it only when the symptoms don\u2019t improve with IVIG or steroids.<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Postnatal_treatment_options\"><\/span><span style=\"font-weight: 400;\">Postnatal treatment options<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Newborns with NAIT may need IVIG or platelet transfusions to increase their platelet levels. All newborns with NAIT must get a head ultrasound to find out whether there is an absence of intracranial bleeding.\u00a0<\/span><br \/>\n&nbsp;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Neonatal_Alloimmune_Thrombocytopenia_FAQs\"><\/span>Neonatal Alloimmune Thrombocytopenia: FAQs<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h4><span style=\"font-weight: 400;\">What is the difference between autoimmune and alloimmune thrombocytopenia?<\/span><\/h4>\n<p><span style=\"font-weight: 400;\">In autoimmune thrombocytopenia, the antibodies that work against the mother\u2019s platelets also attack the baby\u2019s platelets. On the other hand, alloimmune thrombocytopenia occurs when the mother\u2019s immune system produces antibodies specifically against the baby\u2019s platelets.\u00a0<\/span><\/p>\n<h4><span style=\"font-weight: 400;\">What is the cause of NAIT?<\/span><\/h4>\n<p><span style=\"font-weight: 400;\">In NAIT, a mother\u2019s immune system produces antibodies against the paternally-derived human platelet antigens (HPAs) in the baby\u2019s platelets.\u00a0<\/span><\/p>\n<h4><span style=\"font-weight: 400;\">Does NAIT increase the risk of miscarriage?<\/span><\/h4>\n<p><span style=\"font-weight: 400;\">Miscarriage and stillbirth are the most devastating consequences of NAIT. IVIG is one of the gold-standard therapies for at-risk pregnancies.\u00a0<\/span><br \/>\n&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>La trombocitopenia aloinmune neonatal (NAIT) es un trastorno inmunitario poco frecuente pero grave que afecta a fetos y reci\u00e9n nacidos. Seg\u00fan una revisi\u00f3n de 2021, la NAIT afecta a 1 de cada 1000 nacidos vivos en EE. UU.<\/p>","protected":false},"author":13,"featured_media":23829,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":true,"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[7,4],"tags":[17],"class_list":["post-23828","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ivig","category-other-health-conditions","tag-dr-saba-rassouli"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Everything You Need to Know About Neonatal Alloimmune Thrombocytopenia<\/title>\n<meta name=\"description\" content=\"Read comprehensive information about neonatal alloimmune thrombocytopenia. 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En su tiempo libre, le gusta pasear, leer y probar diferentes restaurantes y comidas.","url":"https:\/\/ameripharmaspecialty.com\/es\/author\/saba-rassouli\/"}]}},"uagb_featured_image_src":{"full":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/01\/mother-baby.jpg",1280,853,false],"thumbnail":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/01\/mother-baby-150x150.jpg",150,150,true],"medium":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/01\/mother-baby-300x200.jpg",300,200,true],"medium_large":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/01\/mother-baby-768x512.jpg",768,512,true],"large":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/01\/mother-baby-1024x682.jpg",1024,682,true],"1536x1536":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/01\/mother-baby.jpg",1280,853,false],"2048x2048":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/01\/mother-baby.jpg",1280,853,false],"trp-custom-language-flag":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/01\/mother-baby.jpg",18,12,false],"block-image-html-large":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/01\/mother-baby-600x400.jpg",600,400,true],"ct-gallery":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/01\/mother-baby-330x220.jpg",330,220,true],"ct-section-header":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/01\/mother-baby-1146x380.jpg",1146,380,true],"ct-thumb":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/01\/mother-baby-86x57.jpg",86,57,true],"ct-thumb-large":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/01\/mother-baby-167x111.jpg",167,111,true],"ct-small":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/01\/mother-baby-280x187.jpg",280,187,true],"ct-medium":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/01\/mother-baby-370x247.jpg",370,247,true],"ct-xmedium":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/01\/mother-baby-960x640.jpg",960,640,true],"ct-large":["https:\/\/ameripharmaspecialty.com\/wp-content\/uploads\/2024\/01\/mother-baby.jpg",1280,853,false]},"uagb_author_info":{"display_name":"Dr. Saba Rassouli, PharmD","author_link":"https:\/\/ameripharmaspecialty.com\/es\/author\/saba-rassouli\/"},"uagb_comment_info":0,"uagb_excerpt":"Neonatal alloimmune thrombocytopenia (NAIT) is a rare but serious immune disorder that affects fetuses and newborns. 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